Wireless Sensors Help Detect Surgical Site Infection
Surgical site infections are the most common complication following surgical procedures and account for nearly 20% of all healthcare-associated infections. Complications may include additional surgery, implant removal, delayed wound healing, increased use of antibiotics, and death. Researchers from Rensselaer Polytechnic Institute are investigating an antigen-sensitive hydrogel integrated into a small, simple, inexpensive wireless sensor for the detection of surgical site infections associated with orthopedic implants. Early detection has the potential to guide therapy, improve outcomes, and reduce readmissions, revisions, and costs associated with implant-related infections.
Mesenchymal Stem Cell Exosomes Offer Hope in Healing Chronic Wounds
New research at the University of Miami Miller School of Medicine demonstrates how mesenchymal stem cell exosomes could enhance the growth and migration of normal and chronic wound fibroblasts, and induce the development of new blood vessels in vitro.
Cytokines and Wound Failure
A team from the Uniformed Services University Walter Reed Surgical Critical Care Initiative collected blood, tissue and serum samples from 73 patients who sustained 116 life-threatening combat wounds. They analyzed tissue samples that were taken prior to and during each surgical debridement along with biomarker data and clinical observation. By characterizing patterns of inflammation using computer analytic methods, the team was able to determine the presence of cytokines that predicts the likelihood of wound failure. These predictions could help healthcare providers to stratify risks and make critical, time-sensitive decision as to when to close a wound; both premature and late closing can lead to serious complications for the patient.
Mussel Protein-Based Bioadhesive for Wound Closure
Mechanical fasteners like sutures and staples are used to hold body tissues together, but their use is limited when handling delicate tissues and internal organs. They can cause tissue damage, complicated post-treatment management, and scars. Although tissue adhesives have been made available as an alternative that does not require tissue penetration, most surgical glues do not stick in a wet environment. Korean scientists at Pohang University of Science and Technology have developed a bioadhesive that is inspired by the mechanism that allows mussels to attach to underwater surfaces and insects maintain structural balance and flexibility. The so-called mussel adhesive proteins can be activated by blue light, triggering a photo-oxidation reaction. The tyrosine residues are chemically coupled into dityrosine cross-links, giving rise to a new hydrogel substrate that has structural stability and adhesive properties in wet conditions. The new adhesive hydrogel not only closes an open wound on a bleeding site within less than 60 seconds, but also effectively facilitates the healing process without inflammation or a scar.
Integra LifeSciences Holdings Corporation Acquires TEI Biosciences Inc
Integra LifeSciences Holdings Corporation has completed the acquisition of TEI Biosciences Inc and TEI Medical Inc, a Massachusetts-based, privately held, biomedical company. This new acquisition of TEI complements will allow Integra to expand its reconstructive surgery and regenerative wound care product with the addition of the complementary technology platform SurgiMend and Primatrix, both acellular biologic matrices.
Organogenesis to Introduce New Wound Management Products
Organogenesis recently introduced new PuraPly wound management products, including PuraPly and PuraPly Antimicrobial (PuraPly AM), which are the new additions to the firm's portfolio of advanced wound-care products. PuraPly AM is claimed to be the first FDA-cleared purified collagen matrix with polyhexamethylene biguanide hydrochloride antimicrobial agent. Both FDA 510(k)-cleared Class II medical devices have received approval for acute and chronic wound management across different wound types, such as partial- and full-thickness wounds, pressure ulcers, surgical wounds, trauma wounds, venous and diabetic ulcers. Both products are available in different sizes that will meet the needs of a variety of wound types.