Skip Navigation LinksHome > February 2011 - Volume 114 - Issue 2 > Why Do Similar Studies Conclude Differently When They Are Pe...
Anesthesiology:
doi: 10.1097/ALN.0b013e318207501b
Correspondence

Why Do Similar Studies Conclude Differently When They Are Performed with Nearly the Same Protocol and the Same Skin Conductance Technology and on the Same Population of Patients?

Choo, Eugene K. B.Sc.P.; Montgomery, Carolyne J. M.D., F.R.C.P.C.*; Ansermino, J. Mark M.B.B.Ch., F.R.C.P.C.

Free Access
Article Outline
Collapse Box

Author Information

Back to Top | Article Outline

In Reply:

We thank Dr Storm for the comments regarding our article.1 We agree with Dr Storm that in awake patients, stressors such as nausea, vomiting, and anxiety influence the number of fluctuations in skin conductance (NFSC) and, therefore, limit the specificity of the Medstorm device as a measure of postoperative pain. These variables would inevitability be present in the clinical context of postoperative pain in children.
This is not the first study to demonstrate that the Medstorm device has poor sensitivity and specificity for pain in the postoperative period. A study of 100 adults by Ledowski et al.2 indicated an optimized (by receiver operating characteristic curve analysis) NFSC cutoff of 0.1, which resulted in a sensitivity of 58% and a specificity of 61%, for a numeric pain rating score of more than 5.
We suggest that a test that is sensitive, but not specific, is not clinically useful. Therefore, a cutoff of 0.0 NFSCs would yield a sensitivity of 100% but a specificity of 0% and would clearly not be useful. We suspect that few clinicians would benefit from a device that “gives an indication on when to ask a patient about their pain” when it is relatively simple to routinely ask all patients about their pain level. We believe that the averaging interval should be a magnitude greater than the NFSC. In our clinical experience, postoperative pain does not last for only 15 s nor would it require a pharmaceutical intervention if it did occur for this short period.
The Medstorm device may have utility for detecting intraoperative pain; the variables of movement and anxiety can be appropriately controlled. However, in the complex setting of postoperative pain, the accuracy of NFSC measurements is severely compromised by numerous nonnoxious confounders of sympathetic activity.
Eugene K. Choo, B.Sc.P.
Carolyne J. Montgomery, M.D., F.R.C.P.C.,*
J. Mark Ansermino, M.B.B.Ch., F.R.C.P.C.
*BC Children's Hospital, Vancouver, British Columbia, Canada. cmontgomery@cw.bc.ca.
Back to Top | Article Outline

References

1.Choo EK, Magruder W, Montogomery CJ, Lim J, Brant R, Ansermino M: Skin conductance fluctuations correlate poorly with postoperative self-reported pain measures in school-aged children. Anesthesiology 2010; 113:175–82

2.Ledowski T, Ang B, Schmarbeck T, Rhodes J: Monitoring of sympathetic tone to assess postoperative pain: Skin conductance versus surgical stress index. Anesthesia 2009; 64: 727–31

© 2011 American Society of Anesthesiologists, Inc.

Publication of an advertisement in Anesthesiology Online does not constitute endorsement by the American Society of Anesthesiologists, Inc. or Lippincott Williams & Wilkins, Inc. of the product or service being advertised.
Login

Article Tools

Share