Skip Navigation LinksHome > April 2014 - Volume 259 - Issue 4 > Metabolic Thrift and the Genetic Basis of Human Obesity
Annals of Surgery:
doi: 10.1097/SLA.0000000000000361
Review

Metabolic Thrift and the Genetic Basis of Human Obesity

O'Rourke, Robert W. MD

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Abstract

Evolution has molded metabolic thrift within humans, a genetic heritage that, when thrust into our modern “obesogenic” environment, creates the current obesity crisis. Modern genetic analysis has identified genetic and epigenetic contributors to obesity, an understanding of which will guide the development of environmental, pharmacologic, and genetic therapeutic interventions.

© 2014 by Lippincott Williams & Wilkins.

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