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Use of Platelet-Rich Plasma and Hyaluronic Acid in the Loss of Substance with Bone Exposure

Cervelli, Valerio MD; Lucarini, Lucilla MD; Spallone, Diana MD; Palla, Ludovico MD; Colicchia, Gianfranco Marcello MD; Gentile, Pietro MD; De Angelis, Barbara MD

Advances in Skin & Wound Care: April 2011 - Volume 24 - Issue 4 - pp 176-181
doi: 10.1097/01.ASW.0000396302.05959.d3
Features: Original Investigation

OBJECTIVE: In lower-extremity surgery, the complex wound with bone exposure remains a challenging problem for the plastic surgeon. The purpose of this study was to describe a new therapeutic approach to stimulate the regeneration of the lower-extremity complex wounds based on a combined treatment composed of platelet-rich plasma (PRP) and hyaluronic acid (HA) dressing.

DESIGN: Wounds with posttraumatic bone exposure have been treated with HA dressing alone or in combination with PRP.

PATIENT: Fifteen patients affected by lower-extremity wound with posttraumatic bone exposure have been treated at the Department of Plastic and Reconstructive Surgery, University of Tor Vergata, Rome, Italy.

RESULTS: After a single treatment, the authors observed that the mean re-epithelialization time was 8.1 weeks in 73.3% patients treated with PRP and HA dressing versus the 30% patients treated with HA dressing only.

CONCLUSION: These data confirm the evidence of using PRP technology in the healing of both soft- and hard-tissue wounds. Moreover, the satisfaction of the patient confirms the quality of this study's results.

In this study, the authors describe a new therapeutic approach to stimulate the regeneration of low-extremity complex wounds based on a combined treatment composed of platelet-rich plasma and hyaluronic acid dressing.

Valerio Cervelli, MD, is director; Lucilla Lucarini, MD, is a physician; Diana Spallone, MD, is a physician; Ludovico Palla, MD, is a physician; Gianfranco Marcello Colicchia, MD, is a plastic surgeon; Pietro Gentile, MD, is a plastic surgeon; and Barbara De Angelis, MD, is a plastic surgeon; all in the Department of Plastic and Reconstructive Surgery, University of Tor Vergata, Rome, Italy.

Submitted December 22, 2009; accepted in revised form June 15, 2010.

© 2011 Lippincott Williams & Wilkins, Inc.