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Evidence-based Value of Prophylactic Drainage in Gastrointestinal Surgery: A Systematic Review and Meta-analyses

Petrowsky, Henrik MD*; Demartines, Nicolas MD*; Rousson, Valentin PhD†; Clavien, Pierre-Alain MD, PhD, FACS, FRCS*

Annals of Surgery:
Original Articles and Discussions
Abstract

Objective: To determine the evidence-based value of prophylactic drainage in gastrointestinal (GI) surgery.

Methods: An electronic search of the Medline database from 1966 to 2004 was performed to identify articles comparing prophylactic drainage with no drainage in GI surgery. The studies were reviewed and classified according to their quality of evidence using the grading system proposed by the Oxford Centre for Evidence-based Medicine. Seventeen randomized controlled trials (RCTs) were found for hepato-pancreatico-biliary surgery, none for upper GI tract, and 13 for lower GI tract surgery. If sufficient RCTs were identified, we performed a meta-analysis to characterize the drain effect using the random-effects model.

Results: There is evidence of level 1a that drains do not reduce complications after hepatic, colonic, or rectal resection with primary anastomosis and appendectomy for any stage of appendicitis. Drains were even harmful after hepatic resection in chronic liver disease and appendectomy. In the absence of RCTs, there is a consensus (evidence level 5) about the necessity of prophylactic drainage after esophageal resection and total gastrectomy due to the potential fatal outcome in case of anastomotic and gastric leakage.

Conclusion: Many GI operations can be performed safely without prophylactic drainage. Drains should be omitted after hepatic, colonic, or rectal resection with primary anastomosis and appendectomy for any stage of appendicitis (recommendation grade A), whereas prophylactic drainage remains indicated after esophageal resection and total gastrectomy (recommendation grade D). For many other GI procedures, especially involving the upper GI tract, there is a further demand for well-designed RCTs to clarify the value of prophylactic drainage.

In Brief

Many surgeons consider prophylactic drainage as a method to reduce and detect postoperative complications. On the other hand, there is growing evidence that routine drainage may not be useful or may even be harmful after many GI procedures. There is grade A recommendation that drains do not reduce complications after hepatic, colonic, or rectal resection with primary anastomosis and appendectomy for any stage of appendicitis. The routine use of drains should be revisited.

Author Information

From the *Department of Visceral and Transplant Surgery, University Hospital, Zürich, Switzerland, and the Department of †Biostatistics, University Hospital, Zürich, Switzerland.

Reprints: Pierre-Alain Clavien, MD, PhD, FACS, FRCS, Department of Visceral and Transplant Surgery, University Hospital Raemistrasse 100, CH-8091 Zürich, Switzerland. E-mail: clavien@chir.unizh.ch.

© 2004 Lippincott Williams & Wilkins, Inc.