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Annals of Surgery:
doi: 10.1097/SLA.0b013e3181961d5d
Original Article

Metabolic and Neuroendocrine Consequences of a Duodenal-Jejunal Bypass in Rats on a Choice Diet

Warne, James P. PhD*; Padilla, Benjamin E. MD†; Horneman, Hart F. BS*; Ginsberg, Abigail B. PhD*; Pecoraro, Norman C. PhD*; Akana, Susan F. PhD*; Dallman, Mary F. PhD*

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Abstract

Objective: We sought to examine insulin-sensitive food intake behavior and neuroendocrine and metabolic variables of rats that had undergone a duodenal-jejunal bypass (DJB).

Summary of Background Data: A DJB that circumvents the duodenum and proximal jejunum while leaving the stomach unperturbed rapidly improves insulin sensitivity in type 2 diabetic rats. This segment of proximal small intestine is innervated by the gastroduodenal branch of the vagus nerve, the transection of which influences food intake choices in streptozotocin-diabetic rats.

Methods: Rats were first placed on a choice of chow and lard for 7 days and additionally provided with an enriched liquid diet for another 7 days before surgery and were allowed only the liquid diet for 7 days after either a sham or DJB operation.

Results: After surgery, DJB-operated rats initially consumed less than the sham-operated counterparts. When the rats were subsequently provided with the choice of chow and lard for 7 days, there were no differences in intake between the DJB and sham-operated groups. Similarly, the majority of metabolic and neuroendocrine variables measured were unchanged. However, DJB-operated rats exhibited greater mesenteric white adipose tissue weight, fecal output, arcuate nucleus neuropeptide Y mRNA expression, plasma corticosterone, and glucagon levels together with reduced plasma leptin concentrations.

Conclusions: DJB surgery does not produce significant differences in food intake choices after a period of recovery; however, there are enduring metabolic and neuroendocrine changes, which are collectively important to understanding the beneficial outcomes of the operation.

© 2009 Lippincott Williams & Wilkins, Inc.

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