2008 Best Abstracts of the Meeting: Anesthesiology Editors' Picks
Epidemiology of Anesthesia-related Mortality in the United States, 1999–2005
Li, Guohua M.D., Dr.P.H.*; Warner, Margaret Ph.D.†; Lang, Barbara H. B.S.‡; Huang, Lin M.S.§; Sun, Lena S. M.D.∥
MORTALITY risk associated with anesthesia has been the subject of extensive research for many decades.1–5
In a landmark study involving 10 academic medical centers and 599,500 surgical patients in the United States during 1948–1952, Beecher and Todd6
found that the anesthesia-related death rate was 64 deaths per 100,000 procedures, varying markedly by anesthetic agents, types of providers, and patient characteristics. Based on their study results, Beecher and Todd estimated that the annual number of anesthesia-related deaths in the United States was more than 5,100, or 3.3 deaths per 100,000 population, which was more than twice the mortality attributable to poliomyelitis at that time. The report by Beecher and Todd helped to identify anesthesia safety as a public health problem and spawned many follow-up studies in the United States7–10
and other countries.11–14
This intense research effort has played an important role in the continuing improvement of anesthesia safety. In the advent of new anesthesia techniques, drugs, and enhanced training, anesthesia mortality risk has declined from approximately 1 death in 1000 anesthesia procedures in the 1940s to 1 in 10,000 in the 1970s and to 1 in 100,000 in the 1990s and early 2000s.15–18
It is noteworthy that contemporary estimates of anesthesia mortality risk are based on studies conducted in Europe, Japan, and Australia.17–20
The paucity of anesthesia mortality studies in the United States in recent years is compounded by several factors. First, improvement in anesthesia safety has made anesthesia-related deaths rare events, and studying rare events usually requires large sample sizes and considerable resources. Second, there is not an established national surveillance data system for monitoring anesthesia mortality. Last, clinical practice of anesthesia has expanded so much that it is extremely difficult to gather exposure data. It is estimated that most surgical anesthesia procedures are now performed in ambulatory care settings.21,22
The use of anesthesia for therapeutic and diagnostic purposes is also on the rise.23
After the 1999 publication of the Institute of Medicine’s report on medical error,24
patient safety has become a priority area of health services research. To facilitate the measurement of patient safety and the evaluation of intervention programs, the Agency for Healthcare Research and Quality developed more than 20 patient safety indicators for use with routinely collected hospital inpatient discharge data. Each indicator refers to a group of complications or adverse events identified through specific International Classification of Diseases
, 9th Revision, Clinical Modification codes.25
The first indicator, purportedly measuring the safety of anesthesia, is limited to adverse effects of anesthetics in therapeutic use and overdose of anesthetics. Complications of anesthesia during labor and delivery and systemic complications, such as malignant hyperthermia due to anesthesia, are not included. The objectives of this study are to develop a comprehensive set of anesthesia safety indicators based on the latest version of the International Classification of Diseases
and to apply these indicators to a national data system for understanding the epidemiology of anesthesia-related mortality.
Materials and Methods
The study protocol was reviewed and approved for exemption of informed consent by the Columbia University Institutional Review Board, New York, New York.
The International Statistical Classification of Diseases and Related Health Problems
(ICD) is the standard classification system for recording and reporting diseases, injuries, and other health conditions.26
Sponsored by the World Health Organization, this disease classification system is revised periodically and used by many countries for the compilation of mortality and morbidity data. It also serves as the basis for international comparison of health statistics. The 10th revision (ICD-10) was implemented for coding and classifying mortality data from death certificates in the United States as of January 1, 1999. For the purpose of the current study, we developed a list of ICD-10 codes for medical conditions related to anesthesia or anesthetics (table 1
). These codes were identified by screening all the chapters of ICD-10 and informed by a thorough review of the research literature pertaining to anesthesia mortality and ICD.
In previous studies,6,18
anesthesia-related deaths were usually divided into two groups based on clinical judgment: deaths caused primarily by anesthesia and deaths in which anesthesia played a partial role. In this study, the role anesthesia played in the death was based on the causal chain of events leading to death as identified by the order on the death certificate and ICD coding guidelines. Anesthesia-related deaths were operationally defined as deaths that included one of the anesthesia-related codes (table 1
) as the underlying cause of death or included at least one anesthesia-related code as a listed cause among the multiple causes of death. We grouped the identified ICD-10 codes into four categories: (1) complications of anesthesia during pregnancy, labor, and puerperium; (2) overdose of anesthetics (exclusive of abuse of these substances); (3) adverse effects of anesthetics in therapeutic use; and (4) other complications of anesthesia in surgical and medical care (table 1
). In 5% of the anesthesia-related deaths, there was more than one anesthesia-related ICD-10 code in the multiple causes. For the purposes of this analysis, the death was categorized into the first listed ICD-10 code included in table 1
Mortality data for this study came from the multiple-cause-of-death data files of the National Vital Statistics System, maintained by the National Center for Health Statistics.#
Deaths were limited to those occurring within the United States. US citizens and military personnel who died outside of the United States are not included. The mortality data files are based on death certificates compiled by individual states and contain one record for each decedent. Data collected from the death certificate include information about the decedent’s demographic characteristics and causes of death. Up to 20 ICD-10 codes are recorded for each death. The underlying cause of death is selected from among all listed causes as the medical condition or the circumstance that triggered the chain of morbid events leading directly to death, and a contributing cause is a medical condition that aggravated the morbid sequence resulting in the fatality.27
Using the ICD-10 codes listed in table 1
and the multiple-cause-of-death data files for the years 1999–2005, we identified anesthesia-related deaths. The records for these anesthesia-related deaths served as the mortality data for this study.
Death rates were computed in two ways. First, we calculated the annual rates of anesthesia-related deaths per million population using data from the US Census Bureau for the study period. The annualized population-based death rate is a widely accepted public health measure, reflecting the portion of the general population that dies of a given health problem each year. Second, we estimated the risk of hospital anesthesia-related mortality based on the number of anesthesia-related deaths that occurred in hospitals as inpatients as recorded on the death certificate and national estimates of hospital surgical discharges. National estimates of hospital surgical discharges for the study period were generated from the National Hospital Discharge Survey using the defined surgical procedural codes28
and were used as a proxy measure of exposure to anesthesia among hospital inpatients.
Although mortality data are not subject to sampling error, they may be affected by random variation. Assuming that deaths follow a Poisson probability distribution, the SE associated with the number of deaths is the square root of the number of deaths.29
The National Hospital Discharge Survey data were based on a multistage random sampling scheme, and the national estimate of the annual number of hospital discharges with a surgical procedure had a relative SE of approximately 4%.28
The SEs were calculated using SUDAAN release 9.0.1 (Research Triangle Institute, Research Triangle Park, NC).
During the 7-yr study period, there were a total of 2,211 anesthesia-related deaths. Anesthesia complications were the underlying cause in 241 of these deaths (10.9%) and a contributing factor in the remaining 1,970 deaths (89.1%). Overall, 46.6% of the anesthesia-related deaths were due to overdose of anesthetics; followed by adverse effects of anesthetics in therapeutic use (42.5%); anesthesia complications during pregnancy, labor, and puerperium (3.6%); and other complications of anesthesia (7.3%) (table 2
). Of the 241 deaths with anesthesia/anesthetics as the underlying cause of death, 79.7% resulted from adverse effects of anesthetics in therapeutic use; 19.1% resulted from anesthesia complications during pregnancy, labor, and puerperium; and 1.2% resulted from wrongly placed endotracheal tubes.
The number of anesthesia-related deaths averaged 315 deaths per year, including 34 deaths caused primarily by anesthesia/anesthetics (fig. 1
Males outnumbered females in anesthesia-related deaths by an 80% margin (1,428 vs. 783). The majority (54.9%) of the decedents were aged 25–54 yr.
Population-based Death Rate
The anesthesia-related death rate was 1.1 per million population per year, with the rate for males almost twice the rate for females (1.45 vs.
0.77). The death rate varied with age (fig. 2
). For both sexes, the lowest rate was found in children aged 5–14 yr, and the highest rate was found in those aged 85 yr or older. Males had higher death rates than females throughout the life span, and the gap between sexes was especially pronounced in young and middle-age adults (fig. 2
Mortality Risk among Surgical Inpatients
There were an estimated 105.7 million surgical discharges from US hospitals during the study period. Of the 2,211 anesthesia-related deaths, 867 died in hospitals, 348 died in ambulatory care settings as outpatients, 46 died on arrival, 258 died at homes, 44 died in hospice facilities, 315 died at nursing homes or long-term care facilities, 327 died in other places, and for 6, the place of death was unknown. The estimated mortality risk from anesthesia complications for inpatients was 8.2 (867/105.7 [95% confidence interval, 7.4–9.0]) deaths per million hospital surgical discharges (11.7 [95% confidence interval, 10.3–13.1] for men and 6.2 [95% confidence interval 5.5–7.0] for women). The age pattern in mortality risk generally followed the pattern in population-based death rates, with substantially increased risk in the elderly (fig. 3
Since the first release of the patient safety indicators in 2001, a number of studies have assessed the utility of the individual indicators and in different patient groups.30–34
As a screening tool for identifying potential patient safety problems at the hospital level, patient safety indicators are found to be clinically relevant, effective, and efficient. None of these studies, however, has specifically evaluated the indicator measuring anesthesia safety. As part of our effort to close this research gap, we developed four anesthesia safety indicators based on the latest version of the ICD. These indicators measure more complications and adverse events of anesthesia/anesthetics than the one proposed by the Agency for Healthcare Research and Quality25
and can be used to address the mortality risk. Specifically, we have added a category of complications of obstetric anesthesia, and a category of systemic complications that are rare occurrences but are of special concern to anesthesiologists, such as shock due to anesthesia, malignant hyperthermia due to anesthesia, and failed or difficult intubation. The US Department of Health and Human Services has proposed to Congress to adopt a clinical modification of the ICD-10 codes in reporting clinical diagnoses and procedures by October 2011.**
The anesthesia safety indicators developed in this study need to be validated when ICD-10 Clinical Modification–coded health care utilization data become available.
Other researchers have used ICD-9 codes in studies of anesthesia morbidity and mortality.35,36
Our application of the anesthesia safety indicators to the ICD-10–coded multiple-cause-of-death data files produced several notable findings. First, our results indicate that the numbers of anesthesia-related deaths in the United States averaged approximately 315 deaths per year from 1999 to 2005. Approximately 11% of these deaths were caused primarily by anesthesia/anesthetics. This proportion is consistent with previous studies.17,37,38
The death rate from complications and adverse events associated with anesthesia/anesthetics during the study period was estimated at 1.1 per million population, which represents a 97% reduction compared with the reported rate for the years 1948–1952.6
Based on the number of anesthesia-related deaths occurring in hospitals and hospital surgical discharges, we estimated that the mortality risk of anesthesia for surgical inpatients was 0.82 in 100,000. The risk of anesthesia-related deaths estimated with this methodology is compatible with recent reports from other countries.17,18,20
For example, in Australia, where there is a national registry for anesthesia-related deaths, the mortality risk is estimated to be 0.5 per 100,000.18
Our findings should be interpreted with caution. First, the anesthesia safety indicators developed in this study are based on a limited number of ICD-10 codes, which capture only the death certificates in which an anesthesia complication or adverse event was listed among the multiple causes of death. This limitation can be aggravated when the indicators are applied to hospital discharge data to study anesthesia-related morbidity, because clinical documentation of complications may vary with hospitals and the severity of complications.
Second, our data on anesthesia-related mortality came solely from the multiple-cause-of-death data files of the National Vital Statistics System. As the most authoritative source of national mortality data in the United States, the multiple-cause-of-death data files are known for their completeness of data ascertainment; uniformity in format and content; and standardized protocols for reporting, coding, and processing.39
To reduce coding errors, the National Center for Health Statistics uses automated coding systems in combination with manual checking. In the past decade, the National Center for Health Statistics implemented a series of interventional programs (e.g.
, clearer instructions for data reporting and processing, more timely filing of amendments, electronic death registration, querying the states about specific data items).39
Nevertheless, the validity and reliability of the multiple-cause-of-death data remain a concern. Although previous research has shown a high reliability of the multiple-cause-of-death data for some diseases (such as cancer and external causes),40
their sensitivity and specificity for detecting anesthesia-related deaths have not been rigorously examined. It is likely that the case definition we used in this study may have missed a portion of anesthesia-related mortality, particularly those deaths in which complications and adverse events of anesthesia/anesthetics played only a contributory role. On the other hand, some of the deaths associated with anesthetics or analgesics identified through the ICD-10 codes may not be related to anesthesia practice.
Finally, we based our estimates of death rates on population data and mortality risk on hospital surgical discharges. The population-based rates are valuable from a public health perspective but should be further refined in future studies. Specifically, deaths from complications of anesthesia during pregnancy, labor, and puerperium are confined to women of reproductive age; therefore, the mortality risk should be estimated using age- and sex-appropriate denominator data.
Our estimate of anesthesia-related mortality risk for surgical inpatients is also susceptible to biases. It is conceivable that some of the anesthesia-related deaths occurring in hospitals might have resulted from exposure in ambulatory care settings or from exposure in nonsurgical therapeutic and diagnostic procedures. In addition, it is possible that some deaths that occurred outside of hospitals may have been related to complications from inpatient anesthesia. After a 10-yr hiatus, the National Survey of Ambulatory Surgery from the National Center for Health Statistics was fielded in 2006 with updates to reflect the changing environment in ambulatory surgery. The lack of a comprehensive data system monitoring anesthesia exposure is a problem that has hindered research efforts in the United States and other countries for many years. With the rapid growth of clinical anesthesia services, considering methods for ongoing national surveillance for anesthesia exposure and outcomes is imperative.
The results of our study suggest that the United States has experienced a 97% decrease in anesthesia-related death rates since the late 1940s and the mortality risk from complications and adverse events of anesthesia/anesthetics for surgical inpatients is similar to the reports from other countries, at approximately 1 in 100,000. Our study found that 42.5% of anesthesia-related deaths were attributable to adverse effects of anesthetics in therapeutic use. With the increased use of anesthesia outside of the traditional operating room setting,21,22
continued monitoring of the safety of anesthesia is warranted.
The authors thank Lois Fingerhut, M.A., Diane Makuc, Dr.P.H., and Jennifer Madans, Ph.D. (National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland), for helpful comment on a previous version of the manuscript.
1. Trent J, Gaster E: Anesthetic deaths in 54,128 consecutive cases. Ann Surg 1944; 119:954–8
2. Waters RM, Gillespie NA: Deaths in the operating room. Anesthesiology 1944; 5:113–28
3. Dornette WHL, Orth OS: Death in the operating room. Curr Res Anesth Analg 1956; 35:545–69
4. Hingson RA, Holden WD, Barnes AC: Mechanisms involved in anesthetic deaths: A survey of OR and obstetric delivery room related mortality in the University Hospitals of Cleveland, 1945–1954. NY State J Med 1956; 56:230–5
5. Aitkenhead AR: Injuries associated with anesthesia: A global perspective. Br J Anaesth 2005; 95:95–109
6. Beecher HK, Todd DP: A study of deaths associated with anesthesia and surgery: Based on a study of 599,548 anesthesias in ten institutions, 1948–1952, inclusive. Ann Surg 1954; 140:2–34
7. Schapira M, Kepes ER, Hurwitt ES: An analysis of deaths in the operating room and within 24 hours of surgery. Anesth Analg 1960; 39:149–57
8. Phillips OC, Frazier TM, Graff TD, DeKornfeld TJ: The Baltimore Anesthesia Study Committee. JAMA 1960; 174:2015–9
9. Memery HN: Anesthesia mortality in private practice: A ten-year study. JAMA 1965; 194:1185–8
10. Greene NM, Banister WK, Cohen B, Keet JE, Mancinelli MJ, Welch ET, Welch HJ: Survey of deaths associated with anesthesia in Connecticut. Conn Med 1959; 23:512–8
11. Minuck M: Death in the operating room. Can Anaesth Soc J 1967; 14:197–204
12. Clifton BS, Hotten WIT: Deaths associated with anaesthesia. Br J Anaesth 1963; 35:250–9
13. Harrison GG: Death attributable to anaesthesia: A 10-year survey, 1967–1976. Br J Anaesth 1978; 50:1041–6
14. Gebbie D: Anaesthesia and death. Can Anaesth Soc J 1966; 13:390–6
15. Dripps RD, Lamont A, Eckenhoff JE: The role of anesthesia in surgical mortality. JAMA 1961; 178:261–6
16. Tiret L, Desmonts JM, Hatton F, Vourc’h G: Complications associated with anaesthesia: A prospective survey in France. Can Anaesth Soc J 1986; 33:336–44
17. Arbous MS, Grobbee DE, van Kleef JW, de Lange JJ, Spoormans HH, Touw P, Werner FM, Meursing AEE: Mortality associated with anaesthesia: A qualitative analysis to identify risk factors. Anaesthesia 2001; 56:1141–53
18. Gibbs N, Borton C: Safety of Anaesthesia in Australia: A Review of Anaesthesia Related Mortality, 2000-2002. Report of the Committee convened under the auspices of the Australian and New Zealand College of Anaesthetists. Melbourne, Australian and New Zealand College of Anaesthetists, 2006
19. Kawashima Y, Takahashi S, Suzuki M, Morita K, Irita K, Iwao Y, Seo N, Tsuzaki K, Dohi S, Kobayashi T, Goto Y, Suzuki G, Fujii A, Suzuki H, Yokoyama K, Kugimiya T: Anesthesia-related mortality and morbidity over a 5-year period in 2,363,038 patients in Japan. Acta Anaesthesiol Scand 2003; 47:809–17
20. Mackay P: Safety of Anaesthesia in Australia: A Review of Anaesthesia Related Mortality, 1997–1999. Report of the Committee convened under the auspices of the Australian and New Zealand College of Anaesthetists. Melbourne, Australian and New Zealand College of Anaesthetists, 2002
21. Lagoe RJ, Milliren JH: Changes in ambulatory surgery utilization 1983-88: A community-based analysis. Am J Public Health 1990; 80:869–71
22. Fleisher LA, Pasternak LR, Lyles A: A novel index of elevated risk of inpatient hospital admission immediately following outpatient surgery. Arch Surg 2007; 142:263–8
23. Koch M, Dayan S, Barinholtz D: Office-based anesthesia: An overview. Anesthesiol Clin North America 2003; 21:417–43
24. Institute of Medicine: To Err Is Human: Building a Safer Health Care System. Washington, D.C., National Academy Press, 1999
25. Agency for Healthcare Research and Quality: Patient Safety Indicators, version 3.2. Rockville, Agency for Healthcare Research and Quality, 2008
26. International Statistical Classification of Diseases and Health Related Problems, 10th revision. Geneva, World Health Organization, 1992
27. National Center for Health Statistics: Instructions for Classifying the Underlying Cause-of-Death, ICD-10. Albany, New York, WHO Publications Center, 2008, pp 5–10
28. DeFrances CJ, Hall MJ: 2005 National Hospital Discharge Survey. Adv Data 2007; 12:1–19
29. Kung HC, Hoyert DL, Xu JQ, Murphy SL: Deaths: Final Data for 2005 National Vital Statistics Reports, vol 56, No 10. Hyattsville, Maryland, National Center for Health Statistics, 2008
30. Miller MR, Elixhauser A, Zhan C, Meyer GS: Patient safety indicators: Using administrative data to identify potential patient safety concerns. Health Serv Res 2001; 36:110–32
31. Romano PS, Geppert JJ, Davies S, Miller MR, Elixhauser A, McDonald KM: A national profile of patient safety in U.S. hospitals. Health Aff 2003; 22:154–66
32. Zhan C, Miller MR: Excess length of stay, charges, and mortality attributable to medical injuries during hospitalization. JAMA 2003; 290:1868–74
33. Rosen AK, Rivard P, Zhao S, Loveland S, Tsilimingras D, Christiansen CL, Elixhauser A, Romano PS: Evaluating the patient safety indicators: How well do they perform on Veterans Health Administration data? Med Care 2005; 43:873–84
34. Sedman A, Harris JM II, Schulz K, Schwalenstocker E, Remus D, Scanlon M, Bahl V: Relevance of the Agency for Healthcare Research and Quality Patient Safety Indicators for Children’s hospitals. Pediatrics 2005; 115:135–45
35. Donnelly EF, Buechner JS: Complications of anesthesia. Med Health R I 2001; 84:341–3
36. Lienhart A, Auroy Y, Péquignot F, Benhamou D, Warszawski J, Bovet M, Jougla E: Survey of anesthesia-related mortality in France. Anesthesiology 2006; 105:1087–97
37. Lunn JN, Mushin WW: Mortality associated with anaesthesia. Anaesthesia 1982; 37:856
38. Tikkanen J, Hovi-Viander M: Death associated with anaesthesia and surgery in Finland in 1986 compared to 1975. Acta Anaesthesiol Scand 1995; 39:262–7
39. Anderson R: Quality of Death Certificate Data, Medicolegal Death Investigation System: Workshop Summary. Edited by the Committee for the Workshop on the Medicolegal Death Investigation System. Washington, D.C., The National Academies Press, 2003, pp 40–2
40. Albertsen PC, Walters S, Hanley JA: A comparison of cause of death determination in men previously diagnosed with prostate cancer who died in 1985 or 1995. J Urol 2000; 163:519–23
# Centers for Disease Control, National Center for Health Statistics: Vital Statistics Data. Available at: http://www.cdc.gov/nchs/about/major/dvs/Vitalstatsonline.htm
. Accessed November 17, 2008. Cited Here...
This article has been cited 20 time(s).
Anaesthesia and Intensive Care
National anaesthesia mortality reporting in Australia from 1985-2008
Anaesthesia and Intensive Care, 41(3):
Presse MedicaleShort- and long-term risks and consequences of anesthesiaPresse Medicale
Regional Anesthesia and Pain MedicineSafety During Regional Anesthesia What Do We Know and How Can We Improve Our Practice?Regional Anesthesia and Pain Medicine
Cost Effectiveness Analysis of Anesthesia Providers
Nursing Economics, 28(3):
Canadian Journal of Anaesthesia-Journal Canadien D AnesthesieIncomplete adherence to the ASA difficult airway algorithm is unchanged after a high-fidelity simulation sessionCanadian Journal of Anaesthesia-Journal Canadien D Anesthesie
Canadian Journal of Anesthesia-Journal Canadien D AnesthesieNeuromuscular monitoring, residual blockade, and reversal: Time for re-evaluation of our clinical practiceCanadian Journal of Anesthesia-Journal Canadien D Anesthesie
Langenbecks Archives of SurgeryIONM-guided goiter surgery leading to two-stage thyroidectomy-indication and resultsLangenbecks Archives of Surgery
Bmc AnesthesiologyThe Perioperative Surgical Home: how can it make the case so everyone wins?Bmc Anesthesiology
Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and IrelandTumescent anaesthesiaSurgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
Presse MedicaleAnesthesia in the elderlyPresse Medicale
LancetThe Transfusion Alternatives Preoperatively in Sickle Cell Disease (TAPS) study: a randomised, controlled, multicentre clinical trialLancet
British Journal of AnaesthesiaAnesthesia awareness campaign persistsBritish Journal of Anaesthesia
Clinical Gastroenterology and HepatologyCost-effectiveness of Universal Serologic Screening to Prevent Nontraumatic Hip and Vertebral Fractures in Patients With Celiac DiseaseClinical Gastroenterology and Hepatology
AnesthesiologyLong-term Consequences of Anesthetic ManagementAnesthesiology
Anesthesiology“Innocent Prattle” and the Quality of Scientific DiscourseAnesthesiology
European Journal of Anaesthesiology (EJA)The Helsinki Declaration on Patient Safety in AnaesthesiologyEuropean Journal of Anaesthesiology (EJA)
© 2009 American Society of Anesthesiologists, Inc.
Publication of an advertisement in Anesthesiology Online does not constitute endorsement by the American Society of Anesthesiologists, Inc. or Lippincott Williams & Wilkins, Inc. of the product or service being advertised.