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Advances in Skin & Wound Care:
doi: 10.1097/01.ASW.0000443268.25288.63
Features: Original Investigations

Inactivation of Candida albicans Following Exposure to 624-Nanometer Light from a Supraluminous Diode Array

Guffey, J. Stephen PT, EdD; Payne, William MS, ASCP(MT); James, Leslie BS; Qian, Zhuoyuan BS; Dodson, Carly

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OBJECTIVE: To determine the potential for visible light (405 or 624 nm) to produce an inhibitory effect on Candida albicans. In addition, the study sought to evaluate a series of doses in terms of their respective inhibiting capabilities.

BACKGROUND DATA: The authors have studied the effect of blue light on Staphylococcus aureus and found that a bactericidal outcome can be obtained with low doses of blue light.

METHODS: Candida albicans was tested because of its common appearance in human skin and mucous membrane infections. The organism was treated in vitro with 405-nm (blue) and with 624-nm (red) light emitted from a supraluminous diode array. Doses of 3, 9, 15, 30, and 60 J/cm2 were used. Colony counts were performed and compared with untreated controls using Student t tests and 1-way analysis of variance with Tukey post hoc analysis.

RESULTS: The results revealed no inhibition produced by 405 nm on C albicans (F4,20 = 0.901; P = .482). However, 624 nm did inhibit growth of C albicans at 3, 9, and 30 J/cm2 (F4,20 = 6.064; P = .002).

CONCLUSIONS: Appropriate doses of 624-nm light from a supraluminous diode array can inhibit the growth of C albicans in vitro. Three, 9, and 30 J/cm2 are all effective dose levels.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins. All world rights reserved.


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