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The Effect of Inflow Cannula Length on the Intraventricular Flow Field: An In Vitro Flow Visualization Study Using the Evaheart Left Ventricular Assist Device

May-Newman, Karen*; Moon, Juyeun*; Ramesh, Varsha*; Montes, Ricardo*; Campos, Josue*; Herold, Brian*; Isingoma, Paul*; Motomura, Tadashi; Benkowski, Robert

doi: 10.1097/MAT.0000000000000559
Biomedical Engineering

Left ventricular assist device (LVAD) inflow cannula malposition is a significant risk for pump thrombosis. Thrombus development is influenced by altered flow dynamics, such as stasis or high shear that promote coagulation. The goal of this study was to measure the intraventricular flow field surrounding the apical inflow cannula of the Evaheart centrifugal LVAD, and assess flow stasis, vortex structures, and pulsatility for a range of cannula insertion depths and support conditions. Experimental studies were performed using a mock loop with a customized silicone left ventricle (LV) and the Evaheart LVAD. A transparent inflow cannula was positioned at 1, 2, or 3 cm insertion depth into the LV and the velocity field in the LV midplane was measured for 2 levels of LVAD support: 1800 and 2300 rpm. The LV velocity field exhibits a diastolic vortex ring whose size, path, and strength are affected by the flow conditions and cannula position. During diastole, the large clockwise midplane vortex grows, but its circulation and kinetic energy are reduced with cannula insertion depth. The counterclockwise vortex is smaller and exhibits more complex behavior, reflecting a flow split at 3 cm. Overall, the 1 cm cannula insertion depth produces the flow pattern that exhibits the least apical flow stasis and greatest pulsatility and should correlate to a lower risk of thrombus formation.

From the *Bioengineering Program, San Diego State University, San Diego, California; Evaheart, Inc., Houston, Texas; and B-Squared Medical Device Solutions, Fort Worth, Texas.

Submitted for consideration October 2016; accepted for publication in revised form March 2017.

Disclosure: K. May-Newman is a consultant for B-Squared Medical Device Solutions.

Supported by Evaheart, Inc.

Correspondence: Karen May-Newman, PhD, Department of Mechanical Engineering, San Diego State University, 5500 Campanile Dr., San Diego, CA 92182-1323. Email:

Copyright © 2017 by the American Society for Artificial Internal Organs