ASAIO Journal

Skip Navigation LinksHome > May/June 2014 - Volume 60 - Issue 3 > A Novel Pediatric Biventricular Assist Device: In Vitro Tes...
ASAIO Journal:
doi: 10.1097/MAT.0000000000000060
Pediatric Circulatory Support

A Novel Pediatric Biventricular Assist Device: In Vitro Test Results

Perrodin, Stéphanie F.; Tozzi, Piergiorgio

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Most ventricular assist devices (VADs) currently used in infants are extracorporeal. These VADs require long-term anticoagulation therapy and extensive surgery, and two devices are needed for biventricular support. We designed a biventricular assist device based on shape memory alloy that reproduces the hemodynamic effects of cardiomyoplasty, supporting the heart with a compressing movement, and evaluated its performance in a dedicated mockup system. Nitinol fibers are the device’s key component. Ejection fraction (EF), cardiac output (CO), and generated systolic pressure were measured on a test bench. Our test bench settings were a preload range of 0–15 mm Hg, an afterload range of 0–160 mm Hg, and a heart rate (HR) of 20, 30, 40, and 60 beats/min. A power supply of 15 volts and 3.5 amperes was necessary. The EF range went from 34.4% to 1.2% as the afterload and HR increased, along with a CO from 180 to 6 ml/min. The device generated a maximal systolic pressure of 25 mm Hg. Cardiac compression for biventricular assistance in child-sized heart using shape memory alloy is technically feasible. Further testing remains necessary to assess this VAD’s in vivo performance range and its reliability.

Copyright © 2014 by the American Society for Artificial Internal Organs


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