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doi: 10.1097/ALN.0000446879.21458.99

Perioperative Auto-titrated Continuous Positive Airway Pressure Treatment in Surgical Patients with Obstructive Sleep Apnea: A Randomized Controlled Trial: Erratum

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After publication of this article beginning on page 837 of the October 2013 issue, it was revealed that an interim analysis had been performed midway through this study, resulting in a change in primary outcome measure. The study was initiated in December 2009, with a primary outcome measure of nocturnal oxygen saturation index and secondary outcomes of peri- and postoperative adverse events. An interim analysis was performed in May 2010 after 49 patients had been randomized. Based on this analysis, the primary outcome measure was changed to apnea hypopnea index (AHI). This information was not available during peer review. Given the lack of statistical control for changing primary outcome measure based on an interim analysis, readers should interpret the results of the study with caution and consider them hypothesis generating rather than hypothesis testing.
Additionally, the authors note a mistake in table 2. In the second line of that table, the AHI values for the “All Randomized Patients” APAP (auto-titrated continuous positive airway pressure) group should be 30.1 (22.1, 42.5) and for the “All Randomized Patients” Control group should be 25.6 (18.8, 39.6). Text references to these groups in the Abstract and Results section should be corrected to these values.
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Liao P, Luo Q, Elsaid H, Kang W, Shapiro CM, Chung F. Perioperative auto-titrated continuous positive airway pressure treatment in surgical patients with obstructive sleep apnea: A randomized controlled trial. ANESTHESIOLOGY. 2013;119:837–47

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