Behavioural Pharmacology

Skip Navigation LinksHome > February 2014 - Volume 25 - Issue 1 > Ethanol effects on multiple fixed-interval, fixed-ratio resp...
Behavioural Pharmacology:
doi: 10.1097/FBP.0000000000000011
Short Report

Ethanol effects on multiple fixed-interval, fixed-ratio responding in mice with deletions of the serotonin transporter gene

Lamb, Richard J.a,c; Pinkston, Jonathan W.a,d; Daws, Lynette C.b,c

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Abstract

Serotonin transporter knockout (KO) mice self-administer less ethanol than either heterozygous or wild-type mice; however, the mechanistic basis for this difference remains unclear. Here we examine the possibility that ethanol more readily decreases responding in KO mice, thereby limiting ethanol self-administration. To examine whether KO mice were more sensitive to the response-decreasing effects of ethanol, we administered ethanol (0.2–3.2 g/kg) to mice responding under a multiple fixed-ratio 30-response, fixed-interval 300-s schedule of milk presentation. Ethanol decreased responding similarly in all three genotypes. Fixed-ratio responding tended to be decreased at lower doses than fixed-interval responding. The decreased level of ethanol self-administration in serotonin transporter KO mice is not explained by an increased sensitivity to the response-decreasing effects of ethanol in KO mice, as sensitivity to the response-decreasing effects of ethanol was similar in the KO, heterozygous, and wild-type mice.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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