Objective: The purpose of this study was to determine factors associated with lymph node metastasis among hormonally-responsive breast cancer patients ≥70 years old, and to develop and validate a clinical prediction rule to predict the risk of lymph node metastasis in this population.
Summary Background Data: Nodal evaluation in elderly women with breast cancer remains controversial. The ability to predict which elderly patients may be node-negative may spare them the morbidity of lymph node evaluation.
Methods: Hormone-receptor positive breast cancer patients ≥70 years old who participated in a prospective multicenter trial were divided into a training set (n = 554) and a test set (n = 146). Univariate and multivariate analyses were conducted to determine factors predictive of final nodal status. A clinical prediction rule was developed on the training set, and validated in the independent test set.
Results: Median patient age was 76; median tumor size was 1.4 cm. 15.9% and 16.2% were LN+ in the training and test sets, respectively. On univariate analysis, patient age, tumor size, palpability, grade, and lymphovascular invasion predicted lymph node status. On multivariate analysis, patient age, tumor size, and lymphovascular invasion remained significant. A prediction rule was created; patients were categorized into quartiles by predicted risk. 5.4% and 0% of patients in the lowest quartile were node positive in the training and test sets, respectively.
Conclusion: Some elderly breast cancer patients at low likelihood of lymph node metastasis may be spared lymph node evaluation.
A linear clinical prediction rule was created and validated to predict the likelihood of lymph node metastasis in women ≥70 years of age treated with adjuvant hormonal therapy. Sentinel node biopsy may be avoided in a subset of patients in whom the risk of lymph node metastasis is less than 10%.
From the *Division of Surgical Oncology, Department of Surgery, University of Louisville, Louisville, Kentucky; and the †Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Presented at the American Society of Breast Surgeons Meeting, held in Phoenix, AZ, May 2–6, 2007.
Address correspondence to: Dr. A. Chagpar, 315 East Broadway, Suite #312, Louisville, KY 40202; Phone: (502) 629-6950, Fax: (502) 629-3183, E-mail: firstname.lastname@example.org.