A Novel Pediatric Biventricular Assist Device: In Vitro Test Results

Perrodin, Stéphanie F.; Tozzi, Piergiorgio

doi: 10.1097/MAT.0000000000000060
Pediatric Circulatory Support

Most ventricular assist devices (VADs) currently used in infants are extracorporeal. These VADs require long-term anticoagulation therapy and extensive surgery, and two devices are needed for biventricular support. We designed a biventricular assist device based on shape memory alloy that reproduces the hemodynamic effects of cardiomyoplasty, supporting the heart with a compressing movement, and evaluated its performance in a dedicated mockup system. Nitinol fibers are the device’s key component. Ejection fraction (EF), cardiac output (CO), and generated systolic pressure were measured on a test bench. Our test bench settings were a preload range of 0–15 mm Hg, an afterload range of 0–160 mm Hg, and a heart rate (HR) of 20, 30, 40, and 60 beats/min. A power supply of 15 volts and 3.5 amperes was necessary. The EF range went from 34.4% to 1.2% as the afterload and HR increased, along with a CO from 180 to 6 ml/min. The device generated a maximal systolic pressure of 25 mm Hg. Cardiac compression for biventricular assistance in child-sized heart using shape memory alloy is technically feasible. Further testing remains necessary to assess this VAD’s in vivo performance range and its reliability.

From the Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Submitted for consideration September 2013; accepted for publication in revised form January 2014.

Disclosure: The authors have no conflict of interest to report.

This study was supported by public funds from Cardiomet.

Reprint Requests: Piergiorgio Tozzi, MD, PD, MER, Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 21, 1011 Lausanne, Switzerland. Email: piergiorgio.tozzi@chuv.ch.

Copyright © 2014 by the American Society for Artificial Internal Organs