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The potential of resveratrol against human gliomas

Gagliano, Nicolettaa; Aldini, Giancarlob; Colombo, Grazianoc; Rossi, Ranierid; Colombo, Robertoc; Gioia, Magdaa; Milzani, Aldoc; Dalle-Donne, Isabellac

doi: 10.1097/CAD.0b013e32833498f1
Review Articles

There is growing interest in dietary phytochemicals as potential cancer chemopreventive agents. Resveratrol (3,4′,5-trihydroxy-trans-stilbene), a naturally occurring phytoalexin that is present in grapes, red wine, berries and peanuts, has been studied extensively for its ability to interfere with multistage carcinogenesis. Resveratrol is known to have antioxidant, anti-inflammatory and antiproliferative effects on a variety of cancer cells in vitro and in various animal models. However, the effect(s) of resveratrol in vivo on humans are still controversial. This study discusses current knowledge with regard to the effects of resveratrol in relation to its potential as a chemopreventive and/or chemotherapeutic molecule against human gliomas.

Departments of aHuman Morphology and Biomedical Sciences ‘Cittá Studi’

bPharmaceutical and Toxicological Chemistry ‘Pietro Pratesi’

cBiology, Università degli Studi di Milano, Milan

dDepartment of Evolutionary Biology, University of Siena, Siena, Italy

Correspondence to Dr Nicoletta Gagliano, PhD, Department of Human Morphology and Biomedical Sciences ‘Cittá Studi, Università degli Studi di Milano, School of Medicine, Extracellular Matrix Laboratory, Via Fratelli Cervi 93, 20090 Segrate, Milan, Italy

Tel: +39 2 50330462; fax: +39 2 50330452;

e-mail: nicoletta.gagliano@unimi.it

Received 10 June 2009 Revised form accepted 26 October 2009

© 2010 Lippincott Williams & Wilkins, Inc.