Annals of Surgery

Skip Navigation LinksHome > March 2008 - Volume 247 - Issue 3 > Breast-Conserving Therapy for Centrally Located Breast Cance...
Annals of Surgery:
doi: 10.1097/SLA.0b013e31815b6991
Original Articles

Breast-Conserving Therapy for Centrally Located Breast Cancer

Fitzal, Florian MD*; Mittlboeck, Martina MD†; Trischler, Herwig*; Krois, Wilfried*; Nehrer, Greta MD‡; Deutinger, Maria MD¶; Jakesz, Raimund MD*; Gnant, Michael MD*

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Objective: To analyze whether breast-conserving therapy (BCT) may be an oncologically safe approach and result in a good cosmesis in patients with centrally located breast cancer (CLBC).

Summary Background Data: Only underpowered, retrospective, single-arm studies have suggested that oncoplastic BCT for CLBC may be oncologically safe and may result in a good cosmesis.

Methods: The authors retrospectively analyzed the overall and recurrence-free survival in 1485 patients with breast cancer undergoing BCT comparing CLBC with non-CLBC. Moreover, the authors described 4 different oncoplastic techniques for BCT in patients with CLBC and compared the cosmetic results with simple lumpectomy according to a recently elaborated objective cosmetic evaluation system, the Breast Symmetry Index.

Results: Kaplan-Meier curves show no significant difference in a 5-year overall, local, or distant recurrence-free survival between patients with CLBC and non-CLBC after BCT (94% vs. 96%; 100% vs. 98%; 92% vs. 90%; median follow–up, 35.3 months). The cosmetic outcome after oncoplastic BCT compared with simple lumpectomy differed significantly (Breast Symmetry Index: 22 ± 6%d vs. 44 ± 12%d; P < 0.05).

Conclusions: The results demonstrate that BCT for CLBC is oncologically safe and that oncoplastic techniques improve cosmesis.

© 2008 Lippincott Williams & Wilkins, Inc.


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