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Annals of Surgery:
doi: 10.1097/01.sla.0000217629.94941.cf
Original Articles

Epidemiology and Management of Liver Metastases From Colorectal Cancer

Manfredi, Sylvain MD; Lepage, Côme MD; Hatem, Cyril MD; Coatmeur, Olivier MD; Faivre, Jean PhD; Bouvier, Anne-Marie PhD

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Abstract

Objective/Background: Little is known about the epidemiology and the management of liver metastases from colorectal cancer at a population level. The aim of this population-based study was to report on the incidence, treatment, and prognosis of synchronous and metachronous liver metastases.

Methods: Data were obtained from the population-based cancer registry of Burgundy (France).

Results: The proportion of patients with synchronous liver metastases was 14.5%. Age-standardized incidence rates were 7.6 per 100,000 in males, 3.7 per 100,000 in females. The 5-year cumulative metachronous liver metastasis rate was 14.5%. It was 3.7% for TNM stage I tumors, 13.3% for stage II, and 30.4% for stage III (P < 0.001). The risk of liver metastasis was also associated to gross features. Resection for cure was performed in 6.3% of synchronous liver metastases and 16.9% of metachronous liver metastases. Age, presence of another site of recurrence, and period of diagnosis were independent factors associated with the performance of a resection for cure. The 1- and 5-year survival rates were 34.8% and 3.3% for synchronous liver metastases. Their corresponding rates were, respectively, 37.6% and 6.1% for metachronous liver metastases.

Conclusion: Liver metastases from colorectal cancer remain a substantial problem. More effective treatments and mass screening represent promising approaches to decrease this problem.

© 2006 Lippincott Williams & Wilkins, Inc.

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