Ectopic adrenocorticotropic hormone secretion is responsible for 12% to 17% of all cases of the Cushing syndrome. One of the most commonly described causes of ectopic adrenocorticotropic hormone secretion is small cell carcinoma of the lung. A rare cause includes a functioning neuroendocrine tumor traditionally known as carcinoids that account for 5% of all mediastinal tumors. To our knowledge, all reported cases of mediastinal carcinoids are thymic in origin and only a minority of those is functional. We present a male patient with hypertension, obstructive sleep apnea, and acid-base disorder, in whom further investigation revealed an anterior mediastinal mass and Cushing syndrome.
*Division of Pulmonary and Critical Care Medicine
†Division of Pulmonary and Critical Care Medicine
Departments of ‡Internal Medicine
§Pathology, Bronx Lebanon Hospital Center, Bronx, NY
T.V. and K.B. wrote draft of the manuscript; G.D.-F. and S.V. revised the manuscript critically for important intellectual content and gave final approval of the version to be published. M.N. has been involved in obtaining and revising pathological images.
Disclosure: There is no conflict of interest or other disclosures.
Reprints: Gilda Diaz-Fuentes, MD, FCCP, Division of Pulmonary and Critical Care Medicine, Bronx Lebanon Hospital Center, Bronx, NY 10457 (e-mail: firstname.lastname@example.org).
Received May 24, 2013
Accepted February 17, 2014