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doi: 10.1097/ALN.0000000000000121
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Adductor Canal Block for Total Knee Arthroplasty: The Perfect Recipe or Just One Ingredient?

Mariano, Edward R. M.D., M.A.S. (Clinical Research); Perlas, Anahi M.D., F.R.C.P.C.

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“Although we do not yet have sufficient evidence to support a universal change from [femoral nerve block to adductor canal block for total knee arthroplasty] patients within a multimodal analgesic protocol, perhaps the time is coming.”
IN this issue of ANESTHESIOLOGY, Kim et al.1 compare the motor and analgesic effects of adductor canal block (ACB) and femoral nerve block (FNB) for total knee arthroplasty (TKA) in the context of an established clinical pathway using multimodal analgesia. The management of postoperative pain after TKA remains challenging. Postoperative pain can be moderate to severe; yet, patients are expected to start physical therapy and ambulate as soon as possible after surgery because early rehabilitation may translate into longer-term functional achievements.2
Recent interest in ACB as a regional analgesic technique for TKA3 coincides with the negative light cast on FNB due to previously reported claims that it increases fall risk.4–6 Another article published in this issue of ANESTHESIOLOGY by Memtsoudis et al.7 (including E.R.M.) provides compelling evidence to refute these claims and identifies many other factors associated with increased fall risk other than anesthetic and analgesic selection. However, no one can argue against the need to reduce fall risk; in our study, TKA patients who fell were more likely to go on to suffer additional major cardiac, pulmonary, thromboembolic, or other organ-system complications with higher 30-day mortality compared with TKA patients who did not fall.7 Inpatient falls leading to injury are considered hospital-acquired conditions and “never events” by the Center for Medicare and Medicaid Services (http://www.cms.gov). In some practice settings,4 especially those that may not have comprehensive multicomponent fall prevention programs in place,8 FNB and continuous femoral perineural local anesthetic infusions in particular may not be considered viable options despite providing effective analgesia and decreasing the time to meet discharge criteria.6
The search for the perfect regional analgesic regimen for TKA patients continues. Although we anxiously await the selective local anesthetic that can preferentially anesthetize sensory nerves while sparing motor nerves,9 we need to make the most of our imperfect nonselective local anesthetics in the perioperative management of pain. The innervation of the knee is complex, with contributions from both the lumbar and sacral plexuses. Thus, continuous neuraxial analgesia and femoral and sciatic nerve blocks, in single dose or continuous infusions, have all been used for postoperative pain management after TKA.10,11 Although enthusiasm for ACB with TKA is fairly recent, the technique itself is not. A similar approach has been used to anesthetize the saphenous nerve in the adductor canal to provide analgesia to the medial aspect of the ankle.11–14 For TKA, however, the real question in many anesthesiologists’ minds is: How can an injection of local anesthetic into the adductor canal by itself possibly provide enough analgesia for TKA?
The short answer is: it does not have to. Integrated multimodal analgesic protocols, as defined by the American Society of Anesthesiologists’ practice guidelines on perioperative pain management, use two or more analgesic modalities with different mechanisms of action to provide superior analgesia and limit side effects and adverse events.12 Regional analgesic techniques are usually at the center of these multimodal protocols in a background of nonsteroidal anti-inflammatory drugs, acetaminophen, and low-dose opioids.12 There is a nascent but growing case being made in the contemporary literature to support ACB as the most appropriate regional analgesic technique to be the core of a multimodal analgesic protocol for TKA due to its decreased potential for quadriceps weakness.13,14
The efficacy of ACB for TKA in the setting of oral multimodal analgesia has been previously demonstrated in a proof-of-concept study.15 Similarly, the addition of ACB to a multimodal protocol including local infiltration analgesia provides further improvement in pain scores and ambulation compared with placebo injection.16 Retrospective cohort studies further suggest that the combination of ACB and local infiltration analgesia is associated with enhanced early postoperative ambulation compared with femoral nerve perineural infusions.17,18
The current study1 is one of the first randomized clinical trials to compare the effectiveness of ACBs to FNBs for TKA patients within a multimodal analgesic protocol. All subjects received preoperative and postoperative nonsteroidal anti-inflammatory drugs, acetaminophen, and systemic opioids; all but three subjects received low-dose epidural patient-controlled analgesia with bupivacaine and hydromorphone postoperatively. Subjects were randomly assigned to receive an ACB or FNB preoperatively followed by intraoperative neuraxial anesthesia with local anesthetic only. Quadriceps muscle strength was assessed at 6 to 8 h postoperatively, whereas pain and opioid consumption were monitored for the first 48 h. The ACB group demonstrated greater quadriceps muscle strength at 6 to 8 h (an advantage of 5.2 kgf over the FNB) and was found to be noninferior in terms of pain scores and opioid consumption up to 48 h.1 Although the difference in muscle strength is statistically significant, the clinical relevance of this outcome is still questionable; a recent study comparing ACB with FNB also demonstrated a quadriceps strength advantage postoperatively in TKA patients, but no benefits in mobilization ability.19 Furthermore, the epidural analgesia provided to both groups may have been a confounder in the noninferiority hypothesis testing. We can conclude that ACB does not provide inferior analgesia compared with FNB within this institution’s multimodal protocol, but we do not know whether or not a quadriceps strength advantage at 6 to 8 h postoperatively translates into actual rehabilitative benefits for TKA patients in the short or long term or whether these results can be reproduced in other practice models.
The study by Kim et al. does not report any in-hospital rehabilitation metrics such as ambulation distance, range of motion, ability to perform straight leg raise, time to meet functional independence and discharge eligibility, or short- or long-term functional outcomes. The effects of ACB on these parameters, if any, remain unknown. At the authors’ institution, patients are only “dangled” at the bedside on the day of surgery and begin ambulation on postoperative day 1.1 The physical therapy regimen (i.e., knee immobilizer for the operative extremity, use of a front-wheel walker, number of assistants during ambulation) is not specified. At institutions that brace the operative extremity with a knee immobilizer and provide sufficient assistance, a decrease in quadriceps strength from FNB may not necessarily be a hindrance to ambulation.6,20
The issue of context is an important one as clinical pathways integrating pain management, physical therapy, nursing, and surgical care are often specific to individual institutions. Multimodal analgesia should be interpreted and applied differently based on the practice model, just as there can be many different recipes for the same dish. There is no question that the “recipe” for TKA multimodal analgesia should include regional anesthesia, opioids, and nonopioid analgesic medications, but there may be some latitude with regard to choosing the individual “ingredients.”
The change from FNB to ACB and the maintenance of quadriceps strength have the potential to affect physical therapy outcomes in a way that we have not previously seen. Although the study by Kim et al. provides us with important new information, there is a great deal of work to be done to quantify these potential benefits within the context of different practice models, and many prospective studies are currently underway to evaluate ACB in comparison with FNB. In a recent search of ClinicalTrials.gov using the search terms “adductor canal,” “femoral,” and “knee arthroplasty,” the output generated nine studies—two completed (the current study1 and the study by Jæger et al.19), one terminated, four recruiting but not completed, and two that have not started recruiting. Although we do not yet have sufficient evidence to support a universal change from FNB to ACB for TKA patients within a multimodal analgesic protocol, perhaps the time is coming.
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Competing Interests

Dr. Mariano has received an unrestricted educational funding (paid to his institution) for teaching programs from I-Flow Corporation/Kimberly-Clark (Lake Forest, California) and B Braun (Bethlehem, Pennsylvania). These companies had absolutely no input into any aspect of article preparation. Dr. Perlas declares no competing interests.
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References

1. Kim DH, Lin Y, Goytizolo EA, Kahn RL, Maalouf DB, Manohar A, Patt ML, Goon AK, Lee Y, Ma Y, Ya Deau JT. Adductor canal block versus femoral nerve block for total knee arthroplasty: A prospective randomized controlled trial. ANESTHESIOLOGY. 2014;120:540–50

2. Munin MC, Rudy TE, Glynn NW, Crossett LS, Rubash HE. Early inpatient rehabilitation after elective hip and knee arthroplasty. JAMA. 1998;279:847–52

3. Lund J, Jenstrup MT, Jæger P, Sørensen AM, Dahl JB. Continuous adductor-canal-blockade for adjuvant post-operative analgesia after major knee surgery: Preliminary results. Acta Anaesthesiol Scand. 2011;55:14–9

4. Feibel RJ, Dervin GF, Kim PR, Beaulé PE. Major complications associated with femoral nerve catheters for knee arthroplasty: A word of caution. J Arthroplasty. 2009;24(6 suppl):132–7

5. Sharma S, Iorio R, Specht LM, Davies-Lepie S, Healy WL. Complications of femoral nerve block for total knee arthroplasty. Clin Orthop Relat Res. 2010;468:135–40

6. Ilfeld BM, Duke KB, Donohue MC. The association between lower extremity continuous peripheral nerve blocks and patient falls after knee and hip arthroplasty. Anesth Analg. 2010;111:1552–4

7. Memtsoudis SG, Danninger T, Rasul R, Poeran J, Gerner P, Stundner O, Mariano ER, Mazumdar M. Inpatient falls after total knee arthroplasty: The role of anesthesia type and peripheral nerve blocks. ANESTHESIOLOGY. 2014;120:551–63

8. Miake-Lye IM, Hempel S, Ganz DA, Shekelle PG. Inpatient fall prevention programs as a patient safety strategy: A systematic review. Ann Intern Med. 2013;158(5 Pt 2):390–6

9. Ilfeld BM, Yaksh TL. The end of postoperative pain—A fast-approaching possibility? And, if so, will we be ready? Reg Anesth Pain Med. 2009;34:85–7

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11. Pham Dang C, Gautheron E, Guilley J, Fernandez M, Waast D, Volteau C, Nguyen JM, Pinaud M. The value of adding sciatic block to continuous femoral block for analgesia after total knee replacement. Reg Anesth Pain Med. 2005;30:128–33

12. . Practice guidelines for acute pain management in the perioperative setting: An updated report by the American Society of Anesthesiologists Task Force on Acute Pain Management. ANESTHESIOLOGY. 2012;116:248–73

13. Kwofie MK, Shastri UD, Gadsden JC, Sinha SK, Abrams JH, Xu D, Salviz EA. The effects of ultrasound-guided adductor canal block versus femoral nerve block on quadriceps strength and fall risk: A blinded, randomized trial of volunteers. Reg Anesth Pain Med. 2013;38:321–5

14. Jæger P, Nielsen ZJ, Henningsen MH, Hilsted KL, Mathiesen O, Dahl JB. Adductor canal block versus femoral nerve block and quadriceps strength: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers. ANESTHESIOLOGY. 2013;118:409–15

15. Jenstrup MT, Jæger P, Lund J, Fomsgaard JS, Bache S, Mathiesen O, Larsen TK, Dahl JB. Effects of adductor-canal-blockade on pain and ambulation after total knee arthroplasty: A randomized study. Acta Anaesthesiol Scand. 2012;56:357–64

16. Andersen HL, Gyrn J, Møller L, Christensen B, Zaric D. Continuous saphenous nerve block as supplement to single-dose local infiltration analgesia for postoperative pain management after total knee arthroplasty. Reg Anesth Pain Med. 2013;38:106–11

17. Perlas A, Kirkham KR, Billing R, Tse C, Brull R, Gandhi R, Chan VW. The impact of analgesic modality on early ambulation following total knee arthroplasty. Reg Anesth Pain Med. 2013;38:334–9

18. Mudumbai SC, Kim TE, Howard SK, Workman JJ, Giori N, Woolson S, Ganaway T, King R, Mariano ER. Continuous adductor canal blocks are superior to continuous femoral nerve blocks in promoting early ambulation after TKA. Clin Orthop Relat Res. 2013 [Epub ahead of print]

19. Jæger P, Zaric D, Fomsgaard JS, Hilsted KL, Bjerregaard J, Gyrn J, Mathiesen O, Larsen TK, Dahl JB. Adductor canal block versus femoral nerve block for analgesia after total knee arthroplasty: A randomized, double-blind study. Reg Anesth Pain Med. 2013;38:526–32

20. Cui Q, Schapiro LH, Kinney MC, Simon P, Poole A, Novicoff WM. Reducing costly falls of total knee replacement patients. Am J Med Qual. 2013;28:335–8

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