Pain Medicine: Clinical Science
Ultrasound-guided Multilevel Paravertebral Blocks and Total Intravenous Anesthesia Improve the Quality of Recovery after Ambulatory Breast Tumor Resection
Abdallah, Faraj W. M.D.; Morgan, Pamela J. M.D., F.R.C.P.C.; Cil, Tulin M.D., F.R.C.S.C.; McNaught, Andrew M.D., F.R.C.P.C.; Escallon, Jaime M. M.D., F.R.C.S.C.; Semple, John L. M.D., F.R.C.S.C.; Wu, Wei M.Sc.; Chan, Vincent W. M.D., F.R.C.P.C.
Background: Regional anesthesia improves postoperative analgesia and enhances quality of recovery (QoR) after ambulatory surgery. This randomized, double-blinded, parallel-group, placebo-controlled trial examines the effects of multilevel ultrasound-guided paravertebral blocks (PVBs) and total intravenous anesthesia on QoR after ambulatory breast tumor resection.
Methods: Sixty-six women were randomized to standardized general anesthesia (control group) or PVBs and propofol-based total intravenous anesthesia (PVB group). The PVB group received T1–T5 PVBs with 5 ml of 0.5% ropivacaine per level, whereas the control group received sham subcutaneous injections. Postoperative QoR was designated as the primary outcome. The 29-item ambulatory QoR tool was administered in the preadmission clinic, before discharge, and on postoperative days 2, 4, and 7. Secondary outcomes included block success, pain scores, intra- and postoperative morphine consumption, time to rescue analgesia, incidence of nausea and vomiting, and hospital discharge time.
Results: Data from sixty-four patients were analyzed. The PVB group had higher QoR scores than control group upon discharge (146 vs. 131; P < 0.0001) and on postoperative day 2 (145 vs. 135; P = 0.013); improvements beyond postoperative day 2 lacked statistical significance. None of the PVB group patients required conversion to inhalation gas–based general anesthesia or experienced block-related complications. PVB group patients had improved pain scores on postanesthesia care unit admission and discharge, hospital discharge, and postoperative day 2; their intraoperative morphine consumption, incidence of nausea and vomiting, and discharge time were also reduced.
Conclusion: Combining multilevel PVBs with total intravenous anesthesia provides reliable anesthesia, improves postoperative analgesia, enhances QoR, and expedites discharge compared with inhalational gas- and opioid-based general anesthesia for ambulatory breast tumor resection.
What We Already Know about This Topic
* Regional anesthesia improves quality of recovery after surgery in many studies
* Previous studies with paravertebral blocks in this regard are limited due to high failure rate of landmark-guided techniques
What This Article Tells Us That Is New
* By using ultrasound guidance, quality of recovery was i mproved in 64 women randomized to multilevel paravertebral blocks and total intravenous anesthesia for breast tumor resection compared with general anesthesia with sevoflurane and morphine
PERIPHERAL nerve blocks provide several proven benefits when used as an alternative to general anesthesia (GA) in ambulatory surgery, including improved postoperative analgesia and shortened postanesthesia care unit (PACU) stay.1
There is also evidence that the quality of recovery (QoR), a patient-based outcome measure evaluated by the QoR multidimensional assessment tool,2
may be improved when regional anesthesia techniques replace GA for ambulatory surgery.4
Furthermore, evidence suggesting that the choice of anesthetic technique influences the incidence rates of recurrence and metastasis after tumor resection underscores the importance of reliable GA alternatives.6–11
In fact, several editorials have predicted that the future anesthetic of choice for tumor resection surgery will be one that minimizes the use of inhalational gases and opioids while capitalizing on the role of regional anesthesia techniques.12–15
The combination of thoracic paravertebral blocks (PVBs) and total intravenous anesthesia (TIVA) as an alternative to GA for breast tumor resection has been examined in several trials.16–19
The identified advantages of the landmark-guided PVB technique include reduced postoperative pain, analgesic consumption, opioid-related side effects, and shorter PACU stay. However, the relatively high failure rates in achieving adequate surgical anesthesia associated with the use of landmark-guided PVB technique, reported to vary between 18.816
for procedures more complex than simple lumpectomy, preclude its use as an alternative to conventional GA and may impede the full exploration of its benefits in breast tumor resection. Ultrasound guidance is believed to improve peripheral nerve block success rates.21
An ultrasound-guided PVB technique was first described by Hara et al.23
in 2009, with several alternative approaches subsequently described.24–28
Whether the ultrasound-guided PVB technique combined with TIVA is capable of providing reliable surgical anesthesia for complex ambulatory breast tumor resection procedures, and the impact of this anesthetic technique on the postoperative QoR are areas that have not yet been explored.
This randomized, controlled trial is the first to examine the effects of an anesthetic that combines ultrasound-guided multilevel PVBs with TIVA (devoid of inhalational gas and opioids) on the QoR after ambulatory breast tumor resection. We hypothesized that such an anesthetic technique would enhance the patient-perceived QoR. Our secondary aims were to demonstrate the reliability of such an anesthetic technique and to evaluate its effect on analgesic outcomes (e.g., pain, morphine consumption, incidence of nausea and vomiting, and hospital discharge time).
Materials and Methods
All study procedures were completed at the Women’s College Hospital (from July 2011 to February 2013), a University of Toronto–affiliated ambulatory center located in Toronto, Canada. This single-center study was approved by the Women’s College Hospital Research Ethics Board and registered (NCT01654432) at www.clinicaltrials.gov
after commencement of recruitment. After obtaining written informed patient consent, we enrolled women patients with American Society of Anesthesiologists physical status I to II who were scheduled for elective unilateral breast tumor resection in a prospective, randomized, double-blind, parallel-group, placebo-controlled clinical trial. The surgical procedures performed included partial mastectomy with sentinel lymph node biopsy; mastectomy; mastectomy with sentinel lymph node biopsy; modified radical mastectomy (mastectomy with axillary lymph node dissection); and mastectomy with implant insertion. Recruitment was performed through the preadmission clinic; eligible patients were contacted during their visit before the scheduled procedure and were provided with a printed information package outlining the purpose of the study. Exclusion criteria included nonsuitability for regional anesthesia as deemed by the anesthesiologist assessing the patients in the preadmission clinic; contraindications to PVBs such as coagulopathy, infection, or history of allergy with local anesthetic agents; language barrier; body mass index greater than 35 kg/m2
; age less than 18 or more than 85 yr; and history of gastroesophageal reflux disease. Consenting patients were randomized on a 1:1 ratio with no restrictions to receive either thoracic PVBs at the T1–T5 thoracic levels with TIVA consisting of propofol-based GA (PVB group
) or sham subcutaneous local anesthetic injections with sevoflurane-based GA and opioid-based analgesia (control group
). Randomization was performed by an investigator not involved in patient care using Random Allocation Software 2.0®
(Isfahan University of Medical Sciences, Isfahan, Iran). A computer-generated sequence was used to allocate patients to the study groups; the allocation results were concealed in sealed opaque envelopes, which were not opened until the procedure day. Patients remained blind to the outcome of randomization until the conclusion of the study and the collection of all outcome data.
Unless contraindicated, all patients received premedication with celecoxib 400 mg and acetaminophen 1,000 mg orally 1 h before surgery. After intravenous (IV) access was secured, standard monitoring including noninvasive blood pressure, pulse oximetry, and electrocardiogram was applied; oxygen was also delivered by face mask at a rate of 8 l/min. For anxiolysis and analgesia, all patients received IV midazolam 1–4 mg and/or fentanyl 25–50 μg as needed before block performance. All PVB and sham blocks were performed preoperatively in the prone position at the T1–T5 levels. In both groups, skin preparation with chlorhexidine 2% swabs of the upper back was performed, followed by scanning of the upper thoracic portion of the back, ipsilateral to the surgical side, using a 2–6 MHz curved array ultrasound transducer probe (model Z.one ultra; Zonare, Mountain View, CA) placed in a sterile sleeve. The probe was positioned in the vertical plane approximately 2–2.5 cm lateral to the spinous process to allow a parasagittal view of the transverse processes, parietal pleura, superior costotransverse ligaments, and to localize the desired paravertebral spaces ipsilateral to the surgical side for all patients. A skin wheal was created at the midpoint between two adjacent transverse processes using a 25-gauge needle to inject 1 ml of 1% lidocaine.
Starting with paravertebral space at the T1 level and proceeding caudally to T5, a 22 gauge, 50-mm, blunt insulated nerve block needle (B. Braun Medical Inc., Bethlehem, PA) was introduced in an in-plane approach relative to the ultrasound transducer toward the paravertebral space (fig. 1
The needle was advanced under direct vision in a cephalad orientation to puncture the superior costotransverse ligament at the desired level. We used the hydrolocation technique by injecting 0.5–1 ml saline to localize the needle tip and confirm proper placement in paravertebral space by observing anterior displacement of the parietal pleural upon injection (fig. 1
). A volume of 5 ml ropivacaine 0.5% was then slowly injected after negative aspiration. Patients in the PVB group
received a total volume of 25 ml of local anesthetics for the purpose of this study. For patients in the control group
, ultrasound visualization of the thoracic paravertebral spaces was performed at each of the five levels, while applying pressure to the back, to simulate the procedure and duration of an actual PVB. The subcutaneous skin wheals produced by injecting 1 ml of lidocaine 1% at the designated five thoracic levels also served as sham blocks. All blocks were performed by two anesthesiologists (F.W.A. and P.J.M.).
The anesthesiologist providing intraoperative care was aware of group allocation. All patients received GA with a laryngeal mask airway device. GA was induced with IV propofol 2–4 mg/kg. Muscle relaxation was achieved with rocuronium 0.6 mg/kg when specifically requested by the surgeon. Patients in the control group also received fentanyl 1 µg/kg for induction. IV dexamethasone 4 mg was administered in all patients after induction of GA.
Anesthesia maintenance in the PVB group was achieved with propofol infusion at a rate of 25–50 µg kg−1 min−1, and patients were allowed to breathe spontaneously a 50:50 air:oxygen mixture. Hemodynamic responses (or patient movement) in response to surgical stimuli were treated by propofol boluses and increasing its infusion rate up to 100 µg kg−1 min−1; if ineffective, opioid boluses of fentanyl to a total dose of 1 µg/kg and then morphine to a total dose of 15 mg were administered. If none of the interventions were successful, sevoflurane was administered.
Anesthesia maintenance in the control group was achieved with 1–2 minimum alveolar concentration of sevoflurane or as needed; patients were allowed to breathe spontaneously a 50:50 nitrous oxide:oxygen mixture. Hemodynamic responses or patient movement were treated by morphine boluses as needed to a maximum of 15 mg. Muscle relaxation was reversed with neostigmine 2.5 mg and glycopyrrolate 0.4 mg if muscle relaxants had been administered. Both patient groups received IV ondansetron 4 mg 30 min before the end of surgery, and a warming device (Bair Hugger; Augustine Medical Inc., Eden Praire, MN) attached to a lower body blanket was used to maintain normothermia. Standard monitoring, including electrocardiogram, noninvasive blood pressure, pulse oximetry, and temperature, was used in all patients for the duration of surgery. All intraoperative medications were recorded including any possible opioid supplementation, other anesthetic agents, or conversion to GA.
At the end of the procedure, all patients were transferred to the PACU I where they were monitored until they met the requirements of transfer to the same-day surgery unit (PACU II). PACU nursing staff, unaware of the patient allocation, monitored patients for pain and postoperative nausea and vomiting (PONV). Patients were discharged from PACU II, and eventually from the hospital, once they met the institutional discharge criteria.29
Patients having pain at rest, a Visual Analogue Scale score of 4/10, or patient request for rescue analgesia, were treated with IV morphine in 2–4 mg increments every 5 min as needed up to a total of 15 mg or with IV hydromorphone 0.2–0.4 mg increments every 5 min as needed up to a total dose of 2 mg. Patients having pain in PACU II was treated with subcutaneous morphine 2.5–5 mg or oral oxycodone 5–10 mg.
The first-line treatment of PONV consisted of IV ondansetron 1–2 mg twice as needed. If this proved ineffective, the second-line therapy consisted of IV dimenhydrinate 12.5–25 mg twice as needed. If this proved ineffective, the third-line therapy consisted of IV metoclopramide 10 mg as needed.
Discharged patients received a prescription for acetaminophen–codeine 300 mg/30 mg 1–2 tabs every 4 h as needed, or acetaminophen–oxycodone 325 mg/5 mg if intolerant to codeine.
The primary outcome variable, the QoR, was measured by the ambulatory surgery QoR questionnaire.31
As a validated comprehensive assessment tool,2
the QoR questionnaire is an increasingly popular tool for evaluating anesthetic interventions.32–34
Although the original questionnaire was not designed for the ambulatory anesthesia and surgery setting,33
an ambulatory variant of the questionnaire has been recently introduced and psychometrically tested by Idvall et al
The ambulatory variant is a 29-item patient-based outcome measure that examines relevant postoperative quality of life dimensions such as emotional state (8 items), physical comfort (10 items), psychological support (4 items), and physical independence (5 items), in addition to pain (1 item) and general health (1 item). Each item uses a 5-point Likert scale (1 = none of the time and 5 = all of the time for positive items; the scoring is reversed for negative items).31
The cumulative scores of the ambulatory QoR questionnaire can vary between 29 (extremely poor QoR) and 155 (excellent QoR). A 10-point score difference is considered clinically significant after anesthesia and surgery.3
We used this tool to assess baseline differences between the two groups in the preadmission clinic preoperatively as well as to evaluate the QoR before discharge and on postoperative days (PODs) 2, 4, and 7 via
The onset of sensory block was evaluated as a secondary outcome by the anesthesiologist performing the PVBs every 5 min after the completion of injection for 30 min. Block onset was tested with a 25-gauge needle along the anterior axillary line using a 3-point score: 2 = normal sensation, 1 = decreased sensation to pin prick, or 0 = loss of sensation compared with the normal contralateral chest. PVB success was defined as complete sensory block in all T1–T5 dermatomes within 30 min of injection; in addition, conversion to sevoflurane-based GA was considered block failure. It was decided, a priori, that any patients in the PVB group who did not achieve a complete sensory block in any of the T1–T5 dermatomes by 30 min would not receive supplemental injections and would be excluded from the study. We also recorded any block-related complications, specifically vascular puncture, hematoma formation, intravascular injection, systemic toxicity, paresthesiae, pleural puncture, pneumothorax, and epidural spread.
The analgesic effects of PVBs were sought as secondary outcomes. Postoperative rest pain Visual Analogue Scale scores upon admission to PACU I, discharge from PACU I, discharge from PACU II, as well as on PODs 2, 4, and 7 were recorded. The cumulative doses of intraoperative supplemental opioids and postoperative opioid analgesics were converted to IV and oral morphine equivalents, respectively.35
The time to first request of rescue analgesia since PACU I admission, incidence of PONV, time to meet discharge criteria, and time to actual hospital discharge were also recorded. All outcome data were collected by an independent observer (research assistant) blinded to the group allocation. The success of maintained patient blinding was evaluated after completion of the QoR questionnaire on POD 7 by asking patients which block they thought they had received.
Our sample size estimation for the two-tailed testing of the PVB superiority hypothesis was based on the QoR questionnaire score. We considered a difference in the QoR score at hospital discharge equivalent to 10 as clinically significant3
in the patients who received PVBs and TIVA (PVB group
) compared with patients who received a sham block with sevoflurane-based GA and opioid-based analgesia (control group
). An SD of the QoR score at discharge equivalent to 11.2 was estimated based on our institutional experience with patients undergoing ambulatory breast tumor resection under GA. A power analysis using a type I error estimate of 5% (alpha = 0.05) a power (1-Beta) of 90% indicated that a sample of 27 patients per group would be needed to perform such a comparison. Allowing for an approximate 20% incomplete follow-up or patient drop out, we aimed to enroll a total of 66 patients in this study.
We performed statistical analysis using SAS, version 9.2 (SAS Institute, Inc., Cary, NC). The Kolmogorov–Smirnov test was used to check for normality of distribution. Descriptive statistics were used to analyze the data; continuous data were described using the mean (SD) and ordinal data were described using median (95% CI), whereas categorical data were described using frequencies. For the primary outcome variable-related comparisons, we calculated the median difference and the 95% CI. Variables that were tested by the nonparametric Mann–Whitney U test were presented as median (interquartile range) under the assumption that the shapes of the parent populations from which these data derive do not vary substantially from normality. The nonparametric Mann–Whitney U test was applied when the assumptions of parametric testing with the Student paired t
test were not met. The chi-square test was used for categorical data. The level of significance was considered at a P
value of less than 0.05; and the Bonferroni–Holm adjustment36
was used to obtain the corrected P
) thresholds for outcomes where repeated measurements were performed.
We assessed 172 patients for eligibility to participate in the study (fig. 2
). Of these, 48 patients did not meet the inclusion criteria, 58 declined enrollment, and the remaining 66 patients consented to the study. The allocation of the recruited patients included 34 to the PVB group
and 32 for the control group
. Two patients were later excluded, one from the PVB group
because of protocol breaches and another from the control group
because of an incomplete QoR questionnaire. A total of 64 patients randomized to treatment allocation completed the study, 33 from the PVB group
and 31 from the control group
, and their data were included in the analysis. Data for the primary outcome were complete, and there were minimal missing data for the secondary outcomes. Patient demographic characteristics were similar with no statistically significant differences (P
> 0.05) between groups (table 1
Patients in the PVB group
had significantly higher QoR scores upon discharge from hospital and on POD 2 (24 h postsurgery), producing clinically relevant3
improvements (≥10 points) in their QoR (fig. 3
). The impact of PVBs on the QoR appeared to extend to POD 4; but the difference did not reach statistical significance. The median (95% CI) of the QoR scores upon discharge, on POD 2, and on POD 4 were 146 (143–149), 145 (141–149), and 145 (143–148), respectively, for patients receiving PVB blocks compared with 131 (126–135); P
< 0.0001 with Pc
= 0.0125, 135 (127–144); P
= 0.013 with Pc
= 0.0167, and 143 (137–146); P
= 0.06 with Pc
= 0.025, respectively, for patients in the control group
). The improvement in QoR scores in the PVB group
upon discharge, a median of 15 points, reflected improvements in the dimensions of emotional status (4 points), physical comfort (4 points), physical independence (4 points), postoperative pain (2 points), and perception of general health status at the time of discharge (1 point). Interestingly, all patients attained the same score on the psychological support dimension. The improvement in QoR on POD 2, a median of 10.75 points, reflected improvements in the dimensions of emotional status (1.5 point), physical comfort (1.5 point), physical independence (4.5 points), postoperative pain (2 points), and general health status (1 point). The difference in QoR scores between the two groups was not statistically significant when the questionnaire was conducted preoperatively in the preadmission clinic, on POD 4, and POD 7 (table 2
). It is noteworthy that patients who received the combination of PVBs and TIVA were able to maintain their baseline median QoR scores (score = 145) at hospital discharge (score = 146) and on POD 2 (score = 145) (table 2
and fig. 3
Block success in the T1–T5 dermatomes was documented for all patients in the PVB group
; and no patients were excluded because of block failure. None of the patients in this group required conversion to sevoflurane-based GA; and no patients required admission for hospital stay. Time to achieve complete sensory block in all dermatomes was 10 min (10.3–14.3; table 3
). There were no complications attributable to the PVBs.
Postoperative Visual Analogue Scale pain scores at rest were reduced after PVB on admission to PACU I, admission to PACU II, discharge from PACU II, POD 2, POD 4, and POD 7 (fig. 4
); but the reduction was not statistically significant on PODs 4 and 7. Expressed as median (95% CI), an improvement in the Visual Analogue Scale scores equivalent to 3 (1–5); P
< 0.0001 with Pc
= 0.0083, 2 (1–3); P
= 0.0011 with Pc
= 0.0167, 2 (1–3); P
< 0.0001 with Pc
= 0.01, 1.5 (1–2); P
= 0.001 with Pc
= 0.0125, 0.5 (0–1); P
= 0.05 with Pc
= 0.05, and 0.5 (0–1); P
= 0.04 with Pc
= 0.025, respectively, was observed at the above-mentioned points.
Compared with the control group
, a smaller proportion of the PVB group
patients required intraoperative supplemental opioids; the cumulative dose of opioids administered (converted to IV morphine equivalents) was also significantly lower (table 4
). In addition, a smaller proportion of PVB group
patients required postoperative supplemental opioids in PACU I and II; but there was no difference in the cumulative dose of opioids administered (converted to oral morphine equivalents). The time to first request of rescue analgesia was not different between the two groups (table 4
Patients in the PVB group
experienced significantly reduced incidence of PONV, met PACU discharge criteria earlier (56.6 min or 25%), and had a shorter hospital discharge time (49.7 min or 20.7%; table 4
). The proportion of patients who provided a correct answer to the question “Which block do you think you received?” was neither different between groups nor different from the proportion that provided a wrong answer within the same group.
This study demonstrates that the combination of ultrasound-guided PVBs and TIVA enhances the QoR and seems to allow the preservation of the quality of life compared with inhalational gas- and opioid-based GA in patients undergoing ambulatory breast tumor resection. With the exception of psychological support, patients receiving PVBs had better scores in all dimensions of the QoR questionnaire completed at discharge time compared with patients in the control group. The improvement in the QoR cumulative score persisted into POD 2 and POD 4, but the difference was not statistically significant on POD 4. Our results also demonstrate the reliability of this anesthetic technique for ambulatory breast tumor resection. Additional benefits of this anesthetic technique include improved postoperative pain relief up to 48 h after surgery, reduced PONV, as well as expedited PACU and hospital discharge.
The effect of PVBs and TIVA on the QoR after breast tumor surgery has not been illustrated before. An earlier report37
examined the effect of adding a catheter-based infusion to landmark-guided PVBs on the QoR in patients undergoing ambulatory breast tumor resection. Limited by their trial design that lacked a control group, Buckenmaier et al.
could not assess the impact of PVB per se
on the QoR. Their addition of a PVB infusion also did not show any further benefits over single-injection PVBs. In addition, the preceding work by Marhofer et al.26
that examined the feasibility of an opioid-free anesthetic regimen in breast cancer surgery was observational in nature, limited by the lack of assessment of PVB success, and examined simpler surgical procedures. Moreover, all earlier clinical trials that examined the role of PVBs for the same surgical procedure did not use ultrasound guidance.16–19
–44 This is also the first trial to demonstrate that such an anesthetic technique allows shorter recovery room stay and faster hospital discharge after ambulatory breast tumor resection, a benefit of PVB that has also only been reported in retrospective reviews.45
Advances in the surgical management of breast cancer have reduced mortality and morbidity after breast tumor resection.46–49
Arguably, the patient’s quality of life and ability to resume normal activity postsurgery follow as important endpoints.33
To measure changes in the postoperative quality of life immediately after breast tumor resection, we used an ambulatory variant of the QoR tool, a shorter version that has been shown to be sensitive to up to 14 days after ambulatory procedures.31
Our designation of the QoR as a primary outcome is also in keeping with the trend of adopting patient-related outcomes as measures of the quality of health care.52
The recent increased interest in changes to ambulatory anesthetic interventions that can potentially improve the quality of care seems to reflect the gradual, yet progressive, endorsement and implementation of this trend in anesthetic practice.4
Relying on nerve blocks to provide surgical anesthesia for breast surgery is a challenging endeavor owing to the complexity of breast innervation that is derived from the anterior and lateral branches of the first to seventh intercostal nerves.55
Furthermore, depending on the complexity of surgery, and whether or not concomitant axillary surgical interventions are performed, zones innervated by the superficial cervical plexus, the medial and lateral pectoral nerves,56
as well as the long thoracic and thoracodorsal nerves57
may also be involved. Hence, the block of the intercostobrachial nerve by a T2 PVB may not provide sufficient surgical anesthesia for procedures involving the axilla. This may plausibly explain the lack of difference in postoperative supplemental opioid consumption we observed. Indeed, the majority of patients in the PVB group
requiring postoperative opioids localized the source of their discomfort to the axilla. This may also explain why single-16
and even multilevel20
landmark-guided PVBs, stand alone, have high failure rates (estimates vary between 14.7,60
) in providing adequate surgical anesthesia for more extensive tumor resection procedures. Consequently, the combination of multilevel ultrasound-guided PVBs and TIVA seems to bring into actuality the recommended anesthetic technique12–15
that excludes inhalational gas and opioids.
Postoperative pain and PONV are among the most common causes of prolonged hospital stay after ambulatory surgery;61
this may explain the expedited discharge noted with PVBs. Although improved analgesia and reduced opioid-related side effects are consistent with earlier findings,62
prolonged analgesia lasting into POD 2 is uncommon as it exceeds the duration of long-acting local anesthetics used in single-shot blocks.64
Nevertheless, extended analgesia lasting an average of 23 h (range, 9–38) after PVBs has been described in two earlier reports.60
Although the mechanism for the extended duration of analgesia observed after thoracic PVBs block is unclear, the possible effect of local anesthetic induced sympathectomy66
on postoperative pain has been postulated.67
The results of our study are subject to some limitations. First, the QoR questionnaire we used was tested in the Swedish population; cultural differences between countries68
may limit its generalizability. A more recent short-form QoR questionnaire, the QoR-15, may offer improved utility in the ambulatory setting70
and may overcome the validity limitations of the psychological support dimension of Idvall’s QoR tool31
that were reflected in our results. Second, the awareness of the anesthesiologist providing intraoperative care of patient allocation as well as the propofol-related analgesic effects71
may have influenced our results, particularly the intraoperative opioid consumption. Third, our assessment of sensory block onset risks compromising the blinding of the patients though our evaluation of data indicated adequacy of blinding. In addition, our study design did neither include an additional comparative group that receives both GA and PVBs nor use bispectral index monitoring, which would allow additional appreciation of the effects of GA and PVBs on the QoR. Furthermore, the diversity in the types of surgical procedures studied and the stages of tumor resected may pose further limitations to our conclusions. Finally, our study does not evaluate oncological variables such as disease-free survival though PVBs have been reported to influence this important outcome.73
We conclude that an opioid- and inhalational gas-free anesthetic technique utilizing a combination of multilevel ultrasound-guided PVBs and TIVA provides reliable anesthesia, better QoR, improved postoperative analgesia, as well as a shorter discharge time than conventional GA in patients undergoing ambulatory breast tumor resection. When no contraindications exist, PVBs seem to be a better anesthetic option that may allow the preservation of the quality of life, thus the improvement in postoperative QoR they produce compared with GA should be taken into consideration when designing the management plan for this surgical procedure. Future trials are required to examine the effects of PVBs in other breast surgeries.
The authors thank Mary Li, B.Sc. (Women’s College Hospital, Toronto, Ontario, Canada), Stephen Halpern, M.D., F.R.C.P.C. (Sunnybrook Health Sciences Center, Toronto, Ontario, Canada), and Jean Kronberg, M.D., F.R.C.P.C. (Women’s College Hospital), for their assistance in the various stages of the study.
This study was supported by grant number AHSC–AFP 11–2012 from the Alternate Funding Plan Innovation Fund, Ontario Ministry of Health and Long Term Care (Toronto, Ontario, Canada). Dr. Morgan was supported by a Merit Award from the Department of Anesthesia, University of Toronto (Toronto, Ontario, Canada).
Dr. Chan receives equipment support from BK Medical Systems (Wilmington, Massachusetts), Philips Medical Systems (Bothell, Washington), SonoSite (Bothell, Washington), and Ultrasonix (Richmond, British Columbia, Canada). None of the other authors declares competing interests.
1. Liu SS, Strodtbeck WM, Richman JM, Wu CL. A comparison of regional versus
general anesthesia for ambulatory anesthesia: A meta-analysis of randomized controlled trials. Anesth Analg. 2005;101:1634–42
2. Myles PS, Hunt JO, Nightingale CE, Fletcher H, Beh T, Tanil D, Nagy A, Rubinstein A, Ponsford JL. Development and psychometric testing of a quality of recovery score after general anesthesia and surgery in adults. Anesth Analg. 1999;88:83–90
3. Myles PS, Weitkamp B, Jones K, Melick J, Hensen S. Validity and reliability of a postoperative quality of recovery score: The QoR-40. Br J Anaesth. 2000;84:11–5
4. Bost JE, Williams BA, Bottegal MT, Dang Q, Rubio DM. The 8-item Short-Form Health Survey and the physical comfort composite score of the quality of recovery 40-item scale provide the most responsive assessments of pain, physical function, and mental function during the first 4 days after ambulatory knee surgery with regional anesthesia. Anesth Analg. 2007;105:1693–700
5. Catro-Alves LJ, De Azevedo VL, De Freitas Braga TF, Goncalves AC, De Oliveira GS Jr. The effect of neuraxial versus
general anesthesia techniques on postoperative quality of recovery and analgesia after abdominal hysterectomy: A prospective, randomized, controlled trial. Anesth Analg. 2011;113:1480–6
6. Homburger JA, Meiler SE. Anesthesia drugs, immunity, and long-term outcome. Curr Opin Anaesthesiol. 2006;19:423–8
7. Snyder GL, Greenberg S. Effect of anaesthetic technique and other perioperative factors on cancer recurrence. Br J Anaesth. 2010;105:106–15
8. Santamaria LB, Schifilliti D, La Torre D, Fodale V. Drugs of anaesthesia and cancer. Surg Oncol. 2010;19:63–81
9. Gottschalk A, Sharma S, Ford J, Durieux ME, Tiouririne M. The role of the perioperative period in recurrence after cancer surgery. Anesth Analg. 2010;110:1636–43
10. Cata JP, Guttumukkala V, Sessler DI. How regional analgesia might reduce postoperative cancer recurrence. Eur J Pain Supp. 2011;5:345–55
11. Tavare AN, Perry NJ, Benzonana LL, Takata M, Ma D. Cancer recurrence after surgery: Direct and indirect effects of anesthetic agents. Int J Cancer. 2012;130:1237–50
12. Sessler DI. Long-term consequences of anesthetic management. ANESTHESIOLOGY. 2009;111:1–4
13. Harrop-Griffiths W, Nathanson MH. Regional anaesthesia—The bride at last? Anaesthesia. 2010;65:S1 ii–v
14. Yeager MP, Rosenkranz KM. Cancer recurrence after surgery: A role for regional anesthesia? Reg Anesth Pain Med. 2010;35:483–4
15. Sessler DI. Regional anesthesia and prostate cancer recurrence. Can J Anaesth. 2010;57:99–102
16. Pusch F, Freitag H, Weinstabl C, Obwegeser R, Huber E, Wildling E. Single-injection paravertebral block compared to general anaesthesia in breast surgery. Acta Anaesthesiol Scand. 1999;43:770–4
17. Naja MZ, Ziade MF, Lönnqvist PA. Nerve-stimulator guided paravertebral blockade vs.
general anaesthesia for breast surgery: A prospective randomized trial. Eur J Anaesthesiol. 2003;20:897–903
18. Dabbagh A, Elyasi H. The role of paravertebral block in decreasing postoperative pain in elective breast surgeries. Med Sci Monit. 2007;13:CR464–7
19. Das S, Bhattacharya P, Mandal MC, Mukhopadhyay S, Basu SR, Mandol BK. Multiple-injection thoracic paravertebral block as an alternative to general anaesthesia for elective breast surgeries: A randomised controlled trial. Indian J Anaesth. 2012;56:27–33
20. Najarian MM, Johnson JM, Landercasper J, Havlik P, Lambert PJ, McCarthy D. Paravertebral block: An alternative to general anesthesia in breast cancer surgery. Am Surg. 2003;69:213–8
21. McCartney CJ, Lin L, Shastri U. Evidence basis for the use of ultrasound for upper-extremity blocks. Reg Anesth Pain Med. 2010;35:S10–5
22. Neal JM, Brull R, Chan VW, Grant SA, Horn JL, Liu SS, McCartney CJ, Narouze SN, Perlas A, Salinas FV, Sites BD, Tsui BC. The ASRA evidence-based medicine assessment of ultrasound-guided regional anesthesia and pain medicine: Executive summary. Reg Anesth Pain Med. 2010;35(2 suppl):S1–9
23. Hara K, Sakura S, Nomura T, Saito Y. Ultrasound guided thoracic paravertebral block in breast surgery. Anaesthesia. 2009;64:223–5
24. Ben-Ari A, Moreno M, Chelly JE, Bigeleisen PE. Ultrasound-guided paravertebral block using an intercostal approach. Anesth Analg. 2009;109:1691–4
25. Luyet C, Eichenberger U, Greif R, Vogt A, Szücs Farkas Z, Moriggl B. Ultrasound-guided paravertebral puncture and placement of catheters in human cadavers: An imaging study. Br J Anaesth. 2009;102:534–9
26. Marhofer P, Kettner SC, Hajbok L, Dubsky P, Fleischmann E. Lateral ultrasound-guided paravertebral blockade: An anatomical-based description of a new technique. Br J Anaesth. 2010;105:526–32
27. Renes SH, Bruhn J, Gielen MJ, Scheffer GJ, van Geffen GJ. In-plane ultrasound-guided thoracic paravertebral block: A preliminary report of 36 cases with radiologic confirmation of catheter position. Reg Anesth Pain Med. 2010;35:212–6
28. O Riain SC, Donnell BO, Cuffe T, Harmon DC, Fraher JP, Shorten G. Thoracic paravertebral block using real-time ultrasound guidance. Anesth Analg. 2010;110:248–51
29. Aldrete JA, Kroulik D. A postanesthetic recovery score. Anesth Analg. 1970;49:924–34
30. Aldrete JA. The post-anesthesia recovery score revisited. J Clin Anesth. 1995;7:89–91
31. Idvall E, Berg K, Unosson M, Brudin L, Nilsson U. Assessment of recovery after day surgery using a modified version of quality of recovery-40. Acta Anaesthesiol Scand. 2009;53:673–7
32. Myles PS, Hunt JO, Fletcher H, Solly R, Woodward D, Kelly S. Relation between quality of recovery in hospital and quality of life at 3 months after cardiac surgery. ANESTHESIOLOGY. 2001;95:862–7
33. Herrera FJ, Wong J, Chung F. A systematic review of postoperative recovery outcomes measurements after ambulatory surgery. Anesth Analg. 2007;105:63–9
34. Gornall BF, Myles PS, Smith CL, Burke JA, Leslie K, Pereira MJ, Bost JE, Kluivers KB, Nilsson UG, Tanaka Y, Forbes A. Measurement of quality of recovery using the QoR-40: A quantitative systematic review. Br J Anaesth. 2013;111:161–9
35. Canadian Pharmacists Association. Compendium of Pharmaceuticals and Specialties: The Canadian Drug Reference for Health Professionals. 201045th edition Ottawa Canadian Pharmacists Assoc
36. Holm S. A simple sequentially rejective multiple test procedure. Scan J Statist. 1979;6:65–70
37. Buckenmaier CC III, Kwon KH, Howard RS, McKnight GM, Shriver CD, Fritz WT, Garguilo GA, Joltes KH, Stojadinovic A. Double-blinded, placebo-controlled, prospective randomized trial evaluating the efficacy of paravertebral block with and without continuous paravertebral block analgesia in outpatient breast cancer surgery. Pain Med. 2010;11:790–9
38. Kairaluoma PM, Bachmann MS, Rosenberg PH, Pere PJ. Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery. Anesth Analg. 2006;103:703–8
39. Moller JF, Nikolajsen L, Rodt SA, Ronning H, Carlsson PS. Thoracic paravertebral block for breast cancer surgery: A randomized double-blind study. Anesth Analg. 2007;105:1848–51
40. Boughey JC, Goravanchi F, Parris RN, Kee SS, Kowalski AM, Frenzel JC, Bedrosian I, Meric-Bernstam F, Hunt KK, Ames FC, Kuerer HM, Lucci A. Prospective randomized trial of paravertebral block for patients undergoing breast cancer surgery. Am J Surg. 2009;198:720–5
41. Arunakul P, Ruksa A. General anesthesia with thoracic paravertebral block for modified radical mastectomy. J Med Assoc Thai. 2010;93(suppl 7):S149–53
42. Li NL, Yu BL, Tseng SC, Hsu CC, Lai WJ, Hsieh PF, Peng WL, Chen CM. The effect on improvement of recovery and pain scores of paravertebral block immediately before breast surgery. Acta Anaesthesiol Taiwan. 2011;49:91–5
43. Naja ZM, Naccache N, Ziade F, El-Rajab M, Itani T, Baraka A. Multilevel nerve stimulator-guided paravertebral block as a sole anesthetic technique for breast cancer surgery in morbidly obese patients. J Anesth. 2011;25:760–4
44. Bhuvaneswari V, Wig J, Mathew PJ, Singh G. Post-operative pain and analgesic requirements after paravertebral block for mastectomy: A randomized controlled trial of different concentrations of bupivacaine and fentanyl. Indian J Anaesth. 2012;56:34–9
45. Boughey JC, Goravanchi F, Parris RN, Kee SS, Frenzel JC, Hunt KK, Ames FC, Kuerer HM, Lucci A. Improved postoperative pain control using thoracic paravertebral block for breast operations. Breast J. 2009;15:483–8
46. Veronesi U, Saccozzi R, Del Vecchio M, Banfi A, Clemente C, De Lena M, Gallus G, Greco M, Luini A, Marubini E, Muscolino G, Rilke F, Salvadori B, Zecchini A, Zucali R. Comparing radical mastectomy with quadrantectomy, axillary dissection, and radiotherapy in patients with small cancers of the breast. N Engl J Med. 1981;305:6–11
47. Whelan TJ, Julian J, Wright J, Jadad AR, Levine ML. Does locoregional radiation therapy improve survival in breast cancer? A meta-analysis. J Clin Oncol. 2000;18:1220–9
48. Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, Aguilar M, Marubini E. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med. 2002;347:1227–32
49. Clarke M, Collins R, Darby S, Davies C, Elphinstone P, Evans E, Godwin J, Gray R, Hicks C, James S, MacKinnon E, McGale P, McHugh T, Peto R, Taylor C, Wang YEarly Breast Cancer Trialists’ Collaborative Group (EBCTCG). . Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: An overview of the randomised trials. Lancet. 2005;366:2087–106
50. Gill TM, Feinstein AR. A critical appraisal of the quality of quality-of-life measurements. JAMA. 1994;272:619–26
51. Guyatt GH, Cook DJ. Health status, quality of life, and the individual. JAMA. 1994;272:630–1
52. Rosenthal MB, Frank RG, Li Z, Epstein AM. Early experience with pay-for-performance: From concept to practice. JAMA. 2005;294:1788–93
53. Murphy GS, Szokol JW, Greenberg SB, Avram MJ, Vender JS, Nisman M, Vaughn J. Preoperative dexamethasone enhances quality of recovery after laparoscopic cholecystectomy: Effect on in-hospital and postdischarge recovery outcomes. ANESTHESIOLOGY. 2011;114:882–90
54. De Oliveira GS Jr, Fitzgerald P, Streicher LF, Marcus RJ, McCarthy RJ. Systemic lidocaine to improve postoperative quality of recovery after ambulatory laparoscopic surgery. Anesth Analg. 2012;115:262–7
55. Jaspars JJ, Posma AN, van Immerseel AA, Gittenberger-de Groot AC. The cutaneous innervation of the female breast and nipple-areola complex: Implications for surgery. Br J Plast Surg. 1997;50:249–59
56. Lemay E, Guay J, Côté C, Boivin MC, Varin F. The number of injections does not influence local anesthetic absorption after paravertebral blockade. Can J Anaesth. 2003;50:562–7
57. Macea JR, Fregnani JH. Anatomy of the thoracic wall, axilla and breast. Int J Morphol. 2006;24:691–704
58. Kumar A, Srivastava U, Saxena S, Kannaujia AK, Saraswat N, Mishra AR, Sharma S. Single injection paravertebral block for major cancer breast surgery. J Anaesthesiol Clin Pharmacol. 2009;25:281–4
59. Greengrass R, O’Brien F, Lyerly K, Hardman D, Gleason D, D’Ercole F, Steele S. Paravertebral block for breast cancer surgery. Can J Anaesth. 1996;43:858–61
60. Coveney E, Weltz CR, Greengrass R, Iglehart JD, Leight GS, Steele SM, Lyerly HK. Use of paravertebral block anesthesia in the surgical management of breast cancer: Experience in 156 cases. Ann Surg. 1998;227:496–501
61. Nielsen KC, Steele SM. Outcome after regional anaesthesia in the ambulatory setting—Is it really worth it? Best Pract Res Clin Anaesthesiol. 2002;16:145–57
62. Schnabel A, Reichl SU, Kranke P, Pogatzki-Zahn EM, Zahn PK. Efficacy and safety of paravertebral blocks in breast surgery: A meta-analysis of randomized controlled trials. Br J Anaesth. 2010;105:842–52
63. Tahiri Y, Tran de QH, Bouteaud J, Xu L, Lalonde D, Luc M, Nikolis A. General anaesthesia versus
thoracic paravertebral block for breast surgery: A meta-analysis. J Plast Reconstr Aesthet Surg. 2011;64:1261–9
64. Klein SM, Greengrass RA, Steele SM, D’Ercole FJ, Speer KP, Gleason DH, DeLong ER, Warner DS. A comparison of 0.5% bupivacaine, 0.5% ropivacaine, and 0.75% ropivacaine for interscalene brachial plexus block. Anesth Analg. 1998;87:1316–9
65. Weltz CR, Greengrass RA, Lyerly HK. Ambulatory surgical management of breast carcinoma using paravertebral block. Ann Surg. 1995;222:19–26
66. Cheema SP, Ilsley D, Richardson J, Sabanathan S. A thermographic study of paravertebral analgesia. Anaesthesia. 1995;50:118–21
67. McDonnell JG, Finnerty O, Laffey JG. Stellate ganglion blockade for analgesia following upper limb surgery. Anaesthesia. 2011;66:611–4
68. Chan MT, Lo CC, Lok CK, Chan TW, Choi KC, Gin T. Psychometric testing of the Chinese quality of recovery score. Anesth Analg. 2008;107:1189–95
69. Tanaka Y, Wakita T, Fukuhara S, Nishiwada M, Inoue S, Kawaguchi M, Furuya H. Validation of the Japanese version of the quality of recovery score QoR-40. J Anesth. 2011;25:509–15
70. Stark PA, Myles PS, Burke JA. Development and psychometric evaluation of a postoperative quality of recovery score: The QoR-15. ANESTHESIOLOGY. 2013;118:1332–40
71. Briggs LP, Dundee JW, Bahar M, Clarke RS. Comparison of the effect of diisopropyl phenol (ICI 35, 868) and thiopentone on response to somatic pain. Br J Anaesth. 1982;54:307–11
72. Canavero S, Bonicalzi V, Pagni CA, Castellano G, Merante R, Gentile S, Bradac GB, Bergui M, Benna P, Vighetti S. Propofol analgesia in central pain: Preliminary clinical observations. J Neurol. 1995;242:561–7
73. Exadaktylos AK, Buggy DJ, Moriarty DC, Mascha E, Sessler DI. Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis? ANESTHESIOLOGY. 2006;105:660–4
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