Skip Navigation LinksHome > June 2014 - Volume 27 - Issue 6 > Inactivation of Candida albicans Following Exposure to 624-N...
Advances in Skin & Wound Care:
doi: 10.1097/01.ASW.0000443268.25288.63
Features: Original Investigations

Inactivation of Candida albicans Following Exposure to 624-Nanometer Light from a Supraluminous Diode Array

Guffey, J. Stephen PT, EdD; Payne, William MS, ASCP(MT); James, Leslie BS; Qian, Zhuoyuan BS; Dodson, Carly

Collapse Box

Abstract

OBJECTIVE: To determine the potential for visible light (405 or 624 nm) to produce an inhibitory effect on Candida albicans. In addition, the study sought to evaluate a series of doses in terms of their respective inhibiting capabilities.

BACKGROUND DATA: The authors have studied the effect of blue light on Staphylococcus aureus and found that a bactericidal outcome can be obtained with low doses of blue light.

METHODS: Candida albicans was tested because of its common appearance in human skin and mucous membrane infections. The organism was treated in vitro with 405-nm (blue) and with 624-nm (red) light emitted from a supraluminous diode array. Doses of 3, 9, 15, 30, and 60 J/cm2 were used. Colony counts were performed and compared with untreated controls using Student t tests and 1-way analysis of variance with Tukey post hoc analysis.

RESULTS: The results revealed no inhibition produced by 405 nm on C albicans (F4,20 = 0.901; P = .482). However, 624 nm did inhibit growth of C albicans at 3, 9, and 30 J/cm2 (F4,20 = 6.064; P = .002).

CONCLUSIONS: Appropriate doses of 624-nm light from a supraluminous diode array can inhibit the growth of C albicans in vitro. Three, 9, and 30 J/cm2 are all effective dose levels.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins. All world rights reserved.

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.