Impaired Insulin Metabolism in Periwound Skin Can Affect Healing
Wound healing is impaired in people with diabetes because high levels of glucose in the blood can affect blood vessels, nerves, and the immune system. In Cologne, Germany, researchers demonstrated in a study, using the skin of larvae of the fruit fly Drosophila melanogaster, that slowed insulin metabolism at the wound site can directly affect neighboring cells involved in wound healing. After a skin injury, the periwound cells respond by forming an actomyosin cable around the wound. The ring gradually contracts to seal off the gap until complete healing is achieved. When insulin metabolism is impaired, the formation of actomyosin cable ring is delayed and weak. This results in incomplete or slow wound healing.
Wireless Electroceutical Dressing to Promote Wound Healing
A team of researchers at Ohio State University has created a portable adhesive patch that delivers a continuous, small electrical current. The wireless electroceutical dressing mimics the natural physiological process and harnesses the body's innate response to injury to help wounds heal and destroy biofilm. The new prototype is made of a combination of silk and silver and includes a flexible, portable, and self-contained battery that delivers a continuous, safe, low-level electrical current to the injury. Preliminary data indicated that infected wounds covered by the experimental bioelectric dressing healed better and more quickly than those covered with a plain dressing that is commonly used in the care of wounds. Researchers hypothesize that the electrical currents may disrupt bacteria in 2 ways: by interrupting the production of chemical messages that instruct bacteria to develop biofilms and by weakening the molecular structure of existing biofilms, potentially making them more susceptible to antibiotics or the body's natural immune response.
Fungus Promote Biofilm Formation
Researchers in Pennsylvania and Iowa have discovered that fungal communities found in chronic wounds can form mixed bacterial-fungal biofilms leading to poor healing outcomes. The team followed 100 patients with diabetic foot ulcers over 26 weeks. Eighty percent of the wounds harbored fungi including Cladosporium herbarum that was found in 41% of the samples and Candida albicans found more than one-fifth of the samples. High levels of ascomycetes, or sac fungi, were associated with wounds that took longer than 8 weeks to heal. Although no single species of fungi was associated with poor outcomes, mixed communities were associated with slow healing or complications, such as bone infection and amputation.
Development of Atmospheric Plasma Wound Treatment Device
Advanced Plasma Products and its partners from the Montana State University and the University Of Tennessee are working on the development and testing of the Atmospheric Plasma Wound Applicator device to treat chronic wounds that are difficult to treat. Plasma forms when certain amounts of energy, like heat or more commonly some kind of electricity, passes through a gas.
The collection of free electrons and ionized gas, called plasma, can support wound healing by its antiseptic effects, by stimulation of proliferation and migration of wound relating skin cells, by activation or inhibition of integrin receptors on the cell surface or by its proangiogenic effect.