 Home > March 2008 - Volume 108 - Issue 3
March 2008 - - Issue 3
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Anesthesiology. 108(3):5A, March 2008.
doi: 10.1097/01.anes.0000311261.07483.7f
Isono, Shiroh
Anesthesiology. 108(3):347-349, March 2008.
doi: 10.1097/ALN.0b013e318164cb0b
Gerner, Peter; O'Connor, J Patrick
Anesthesiology. 108(3):349-350, March 2008.
doi: 10.1097/ALN.0b013e318164938c
Clark, J David
Anesthesiology. 108(3):351-352, March 2008.
doi: 10.1097/ALN.0b013e318164937c
Simonnet, Guy
Anesthesiology. 108(3):352-354, March 2008.
doi: 10.1097/ALN.0b013e3181650edd
Burnham, Ellen L.
Anesthesiology. 108(3):354-356, March 2008.
doi: 10.1097/ALN.0b013e318164cae1
Kodali, Bhavani-Shankar; Chandrasekhar, Sobhana; Bulich, Linda N.; Topulos, George P.; Datta, Sanjay
Anesthesiology. 108(3):357-362, March 2008.
doi: 10.1097/ALN.0b013e31816452d3
There are significant airway changes in women during labor and delivery. It is prudent to reexamine the airway just before initiation of anesthesia during the intrapartum or immediate postpartum period.
Totah, Rheem A.; Sheffels, Pamela; Roberts, Toni; Whittington, Dale; Thummel, Kenneth; Kharasch, Evan D.
Anesthesiology. 108(3):363-374, March 2008.
doi: 10.1097/ALN.0b013e3181642938
Stereoselective methadone metabolism in human liver microsomes is mainly mediated by CYP2B6, and CYP2B6 seems responsible for clinical methadone metabolism and clearance. This may have implications for methadone dosing and clinical outcome.
Tait, Alan R.; Voepel-Lewis, Terri; Burke, Constance; Kostrzewa, Amy; Lewis, Ian
Anesthesiology. 108(3):375-380, March 2008.
doi: 10.1097/ALN.0b013e318164ca9b
Anesthesiologists are now presented with a greater number of adult and pediatric patients who are significantly overweight. This prospective study examined the relationship between age adjusted body mass index, preoperative comorbidities, and perioperative outcome in children. Obese children had a significantly higher prevalence of comorbidities than nonobese children. Furthermore, obese children had a higher incidence of difficult mask ventilation, airway obstruction, major oxygen desaturation (>10% of baseline), and overall critical respiratory adverse events. Identification and awareness of risk factors for perioperative complications will be important in optimizing the anesthetic management of these children.
Peyton, Philip J.; Horriat, Maryam; Robinson, Gavin J. B.; Pierce, Robert; Thompson, Bruce R.
Anesthesiology. 108(3):381-387, March 2008.
doi: 10.1097/ALN.0b013e318164caf3
The second gas effect on arterial sevoflurane partial pressures is two to three times more powerful than the effect on end-expired partial pressures, because of inhomogeneity of distribution of blood flow and gas uptake in the lung.
Illman, Hanna; Antila, Heikki; Olkkola, Klaus T.
Anesthesiology. 108(3):388-391, March 2008.
doi: 10.1097/ALN.0b013e318164cacb
Nitrous oxide does not affect the infusion requirements of rocuronium.
Lam, Chen-Fuh; Liu, Yen-Chin; Hsu, Jen-Kuo; Yeh, Pei-An; Su, Ting-Ya; Huang, Chien-Chi; Lin, Ming-Wei; Wu, Ping-Ching; Chang, Pei-Jung; Tsai, Yu-Chuan
Anesthesiology. 108(3):392-401, March 2008.
doi: 10.1097/ALN.0b013e318164ca64
This study demonstrates that transplantation of circulating endothelial progenitor cells improves endothelial function of the injured pulmonary artery and attenuates damage of alveolar-capillary barrier in acute lung injury.
Hirose, Ryutaro; Xu, Fengyun; Dang, Kim; Liu, Tao; Behrends, Matthias; Brakeman, Paul R.; Wiener-Kronish, Jeanine; Niemann, Claus U.
Anesthesiology. 108(3):402-414, March 2008.
doi: 10.1097/ALN.0b013e318164cff8
Transient hyperglycemia aggravates renal ischemia-reperfusion injury. Hyperglycemia that exists before and during ischemia-reperfusion causes more severe renal injury than hyperglycemia that occurs after the initiation of ischemia-reperfusion.
Raphael, Jacob; Zuo, Zhiyi; Abedat, Suzan; Beeri, Ronen; Gozal, Yaacov
Anesthesiology. 108(3):415-425, March 2008.
doi: 10.1097/ALN.0b013e318164cab1
Isoflurane preconditioning increased hypoxia inducible factor-1 expression and activity. Inhibiting hypoxia inducible factor 1 by rapamycin abolished isoflurane-induced cardioprotection, suggesting that isoflurane preconditioning may be mediated via hypoxia inducible factor 1 and mammalian target of rapamycin signaling.
Jia, Baosen; Crowder, C Michael
Anesthesiology. 108(3):426-433, March 2008.
doi: 10.1097/ALN.0b013e318164d013
The volatile anesthetics halothane and isoflurane induce a delayed preconditioning protective response against hypoxic, azide, and thermal injury in the invertebrate Caenorhabditis elegans.
Sandstrom, David J.
Anesthesiology. 108(3):434-446, March 2008.
doi: 10.1097/ALN.0b013e318164cfda
Isoflurane-induced presynaptic inhibition in Drosophila motoneurons was studied using electrophysiology, genetics, and simulation. Simulations suggesting activation of a voltage-insensitive, hyperpolarizing current were supported by the presence of an isoflurane-activated leak in motoneuron somata.
Ishizeki, Junko; Nishikawa, Koichi; Kubo, Kazuhiro; Saito, Shigeru; Goto, Fumio
Anesthesiology. 108(3):447-456, March 2008.
doi: 10.1097/ALN.0b013e318164cfba
Amnestic concentrations of sevoflurane inhibit long-term potentiation of hippocampal CA1 neurons through γ-aminobutyric acid-mediated mechanisms and may thereby impair memory function.
Dahmani, Souhayl; Paris, Andrea; Jannier, Virginie; Hein, Lutz; Rouelle, Danielle; Scholz, Jens; Gressens, Pierre; Mantz, Jean
Anesthesiology. 108(3):457-466, March 2008.
doi: 10.1097/ALN.0b013e318164ca81
Dexmedetomidine, an α2-adrenoceptor agonist, increases extracellular signal-regulated protein kinase 1 and 2 phosphorylation in the hippocampus. This effect is independent of α2 adrenoceptors and is most likely to be mediated via the imidazoline I1 receptors.
Minville, Vincent; Laffosse, Jean-Michel; Fourcade, Olivier; Girolami, Jean-Pierre; Tack, Ivan
Anesthesiology. 108(3):467-472, March 2008.
doi: 10.1097/ALN.0b013e3181649333
The authors describe a new mouse model of fracture pain that could be useful to investigate mechanisms of pain in genetically modified animals.
Freeman, Katie T.; Koewler, Nathan J.; Jimenez-Andrade, Juan M.; Buus, Ryan J.; Herrera, Monica B.; Martin, Carl D.; Ghilardi, Joseph R.; Kuskowski, Michael A.; Mantyh, Patrick W.
Anesthesiology. 108(3):473-483, March 2008.
doi: 10.1097/ALN.0b013e3181649351
The authors of this study characterize skeletal pain in a previously validated rat femur fracture model. This model may help to define the mechanisms driving skeletal pain and develop new therapies for treating fracture pain.
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