Improvement in Blood Glucose Control in Patients With Diabetes After Implantation of Left Ventricular Assist Devices

Guglin, Maya*; Maguire, Kim; Missimer, Taylor*; Faber, Cristiano; Caldeira, Christiano

ASAIO Journal:
doi: 10.1097/MAT.0000000000000064
Adult Circulatory Support

Some reports suggest that the course of diabetes mellitus (DM) in heart failure (HF) may improve after implantation of left ventricular assist devices (LVADs). The objective of our study was to explore longitudinal changes in glycosylated hemoglobin (HbA1C) in patients with diabetes mellitus with advanced HF post-LVAD implantation. We retrospectively reviewed the records of all patients who received LVADs at our institution between 2002 and 2012 and selected those who 1) survived posthospital discharge and 2) had DM. We collected data on HbA1C before and after implantation of LVADs, daily doses of insulin, and antidiabetic drugs. Comparisons were done using Student’s t-test. A total of 50 patients met the inclusion criteria. HbA1C was 7.6 ± 1.6 before LVAD, 5.7 ± 0.9 within 3 months after the LVAD implant (p = 0.0001), 6.1 ± 1.0 (p = 0.004 in comparison with pre-LVAD level) in 3–6 months after the implant, 6.3 ± 1.0 (p = 0.01) in 6–9 months, and 5.3 ± 0.1 in 9–12 months (p = 0.002). There were no significant changes in body mass index. Favorable changes in clinical course of diabetes in patients with HF occur after the implantation of LVADs, persist for at least 1 year after the implant, and are likely associated with improved hemodynamics and metabolism after normalization of cardiac output.

Author Information

From the *Department of Cardiology, University of South Florida, Tampa, Florida; Department of Medicine, University of South Florida, Tampa, Florida; and Advanced Cardiothoracic Surgery and Tampa General Hospital, Tampa, Florida.

Submitted for consideration December 24, 2013; accepted for publication in revised form February 5, 2014.

Disclosures: The authors have no conflicts of interest to report.

Reprint Requests: Maya Guglin, MD, PhD, FACC, Department of Cardiology, University of South Florida, 2 Tampa General Circle, Tampa, FL 33606. Email:

Copyright © 2014 by the American Society for Artificial Internal Organs