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Aggressive Hepatectomy for the Curative Treatment of Bilobar Involvement of Type IV-A Bile Duct Cyst

Dong, Jia-Hong MD, PhD, FACS; Yang, Shi-Zhong MD, PhD; Xia, Hong-Tian MD; Duan, Wei-Dong MD, PhD; Ji, Wen-Bin MD; Gu, Wan-Qing MD; Liang, Bin MD, PhD; Huang, Zhi-Qiang MD

Annals of Surgery:
doi: 10.1097/SLA.0b013e318285769e
Original Articles
Abstract

Objective: To analyze the risk and benefit of aggressive hepatectomy for the curative treatment of bilobar bile duct cysts (BDCs) of type IV-A.

Background: Conventional surgical treatment of bilobar BDCs of type IV-A is extrahepatic cyst excision, followed by biliodigestive anastomosis. The role of hepatectomy in the treatment of bilobar BDCs remains unclear.

Methods: Between January 2006 and December 2011, a total of 28 patients with bilobar BDCs who underwent an aggressive hepatectomy were identified from a prospective database. Perioperative and long-term outcomes in these patients were compared with 18 patients with bilobar BDCs who received conventional surgical treatment.

Results: Patient characteristics such as age, sex, and clinical presentation were similar in both groups. Cystic dilatation of bile ducts was curatively resected in all 28 patients undergoing aggressive hepatectomy. Postoperative morbidity (57.1% vs 22.2%, P = 0.020), but not mortality (3.6% vs 0%, P = 1.000), in patients who underwent aggressive hepatectomy was significantly increased when compared with those who received conventional surgical treatment. Clearance rate of intrahepatic stones was significantly higher after aggressive hepatectomy than that after conventional surgical treatment (100.0% vs 45.5%, P < 0.001). Twenty-seven of 28 patients (96.4%), except 1 patient who met in-hospital death, achieved a symptom-free status after aggressive hepatectomy during a mean follow-up of 31 months. In contrast, during a mean follow-up of 37 months, 7 patients (38.9%, 7/18) remained free of biliary symptoms after conventional surgical treatment. The long-term outcomes between aggressive hepatectomy and conventional surgical treatment were significantly different (P < 0.001). In addition, no malignant transformation occurred after aggressive hepatectomy. However, intrahepatic cholangiocarcinoma has developed in the remnant BDC in 2 of 18 patients (11.1%) receiving conventional surgical treatment during follow-up.

Conclusions: Aggressive hepatectomy, a challenging procedure, provides an efficient treatment option for some selected patients with bilobar BDCs of type IV-A. The role of aggressive hepatectomy in the curative treatment of bilobar BDCs of type IV-A should be paid particular attention in the future.

In Brief

In this study, perioperative and long-term outcomes in 28 patients with bilobar bile duct cysts (BDCs) of type IV-A who received an aggressive hepatectomy were compared with 18 patients with bilobar BDCs who underwent conventional surgical treatment. The authors conclude that aggressive hepatectomy is both a challenging procedure and an efficient treatment option for type IV-A bilobar BDCs.

Author Information

From the Hospital & Institute of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing, China.

Reprints: Jia-Hong Dong, MD, PhD, FACS, Hospital & Institute of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China. E-mail: dongjh301@163.com.

J-H. Dong and S-Z. Yang contributed equally to this work. S-Z. Yang now works in 401 Hospital in Qingdao, China.

Supported in part by the China National Key S&T Major Projects (No. 2008ZX10002-026).

Disclosure: The authors declare no conflicts of interest.

© 2013 by Lippincott Williams & Wilkins.