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Effects of sodium butyrate in animal models of mania and depression: implications as a new mood stabilizer

Resende, Wilson R.; Valvassori, Samira S.; Réus, Gislaine Z.; Varela, Roger B.; Arent, Camila O.; Ribeiro, Karine F.; Bavaresco, Daniela V.; Andersen, Monica L.; Zugno, Alexandra I.; Quevedo, João

doi: 10.1097/FBP.0b013e32836546fc
Research Reports

Bipolar disorder is a severe mood disorder with high morbidity and mortality. Despite adequate treatment, patients continue to have recurrent mood episodes, residual symptoms, and functional impairment. Some preclinical studies have shown that histone deacetylase inhibitors may act on depressive-like and manic-like behaviors. Therefore, the aim of the present study was to evaluate the effects of sodium butyrate (SB) on behavioral changes in animal models of depression and mania. The animals were submitted to protocols of chronic mild stress or maternal deprivation for induction of depressive-like behaviors and subjected to amphetamine, or ouabain administration for induction of manic-like behaviors. SB reversed the depressive-like and manic-like behaviors evaluated in the animal models. From these results we can suggest that SB may be a potential mood stabilizer.

aLaboratory of Neurosciences, National Institute for Translational Medicine (INCT-TM), and Center of Excellence in Applied Neurosciences of Santa Catarina (NENASC), Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, Santa Catarina

bDepartment of Psychobiology, University Federal of São Paulo, São Paulo, Brazil

Correspondence to Samira S. Valvassori, PhD, Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC 88806-000, Brazil E-mail: samiravalvassori@unesc.net

Received January 27, 2013

Accepted July 2, 2013

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