Home Current Issue Previous Issues Podcasts Online First ASA Practice Parameters CME For Authors Journal Info
Skip Navigation LinksHome > June 2013 - Volume 118 - Issue 6 > From Fish Poison to Merck Picrotoxin
Anesthesiology:
doi: 10.1097/ALN.0b013e31829a0b4b
Anesthesiology Reflections from the Wood Library-Museum

From Fish Poison to Merck Picrotoxin

Bause, George S. M.D., M.P.H.

Free Access
Collapse Box

Author Information

Figure. No caption a...
Image Tools
For countless centuries, many fishermen in South and Southeast Asia used a stupefying fish poison derived from the seeds of the fishberry shrub (Anamirta cocculus). Picrotoxin, the active ingredient of fishberry seeds, acts as a noncompetitive GABAA receptor antagonist. A neurostimulant and occasional convulsant, picrotoxin can block chloride conductance enhanced by GABAA receptor agonists such as propofol and barbiturates. Thus, picrotoxin has been employed to investigate anesthetic mechanisms of action at the GABAA receptor, as well as used as an antidote for barbiturate toxicity. Manufactured by Merck in Germany, the bottle of picrotoxin (above) is now part of the collection of the Wood Library-Museum.

© 2013 American Society of Anesthesiologists, Inc.

Publication of an advertisement in Anesthesiology Online does not constitute endorsement by the American Society of Anesthesiologists, Inc. or Lippincott Williams & Wilkins, Inc. of the product or service being advertised.
Login

Article Tools

Images

Share