Systemic Medication for the Treatment of Diabetic Foot Ulcers
Foot ulcers are a common complication from diabetes than can lead to hospitalization and lower limb amputation. In the prospective randomized, double-blinded, placebo-controlled clinical trial, 216 participants with diabetic foot ulcers free of visible infection were assigned to receive either the tissue repair drug polydeoxyribonucleotide (PDRN) or a placebo. After 2 months, 37% of the patients who were treated with PDRN had their ulcers completely closed, compared with nearly 19% of the patients who received the placebo.
Engineered Skin Grafts Contain Blood and Lymph Vessels
Researchers at the University of Zurich, Switzerland, have successfully engineered a skin graft that is similar to full-thickness skin containing functional blood and lymphatic capillaries. Only a limited area of skin is required to be removed from individual patients to engineer a complex skin graft in the laboratory. There are advantages of a full-thickness graft, including less scarring. In addition, the lymphatic and blood capillaries will prevent the accumulation of tissue fluid and ensure rapid blood supply to improve the survival of skin graft. This innovation is a major advance in molecular tissue biology and regenerative medicine.
Wound Dressing Incorporate Bioelectriceuticals Technology
Procellera from Vomaris Wound Care is the first wireless microcurrent-generating dressing that produces electrical fields through its matrix of microcell batteries. This dressing and its wireless microcurrents have been found to enhance keratinocyte migration (a critical event in wound re-epithelialization), compared to controls in in-vitro laboratory testing. The substantial potential of this technology has been unveiled through hard core interdisciplinary mechanistic science. Researchers identified several mechanisms behind potential benefits of bioelectriceuticals in wound care, including hydrogen peroxide production to deter bacteria proliferation; phosphorylation of redox-sensitive IGF1R to facilitate cell migration; and reduction of protein thiols and increase in integrin expression, both of which are known to promote intracellular and extracellular communication. The technology can also increase keratinocyte mitochondrial membrane potential to improve its cell motility capacity.
Health Coaching to Help People with Diabetes
People with diabetes are at a higher risk of suffering oral health problems, such as periodontitis, caries, dry mouth, fungal infections, and wounds. Researchers at the University of Copenhagen Health reported that health coaching have helped people with diabetics to feel empowered, boost their self-efficacy and assume responsibility for their oral health. Motivational health coaching by professionals reaches out to high-risk groups and provides personal guidance on topics like diet, stress management, and dental care. Coaching is superior to patients who simply receive information about dental health from printed brochures. Patients attended coaching achieved a significant decline in blood sugar and periodontitis by as much as 50% over 6 months.
Birch Extract for Wound Healing
Scientists from the Institute of Pharmaceutical Sciences of the University of Freiburg have discovered the molecular mechanism behind the wound-healing effect of an extract from the outer white layer of the tree's bark. The birch bark extract contains betulin, which could enhance the inflammatory response to help remove foreign bacteria and dead tissue in the initial phase of wound healing. During the later phase of wound healing, betulin and lupeol in the birch extract activate proteins that are involved in the restructuring of the actin cytoskeleton, which gives the cell its shape with the help of the structural protein actin. This allows keratinocytes to migrate more quickly into the wound for healing.
Dermagraft Is Sold to Organogenesis
Shire plc announced that it has entered into a definitive agreement pursuant to which it has sold its Dermagraft assets to Organogenesis Inc. Dermagraft is a living skin substitute indicated for use in the treatment of full-thickness diabetic foot ulcers and is approved for use in the United States and Canada.
ConvaTec Launches New Aquacel Ag+ Wound Dressings
A majority of chronic wounds contain biofilm produced by colonies of bacteria to protect themselves. It is difficult to remove, reforms quickly, and is a key cause of delayed wound healing. ConvaTec has announced the launch of new Aquacel Ag+ wound dressings in countries in the European Union, Canada, Hong Kong, and Malaysia. The new technology destroys wound biofilm and reduces infection-causing bacteria in an in vitro biofilm model, according to the manufacturer.