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Comparative Bone Regeneration Potential Studies of Collagen, Heparin and Polydopamine coated Multichannelled BCP Granules.

Lee, Gun Hee; Makkar, Preeti; Paul, Kallyanshis; Lee, Byong Taek
doi: 10.1097/MAT.0000000000000582
Original Article: PDF Only

The present work is a comparative assessment of the bone regeneration potentiality of bone substitutes comprised of bioactive polymer coated biphasic calcium phosphate (BCP) granules. The bone substitutes were primarily composed of multichanneled BCP granules which were coated separately with biochemical polymer coatings, namely collagen, heparin or polydopamine, using chemical methods. The morphological features and chemical structure of the granules and surface coatings were characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) respectively. The biological characterizations in terms of cellular interaction with the bone substitutes invitro (MTT assay and proliferation) and invivo (bone regeneration efficacy) were carried out and compared with uncoated BCP granules. It was found that polydopamine coated BCP granules were superior to the others with respect to promoting more rapid healing. Therefore, PD-MCG system can be used as a promising injectable bone substitute for clinical applications.

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