Skip Navigation LinksHome > August 2013 - Volume 26 - Issue 8 > Improvement of Periulcer Skin Condition in Venous Leg Ulcer...
Advances in Skin & Wound Care:
doi: 10.1097/01.ASW.0000431237.22658.15
Features: Original Investigations

Improvement of Periulcer Skin Condition in Venous Leg Ulcer Patients: Prospective, Randomized, Controlled, Single-blinded Clinical Trial Comparing a Biosynthetic Cellulose Dressing with a Foam Dressing

Dini, Valentina MD; Romanelli, Marco MD, PhD; Andriessen, Anneke PhD, PA; Barbanera, Sabrina MD; Bertone, Maria Stefania NT; Brilli, Cinzia RN; Abel, Martin PhD

Collapse Box


OBJECTIVES: The aim of this study was to investigate the influence of a biosynthetic cellulose wound dressing (BWD) to stimulate wound healing in patients with a venous leg ulcer on periulcer skin condition when compared with standard care using a foam dressing.

METHODS: Each patient with a venous ulcer received compression therapy with a short stretch bandage system and either a BWD + foam (study group [SG]) or foam (control group [CG]). Periulcer skin condition was compared with the untreated lower leg skin and the forearm skin, using noninvasive parameters, comparing day 0 versus day 28 results. Ulcers were further evaluated for healing rate. The study period was 28 days, and the follow-up period was 12 weeks. Fifty patients were recruited to the study, of which N = 46 (SG, n = 26; CG, n = 20) completed the 28-day study period and were included in the analysis.

RESULTS: The BWD showed a more improved periulcer skin condition versus the CG. Transepidermal water loss was significantly less in the SG (P = .003), as well as the results shown with the chromatometer (P =. 05). Ulcer healing rate was also statistically significant in favor of the SG (P = .0001).

CONCLUSION: Treatment for the BWD + foam group was shown to be safe and significantly improved periwound skin condition, leading to more expeditious wound healing than treatment with foam alone.

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins. All world rights reserved.


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.