A 55-year-old man developed cerebral air embolism after transbronchial lung biopsy of a lung mass. Only 3 such cases have been reported previously, in patients with miliary tuberculosis, amyloidosis, and interstitial lung disease. Our patient did not have a diffuse interstitial lung disease and is the only survivor of this extremely rare complication. His neurologic deficits resolved completely, and progressive disappearance of air on serial computed tomography examination of the brain is also documented. Cerebral air embolism after transbronchial biopsy can occur in patients with lung cancer.