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Sprayed Cultured Epithelial Autografts for Deep Dermal Burns of the Face and Neck

Hartmann, Bernd MD*; Ekkernkamp, Aline*; Johnen, Christa MD†; Gerlach, Jörg C. MD, PhD†; Belfekroun, Claudia*; Küntscher, Markus V. MD, PhD*

Annals of Plastic Surgery:
doi: 10.1097/01.sap.0000250647.39784.bb
Advances in Plastic Surgery
Abstract

The objective of this study was the assessment of clinical results after sprayed application of cultured epithelial autograft (CEA) suspensions onto deep dermal burn wounds of the face and neck.

Nineteen patients with deep dermal burns of the face and neck were included into a prospective study. The average total body surface area burn was 15.1% (7%–46%; median: 13%). The average Abbreviated Burn Severity Index (ABSI) was 6.7 points (4–12 points; median: 7 points). The application of sprayed CEA suspension was performed onto an average body surface area of 2% (0.5–5%; median: 2%). Thirteen patients were recruited for clinical follow-up after an average of 10 months (3–18 months).

The average Vancouver Scar Scale score at follow-up was 2.4 ± 2.2 points (range, 0–8 points), and the average Donnersmarck and Hörbrand score was 9.3 ± 6.8 points (range, 0–22). Four patients had less than 9 months’ follow-up. Excluding these patients from the analysis resulted in an average Vancouver Scar Scale score of 1.3 ± 0.9 points (range, 0–3 points) and an average Donnersmarck and Hörbrand score of 8.0 ± 7.4 points (range 0–22) for the remaining 9 patients.

Our data show that enzymatic and careful surgical debridement and consecutive application of CEA suspensions using a spray technique results in excellent cosmetic outcomes compared with any other method.

In Brief

Thirteen patients with deep dermal burns of the face and neck were treated with enzymatic and surgical debridement, followed by the topical spraying of cultured epithelial autograft suspensions over a median 2% of TBSA. Scar quality was found to be superior to other methods of resurfacing.

Author Information

From the *Burn Center/Department for Plastic Surgery, Unfallkrankenhaus Berlin, Germany; and †Charité, Campus Virchow-Clinic, Department of Surgery, University Medicine of Berlin, Germany.

Received September 21, 2006 and accepted for publication October 5, 2006.

Reprints: Markus V. Küntscher, MD, PhD, Burn Center/Department for Plastic Surgery, Unfallkrankenhaus Berlin, Warener Str. 7, 12683 Berlin, Germany. E-mail: markus.kuentscher@ukb.de.

© 2007 Lippincott Williams & Wilkins, Inc.