Current hollow fiber membrane lungs feature a predominantly straight blood path length across the fiber bundle, resulting in limited O2 transfer efficiency because of the diffusion boundary layer effect. Using computational fluid dynamics and optical flow visualization methods, a hollow fiber membrane lung was designed comprising unique concentric circular blood flow paths connected by gates. The prototype lung, comprising a fiber surface area of 0.28 m2, has a rated flow of 2 L/min, and the oxygenation efficiency is 357 ml/min/m2. The CO2 clearance of the lung is 200 ml/min at the rated blood flow. Given its high gas transfer efficiency, as well as its compact size, low priming volume, and propensity for minimal thrombogenicity, this lung design has the potential to be used in a range of acute and chronic respiratory support applications, including providing total respiratory support for infants and small children and CO2 clearance in adults.
From the *Department of Surgery, University of Michigan, Ann Arbor, Michigan; †Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan; and ‡Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Aachen, Germany.
Submitted for consideration November 2016; accepted for publication in revised form May 2017.
This work was supported by the NIH 2R01 HD015424-29. Supported, in part, by the Excellence Initiative of the German federal and state governments in the framework of the I3TM Seed Fund Program.
Disclosure: The authors have no conflicts of interest to report.
Correspondence: Robert H. Bartlett, University of Michigan ECLS Laboratory, 1150 W. Medical Center Drive, B560 MSRBII, Ann Arbor, MI 48109. Email: email@example.com.