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Factor V Leiden in Greek thrombophilia patients: relationship with activated protein C resistance test and levels of thrombin-antithrombin complex and prothrombin fragment 1+2.

Lambropoulos, A. F.; Foka, Z.; Makris, M.; Daly, M.; Kotsis, A.; Makris, P. E.

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We studied 172 Greek patients (72 men aged 44.0 x 16.7 years and 100 women aged 46.5 x 14.1 years) with an unexplained thrombophilic tendency. One hundred and four apparently healthy persons (63 men aged 34.2 x 10.0 years and 41 women aged 37.1 x 13.3 years) were included as a control group. We performed the activated protein C resistance (APC-r) test using a clotting test (Chromogenix kit), detection of factor V Leiden using polymerase chain reaction (PCR)-restriction fragment length polymorphisms and measurement of thrombin-antithrombin complexes (TAT) and prothrombin fragment 1+2 (F1+2) levels with an immunoenzymatic assay. The normal range for the APC-r test (> 2.12) was determined from the controls. The factor V Leiden mutation was found in 31.9% of all the patients tested, in 28.1% of the unrelated patients with documented thrombophilic tendency of unknown origin and in 4.8% of the healthy controls. The APC-r test had a sensitivity of 0.42 and a specificity of 0.91 for the detection of factor V Leiden. Furthermore, we found no significant difference in levels of TAT and F1+2 between patients with and without the mutation and there was no correlation between aPC-r values and levels of TAT and F1+2.

(C) Lippincott-Raven Publishers.


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