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doi: 10.1097/ALN.0b013e31826f9143
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Neuromuscular Monitoring: More than Meets the Eye

Donati, François Ph.D., M.D.

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“In practice, reversal and recovery should be guided by adductor pollicis response, and if needed, a switch from facial to ulnar nerve stimulation should be accomplished at the end of the surgical procedure.”
PERSISTING neuromuscular blockade after anesthesia, commonly referred to as residual paralysis, is a well-recognized entity, but anesthesiologists do not always apply sound principles into clinical practice. This issue of ANESTHESIOLOGY contains yet another report describing an unacceptably high incidence of measured train-of-four (TOF) ratio less than 0.9 (42%) in the postanesthesia recovery unit (PACU), in spite of widespread use of neuromuscular monitoring.1 This situation occurred because the well-known differences in the responses of muscles at different monitoring sites were ignored or misinterpreted.
A smooth and rapid recovery depends on full return of neuromuscular function in muscles that ensure adequate breathing. The diaphragm recovers earlier than the adductor pollicis after a neuromuscular blocking agent,2 but return of diaphragmatic strength does not imply that the respiratory system as a whole functions normally. Upper airway muscles contract in synchrony with the diaphragm to ensure airway patency.3 They also play a role after anesthesia to clear secretions and regurgitated stomach content. These upper airway muscles are particularly sensitive to neuromuscular blocking agents. Mean geniohyoid and adductor pollicis recovery times are similar, and in some patients, the geniohyoid muscle takes longer to recover.4 The masseter is at least as sensitive as the adductor pollicis to neuromuscular blocking agents.5 Upper esophageal tone decreases and incidence of aspiration increases when the TOF ratio at the adductor pollicis is less than 0.9.6 Upper airway obstruction is a common finding in patients with residual neuromuscular blockade.7 The risk of significant neuromuscular weakness in upper airway muscles is greater when the TOF ratio at the adductor pollicis muscle is less than 0.9, so the adductor pollicis muscle response following ulnar nerve stimulation can be used as a guide for recovery. However, this association has been validated for the adductor pollicis only, not for other popular monitoring sites such as the muscles around the eye, which contract in response to facial nerve stimulation. The study by Thilen et al.1 illustrates this point very well.
There has been some confusion in the literature regarding the name of the muscle that moves the eyebrow in response to facial nerve stimulation. Earlier studies erroneously attributed the response to the orbicularis oculi.2 But movement of the eyebrow is because of the corrugator supercilii, which is solicited when frowning.8 Irrespective of the name of the muscle that contracts in response to facial nerve stimulation, the results of eyebrow twitching studies are clear: muscles around the eye recover early, much like the diaphragm, and earlier than upper airway muscles or the adductor pollicis.2,8 It follows that facial nerve stimulation should not be used to guide reversal and recovery.
Dose and timing recommendations for reversal are based on recovery at the adductor pollicis. When the recognized target for neuromuscular recovery was a TOF ratio of 0.7, it was suggested to administer neostigmine when at least two twitches were visible. With the new TOF threshold of 0.9, it is advisable to wait until four twitches are present, whether there is detectable fade or not.9 However, these recommendations apply only to the adductor pollicis. It is expected that when four twitches are seen at the corrugator supercilii, the adductor pollicis twitch count might be less, and there could be no twitch at all. Thus, if the timing of neostigmine administration is based on facial nerve monitoring, and even if four eyebrow responses are detected, the risk of residual paralysis is expected to be high. This is exactly what Thilen et al.1 found in this issue of ANESTHESIOLOGY. They measured adductor pollicis TOF ratio by acceleromyography in the PACU in patients who had their intraoperative neuromuscular monitoring performed at the thumb or the eye, according to the preference of the anesthesiologist. A TOF ratio less than 0.9 in the PACU was more frequent in patients monitored at the eye in the operating room (52%) than in patients monitored at the thumb (22%), in spite of a comparable number of twitches seen in both groups: four twitches were seen in most patients, whether monitoring site was the eye (86%) or the thumb (88%). Interestingly, the eye was chosen as the monitoring site in two thirds of cases, suggesting that the known differences between monitoring sites were not appreciated by most anesthesiologists. The message here is clear: monitoring to guide reversal and recovery should be performed at the adductor pollicis muscle.
Still, the study by Thilen et al. raises a few questions. Why, for example, did as many as 22% of patients monitored at the wrist have a TOF ratio less than 0.9 when reasonable doses of neostigmine were usually given, four twitches were seen in most patients, and assessment in the PACU was carried out after neostigmine had time to be effective (20 min)? The patients who had inadequate recovery may have received neostigmine when fewer than four twitches were visible, or were evaluated a short time after neostigmine, or did not receive any neostigmine. But another factor might play a role: there are subtle sensitivity differences between the different intrinsic muscles of the hand. The muscles of the hypothenar eminence, which move the little finger, recover earlier than the adductor pollicis.10 In practice, it is not uncommon to observe four twitches at the little finger when there is only one or none at all at the thumb. Thus, it is possible that in some instances, recovery at the little finger was interpreted as “four twitches present,” although fewer were in fact present at the adductor pollicis. It is suggested to either feel the movement of the thumb to assess readiness for reversal or stimulate over the adductor pollicis muscle.11
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The ultimate objective is to avoid the complications of residual paralysis, and evidence suggests that the risk of adverse events,7 subjective feeling of weakness,12 and length of stay in the PACU13 increase markedly when TOF ratio at the adductor pollicis is less than 0.9. This does not mean that there is a cliff at an adductor pollicis TOF ratio of 0.9. Some patients do well in spite of a TOF ratio less than 0.9, whereas others might have difficulties in spite of a TOF ratio greater than 0.9. In Thilen et al.’s1 study, two patients with a TOF ratio of zero felt weak, but did not need active treatment. However, in terms of risk management, the incidence and severity of residual paralysis increase as the TOF ratio decreases. For example, Murphy et al.7 studied patients in whom respiratory difficulties were detected in the PACU, and compared them with a control group without such events. Mean TOF ratio was 0.62 in the subjects with respiratory complications, and only 9.5% had a TOF ratio of more than 0.9. In contrast, mean TOF ratio was 0.98 in the control group, and 90.5% of patients had a TOF ratio of more than 0.9. From these and other data, a mental model for the risk of complications from residual paralysis can be derived (fig. 1). The actual shape of the curve certainly depends on the definition of complications and type of patient. Because the weak link in neuromuscular recovery is the upper airway, it is likely that the curve is pushed to the right, meaning increased risk, in patients with conditions where either respiratory function as a whole and/or airway patency are compromised. Although in most patients most of the upper airway muscles have a similar recovery profile as the adductor pollicis, recovery of some muscles in some individuals might be delayed, with subsequent risk for impaired airway integrity even after recovery to an adductor pollicis TOF of close to 1.0. There is no direct evidence to help identify which individuals may be susceptible to delayed upper airway recovery, but it would appear prudent to pay special attention to patients at risk.
The clinical study performed by Thilen et al.1 confirms what other studies indicated: ulnar nerve-adductor pollicis rather than facial nerve-corrugator supercilii monitoring should be used as a guide to timing of reversal or adequacy of recovery. The presence of four twitches at the adductor pollicis or the thumb following ulnar nerve stimulation should be ascertained before administration of neostigmine. Movement of the thumb should be seen or felt, disregarding movement of other fingers. The same principles apply when using sugammadex, because the proper dose depends on recovery at the thumb, not at the eye. When considering neuromuscular recovery, the corrugator supercilii behaves like the diaphragm, but it takes more than the diaphragm to breathe adequately; upper airway muscles, which follow approximately the same recovery profile as the adductor pollicis, are important respiratory muscles. In practice, reversal and recovery should be guided by adductor pollicis response, and if needed, a switch from facial to ulnar nerve stimulation should be accomplished at the end of the surgical procedure. There is more than meets the eye; a hand is needed.
François Donati Ph.D., M.D.,
Department of Anesthesiology, Hôpital Maisonneuve-Rosemont and Université de Montréal, Montréal, Québec, Canada. francois.donati@umontreal.ca
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