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The effects of preloading infusion with hydroxyethyl starch 200/0.5 or 130/0.4 solution on hypercoagulability and excessive platelet activation of patients with colon cancer

Liang, Huaa,b; Yang, Cheng-Xiangb; Li, Hengb; Wen, Xian-Jieb; Zhou, Qiao-Lingb; Gu, Miao-Ninga

Blood Coagulation & Fibrinolysis: July 2010 - Volume 21 - Issue 5 - p 406–413
doi: 10.1097/MBC.0b013e328337551f
Original Article

Hypercoagulability and excessive platelet activation account for a significant percentage of mortality and morbidity in cancer patients. In order to test the hypothesis that preloading infusion (PLI) with 6% hydroxyethyl starch 200/0.5 (HES 200), or 6% hydroxyethyl starch 130/0.4 (HES 130) solution can attenuate the hypercoagulable state and inhibit excessive platelet activation of patients with colon cancer, we selected 35 colon cancer patients undergoing laparoscopic-assisted radical colectomy. They were received randomly a test of 15 ml/kg of either HES 200 (n = 17), or HES 130 (n = 18) over a 30-min period preoperatively. In addition, fifteen healthy volunteers were selected as normal control group. Coagulation function was assessed by thrombelastography (TEG), platelet glycoprotein IIb/IIIa and CD62P was analyzed by flow cytometry before PLI, the end of PLI, 1 h after PLI, and 1 h after the end of surgery. Results demonstrated that hypercoagulable state indicated by TEG and excessive platelet activation was found in patients with colon cancer. We found that preloading infusion with HES 200/0.5 can inhibit platelet activation, and the two solutions, especially HES 200/0.5, compromised TEG parameters that indicated hypercoagulability of patients with colon cancer during perioperative period.

aDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, China

bDepartment of Anesthesiology, Affiliated FoShan Hospital of SUN YAT-SEN University, FoShan, China

Received 16 November, 2009

Revised 4 January, 2010

Accepted 4 January, 2010

Correspondence to Hua Liang M.D., Department of Anesthesiology, Affiliated FoShan Hospital of SUN YAT-SEN University, DaFuNan Road 3, FoShan 528000, China Tel: +86 15815960939; fax: +86 757 83162513; e-mail: lhlh2003@126.com

© 2010 Lippincott Williams & Wilkins, Inc.