You could be reading the full-text of this article now if you...

If you have access to this article through your institution,
you can view this article in

Sarcopenia Impacts on Short- and Long-term Results of Hepatectomy for Hepatocellular Carcinoma

Voron, Thibault MD*,‡; Tselikas, Lambros MD†,‡; Pietrasz, Daniel MD*,‡; Pigneur, Frederic MD†,‡; Laurent, Alexis MD, PhD*,‡; Compagnon, Philippe MD, PhD*,‡; Salloum, Chady MD*,‡; Luciani, Alain MD, PhD†,‡,§; Azoulay, Daniel MD, PhD*,‡

Annals of Surgery:
doi: 10.1097/SLA.0000000000000743
Original Articles
Abstract

Objective: To evaluate the prevalence of sarcopenia among European patients with resectable hepatocellular carcinoma (HCC) and to assess its prognostic impact on overall and disease-free survival.

Background: Identification of preoperative prognostic factors in liver surgery for HCC is required to better select patients and improve survival. Recent studies have shown that preoperative discrimination of patients with low skeletal muscle mass (sarcopenic patients) using computed tomography was associated with morbidity and mortality after liver and colorectal surgery. Assessment of sarcopenia could be used to evaluate patients before hepatectomy for HCC.

Methods: All consecutive patients who underwent hepatectomy for HCC in our institution, between February 2006 and September 2012, were included. Univariate and multivariate analyses evaluating prognostic factors of postoperative mortality and cancer recurrence were performed, including preoperative, surgical, and histopathological factors.

Results: Among 198 patients who underwent hepatectomy for HCC, 109 patients had an available computed tomographic scan and represent the study cohort. After a median follow-up of 21.23 months, 27 patients (24.8%) died. There were 20 deaths among the 59 patients who had sarcopenia and only 7 deaths in the nonsarcopenic group. Sarcopenic patients had significantly shorter median overall survival than nonsarcopenic patients (52.3 months vs 70.3 months; P = 0.015). On multivariate analysis, sarcopenia was found to be an independent predictor of poor overall survival (hazard ratio = 3.19; P = 0.013) and disease-free survival (hazard ratio = 2.60; P = 0.001).

Conclusions: Sarcopenia was found to be a strong and independent prognostic factor for mortality after hepatectomy for HCC in European patients and could be used to evaluate eligibility of patients with HCC before surgery.

In Brief

Sarcopenia is associated with morbidity and mortality in colorectal and liver surgery. The aims of this retrospective study were to evaluate the prevalence of sarcopenia among European patient with resectable hepatocellular carcinoma and to assess its prognostic impact on overall and disease-free survival.

Author Information

Departments of *Digestive and Hepatobiliary Surgery

Radiology, Henri-Mondor Hospital, AP-HP, Créteil, France

Université Paris Est, Faculté de Médecine Créteil, Créteil, France; and

§INSERM, U 955, Equipe 18, Creteil, F-94010, France.

Reprints: Thibault Voron, MD, Department of Digestive and Hepatobiliary Surgery, Henri-Mondor Hospital, Université Paris Est, 94010 Créteil, France. E-mail: thibault.voron@gmail.com; or Daniel Azoulay, MD, PhD, Department of Digestive and Hepatobiliary Surgery, Henri-Mondor Hospital, Université Paris Est, 94010 Créteil, France. E-mail: daniel.azoulay.hmn@gmail.com.

Disclosure: The authors declare that they have nothing to disclose.

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.