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Variable association between Chlamydophila psittaci infection and ocular adnexal lymphomas: methodological biases or true geographical variations?

Decaudin, Didiera; Dolcetti, Riccardoe; de Cremoux, Patriciab; Ponzoni, Mauriliof g; Vincent-Salomon, Anneb; Doglioni, Claudiof g; Dendale, Rémic; Escande, Marie-Christineb; Rouic, Livia Lumbroso-Led; Ferreri, Andrés J.M.g h

doi: 10.1097/CAD.0b013e32830b58c4
Review

Since the first publication in 2004, a large number of reports have raised the question of an association between ocular adnexal lymphoma and Chlamydia psittaci. The results of this scientific debate, however, remain controversial. The primary objective of this paper was therefore to raise important questions concerning the interpretation of the different and heterogeneous data on the association between Chlamydophila psittaci and ocular adnexal lymphoma, namely the impact of the methodology used and the epidemiological variability of seroprevalence of C. psittaci antibodies. This paper also provides some methodological suggestions for future studies in the field of chlamydia–lymphoma associations.

aDepartment of Clinical Hematology/Laboratory of Pre-clinical Investigation

Departments of bTumor Biology

cRadiation Oncology

dOphthalmology, Institut Curie, France

eCancer Bio-Immunotherapy Unit, Department of Medical Oncology, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano

fPathology Unit

gUnit of Lymphoid Malignancies

hMedical Oncology Unit, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy

Correspondence to Dr Didier Decaudin, MD, PhD, Service d'Hématologie, Institut Curie, 26 rue d'Ulm, 75.248 Paris cedex 05, France

Tel: +33 1 44 32 46 90; fax: +33 1 53 10 40 11;

e-mail: didier.decaudin@curie.net

Received 11 May 2008 Revised form accepted 4 June 2008

© 2008 Lippincott Williams & Wilkins, Inc.