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Anesthesiology:
doi: 10.1097/01.anes.0000450452.00839.45
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Anesthesiology

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On The Cover:

Ketamine, used for more than 60 yr as a sedative, analgesic, and anesthetic, is now being explored as a rapidly acting antidepressant. An article in this month’s issue highlights the metabolites which may be responsible for this rapid antidepressant effect. (Illustration by A. Johnson, Vivo Visuals.)
* van Velzen and Dahan: Ketamine Metabolomics in the Treatment of Major Depression, p. 4
* Paul et al.: (R,S)-Ketamine Metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine Increase the Mammalian Target of Rapamycin Function, p. 149

© 2014 American Society of Anesthesiologists, Inc.

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