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Annals of Surgery:
doi: 10.1097/SLA.0000000000000375
Original Articles

Hospital Volume and Operative Mortality in the Modern Era

Reames, Bradley N. MD, MS; Ghaferi, Amir A. MD, MS; Birkmeyer, John D. MD; Dimick, Justin B. MD, MPH

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Author Information

From the Center for Healthcare Outcomes and Policy, University of Michigan, Ann Arbor, MI.

Reprints: Bradley N. Reames, MD, MS, Center for Healthcare Outcomes and Policy, University of Michigan, Building 16, Room 100N-08, 2800 Plymouth Road, Ann Arbor, MI 48109. E-mail: breames@umich.edu.

Disclosure: B.N.R. is supported by a grant from the National Cancer Institute (5T32CA009672-23). J.B.D. is supported by grant from the National Institute on Aging (5R01AG039434-03). These funding sources had no involvement in the manuscript herein. B.N.R. and A.A.G. have no conflicts of interest or disclosures related to the content of this manuscript. Both J.D.B. and J.B.D. have an equity interest in ArborMetrix, Inc, which provides software and analytics for measuring hospital quality and efficiency. The company had no role in this study.

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Abstract

Objective: To determine whether the relationship between hospital volume and mortality has changed over time.

Background: It is generally accepted that hospital volume is associated with mortality in high-risk procedures. However, as surgical safety has improved over the last decade, recent evidence has suggested that the inverse relationship has diminished or been eliminated.

Methods: Using national Medicare claims data from 2000 through 2009, we examined mortality among 3,282,127 patients who underwent 1 of 8 gastrointestinal, cardiac, or vascular procedures. Hospitals were stratified into quintiles of operative volume. Using multivariable logistic regression models to adjust for patient characteristics, we examined the relationship between hospital volume and mortality, and assessed for changes over time. We performed sensitivity analyses using hierarchical logistic regression modeling with hospital-level random effects to confirm our results.

Results: Throughout the 10-year period, a significant inverse relationship was observed in all procedures. In 5 of the 8 procedures studied, the strength of the volume-outcome relationship increased over time. In esophagectomy, for example, the adjusted odds ratio of mortality in very low volume hospitals compared to very high volume hospitals increased from 2.25 [95% confidence interval (CI): 1.57–3.23] in 2000–2001 to 3.68 (95% CI: 2.66–5.11) in 2008–2009. Only pancreatectomy showed a notable decrease in strength of the relationship over time, from 5.83 (95% CI: 3.64–9.36) in 2000–2001, to 3.08 (95% CI: 2.07–4.57) in 2008–2009.

Conclusions: For all procedures examined, higher volume hospitals had significantly lower mortality rates than lower volume hospitals. Despite recent improvements in surgical safety, the strong inverse relationship between hospital volume and mortality persists in the modern era.

Evidence that hospital volume influences outcomes has been verified in nearly every major type of surgery.1–3 This body of work highlighted important and previously unrecognized variations in hospital performance and ignited efforts to improve surgical quality among poorly performing hospitals. In an effort to reduce these variations among hospitals, new health policy and quality improvement initiatives, such as public reporting, pay-for-performance, and surgical checklists, have been implemented to promote best practice and improve standards of care.4–7 Over the last decade, surgical mortality rates have significantly decreased throughout the country, possibly due to these measures.8–10

As a result, it is unclear whether the volume-outcome relationship has persisted in the modern era. Recent improvements in surgical outcomes could change the relationship between volume and outcome in 2 possible ways. First, advances in surgical care could weaken or eliminate the influence of hospital volume on patient outcomes. Alternatively, despite absolute decreases in mortality, relative differences may persist between hospitals and the relationship endures over time. Recently published evidence supports the former hypothesis, asserting that the volume-outcome relationship is severely attenuated in recent years.11 However, this single study represents only a subset of US hospitals in 1 year and may not be generalizable to all hospitals or longer periods. Given the incorporation of volume standards into several health policy initiatives (eg, Centers of Excellence,12 Leapfrog Initiative13,14), as well as accreditation processes and local credentialing decisions, it is important for policymakers and surgical leaders to understand whether the volume-outcome relationship has changed over time.

Given this uncertainty, we sought to evaluate whether the relationship between hospital volume and operative mortality has changed during a recent 10-year period, using a national data set of high-risk patients. To do this, we examined the risk-adjusted operative mortality of Medicare patients undergoing 1 of 8 complex gastrointestinal, cardiac, or vascular procedures at hospitals in the lowest and highest quintiles of operative volume during the years 2000 to 2009.

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METHODS

Data Source and Study Population

To complete this study, we utilized analytic files for the years 2000 to 2009 from the Center for Medicare and Medicaid Services. The Medicare Provider Analysis and Review file, which contains hospital discharge records for fee-for-service acute care hospitalizations of all Medicare beneficiaries not enrolled in managed care plans, was used to create the main data sets for analysis, and the Medicare Denominator file was used to determine vital status of patients 30 days after surgery. The institutional review board of the University of Michigan and the Center for Medicare and Medicaid Services approved this protocol and waived the requirement for informed consent.

We identified patients between the ages of 65 and 99 years who underwent 1 of 3 gastrointestinal (colectomy, esophagectomy, and pancreatectomy), 3 cardiac (aortic valve replacement, mitral valve replacement, and coronary artery bypass grafting), or 2 vascular procedures (abdominal aortic aneurysm repair and carotid endarterectomy) during the study period, using appropriate procedure codes from the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM). Patients undergoing open, laparoscopic, minimally invasive, and endovascular approaches were included in this analysis. These procedures were selected prospectively as they represent commonly performed complex elective procedures with nontrivial risks of mortality, for which previous literature has reported an association between volume and operative mortality of varying strengths.1,2,15

To minimize confounding and increase the homogeneity of our sample, we utilized multiple restrictions. Patients who underwent a repair of an abdominal aortic aneurysm were excluded if they had accompanying diagnosis or procedure codes suggesting a rupture of the aneurysm, presence of a thoracoabdominal aneurysm, or dissection. We also excluded patients who underwent simultaneous coronary artery bypass grafting and valve surgery. For the 3 gastrointestinal procedures identified, we included operations for both benign and malignant disease in the final analysis.

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Hospital Volume

In this analysis, hospital volume for each procedure was defined as total volume of operations performed in Medicare beneficiaries during each 2-year period. Two-year periods were chosen to improve the reliability and power of model estimates and minimize statistical noise, which would be increased in 1-year periods. To more accurately estimate the volume at each center, the restrictions mentioned above were not applied when determining overall hospital volume, and only thoracoabdominal aneurysms associated with elective abdominal aortic aneurysm repair were excluded. To better understand the relationship between volume and mortality, volume was first evaluated as a continuous variable. To simplify the presentation of results, and to allow for understanding in the context of current literature, we also created a categorical variable detailing 5 categories of hospital volume: very low, low, medium, high, and very high. For each procedure, hospitals were ranked in order of increasing total 2-year hospital volume, and categories were created by defining prospective whole number cutoffs that would separate all patients into 5 quintiles of equal size.

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Assessment of Outcomes

Our primary outcome measure was operative mortality, defined as the rate of death before hospital discharge, or within 30 days of the index procedure for patients discharged before that date. As with previous literature in this area, late in-hospital mortality was included to allow for a more accurate understanding of operative mortality, as many patients who die after surgery first experience 1 or multiple complications and a prolonged hospitalization of more than 30 days. The relationship between hospital volume and operative mortality was evaluated separately for each 2-year period, and longitudinal trends were observed.

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Statistical Analysis

We used multivariable logistic regression to examine the relationship between hospital volume and operative mortality during the 10-year study period, after adjusting for patient characteristics, year of the procedure, and surgical approach (when that data was available). The patient was used as the unit of analysis, with volume characterized at the hospital level. For each procedure, we fitted a separate model against the hospital volume variable for each 2-year period. To account for the lack of independence of deaths within hospitals, or clustering, we calculated robust standard errors.

To account for differences in patient characteristics within individual hospitals, we adjusted for age, sex, race (black or nonblack) and their interactions, urgency or emergency of the admission, the presence of coexisting conditions, and socioeconomic status. For this last variable, we constructed a summary measure of socioeconomic status for each US ZIP code using data on income, education, and occupation from the 2000 US Census and linked this information to the patient's ZIP code of residence in the Medicare files. The individual variables chosen and methods for calculating the summary measure were based on previously developed methods.16 Coexisting conditions were identified by their appropriate ICD-9-CM codes and were defined with the Elixhauser method, which uses ICD-9-CM codes to classify secondary diagnoses recorded on the Medicare Provider Analysis and Review record into 30 different comorbid conditions.17 Final risk-adjustment models had C statistics ranging from 0.716 (for mitral valve replacement) to 0.821 (for colectomy).

To confirm the accuracy of our final risk-adjustment models, we performed sensitivity analyses using hierarchical logistic regression modeling with hospital-level random effects. Because these models are complex and prone to failure (nonconvergence), we simplified the regression by first creating a predictive score for operative mortality using all available patient covariates. This summary risk score was used to model the relationship between hospital volume and operative mortality after adjustment for patient characteristics and year of procedure. This was performed for all procedures except esophagectomy and carotid endarterectomy, which were too unstable given the small numbers of patients or events. Results of hierarchical modeling, using both continuous and categorical measures of hospital volume, were then compared to the results of multivariable logistic regression modeling with robust standard errors.

For all statistical tests, P values are 2 tailed, and alpha is set at 0.05. All analyses were performed using STATA version 12.1 (StataCorp, College Station, TX).

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RESULTS

Between the years 2000 and 2009, 3,282,127 patients underwent 1 of the 8 specified procedures. Table 1 shows the number of patients in each model, as well as patient demographic information, within quintiles of very low and very high volume for each procedure and period. The criteria used to create quintiles varied between procedures because of the different frequencies at which each operation was performed. During the study period, coronary artery bypass grafting, colectomy, and carotid endarterectomy were the most commonly performed procedures, whereas pancreatectomy and esophagectomy were performed the least. The total Medicare volume decreased for coronary artery bypass grafting, carotid endarterectomy, and mitral valve replacement during the 10-year period, whereas it remained stable for esophagectomy and increased for abdominal aortic aneurysm repair, aortic valve replacement, and pancreatectomy. In general, sex showed minimal variation between very low and very high volume hospitals. Although cardiac procedures showed similar rates of nonelective admissions in both groups, other operations revealed higher rates in very low volume hospitals, with the largest discrepancies observed in esophagectomy and pancreatectomy. Very low volume hospitals cared for more African American patients, patients with 3 or more comorbidities, and patients older than 75 years.

Table 1
Table 1
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Table 2 lists the total number of hospitals performing each procedure, as well as the number of hospitals and the volume thresholds contained within quintiles of very low and very high volume for each procedure and period. For all 3 gastrointestinal procedures and abdominal aortic aneurysm repair, the number of hospitals performing the operation decreased, whereas the volume threshold of the very high volume quintile increased. All 3 cardiac procedures showed increases in the total number of hospitals performing the operation, but the effects on volume thresholds varied.

Table 2
Table 2
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Adjusted mortality for most operations decreased during the 10-year study period, as shown in Figure 1. The largest decreases in mortality were seen after esophagectomy, which decreased from 13.6% in 2000, to 9.8% in 2009 (difference of 3.8%), and after pancreatectomy, which decreased from 10.2% to 6.8% (difference of 3.4%). Mortality after carotid endarterectomy remained relatively stable, and it varied from 1.0% to 1.2% over the 10-year period. Colectomy showed a slight increase, from 9.0% to 9.4%.

Figure 1
Figure 1
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The influence of hospital volume on risk-adjusted mortality is shown in Table 3. A significant inverse relationship was observed in all procedures and nearly every 2-year period studied. When examined as a continuous variable, identical results were obtained (data not shown). No relationship was significant as a categorical variable that was not significant as a continuous variable (P < 0.05). Throughout most of the period, hospital volume had the greatest influence on mortality after pancreatectomy. The adjusted odds ratio (AOR) of mortality was 5.83 [95% confidence interval (CI): 3.64–9.36] in 2000 and 3.08 (95% CI: 2.07–4.57) in 2009. Esophagectomy also exhibited a strong inverse relationship throughout the period and exhibited the highest odds of mortality during the years 2008–2009 (AOR: 3.68, 95% CI: 2.66–5.11). Colectomy exhibited the weakest significant association, with an AOR of 1.08 (95% CI: 1.01–1.15) in 2000 and 1.20 (95% CI: 1.13–1.28) in 2009. Only carotid endarterectomy during the years 2006–2007 did not have a significant relationship.

Table 3
Table 3
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Figure 2 illustrates the trend in AORs between the years 2000 and 2009 for each procedure. Over the 10-year period, the risk-adjusted odds of mortality in very low volume hospitals increased for coronary artery bypass grafting, aortic valve replacement, mitral valve replacement, colectomy, and esophagectomy. AORs remained stable for carotid endarterectomy and abdominal aortic aneurysm repair and showed a substantial decrease for pancreatectomy.

Figure 2
Figure 2
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Sensitivity analyses using hierarchical logistic regression models with hospital-level random effects revealed similar results (in both estimates and significance) for nearly all procedures and years. This held true using both continuous and categorical measures of hospital volume. Only colectomy in the years 2000–2001 revealed a discrepancy, as the hierarchical model failed to reach statistical significance (AOR: 1.06, 95% CI: 0.991–1.14, compared with 1.08, 95% CI: 1.01–1.15, for the logistic model with robust standard errors).

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DISCUSSION

In a large, national data set of Medicare patients, we found that both absolute and relative differences in adjusted mortality between hospitals with the lowest and highest volume persist in the modern era. This relationship endures despite significant improvements in adjusted mortality over the 10-year period. As shown in previous studies, the strength of the relationship varies between procedures. Given these findings, in the absence of more granular data regarding a hospital's performance, for certain high-risk procedures hospital volume remains a useful proxy of surgical quality.

Over the last 10 years, a large body of literature supporting the presence of a hospital volume-outcome relationship, including numerous systematic reviews,18–25 has been developed. An early definitive systematic review on the subject was performed by Halm and colleagues and reported a significant association across a wide range of procedures and conditions.26 More recently, Pieper and colleagues performed a review and synthesis of systematic reviews on the topic.27 They evaluated systematic reviews of 14 different procedures across a wide range of specialties and found evidence to support a significant relationship in almost all procedures examined.

One particular study of recent data, however, has gained attention for failing to reveal a significant volume effect in 4 high-risk procedures traditionally thought to exhibit the relationship.11 In that work, LaPar and colleagues cite concerns regarding the characterization of volume and type of models used in previous publications and conclude that hospital volume should not be used as a measure of hospital quality. Although interesting, this study has been criticized for methodological concerns due to small sample size and potentially unstable statistical models.28 Nonetheless, in this study, using a much larger data set over a longer period of time, we demonstrate that despite significant improvements in surgical safety, the inverse relationship between hospital volume and operative mortality persists in the modern era. In our analysis, this relationship is significant regardless of how volume is characterized or the relationship is modeled.

This study has several limitations. First, given this analysis only includes Medicare patients, it may not be generalizable to patients younger than 65 years. Nevertheless, this cohort includes a substantial number of all patients undergoing the procedures in question and represents a subset of patients with increased risks of morbidity and mortality for whom these results may be most applicable. A second limitation is the potential misclassification of hospital volume when only Medicare procedures are considered. Although some hospitals with high volumes of non-Medicare patients may be misclassified, this misclassification would bias our results toward the null hypothesis (no relationship between volume and mortality). Third, this study utilizes a large administrative database, which can be limited by miscoding and imprecision,29–31 and lacks the granular clinical details of patient disease process, illness severity, or type of surgical approach (for some operations). Although this lack of detail may limit determination of which surgical approach was used for an individual patient in certain operations, inclusion of patients undergoing both traditional and minimally invasive approaches and adjustment for operative approach when possible (endovascular AAA repair and laparoscopic colectomy) ensures that selection bias due to choice of surgical approach is minimized. Furthermore, although miscoding errors are likely to be random and therefore do not introduce bias into the results, certain inequalities were found within some study cohorts. For instance, more African Americans, patients with multiple comorbidities, and patients older than 75 years were treated at very low volume centers. Despite this, we were able to adjust for many important patient characteristics and conditions, and the results of these models coincide with numerous previously published reports.

Although the inverse relationship between hospital volume and operative mortality persists in the modern era, this does not mean that volume should be an exclusive measure of surgical quality. Instead, a balanced approach to quality measurement should be used. There are 2 main policy approaches to improving surgical quality; the particular measure chosen should be tailored to the clinical context. First, for high-risk procedures that are less frequently performed—such as esophagectomy and pancreatectomy—direct measures of surgical outcomes (mortality and morbidity rates) will not be statistically reliable metrics for policy decisions. In these settings, hospital volume remains a useful proxy measure of surgical quality and allows for selective referral of patients to the best performing hospitals. Indeed, recent work has shown that market concentration of certain procedures has improved surgical outcomes in high-risk patients.9

Alternatively, for frequently performed procedures such as cardiac surgery and colectomy, direct measurement of surgical outcomes (such as, major and minor complications and functional outcomes) offers reliable evidence of a hospital's surgical quality. For patients undergoing these types of procedures, continuous risk-adjusted outcomes measurement should be used to assess the quality of care. Moreover, when systematic data measurement is coupled with regular performance feedback in the form of a regional collaborative improvement program, significant improvements in the quality of care can be achieved. Numerous studies have reported decreased morbidity and mortality rates, and decreased costs, associated with regional quality collaboratives.32–36

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CONCLUSIONS

There is no doubt surgical outcomes have improved over the last decade. Advances in operative technique, surgical checklists, performance-related payment, selective referral, and outcomes feedback have each contributed to these improvements in some way.10 As health care reform continues to exert pressure on providers to improve outcomes, leaders in surgical policy must consider quality measures within the context that they are used and appropriately match them to the best approach: selective referral or continuous quality improvement. The question is not whether a volume-outcome relationship exists, but how do we use that information to benefit patients. In any policy discussion, the potential benefits of selective referral highlighted in this article must be balanced against the possible unintended consequences, including limits to access that could be most pronounced in disadvantaged populations. However, given the results of this study, it is essential that stakeholders maintain a multifaceted approach to quality improvement. One such component, at least for Medicare patients undergoing certain high-risk operations, is the use of hospital volume as a proxy measure for surgical quality.

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cardiac surgery; gastrointestinal surgery; health policy; health services research; hospital volume; operative mortality; quality improvement; surgical outcomes; vascular surgery

© 2014 by Lippincott Williams & Wilkins.

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