Ionic Fluid to Fight Biofilm
Biofilm-forming bacteria account for approximately 80% of total bacterial infections and the unique structure render bacteria inside biofilm resistant to antibiotics. A research team from Los Alamos National Laboratory has identified a unique class of materials, known as ionic liquids (eg, choline-geranate) that are more effective than bleach in neutralizing biofilm-forming pathogens with minimal cytotoxicity effects on human cell. The ionic liquids are able to penetrate through the skin and may also help the transdermal delivery of drugs.
Wound Healing Delayed by Neutrophil Extracellular Traps
Delayed wound healing is a common complication of people with diabetes. According to scientists from the Boston Children’s Hospital’s Program in Cellular and Molecular Medicine, wound healing is impeded by excessive release of neutrophil extracellular traps (NETs) in diabetic mice. Although NETs are produced by neutrophils as part of an inflammatory response during the healing process, the NETs form a dense, toxic mesh that could interfere with the migration of new skin cells to the wound base. Mice treated with DNase 1 (an enzyme that breaks up DNA and disables NETs) displayed better healing by 20% compared with untreated animals.
Innovative Nitric Oxide Generating Wound Dressing for Diabetic Foot Ulcers
Diabetic foot ulcers are the leading cause of nontraumatic-related amputation and severe disability. EdixoMed Limited (Manchester, United Kingdom) had developed and launched an innovative nitric oxide-generating wound dressing (NOx). Nitric oxide is a potent vasodilator and broad-spectrum antimicrobial agent and is released by the dressing in a controlled and sustained fashion that mimics the natural physiological production in normal skin. Nitric oxide may correct ischemia and infection. A randomized controlled clinical study that involved 120 patients with chronic diabetic foot ulcers in the United Kingdom demonstrated promising clinical outcomes. Two-thirds of the patients treated with nitric oxide generating dressing (NOx) achieved wound area reduction by more than 90% compared with one-third of the patients who received standard care.
New Products with Dialkylcarbamoylchloride (DACC) Technology
BSN Medical (Hamburg, Germany) has introduced 3 new wound care products that incorporate products dialkylcarbamoylchloride (DACC) technology. DACC Technology attracts bacteria into the dressing material and inactivates them. These products include Cutimed sorbact hydroactive B dressing for wounds with low to moderate exudate levels, Cutimed siltec sorbact foam dressing with siltec foam structure for heavy exudative wounds, and Leukomed sorbact for surgical sites.
New Collagen Wound Dressings for Oral Wounds
NovaBone (Jacksonville, Florida) has received approval from the FDA to launch 2 new collagen wound dressings. NovaTape and NovaPlug are designed to manage oral wounds and sores, including dental sores, oral ulcers, periodontal surgical wounds, suture sites, burns, extraction sites, and surgical/traumatic wounds.