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Advances in Skin & Wound Care:
doi: 10.1097/01.ASW.0000431237.22658.15
Features: Original Investigations

Improvement of Periulcer Skin Condition in Venous Leg Ulcer Patients: Prospective, Randomized, Controlled, Single-blinded Clinical Trial Comparing a Biosynthetic Cellulose Dressing with a Foam Dressing

Dini, Valentina MD; Romanelli, Marco MD, PhD; Andriessen, Anneke PhD, PA; Barbanera, Sabrina MD; Bertone, Maria Stefania NT; Brilli, Cinzia RN; Abel, Martin PhD

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Abstract

OBJECTIVES:

The aim of this study was to investigate the influence of a biosynthetic cellulose wound dressing (BWD) to stimulate wound healing in patients with a venous leg ulcer on periulcer skin condition when compared with standard care using a foam dressing.

METHODS:

Each patient with a venous ulcer received compression therapy with a short stretch bandage system and either a BWD + foam (study group [SG]) or foam (control group [CG]). Periulcer skin condition was compared with the untreated lower leg skin and the forearm skin, using noninvasive parameters, comparing day 0 versus day 28 results. Ulcers were further evaluated for healing rate. The study period was 28 days, and the follow-up period was 12 weeks. Fifty patients were recruited to the study, of which N = 46 (SG, n = 26; CG, n = 20) completed the 28-day study period and were included in the analysis.

RESULTS:

The BWD showed a more improved periulcer skin condition versus the CG. Transepidermal water loss was significantly less in the SG (P = .003), as well as the results shown with the chromatometer (P =. 05). Ulcer healing rate was also statistically significant in favor of the SG (P = .0001).

CONCLUSION:

Treatment for the BWD + foam group was shown to be safe and significantly improved periwound skin condition, leading to more expeditious wound healing than treatment with foam alone.

Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins

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