Skip Navigation LinksHome > February 2010 - Volume 21 - Issue 2 > Radiation recall dermatitis triggered by multi-targeted tyro...
Anti-Cancer Drugs:
doi: 10.1097/CAD.0b013e328333d679
Case Reports

Radiation recall dermatitis triggered by multi-targeted tyrosine kinase inhibitors: sunitinib and sorafenib

Chung, Caroline; Dawson, Laura A.; Joshua, Anthony M.; Brade, Anthony M.

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Abstract

Small molecule tyrosine kinase inhibitors are rapidly being integrated into the management of cancer. This is the first report of sorafenib and sunitinib, both small molecule tyrosine kinase inhibitors of vascular endothelial growth factor and platelet-derived growth factor receptors, triggering radiation recall dermatitis. The pathophysiology of radiation recall is poorly understood, and several possible mechanisms have been proposed. The clinical presentations of these two cases were consistent with one hypothesized mechanism of radiation recall, an idiosyncratic drug hypersensitivity reaction.

© 2010 Lippincott Williams & Wilkins, Inc.

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