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Treatment Strategy for Main Duct Intraductal Papillary Mucinous Neoplasms of the Pancreas Based on the Assessment of Recurrence in the Remnant Pancreas After Resection: A Retrospective Review

Tamura, Koji MD*; Ohtsuka, Takao MD, PhD*; Ideno, Noboru MD*; Aso, Teppei MD*; Shindo, Koji MD; Aishima, Shinichi MD, PhD; Ohuchida, Kenoki MD, PhD*; Takahata, Shunichi MD, PhD*; Ushijima, Yasuhiro MD, PhD; Ito, Tetsuhide MD, PhD§; Oda, Yoshinao MD, PhD; Mizumoto, Kazuhiro MD, PhD*; Tanaka, Masao MD, PhD, FACS*

doi: 10.1097/SLA.0b013e3182a690ff
Original Articles

Objectives: To clarify the recurrence pattern after resection of main duct intraductal papillary mucinous neoplasms (MD-IPMNs) using molecular analyses and determine the most adequate treatment strategy.

Background: The most appropriate resection line for MD-IPMNs remains an unresolved issue.

Methods: Medical records of 56 patients with pancreatectomy were retrospectively reviewed. Histological subtypes and Kras/GNAS mutations were assessed in patients with recurrence in the remnant pancreas.

Results: Forty-nine patients underwent partial pancreatectomy and 7 underwent total pancreatectomy. Thirty-six patients (64%) had malignant MD-IPMNs. Recurrence was observed in 7 of 49 patients (14%), including 6 with malignant IPMNs and 1 with pancreatic ductal adenocarcinoma, all of whom underwent remnant pancreatectomy. The cumulative disease-specific survival rate of patients with pancreatic recurrence was greater than that of patients with extrapancreatic recurrence (P < 0.001). Although the pancreatic margin status at the initial operation did not affect the pancreatic recurrence rate, all 4 recurrent IPMNs examined had histological subtypes and Kras/GNAS mutations identical to those of the initial lesions. Four patients experienced recurrence in the remnant pancreas or systemic recurrence after resection of high-grade dysplasia of MD-IPMN. Three of the 56 patients had concomitant pancreatic ductal adenocarcinomas and MD-IPMNs.

Conclusions: One-step total pancreatectomy can be avoided, and remnant total pancreatectomy would lead to favorable outcomes even in patients with pancreatic recurrence, some cases of which seem to involve residual lesions. Postoperative surveillance of high-grade dysplasia should be performed as if malignant, and close attention should be paid to the occurrence of concomitant pancreatic ductal adenocarcinomas in patients with MD-IPMNs.

In view of histological subtypes and Kras/GNAS mutations, recurrent lesions in the remnant pancreas after resection of main duct intraductal papillary mucinous neoplasms seem to involve residual lesions at the initial operation. However, remnant pancreatectomy would lead to a favorable outcome, and 1-step total pancreatectomy can be avoided in patients with negative margins.

Departments of *Surgery and Oncology

Anatomic Pathology

Clinical Radiology, and

§Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Reprints: Masao Tanaka, MD, PhD, FACS, Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. E-mail: masaotan@med.kyushu-u.ac.jp.

Supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI grant numbers 22591524, 23390327, 24659613, 24592030, 24390319, 23659654, 24390318, and 23659655.

Disclosure: The authors declare no conflicts of interest.

© 2014 by Lippincott Williams & Wilkins.