Anesthesiology

Edwards, David A.; Shah, Hina P.; Cao, Wengang; Gravenstein, Nikolaus; Seubert, Christoph N.; Martynyuk, Anatoly E.

Anesthesiology. 112(3):567-575, March 2010.

doi: 10.1097/ALN.0b013e3181cf9138

Sevoflurane has been reported to cause epileptiform electroencephalographic activity and seizure-like movements. Because of concerns for neonatal anesthetic toxicity, the authors tested the hypothesis that sevoflurane induced seizures and neurotoxicity may be diminished by the Na+–K+–2Cl− cotransporter 1 inhibitor, bumetanide. During anesthesia maintenance with sevoflurane, the electroencephalography exhibited distinctive episodes of epileptic seizures in 40% of rats from postnatal days 4 through 8. Bumetanide decreased seizures in these rats. These results support the possibility that excitatory output of sevoflurane-potentiated γ-aminobutyric acid type A/glycine systems may contribute to epileptogenic and neurotoxic effects in early postnatal rats.

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Anesthesiology. 112(3):530-545, March 2010.

doi: 10.1097/ALN.0b013e3181c4c7d8

The American Society of Anesthesiologists Task Force on Infectious Complications Associated with Neuraxial Techniques presents a Practice Advisory addressing the prevention, diagnosis, and management of infectious complications associated with neuraxial techniques. This Advisory is intended to identify or describe patients at increased risk of infectious complications, describe techniques for reducing infectious risk, and describe interventions to improve outcomes after the occurrence of infectious complications.

Yu, Binglan; Shahid, Mohd; Egorina, Elena M.; Sovershaev, Mikhail A.; Raher, Michael J.; Lei, Chong; Wu, Mei X.; Bloch, Kenneth D.; Zapol, Warren M.

Anesthesiology. 112(3):586-594, March 2010.

doi: 10.1097/ALN.0b013e3181cd7838

Nitric oxide scavenging by PolyHeme (Northfield Laboratories, Evanston, IL) or tetrameric hemoglobin in animals with endothelial dysfunction sensitizes them to the vasoconstrictor effect.

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Perry, Tjörvi E.; Muehlschlegel, Jochen D.; Liu, Kuang-Yu; Fox, Amanda A.; Collard, Charles D.; Body, Simon C.; Shernan, Stanton K.; for the CABG Genomics Investigators

Anesthesiology. 112(3):607-613, March 2010.

doi: 10.1097/ALN.0b013e3181cea3b5

Preoperative C-reactive protein risk categories is shown to predict adverse cardiovascular outcomes in nonsurgical population-based cohorts. It also predicts long-term mortality and extended hospital length of stay in patients undergoing coronary artery bypass graft surgery.

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Tsui, Ban C. H.; Suresh, Santhanam

Anesthesiology. 112(3):719-728, March 2010.

doi: 10.1097/ALN.0b013e3181c5e03a

This review presents a summary of relevant anatomy, techniques used, and outcomes (based on controlled or comparative studies) as described in current published literature on ultrasound guidance of neuraxial blocks.

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Chorney, Jill MacLaren; Kain, Zeev N.

Anesthesiology. 112(3):751-755, March 2010.

doi: 10.1097/ALN.0b013e3181cb5ade

This article advances the concept of family-centered pediatric perioperative care by providing a practical and clinically relevant model of delivery of care in this manner.