Anesthesiology

Ausset, Sylvain; Auroy, Yves; Verret, Catherine; Benhamou, Dan; Vest, Philippe; Cirodde, Audrey; Lenoir, Bernard

Anesthesiology. 113(3):529-540, September 2010.

doi: 10.1097/ALN.0b013e3181eaacc4

The aim of this study was to assess the impact of changes in practice on both the incidence of postoperative myocardial infarction (PMI) measured by troponin Ic and long-term cardiac outcome. During a 3-yr period, the incidences of PMI and major adverse cardiac events (MACE) were used as result indicators for quality of care. Incidences of PMI and MACE were 8.9% versus 3.9% and 8.1% versus 1.9% before and after changes in practice, respectively. The postoperative care policy after major orthopedic surgery was strongly correlated with both short-term (i.e., PMI) and long-term cardiac outcome.

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Levy, Jerrold H.; Key, Nigel S.; Azran, Marc S.

Anesthesiology. 113(3):726-745, September 2010.

doi: 10.1097/ALN.0b013e3181ebdb15

The impact of the new, oral anticoagulants being developed for use in the perioperative setting will depend on the balance between efficacy and safety, improved convenience for patient and physician, and any potential cost-effectiveness benefits.

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Yuki, Koichi; Astrof, Nathan S.; Bracken, Clay; Soriano, Sulpicio G.; Shimaoka, Motomu

Anesthesiology. 113(3):600-609, September 2010.

doi: 10.1097/ALN.0b013e3181e89a77

Sevoflurane inhibits lymphocyte function-associated antigen-1 by binding to the allosteric cavity. This allosteric mode of action has been previously observed in isoflurane and might explain the underlying mechanisms by which sevoflurane and isoflurane modulate the immune system.

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Libert, Nicolas; Tourtier, Jean-Pierre; Védrine, Lionel; Chargari, Cyrus

Anesthesiology. 113(3):704-712, September 2010.

doi: 10.1097/ALN.0b013e3181ed098d

While potentially improving overall survival, inhibitors of vascular endothelial growth factor are subject to considerable uncertainty concerning potential side effects. For anesthesiologists, this translates into new challenges when assessing perioperative risks in patients undergoing surgery.

Moon, Jee Y.; Lee, Pyung-Bok; Nahm, Francis Sahngun; Kim, Yong-Chul; Choi, Jong-Bum

Anesthesiology. 113(3):666-671, September 2010.

doi: 10.1097/ALN.0b013e3181e898e8

Cervical epidural pressure was higher in prone than in sitting position and was not consistently negative even in sitting position. This suggests that the hanging drop technique is inappropriate for identifying the cervical epidural space in either position.

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Bruehl, Stephen

Anesthesiology. 113(3):713-725, September 2010.

doi: 10.1097/ALN.0b013e3181e3db38

The pathophysiology of complex regional pain syndrome is complex and multifactorial, involving both peripheral and central mechanisms. This review summarizes the current research literature regarding several key mechanisms that seem to contribute to this pain condition.

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