Skip Navigation LinksHome > March/April 2014 - Volume 3 - Issue 2 > Ghrelin Levels in Patients With Primary Open-Angle Glaucoma
Asia-Pacific Journal of Ophthalmology:
doi: 10.1097/APO.0000000000000048
Laboratory Science

Ghrelin Levels in Patients With Primary Open-Angle Glaucoma

Ghanem, Asaad A. MD*; Mady, Salah E. MD; Attia, Tarek N. MD; Khattab, Abeer M. MD*; Arafa, Lamiaa F. MD

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Abstract

Purpose

This study was aimed to assess the levels of ghrelin in aqueous humor and plasma of human eyes with primary open-angle glaucoma (POAG) and to correlate their concentrations with the severity of glaucoma.

Design

This was a case-control, prospective study.

Methods

Fifty patients with POAG and 35 patients with senile nonpathologic cataract (control group) were enrolled in the study prospectively. Aqueous humor samples were obtained by paracentesis from patients with glaucoma and cataract who underwent elective surgery. Aqueous humor and corresponding plasma samples were analyzed for ghrelin concentrations by radioimmunoassay diagnostic kits assay.

Results

Ghrelin levels were significantly lower in aqueous humor of patients with POAG with respect to the comparative group of patients with cataract (P < 0.001). There was no significant difference in the levels of ghrelin in the plasma of patients with POAG and that of patients with cataract. A positive correlation was found between plasma/aqueous humor ghrelin concentration in patients with POAG versus the control group (P < 0.001). No significant correlation was found between the levels of ghrelin and the severity of visual field loss.

Conclusions

Lower levels of aqueous humor ghrelin may be associated with POAG and may be a consequence of glaucomatous damage.

Copyright © 2014 by Asia Pacific Academy of Ophthalmology

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