Objective: To identify clinical hallmarks associated with recovery of gastrointestinal transit.
Background: Impaired gastrointestinal transit or postoperative ileus largely determines clinical recovery after abdominal surgery. However, validated clinical hallmarks of gastrointestinal recovery to evaluate new treatments and readiness for discharge from the hospital are lacking.
Methods: Gastric emptying and colonic transit were scintigraphically assessed from postoperative day 1 to 3 in 84 patients requiring elective colonic surgery and were compared with clinical parameters. The clinical hallmark that best reflected recovery of gastrointestinal transit was validated using data from a multicenter trial of 320 segmental colectomy patients.
Results: Seven of 84 patients developed a major complication with paralytic ileus characterized by total inhibition of gastrointestinal motility and were excluded from further analysis. In the remaining patients, recovery of colonic transit (defined as geometric center of radioactivity ≥2 on day 3), but not gastric emptying, was significantly correlated with clinical recovery (ρ = −0.59, P < 0.001). Conversely, the combined outcome measure of tolerance of solid food and having had defecation (SF + D) (area under the curve = 0.9, SE = 0.04, 95% CI = 0.79–0.95, P < 0.001), but not time to first flatus, best indicated recovery of gastrointestinal transit with a positive predictive value of 93% (95% CI = 78–99). Also in the main clinical trial, multiple regression analysis revealed that SF + D best predicted the duration of hospital stay.
Conclusions: Our data indicate that the time to SF + D best reflects recovery of gastrointestinal transit and therefore should be considered as primary outcome measure in future clinical trials on postoperative ileus.
(Netherlands National Trial Register, number NTR1884 and NTR222)
Up to date, there exists no consensus upon what hallmark is most clinically meaningful for identifying recovery of motility of the gut. This study is the first to determine the relationship between clinical symptoms and objectively determined colonic transit in a large cohort of postoperative patients.
Departments of *Gastroenterology
§Clinical Epidemiology and Biostatistics
¶Nuclear Medicine, Academic Medical Center, Amsterdam, the Netherlands
‖Department of Gastroenterology, University Hospital Leuven, Catholic University of Leuven, Leuven, Belgium.
Reprints: Guy E. E. Boeckxstaens, MD, PhD, Department of Gastroenterology, University Hospital Leuven, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium. E-mail firstname.lastname@example.org.
Disclosure: G. Boeckxstaens and S. van Bree (VICI) were supported by governmental grants from the Netherlands Organization for Scientific Research (NWO) and G. Boeckxstaens by a governmental grant (Odysseus program, G.0905.07) of the Flemish “Fonds Wetenschappelijk Onderzoek” (FWO). The authors declare no conflicts of interest.
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