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Journal of Bronchology & Interventional Pulmonology:
doi: 10.1097/LBR.0000000000000060
Case Reports

Unusual Triad of Obstructive Sleep Apnea, Uncontrolled Hypertension, and Severe Hypokalemia Due to Ectopic Adrenocorticotropic Secretion

Venkatram, Sindhaghatta MD, FCCP*; Vakde, Trupti MD; Badipatla, Kanthi MD; Niazi, Masooma MD§; Diaz-Fuentes, Gilda MD, FCCP*

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Abstract

Ectopic adrenocorticotropic hormone secretion is responsible for 12% to 17% of all cases of the Cushing syndrome. One of the most commonly described causes of ectopic adrenocorticotropic hormone secretion is small cell carcinoma of the lung. A rare cause includes a functioning neuroendocrine tumor traditionally known as carcinoids that account for 5% of all mediastinal tumors. To our knowledge, all reported cases of mediastinal carcinoids are thymic in origin and only a minority of those is functional. We present a male patient with hypertension, obstructive sleep apnea, and acid-base disorder, in whom further investigation revealed an anterior mediastinal mass and Cushing syndrome.

Copyright © 2014 by Lippincott Williams & Wilkins

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