doi: 10.1097/ALN.0b013e31827e3bf1

In Reply

Eckenhoff, Roderic G. M.D.

Free Access
Article Outline
Collapse Box

Author Information

Dr. Kopp raises an important point that Dr. Planel and I should have mentioned in our editorial.1 There is no question that mitochondria, reactive oxygen species, and various neurodegeneration pathways, including tauopathy, are linked in some way. And there is also no question that we often treat patients (and animals and cells in our studies) with oxygen as if it is inert. It is most certainly not. However, there is a dearth of literature on the effect of inhaled oxygen on any of the neurodegenerative diseases, so it is not yet clear whether the hypothetical concern raised by Dr. Kopp is real and if so, of what magnitude? Until such data become available, it is important to take Dr. Kopp’s advice and adequately control our studies with respect to oxygen.
Roderic G. Eckenhoff, M.D.
, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Back to Top | Article Outline


1. Eckenhoff RG, Planel E. Postoperative cognitive decline: Where art tau? ANESTHESIOLOGY. 2012;116:751–2

© 2013 American Society of Anesthesiologists, Inc.

Publication of an advertisement in Anesthesiology Online does not constitute endorsement by the American Society of Anesthesiologists, Inc. or Lippincott Williams & Wilkins, Inc. of the product or service being advertised.

Article Tools