We report a case of pneumatocele (PC) caused by bronchoscopy and bronchoalveolar lavage performed in a patient with human immunodeficiency virus infection. We speculate that coughing during the bronchoscopy may have contributed to the pathophysiology. A PC is a gas-filled cystic cavity in the lung parenchyma and the mechanism of formation is a 1-way valve that only allows airflow into the cavity. PCs have been described as a congenital malformation, in necrotizing infections, in chronic obstructive pulmonary disease, in hydrocarbon ingestion with aspiration, in human immunodeficiency virus positive adults with Pneumocystis jiroveci pneumonia, and as a result of blunt thoracic trauma. These lesions frequently resolve spontaneously. Most investigators suggest that the treatment is conservative with close follow-up, and invasive approaches should be reserved for patients who develop complications. Features such as fever, cough, and tachypnea, more than 50% involvement of hemithorax, persistent atelectasis, presence of a bronchopleural fistula, and infection in a PC should prompt image-guided transthoracic aspiration and catheter drainage or surgery.