Skip Navigation LinksHome > December 2006 - Volume 105 - Issue 6 > Survey of Anesthesia-related Mortality in France
Anesthesiology:
Clinical Investigations

Survey of Anesthesia-related Mortality in France

Lienhart, André M.D.*; Auroy, Yves M.D.†; Péquignot, Françoise‡; Benhamou, Dan M.D.§; Warszawski, Josiane Ph.D., M.D.∥; Bovet, Martine#; Jougla, Eric Ph.D.**

Free Access
Article Outline
Collapse Box

Author Information

Collapse Box

Abstract

Background: This study describes a nationwide survey that estimates the number and characteristics of anesthesia-related deaths for the year 1999.
Methods: Death certificates from the French national mortality database were selected from the International Classification of Diseases, Ninth Revision codes using a variable sampling fraction. Medical certifiers were sent a questionnaire (response rate, 97%), and the anesthesiologist in charge was offered a peer review (acceptance rate, 97%). Files were reviewed to determine the mechanism of each perioperative death and its relation to anesthesia. Mortality rates were calculated using the number of anesthetic procedures estimated from a national 1996 survey and compared with a previous (1978–1982) nationwide study.
Results: Among the 4,200 certificates analyzed, 256 led to a detailed evaluation. The death rates totally or partially related to anesthesia for 1999 were 0.69 in 100,000 (95% confidence interval, 0.22–1.2 in 100,000) and 4.7 in 100,000 (3.1–6.3 in 100,000), respectively. The death rate increased from 0.4 to 55 in 100,000 for American Society of Anesthesiologists physical status I and IV patients, respectively. Rates increased with increasing age. Although concerns regarding aspiration of gastric contents remain, intraoperative hypotension and anemia associated with postoperative ischemic complications were the associated factors most often encountered. Deviations from standard practice and organizational failure were often found to be associated with death.
Conclusion: In comparison with data from a previous nationwide study (1978–1982), the anesthesia-related mortality rate in France seems to be reduced 10-fold in 1999. Much remains to be done to improve compliance of physicians to standard practice and to improve the anesthetic system process.
ANESTHESIA is commonly regarded as a high-risk activity. Many experts acknowledge however that “very impressive” safety improvements have been made in this field,††,‡‡ 1,2 leading some investigators to conclude that anesthesia-related mortality has decreased in the previous two decades. The scientific basis supporting this opinion has been questioned because of variable methodology and operational definitions to evaluate the trends.3,4 No large-scale study has been performed at the national level to confirm whether the anesthesia-related death rate has indeed decreased. In France, reliable data on anesthesia-related mortality have been collected by the National Institutes of Health and Medical Research for the period 1978–1982.5 Many safety procedures have been adopted since this period, leading the French Society of Anesthesia and Intensive Care to conduct a national survey in cooperation with the National Institutes of Health and Medical Research to estimate the number and characteristics of anesthesia-related deaths in France for the year 1999. A previously published calculation of the number of anesthetic procedures performed in France in 1996 was used to estimate anesthesia-related mortality rates for 1999.6 Events associated with death were also analyzed.
Back to Top | Article Outline

Materials and Methods

Number of Anesthesia-related Deaths
The survey and subsequent data analysis were performed between 2001 and 2003. The number of anesthesia-related deaths was estimated by sampling the 537,459 French death certificates for 1999 (except deaths from French overseas territories). A sample of these certificates was then analyzed, and when necessary, the certifiers (i.e., physicians who had filled out the medical part of the death certificate) and anesthesiologists involved were queried about the case.
A list of all International Classification of Diseases, Ninth Revision (1CD-9) codes7 that might relate to anesthesia care or anesthesia-related complications was created, and then that list was used to identify death certificates worthy of review. Complete analysis of ICD-9 codes was performed by three anesthesiologists and three epidemiologists (nosologists) to identify and select all aforementioned codes. A group named “interventional deaths,” including (1) all codes that suggest any relation with an anesthetic and (2) all codes describing any complication related to any medical, obstetric, or surgical or interventional procedure (including endoscopic procedures), was created. In addition, any death certificate that was detected during encoding process and in which a surgical, endoscopic, or obstetric procedure was mentioned (whether or not the patient’s death was related to this procedure) was added. Another group named “violent death,” including in-hospital deaths secondary to an external cause (ICD-9 codes: trauma, traffic accident, falls, other types of accidents, and so on), was created.
Among these certificates, a sample was drawn by stratified randomization using the following sampling fractions. For interventional deaths, the sampling fraction (SF) was 1/1 when the medical certifier had suggested that anesthesia had played a role (i.e., the word anesthesia mentioned in any item of the form) (n = 281); for other interventional deaths, the SF was 1/1 for patients aged younger than 40 yr (n = 734), 1/7 for those aged 40–74 yr (n = 923), and 1/11 for those aged 75 yr or older (n = 921); for violent deaths, the SF was 1/10 (n = 841). These various SFs were chosen to obtain the largest number of anesthesia-related deaths. In addition, we randomly selected certificates of 500 patients who had died in the hospital (SF = 1/365; n = 500) but in which preselected ICD-9 codes had not been found by the initial triage. This last selection was aimed to verify whether interventional deaths could have been missed.
Fig. 1
Fig. 1
Image Tools
Three anesthesiologists independently surveyed all the death certificates selected (n = 4,200). They excluded from further analysis death cases based on the four preestablished following criteria (cases were excluded only when all three experts agreed): (1) Anesthesia is never associated with the procedure mentioned (e.g., overdose of IV opiate in a drug addict patient); (2) the medical history totally explained why death occurred, whatever the anesthesiologist might have done; and (3) a long event-free interval between the procedure and the event leading to death was ascertained (fig. 1). For the remaining certificates, each medical certifier was sent a questionnaire (n = 1,491). The questionnaire asked the certifier to provide the reason, type, and date of the procedure; the type of anesthetic procedure used, if any; the associated diseases and the American Society of Anesthesiologists (ASA) physical status; a chronologic description of events and complications that had led to death; where the death occurred (operating room, postanesthesia care unit, intensive care unit, or any other unit); and contact information about the physician having the best knowledge of the case (the certifier may not be well aware of the patient’s history). The response rate to this questionnaire was 97% (1,452 of 1,491 cases), although reminders were necessary for some certifiers who did not answer the first query. When any additional information was believed to be necessary, the certifier was sent another query.
Fig. 2
Fig. 2
Image Tools
A committee of experts independently analyzed the returned questionnaires and resolved any discrepancy in interpretation of the case by collective discussion. The expert committee was composed of the three experts who had formerly reviewed the medical certificates and of three other experts suggested by the French Society of Anesthesia and Intensive Care Board from a list of officers. For cases for which the role of anesthesia could not be eliminated (i.e., the procedure performed or the health status of the patient could not in itself explain the death) (n = 235), the anesthesiologist involved in the procedure suspected to have been the primary event leading to death was asked to undergo a peer review through an interview where the details of the case were discussed (fig. 2). Peers were anesthesiologists working in a separate country area and who had volunteered to participate in the process. The peers had previously been trained by the expert committee during at least one session, where the goals of the study were explained, practical information on how to fill out the questionnaire was given, and guidance to solve delicate communication problems with their colleague were discussed. Specifically, when a different opinion emerged about any aspect of the analysis of the file that could not be solved by discussion, peers were asked to add a personal comment on the questionnaire before sending it rather than to try to convince their colleague to accept a different view. Each peer anesthesiologist met his or her colleague in the institution where the anesthetic event had occurred and spent 2 to 3 h together to fill out the questionnaire. The form (52 pages) was made of multiple-choice questions describing in detail the patient’s history, the case and the events until death, and open questions to which the anesthesiologist involved could answer by providing personal input and opinion. A colleague was asked to participate when the original anesthesiologist was not available (5% of cases). Each peer anesthesiologist was involved in not more than three interviews. Participation of the peers was uncompensated (reimbursement for travel expenses only). In situations where conclusion could not be obtained with the available information, the expert committee could confidentially ask the peer in charge of the case for additional data or could request a complementary analysis by an external academic expert. A copy of any relevant data from the medical file (particularly the anesthesia sheet) was attached and sent to the expert committee for review. Confidentiality was ensured at each step (excluding any patient, physicians, hospital, and city detail). The acceptance rate for the peer review was 97% (227 of 235 cases), sometimes after several phone calls and/or letters.
The experts separately analyzed each questionnaire and then discussed their personal views until obtaining complete concordance on each case. For each file, six items were recorded to summarize the case:
1. Provide a clinically pertinent summary of the case.
Fig. 3
Fig. 3
Image Tools
2. Identify the pathophysiologic process that best described the sequence of events. A graphical representation of the main pathophysiologic processes that could be encountered was prepared beforehand and applied to each case (fig. 3).
3. Identify if any deviation from rules, standards, or recommendations had occurred. To prepare this step, a detailed list of all existing recommendations that apply to French Anesthesiology practice was established by the investigators. Additional deviations were included (even though they could not be related to any published guidelines) if all three experts agreed that practice was obviously inadequate in comparison with contemporary practice at the time of the event. Deviations were retained only they were believed to have played a role in the process of death.
4. Describe the root causes that could be noted from questionnaire analysis or through discussion with the anesthesiologist involved. These causes were described using a simplified classification based on current frameworks for analyzing risk and safety in clinical medicine8 and were searched in seven fields: institutional context, organizational and management, work environment, team, staff, tasks, and patient factors.
5. Determine the causal role of anesthesia in the process leading to death using a three-point scale where 0 means “not anesthesia related” (which includes deaths totally explained by surgery or comorbidities and deaths explained by surgery or comorbidities in which anesthetic care could have played only a minor role), 1 means “partially related to anesthesia” (i.e., deaths explained by surgery or comorbidities but in which the role of anesthetic care was not minor), and 2 means “totally related” (i.e., deaths exclusively explained by anesthetic care). For the purpose of the study, anesthesia was defined as a medical specialty taking care of the patient in the operating room and the postanesthesia care unit but also involved in the perioperative process including blood transfusion, analgesic techniques, and thromboembolic prophylaxis during the first 2 or 3 postprocedural days. Only anesthetic procedures performed by anesthesiologists or under their supervision were considered. Anesthetic procedures performed in intensive care units or in resuscitation ambulances were excluded.
6. Describe how reliable the conclusions were, using a two-class (high–low) stratification.
This final six-point summary had been previously tested using cases obtained from a pilot study, by a group of 22 anesthesiologists not involved in the analysis process.
Back to Top | Article Outline
Number of Anesthetic Procedures
The number of anesthetic procedures performed in 1999 was estimated by a national survey conducted in 1996 from a sample of 62,000 anesthetic procedures performed in all French hospitals and clinics.6 The estimated number of anesthetic procedures was 7,756,121 (95% confidence interval, 7,375,054–8,137,188), of which 12% were performed in patients classified as ASA physical status of 3 or greater, and 27% were performed in patients older than 65 yr.6
Back to Top | Article Outline
Statistical Analysis
The total number of anesthesia-related deaths was estimated by taking into account the two-stage sampling with unequal selection probabilities. The Horvitz-Thompson estimator was used for each total. Weights were the inverse of the observed instead of the theoretical sampling fraction to partially adjust for the nonresponse bias. A finite population correction was used. Confidence intervals of totals were estimated by adding variances of each stratum. The annual estimation was then calculated by taking into account the notion of rare events (Poisson distribution).
The mortality rate was estimated as the ratio of the population total of anesthesia-related deaths estimated from that survey and the population total of anesthetic procedures estimated from the 1996 survey. The variance of each ratio was estimated by using the Taylor linearization method.9
Statistical analyses were performed by using Stata Statistical Software (Release 7.0 for Windows; Stata Corporation, College Station, PA), in particular by using the specific (svy) commands for survey data.
The variation in reliability (high − low) of anesthesia accountability was evaluated in a complementary analysis in which the relation with anesthesia was increased by one step for low-reliability cases to avoid underestimation in cases for which an agreement between expert opinions was difficult to reach and for which we remained unsure of our analysis (i.e., nonrelated cases with low reliability were classified as partially related, and partially related cases with low reliability were classified as anesthesia related).
Back to Top | Article Outline

Results

Table 1
Table 1
Image Tools
Characteristics of patients who died and circumstances and types of surgery are summarized in table 1. The estimated rate of deaths totally related to anesthesia was 0.69 in 100,000 anesthetic procedures (95% confidence interval, 0.2–1.2 in 100,000) in the whole population, i.e., 1 death for every 145,500 anesthetic procedures (fig. 2).
The estimated rate of deaths partially related to anesthesia was 4.7 in 100,000 anesthetic procedures (3.1–6.3 in 100,000), i.e., 1 death for every 21,200 anesthetic procedures. The estimated rate of deaths partially and totally related to anesthesia was 5.4 in 100,000 anesthetic procedures (3.7–7.1 in 100,000), i.e., 1 death for every 18,500 anesthetic procedures.
Additional analysis in which the reliability of the relation between anesthesia and death was explored led to the following “corrected” rates: rate of deaths totally related to anesthesia: 1.2 in 100,000 (0.6–1.8 in 100,000); rate of deaths partially related to anesthesia: 5.3 in 100,000 (3.6–7.1 in 100,000); and rate of deaths partially and totally related to anesthesia: 6.5 in 100,000 anesthetic procedures (4.6–8.4 in 100,000).
Table 2
Table 2
Image Tools
The mortality rate increased with age and ASA physical status as shown in table 2. The 95% confidence intervals of mortality rates in the highest and the lowest categories of age or ASA score did not overlap. Forty-two percent of the deaths totally or partially related to anesthesia occurred within 24 h of the procedure; 23% of patients died later than 72 h after the procedure. The event leading to death occurred during induction of anesthesia in 12% of the deaths totally or partially attributable to anesthesia, during maintenance for 26%, in the postanesthesia care unit for 22%, and after the recovery period for 40%.
Fig. 4
Fig. 4
Image Tools
Pathophysiologic mechanisms associated with death are described using a tree presentation in figure 4, the width of each bar representing the relative importance of the mechanism. Overall, three main situations were identified: coronary artery disease and perioperative ischemia often triggered by anemia, true hypovolemia (associated with hemorrhage), or relative hypovolemia and aspiration of gastric contents.
Table 3
Table 3
Image Tools
Types of deviations from standard practice are presented in table 3. In 2% of cases partially or totally related to anesthesia, no deviation was found, whereas for all other patients, at least one cause of substandard practice was identified. In 56% of cases, more than four deviations were recorded. For deviations occurring during induction of anesthesia, the use of a too-large dose was found by experts in 38% of cases. In nearly 60% of urgent abdominal surgery procedures, a rapid sequence induction technique was not correctly performed. Inadequate management of hypotension was identified in 39% of substandard intraoperative care.
Table 4
Table 4
Image Tools
One or several root causes grouped in seven arbitrarily defined fields (institutional context, organizational and management, work environment, team, staff, tasks, and patient factors) were identified in 91% of cases (table 4). Deficiencies in teamwork that could have promoted the occurrence of the event leading to death or could have played an aggravating role (and might have led to death) were found by experts in more than half of the cases. Overall, the most frequently encountered root causes were related to scheduling of surgical activity, deficiencies in communication between caregivers, and inadequate matching between necessary resources (human, technical, or logistic).
Back to Top | Article Outline

Discussion

In the current survey, an anesthesia-related mortality rate (totally or mainly related) of 5.4 in 100,000 anesthetic procedures (95% confidence interval, 3.7–7.1 in 100,000) was observed. The mortality rate increased with advancing age and with more impaired ASA physical status. Although airway management and postoperative respiratory complications remained important causes, no deaths related to hypoxia during recovery or equipment problems were found. Intraoperative hypotension and anemia are now the most important concerns associated with the occurrence of postoperative myocardial ischemia and infarction. Prudent comparison with the nationwide 1978–1982 survey suggests a 10-fold decrease in anesthesia mortality rate within this 20-yr time frame.
Anesthesia-related deaths are rare events and are difficult to study. The identification of such rare events by the longitudinal follow-up of a cohort study would require inclusion of millions of anesthetized patients. For practical and methodologic reasons, such a study is unrealistic. Furthermore, a specific registry of postanesthetic deaths does not exist in hospitals and clinics in France. By contrast, it is mandatory to report all deaths to the national mortality database using death certificates, which ensures exhaustiveness. Each death certificate described a mean of 3.3 causes or contributing factors, and this minimized the risk of missing cases. However, the large number of 537,459 death certificates obliged us to consider many steps in our sample selection. To avoid underestimation, the selection process was based on nonrestrictive criteria at the initial step. The primary step discarded only certificates for which any relation with surgery or anesthesia could be obviously ruled out (e.g., death due to multiple metastases with a primary cancer treated by surgery years before). To minimize the risks related to misinterpretation of the causes described in the death certificate, three experts independently performed the initial selection. We excluded cases in which the medical history totally explained why death occurred, whatever the anesthesiologist might have done. These cases mainly included very sick patients undergoing high-risk surgery. In these situations, death was not due (partially or totally) to anesthesia but to the underlying disease. Had the study been devoted to human error, these cases should not have been excluded because anesthesiologists’ errors may occur more easily during urgent and stressful care.
Any case for which the slightest concern arose regarding the role of anesthesia was kept for further analysis, even if concern arose for only one of the three experts. The response rate at any step of the study process was extremely high, and this also minimizes the risk of underestimation. The large communication campaign preceding the study might have contributed to the high acceptance rate.
The initial selection process was validated by reviewing a sample of 500 hospital deaths in which no preselected ICD-9 codes were found and no surgical or anesthesia-related death was found in this additional sample. Finding no event in a sample does not, however, necessarily mean that the event can never occur. Statistical analysis suggests that our underestimation, if any, was small. By taking the upper limit of the 95% confidence interval and applying this information to the whole database studied, it was found that a maximum error of 6.7% could have occurred. That is, the worst scenario would be that we studied only 93.3% of all in-hospital deaths. With the hypothesis that the proportion of anesthetic deaths in this additional 6.7% sample would be similar to that of the whole database, we would thus have missed less than one anesthetic death.
Another limitation might come from the different periods used to measure the number of anesthetic procedures and anesthesia-related mortality (1996 vs. 1999). The error, if any, again seems minimal because data from the French Ministry of Health providing the number of procedures and their type do not show any increase in anesthetic activity during this small time frame.10,11 A small reduction is even suggested, between 1% and 5%, depending on the parameter used to estimate surgical activity. However, this bias would lead to a slight overestimate of anesthetic deaths.
Defining causes and consequences in a healthcare process as well as defining precisely the cause of death is an extremely difficult and complex task. Summarizing the mechanisms of death in a single word, as often found in previous studies,4,12–15 is overly simplistic, explaining why we have decided to present data using a pathophysiologic tree in which the main factors associated with death are described. This presentation also avoids counting the same case several times.
Moreover, for a given final outcome, the healthcare process might have been very different and highly variable actions and process deviations might be seen. Conversely, a given dysfunction (genotype) might lead to complications with highly variable clinical presentation (phenotype).16 To help describe factors associated with poor outcomes, we searched in our cases the most important root causes, using a classification inspired from Vincent et al.8 It is obvious, however, that because cases were analyzed long after the event had occurred and because all participants were not interviewed, our root cause analysis is only a rough estimate, and it cannot be guaranteed that all human and system factors that contributed to the poor outcome were disclosed.
Another difficulty that was faced is hindsight bias (which should be differentiated from outcome bias). Hindsight bias is indeed the exaggerated extent to which individuals indicate they would have predicted the event beforehand.3,17 Reduction of this bias is difficult, but one way could be to systematically ask people to consider all other possible solutions that could explain what happened and how it happened. The pathophysiologic tree was also built and tested beforehand to reduce hindsight bias.
The various causes of medical complications and their complexity are factors that limit the use of traditional statistical tools and explain why expert opinions are used. This is why we structured case analysis in well-separated steps, in which the decision to link the event with anesthesia was the final one. Differentiation between “deaths partially related to anesthesia” and deaths not related to anesthesia “in which anesthetic care could have played only a minor role” was indeed often difficult. We tried to take into account this difficulty by asking experts to indicate how reliable their decision was. For low-reliability cases, the causal relation with anesthesia was increased by one level in a complementary analysis, with the voluntary aim at causing overestimation rather than underestimation. Again, this analysis showed that errors produced by a change in classification, if any, would have only slightly modified the results.
Because we sought information from anesthesiologists involved in candidate cases long after the event had occurred, recall bias might be a problem. Arguably, they may not have had further contact with the patients after their anesthetics and might not even have been aware that some of them had died. Besides their likely inability to recall relevant detail not mentioned on their anesthetic record is the likelihood that they might readily associate the adverse events (e.g., hypotension) with the subsequent death, without recognizing that similar events occur commonly in patients who do not die. To reduce this bias, a copy of the most important medical documents (made anonymous during the on-site visit) was made available to the experts. Moreover, at each time significant disagreement between the anesthesiologist involved and the peer anesthesiologist (who reviewed the case) was noticed, additional questions from the expert committee were transmitted to the peer by the research assistants.
The rate of deaths totally related to anesthesia was close to other published values.4,12,14 Several traditional causes of death were identified, but consequences of hemorrhage and anemia played a role that was found to be disturbing. It was indeed estimated from this survey that nearly 100 deaths occur perioperatively in France each year as the result of inadequate blood management. Surprisingly, more deaths partially related to delayed or absent blood transfusion were observed, and only a small proportion of complications occurred after an episode of transfusion, emphasizing the safety of today’s blood transfusion. In many cases, point-of-care monitoring of hemoglobin was not used to estimate blood loss, although it is likely that these inexpensive devices were already available in most hospitals at that time. Blood loss associated with delayed or absent blood transfusion caused intraoperative hypotension and hypovolemic shock but also postoperative myocardial ischemia and infarction in patients with preexisting coronary artery disease. Our analysis indeed suggested that thresholds used by the physicians in charge were sometimes lowered too much, leading to delayed or absent transfusion in cases where experts believed it would have been necessary. It is difficult to determine the role of the current, more restrictive guidelines for blood transfusion and the persisting reluctance to use blood transfusion that had been generated by the human immunodeficiency virus epidemics in the occurrence of these complications related to delayed transfusion.
Respiratory complications, although less frequently associated with death, remain a significant problem. The role of aspiration of gastric contents remains disturbing but comparable to the rate found in previous studies.18 This is especially concerning because in the French 1978–1982 survey, aspiration of gastric contents was also a prominent cause of death or brain damage from a respiratory complication (40%), and audits of practice showed at the same period that important recommendations regarding prophylaxis of aspiration were not followed by many French anesthetists.19 Although more recent surveys performed in France and assessing obstetric anesthesia practices suggest that deviations are now much less common in this field,20 substandard care remains for patients undergoing urgent abdominal surgery, which has been shown to be the current most common situation in which aspiration occurs.21,22
Root causes were found in the majority of the files that were analyzed. As mentioned previously, this analysis likely leads to an underestimate of the real role of system dysfunction, because files were analyzed long after the event and only one actor was interviewed. Even with this important limitation, our data confirm that errors are not confined “at the sharp end” but result from the often unforeseeable combination of human and organizational failures in the presence of some weakness or gap in the system’s many barriers and safeguards.23,24 This has also been suggested in a recent anesthesia mortality study25 which showed that an adequate anesthetic management process can positively influence anesthesia-related mortality. Barriers to implementing patient safety systems should be alleviated by introducing a formal culture of safety in the operating room environment.26 Other actor-centered improvements are needed. For example, one can remain perplexed when trying to understand the following: Why did experienced physicians use such large doses of anesthetic agents in elderly patients while pharmacodynamic changes associated with aging are so well known? Why did experienced physicians inadequately treat hypotension and not use direct vasoconstrictors when ephedrine was clearly ineffective?27 Maintenance of competence and medical education, as well as implementation of a safety culture, are needed to improve anesthesia safety.
Fig. 5
Fig. 5
Image Tools
The evolution over the past decades of the rate of mortality related to anesthesia is a matter of controversy.4 One of the main causes of this controversy is that it is difficult to compare the various study methods and their results. Few data are available within the same country. In France, a study performed between 1978 and 1982 examined the role of anesthesia-related mortality and found 1 death totally related to anesthesia for 13,200 anesthetic procedures,5 yielding a rate of anesthesia deaths of 7.6 in 100,000. Therefore, the current study suggests that the anesthesia-related mortality rate has decreased 10-fold in France during the past 20 yr. Because these rates may be confounded by a change in the characteristics of the population anesthetized, comparison of rates in ASA physical status III and IV patients permits more accurate analysis and also confirms this significant decline between the two periods (fig. 5). Because the rate of ASA physical status III and IV patients has also increased severalfold in the more recent study and given the fact that these patients are not undergoing preferentially low-risk procedures, concluding that anesthesia-related mortality has declined overall seems sound (fig. 5).
This decline is observed in two surveys designed to estimate the annual nationwide number of both anesthetic procedures and anesthesia-related deaths. Both surveys included only anesthetic procedures that were performed by anesthesiologists or under their supervision, whereas procedures performed in intensive care units or ambulances were excluded. The definitions of deaths related to the anesthetic procedure were also similar. The participation rates of French anesthesiologists in both surveys were very high: 87% in 1978–1982 and 94% in 1999. External validation was performed in both surveys to estimate the completeness of the data collection. Because anesthesia is performed in France only by specialists in formally approved structures (hospitals and clinics), there is a low risk that cases might have been missed in either survey. Finally, because thromboprophylaxis is part of the anesthesiologist’s role in France, those deaths believed to be due to postoperative thromboembolism were included among anesthesia-related deaths in the 1999 study, although they were not in the 1978–1982 survey. This might have included a significant bias (overestimated rate in the 1999 study) in the computation of anesthesia-related deaths. This is unlikely, however, because we did not observe any case for which pulmonary embolism was a factor in our sample.
In 1978–1982, only deaths occurring during the first 24 h after surgery were included in the analysis. By contrast, deaths occurring long after the anesthetic procedure were included in the 1999 analysis. Because 58% of the deaths occurred more than 24 h after surgery in the 1999 study, there was a relative underestimation of the anesthesia-related deaths in 1978–1982, and this reinforces our conclusions. Moreover, the increased number of guidelines now in place allows for a more precise classification of substandard practices. Although the willingness to attribute causality to anesthesia might have changed between the two study periods (it is difficult to be certain which direction the bias is in), we believe that underestimation was more likely in the previous survey. The role of human error is a factor that was not considered 20 yr ago and is more likely to influence judgment of experts in the current survey (toward an increased role of anesthesia care in the process leading to death). Moreover, in the current era, more data are available that tend to strengthen certain explanations. Therefore, today, if there is a case of difficult intubation but the patient later dies, the pulse oximetry and capnography data might prove that oxygenation and ventilation were maintained throughout. In the previous era, such cases might be assumed to be due to anesthesia care, even though the physiologic connection might not have been there.
Beside the decreased mortality rate, qualitative trends also appear. Hypoxia during the recovery period and the variable conditions of recovery monitoring, which was often found in 1978–1982, was not observed in 1999. Several factors likely contribute to this decline. Some are universal, i.e., introduction of pulse oximetry28 and use of modern anesthetics with more rapid offset,29 but some are specific to this country. Results from the 1978–1982 survey were discussed with French healthcare authorities, and this led to the promulgation of a series of laws centered on anesthesia care in 1985–1994.30,31 Postanesthesia care units and postprocedural stay in these units became mandatory in every surgical institution while supervision personnel and monitoring techniques were defined.
In conclusion, taking into account the numerous limitations of this study, we found that the overall rate of anesthesia-related mortality is currently 5.4 in 100,000 but increases in ASA physical status III and IV patients. Comparison of these data with a previously performed survey in the same country suggests a 10-fold decrease in the rate of anesthesia-related deaths.
The French Society of Anesthesia and Intensive Care thanks all of the physicians who answered the questionnaire and those involved in the inquiries. The authors also appreciate the support of the other medical Societies and the National Council of Physicians. Bruno Riou, M.D. (Professor of Anesthesia and Intensive Care, Hôpital de la Pitié-salpétrière, Paris, France), Yves Diraison, M.D. (Professor of Anesthesia and Intensive Care, Service d’Anesthésie-Réanimation, Hôpital d’Instruction des Armées du Val de Grâce, Paris, France), and Bernard Lenoir, M.D. (Professor of Anesthesia and Intensive Care, Service d’Anesthésie-Réanimation, Hôpital d’Instruction des Armées Percy, Clamart, France), took part in the analysis of the files, and Marie-Claire Laxenaire, M.D. (Professor of Anesthesia and Intensive Care, Hôpital Central, Nancy Cedex, France), was involved in the analysis of files related to anaphylaxis. Françoise Laurent, M.D. (Institut National pour la Santé et la Recherche Médicale–Unité CépiDc, Le Vésinet, France), allowed easier access to the database, especially by preparing the death certificate visualization. François Clergue, M.D. (Professor of Anesthesia, and Chairman, Hôpital Cantonal de Genève, Geneva, Switzerland), Bruno Riou, M.D. (see above), and Daniel I. Sessler, M.D. (Chair, Department of Outcomes Research, Cleveland Clinic Foundation, Cleveland, Ohio; Director, Outcomes Research Institute, and Weakley Professor of Anesthesiology, University of Louisville, Louisville, Kentucky), reviewed the manuscript.
Back to Top | Article Outline

References

1. Committee on Quality of Health Care in America: To Err Is Human: Building a Safer Health System. Edited by Donaldson M. Washington, D.C., National Academy Press, 1999, p 27

2. Department of Health: Building a Safer NHS for Patients: Implementing an Organisation with a Memory. London, The Stationery Office, 2001, p 58

3. Arkes HR, Faust D, Guilmette TJ, Hart K: Eliminating the hindsight bias. J Appl Psychol 1998; 73:305–7

4. Lagasse RS: Anesthesia safety: Model or myth? A review of the published literature and analysis of current original data. Anesthesiology 2002; 97:1609–17

5. Tiret L, Desmonts JM, Hatton F, Vourc’h G: Complications associated with anaesthesia–a prospective survey in France. Can Anaesth Soc J 1986; 33:336–44

6. Clergue F, Auroy Y, Pequignot F, Jougla E, Lienhart A, Laxenaire MC: French survey of anesthesia in 1996. Anesthesiology 1999; 91:1509–20

7. Classification Internationale de Maladies 9ème révision (1975). Genève, Organisation Mondiale de la Santé, 1977, pp 1–781

8. Vincent C, Taylor-Adams S, Chapman EJ, Hewett D, Prior S, Strange P, Tizzard A: How to investigate and analyse clinical incidents: Clinical risk unit and association of litigation and risk management protocol. BMJ 2000; 320:777–81

9. Breslow NE: Case-control study, two-phase, Encyclopedia of Biostatistics. Edited by Armitage P, Colton T. Chichester, United Kingdom, John Wiley & Sons, 1998, pp 532–40

10. Statistique annuelle des établissements de santé SAE 1996. Paris, Direction de la recherche des études de l’évaluation et des statistiques, 1999, pp 1–105

11. Thomson E: Statistique annuelle des établissements de santé 1999. Paris, Direction de la recherche des études de l’évaluation et des statistiques, 2001, pp 1–137

12. Kawashima Y, Takahashi S, Suzuki M, Morita K, Irita K, Iwao Y, Seo N, Tsuzaki K, Dohi S, Kobayashi T, Goto Y, Suzuki G, Fujii A, Suzuki H, Yokoyama K, Kugimiya T: Anesthesia-related mortality and morbidity over a 5-year period in 2,363,038 patients in Japan. Acta Anaesthesiol Scand 2003; 47:809–17

13. Pedersen T, Eliasen K, Henriksen E: A prospective study of mortality associated with anaesthesia and surgery: Risk indicators of mortality in hospital. Acta Anaesthesiol Scand 1990; 34:176–82

14. Warden JC, Horan BF: Deaths attributed to anaesthesia in New South Wales, 1984-1990. Anaesth Intensive Care 1996; 24:66–73

15. Arbous MS, Grobbee DE, van Kleef JW, de Lange JJ, Spoormans HH, Touw P, Werner FM, Meursing AE: Mortality associated with anaesthesia: A qualitative analysis to identify risk factors. Anaesthesia 2001; 56:1141–53

16. Hollnagel E: Cognitive Reliability and Error Analysis Method: CREAM. New York, Elsevier, 1998, p 19

17. Henriksen K, Kaplan H: Hindsight bias, outcome knowledge and adaptive learning. Qual Saf Health Care 2003; 12:ii46–50

18. Olsson GL, Hallen B, Hambraeus-Jonzon K: Aspiration during anaesthesia: A computer-aided study of 185,358 anaesthetics. Acta Anaesthesiol Scand 1986; 30:84–92

19. Benhamou D: French obstetric anaesthetists and acid aspiration prophylaxis. Eur J Anaesthesiol 1993; 10:27–32

20. Tourtier JP, Compain M, Petitjeans F, Villevieille T, Chevalier JF, Mercier FJ, Benhamou D: Acid aspiration prophylaxis in obstetrics in France: A comparative survey of 1998 versus 1988 French practice. Eur J Anaesthesiol 2004; 21:89–94

21. Warner MA, Warner ME, Weber JG: Clinical significance of pulmonary aspiration during the perioperative period. Anesthesiology 1993; 78:56–62

22. Neelakanta G, Chikyarappa A: A review of patients with pulmonary aspiration of gastric contents during anesthesia reported to the Departmental Quality Assurance Committee. J Clin Anesth 2006; 18:102–7

23. Reason J: Safety in the operating theatre: II. Human error and organisational failure. Qual Saf Health Care 2005; 14:56–60

24. Reason J: Human Error. Cambridge, United Kingdom, Cambridge University Press, 1990, pp 1–302

25. Arbous MS, Meursing AE, van Kleef JW, de Lange JJ, Spoormans HH, Touw P, Werner FM, Grobbee DE: Impact of anesthesia management characteristics on severe morbidity and mortality. Anesthesiology 2005; 102:257–68

26. Amalberti R, Auroy Y, Berwick D, Barach P: Five system barriers to achieving ultrasafe health care. Ann Intern Med 2005; 142:756–64

27. Callum KG, Gray AJ, Hoile RW, Ingram GS, Martin IC, Sherry KM, Whimster F: Extremes of age, the 1999 Report of the National Confidential Enquiry into Perioperative Deaths, London National Confidential Enquiry into Perioperative Deaths. London, National Confidential Enquiry into Perioperative Deaths, 1999, pp 55–102

28. Pedersen T, Moller AM, Pedersen BD: Pulse oximetry for perioperative monitoring: Systematic review of randomized, controlled trials. Anesth Analg 2003; 96:426–31

29. Scott LJ, Perry CM: Remifentanil: A review of its use during the induction and maintenance of general anaesthesia. Drugs 2005; 65:1793–823

30. Ministère des Affaires Sociales et de la Solidarité Nationale: Circulaire DGS/3A/431/4B du 27 juin 1985 relative à la sécurité des malades anesthésiés dans les établissements sanitaires hospitaliers publics et privés. Ministère des Affaires Sociales et de la Solidarité Nationale. Paris, Direction Générale de la Santé, 1985, p 4

31. Ministère des Affaires Sociales de la Santé et de la Ville: Décret n° 94-1050 du 5 décembre 1994 relatifs aux conditions techniques de fonctionnement des établissements de santé en ce qui concerne la pratique de l’anesthésie et modifiant le code de santé publique. Paris, Journal Officiel de la République Française, 1994, pp 17383–85

†† Anesthesia Patient Safety Foundation. Available at: www.apsf.org. Accessed April 12, 2006. Cited Here...
‡‡ Agency of Healthcare Research and Quality. Available at: www.ahrq.gov. Accessed July 19, 2006. Cited Here...

Cited By:

This article has been cited 81 time(s).

Anaesthesia and Intensive Care
National anaesthesia mortality reporting in Australia from 1985-2008
Gibbs, NM
Anaesthesia and Intensive Care, 41(3): 294-301.

Minerva Anestesiologica
Association of intraoperative blood pressure instability with adverse outcomes after liver transplantation
De Maria, S; Nurnberg, J; Lin, HM; Contreras-Saldivar, AG; Levin, M; Flax, K; Groth, D; Vullo, J; Rocca, J; Florman, S; Reich, DL
Minerva Anestesiologica, 79(6): 604-616.

Canadian Journal of Anesthesia-Journal Canadien D Anesthesie
Neuromuscular monitoring, residual blockade, and reversal: Time for re-evaluation of our clinical practice
Plaud, B
Canadian Journal of Anesthesia-Journal Canadien D Anesthesie, 60(7): 634-640.
10.1007/s12630-013-9952-4
CrossRef
Swiss Medical Weekly
Improving patient safety in medicine: is the model of anaesthesia care enough?
Haller, G
Swiss Medical Weekly, 143(): -.
ARTN w13770
CrossRef
Canadian Journal of Anesthesia-Journal Canadien D Anesthesie
Anesthesiologists' learning curves for bedside qualitative ultrasound assessment of gastric content: a cohort study
Arzola, C; Carvalho, JCA; Cubillos, J; Ye, XY; Perlas, A
Canadian Journal of Anesthesia-Journal Canadien D Anesthesie, 60(8): 771-779.
10.1007/s12630-013-9974-y
CrossRef
Gynecologie Obstetrique & Fertilite
Improving healthcare: safety lessons from anesthesia, prospects for perinatology?
Mignon, A; Goffinet, F
Gynecologie Obstetrique & Fertilite, 37(): 820-823.
10.1016/j.gyobfe.2009.08.013
CrossRef
Annales Francaises D Anesthesie Et De Reanimation
Quality indicator survey of anaesthesia records in hospitals of Aquitaine
Hubert, B; Ausset, S; Auroy, Y; Billard-Decre, C; Tricaud-Vialle, S; Djihoud, A
Annales Francaises D Anesthesie Et De Reanimation, 27(3): 216-221.
10.1016/j.annfar.2007.12.008
CrossRef
Otolaryngology-Head and Neck Surgery
Six Sigma tympanostomy tube insertion: Achieving the highest safety levels during residency training
Isaacson, G
Otolaryngology-Head and Neck Surgery, 139(3): 353-357.
10.1016/j.otohns.2008.06.012
CrossRef
Transfusion Clinique Et Biologique
Blood conservation approaches in surgical patients
Rosencher, N; Bellamy, L; Chabbouh, T; Arnaout, L; Ozier, Y
Transfusion Clinique Et Biologique, 15(5): 294-302.
10.1016/j.tracli.2008.09.024
CrossRef
Annales Francaises D Anesthesie Et De Reanimation
Pulmonary aspiration: Epidemiology and risk factors
Landreau, B; Odin, I; Nathan, N
Annales Francaises D Anesthesie Et De Reanimation, 28(3): 206-210.
10.1016/j.annfar.2009.01.020
CrossRef
British Journal of Surgery
Influence of general health and degree of surgical insult on long-term survival
Kennedy, RR; Lee, A; Frizelle, FA
British Journal of Surgery, 97(5): 782-788.
10.1002/bjs.6960
CrossRef
Transfusion Clinique Et Biologique
Risk analysis of postoperative anemia through biological databases querying
Ausset, S; Donat, N; Foisseau, V; Cirodde, A; Clavier, B; Auroy, Y
Transfusion Clinique Et Biologique, 15(4): 168-173.
10.1016/j.tracli.2008.08.001
CrossRef
Acta Anaesthesiologica Scandinavica
The occurrence of intra-operative hypotension varies between hospitals: observational analysis of more than 147,000 anaesthesia
Taffe, P; Sicard, N; Pittet, V; Pichard, S; Burnand, B
Acta Anaesthesiologica Scandinavica, 53(8): 995-1005.
10.1111/j.1399-6576.2009.02032.x
CrossRef
Regional Anesthesia and Pain Medicine
Safety During Regional Anesthesia What Do We Know and How Can We Improve Our Practice?
Benhamou, D; Auroy, Y; Amalberti, R
Regional Anesthesia and Pain Medicine, 35(1): 1-3.
10.1097/AAP.0b013e3181c99564
CrossRef
Annales Francaises D Anesthesie Et De Reanimation
The decrease of preoperative autologous transfusion in France has not been linked to an increase of homologous red cell concentrates
Daurat, G; Duedari, N; Schved, JF
Annales Francaises D Anesthesie Et De Reanimation, 27(2): 141-147.
10.1016/j.annfar.2007.11.011
CrossRef
Annales Francaises D Anesthesie Et De Reanimation
Root cause analysis: Too few or too much?
Braillon, A; Sfez, M
Annales Francaises D Anesthesie Et De Reanimation, 27(6): 519.
10.1016/j.annfar.2008.05.002
CrossRef
Anaesthesia
Mortality related to anaesthesia in France: analysis of deaths related to airway complications
Auroy, Y; Benhamou, D; Pequignot, F; Bovet, M; Jougla, E; Lienhart, A
Anaesthesia, 64(4): 366-370.
10.1111/j.1365-2044.2008.05792.x
CrossRef
Annales Francaises D Anesthesie Et De Reanimation
In memorial Claude Guilmet (1919-2008)
Benhamou, D; Mercier, FJ
Annales Francaises D Anesthesie Et De Reanimation, 28(2): 115-118.

International Orthopaedics
Trends in mortality, complications, and demographics for primary hip arthroplasty in the United States
Liu, SS; Della Valle, AG; Besculides, MC; Gaber, LK; Memtsoudis, SG
International Orthopaedics, 33(3): 643-651.
10.1007/s00264-008-0549-4
CrossRef
Presse Medicale
Short- and long-term risks and consequences of anesthesia
Bonnet, F; Berger, J
Presse Medicale, 38(): 1586-1590.
10.1016/j.lpm.2009.08.001
CrossRef
Annales Francaises D Anesthesie Et De Reanimation
Experiment of an anesthetic adverse events reporting
Thevenin, A; Chenet, V; Schlumberger, S; Fischler, M
Annales Francaises D Anesthesie Et De Reanimation, 28(): 838-843.
10.1016/j.annfar.2009.08.002
CrossRef
International Journal of Radiation Oncology Biology Physics
Improving patient safety in anesthesia: A success story?
Botney, R
International Journal of Radiation Oncology Biology Physics, 71(1): S182-S186.
10.1016/j.ijrobp.2007.05.095
CrossRef
Annales Francaises D Anesthesie Et De Reanimation
Is the surgical safety checklist a significant improvement?
Benhamou, D
Annales Francaises D Anesthesie Et De Reanimation, 28(5): 426-428.
10.1016/j.annfar.2009.03.006
CrossRef
Current Pharmaceutical Design
Hypersensitivity Reactions to Neuromuscular Blocking Agents
Mertes, PM; Aimone-Gastin, I; Gueant-Rodriguez, RM; Mouton-Faivre, C; Audibert, G; O'Brien, J; Frendt, D; Brezeanu, M; Bouaziz, H; Gueant, JL
Current Pharmaceutical Design, 14(): 2809-2825.

British Journal of Anaesthesia
Hyponatraemia-related death after paediatric surgery still exists in France
Auroy, Y; Benhamou, D; Pequignot, F; Jougla, E; Lienhart, A
British Journal of Anaesthesia, 101(5): 741.
10.1093/bja/aen282
CrossRef
Anesthesia and Analgesia
Monitoring Quality and Safety in Anesthesia: Are Large Numbers Enough?
Benhamou, D; Auroy, Y; Amalberti, R
Anesthesia and Analgesia, 107(5): 1458-1460.
10.1213/ane.0b013e318189476b
CrossRef
Annales Francaises D Anesthesie Et De Reanimation
Acute traumatic haemorrhagic shock and transfusion: What's new in 2009?
Morel, N; Morel, O; Chimot, L; Lortet, V; Julliac, B; Lelias, A; Merson, L; Dabadie, P
Annales Francaises D Anesthesie Et De Reanimation, 28(3): 222-230.
10.1016/j.annfar.2008.12.023
CrossRef
Bmc Public Health
Using vital statistics to estimate the population-level impact of osteoporotic fractures on mortality based on death certificates, with an application to France (2000-2004)
Ziade, N; Jougla, E; Coste, J
Bmc Public Health, 9(): -.
ARTN 344
CrossRef
Annales Francaises D Anesthesie Et De Reanimation
Anaesthetic agents in children: risk or benefit?
Constant, I
Annales Francaises D Anesthesie Et De Reanimation, 26(6): 516-523.

Anesthesia and Analgesia
The importance of increased neck circumference to intubation difficulties in obese patients
Gonzalez, H; Minville, V; Delanoue, K; Mazerolles, M; Concina, D; Fourcade, O
Anesthesia and Analgesia, 106(4): 1132-1136.
10.1213/ane.0b013e3181679659
CrossRef
Annales Francaises D Anesthesie Et De Reanimation
Survey of anaesthesia-related mortality in France: The role of aspiration of gastric contents
Auroy, Y; Benhamou, D; Pequignot, F; Jougla, E; Lienhart, A
Annales Francaises D Anesthesie Et De Reanimation, 28(3): 200-205.
10.1016/j.annfar.2008.12.018
CrossRef
Digestion
Sedation in Gastrointestinal Endoscopy: An Anesthesiologist's Perspective
Van der Linden, P
Digestion, 82(2): 102-105.
10.1159/000285525
CrossRef
Journal of Hepatology
Mortality related to chronic hepatitis B and chronic hepatitis C in France: Evidence for the role of HIV coinfection and alcohol consumption
Marcellin, P; Pequignot, F; Delarocque-Astagneau, E; Zarski, JP; Ganne, N; Hillon, P; Antona, D; Bovet, M; Mechain, M; Asselah, T; Desenclos, JC; Jougla, E
Journal of Hepatology, 48(2): 200-207.
10.1016/j.jhep.2007.09.010
CrossRef
Anaesthesist
Fatalities due to nitrous oxide. Complications from mistakes in nitrous oxide supply
Herff, H; Paal, P; Lindner, KH; von Goedecke, A; Keller, C; Wenzel, V
Anaesthesist, 57(): 1006-1010.
10.1007/s00101-008-1434-7
CrossRef
Annales Francaises D Anesthesie Et De Reanimation
Allergic risk during paediatric anaesthesia
Dewachter, P; Mouton-Faivre, C
Annales Francaises D Anesthesie Et De Reanimation, 29(3): 215-226.
10.1016/j.annfar.2009.11.014
CrossRef
Annales Francaises D Anesthesie Et De Reanimation
Risks in paediatric anaesthesia
Murat, I; Humblot, A; Girault, L
Annales Francaises D Anesthesie Et De Reanimation, 28(): 666-670.
10.1016/j.annfar.2009.06.013
CrossRef
Orthopaedics & Traumatology-Surgery & Research
Total hip arthroplasty for osteoarthritis in patients aged 80 years or older: Influence of co-morbidities on final outcome
de Thomasson, E; Caux, I; Guingand, O; Terracher, R; Mazel, C
Orthopaedics & Traumatology-Surgery & Research, 95(4): 249-253.
10.1016/j.otsr.2009.03.011
CrossRef
Annales Francaises D Anesthesie Et De Reanimation
Sugammadex: something new to improve patient safety or simply a gadget?
Plaud, B
Annales Francaises D Anesthesie Et De Reanimation, 28(): S64-S69.

Minerva Anestesiologica
Risk management in anesthesia
Cabrini, L; Levati, A
Minerva Anestesiologica, 75(): 638-643.

Anaesthesia
Fatal errors in nitrous oxide delivery
Herff, H; Paal, P; von Goedecke, A; Lindner, KH; Keller, C; Wenzel, V
Anaesthesia, 62(): 1202-1206.
10.1111/1365-2044.2007.05193.x
CrossRef
Anaesthesia, Pain, Intensive Care and Emergency: A.P.I.C.E
Side effects induced by anaesthetic manipulation or by surgical operation
Leykin, Y; Noal, N
Anaesthesia, Pain, Intensive Care and Emergency: A.P.I.C.E, (): 333-341.

Annales Francaises D Anesthesie Et De Reanimation
Standardization-communication: Two targets for health care safety
Clergue, F
Annales Francaises D Anesthesie Et De Reanimation, 28(5): 423-425.
10.1016/j.annfar.2009.03.007
CrossRef
British Medical Journal
Breaking the mould in patient safety
Degos, L; Amalberti, R; Bacou, J; Carlet, J; Bruneau, C
British Medical Journal, 339(): -.
ARTN b2585
CrossRef
Transfusion Clinique Et Biologique
What is the future of blood safety and which safety strategy for an ultrasafe system?
Amalberti, R
Transfusion Clinique Et Biologique, 16(2): 80-85.
10.1016/j.tracli.2009.03.007
CrossRef
Gastroenterology
Endoscopist-Directed Administration of Propofol: A Worldwide Safety Experience
Rex, DK; Deenadayalu, VP; Eid, E; Imperiale, TF; Walker, JA; Sandhu, K; Clarke, AC; Hillman, LC; Horiuchi, A; Cohen, LB; Heuss, LT; Peter, S; Beglinger, C; Sinnott, JA; Welton, T; Rofail, M; Subei, I; Sleven, R; Jordan, P; Goff, J; Gerstenberger, PD; Munnings, H; Tagle, M; Sipe, BW; Wehrmann, T; Di Palma, JA; Occhipinti, KE; Barbi, E; Riphaus, A; Amann, ST; Tohda, G; McClellan, T; Thueson, C; Morse, J; Meah, N
Gastroenterology, 137(4): 1229-1237.
10.1053/j.gastro.2009.06.042
CrossRef
Gastrointestinal Endoscopy
Propofol sedation during endoscopic procedures in private practice: the case for capnography to make 1-nurse endoscopy acceptable
Froehlich, F; Milliet, N
Gastrointestinal Endoscopy, 67(6): 1008.
10.1016/j.gie.2007.12.034
CrossRef
Annales Francaises D Anesthesie Et De Reanimation
The seventh report of the confidential enquiries into maternal deaths in the United Kingdom: Comparison with French data
Benhamou, D; Chassard, D; Mercier, FJ; Bouvier-Colle, MH
Annales Francaises D Anesthesie Et De Reanimation, 28(1): 38-43.
10.1016/j.annfar.2008.11.002
CrossRef
Transfusion Clinique Et Biologique
Blood requirements and transfusion practice evolution in surgery
Boisson, C; Cuvillon, R; Macheboeuf, M; Ripart, J
Transfusion Clinique Et Biologique, 15(5): 254-258.
10.1016/j.tracli.2008.09.020
CrossRef
Immunology and Allergy Clinics of North America
Perioperative Anaphylaxis
Mertes, PM; Lambert, M; Gueant-Rodriguez, RM; Aimone-Gastin, I; Mouton-Faivre, C; Moneret-Vautrin, DA; Gueant, JL; Malinovsky, JM; Demoly, P
Immunology and Allergy Clinics of North America, 29(3): 429-+.
10.1016/j.iac.2009.04.004
CrossRef
Clinics
Mortality in Anesthesia: A Systematic Review
Braz, LG; Braz, DG; da Cruz, DS; Fernandes, LA; Modolo, NSP; Brazi, JRC
Clinics, 64(): 999-1006.
10.1590/S1807-59322009001000011
CrossRef
Annales Francaises D Anesthesie Et De Reanimation
Guidelines on difficult airway management have been updated: What about the future?
Cros, AM
Annales Francaises D Anesthesie Et De Reanimation, 27(1): 1-2.
10.1016/j.annfar-.2007.10.019
CrossRef
Anesthesia and Analgesia
The pivotal role of vasopressin in refractory anaphylactic shock
Schurnmer, C; Wirsing, M; Schummer, W
Anesthesia and Analgesia, 107(2): 620-624.
10.1213/ane.0b013e3181770b42
CrossRef
Transfusion Clinique Et Biologique
Changes in transfusion practice for surgery
Lienhart, A
Transfusion Clinique Et Biologique, 14(6): 533-537.
10.1016/j.tracli.2008.01.005
CrossRef
Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
Tumescent anaesthesia
Conroy, PH; O'Rourke, J
Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, 11(4): 210-221.
10.1016/j.surge.2012.12.009
CrossRef
Annales Francaises D Anesthesie Et De Reanimation
Perioperative management based on kinetics of bleeding during total primary arthroplasty
Irisson, E; Kerbaul, F; Parratte, S; Hemon, Y; Argenson, JN; Rosencher, N; Bellamy, L
Annales Francaises D Anesthesie Et De Reanimation, 32(3): 170-174.
10.1016/j.annfar.2012.12.005
CrossRef
Annales Francaises D Anesthesie Et De Reanimation
Need for integration and working conditions of locum anaesthesiologists in community hospitals of a French administrative area
Lieutaud, T
Annales Francaises D Anesthesie Et De Reanimation, 32(6): 409-415.
10.1016/j.annfar.2013.04.010
CrossRef
Acta Obstetricia Et Gynecologica Scandinavica
Transfusion practices in postpartum hemorrhage: a population-based study
Bonnet, MP; Deneux-Tharaux, C; Dupont, C; Rudigoz, RC; Bouvier-Colle, MH
Acta Obstetricia Et Gynecologica Scandinavica, 92(4): 404-413.
10.1111/aogs.12063
CrossRef
Medical Science Monitor
Risk factors for intraoperative hypotension during thyroid surgery
Kalezic, N; Stojanovic, M; Ladjevic, N; Markovic, D; Paunovic, I; Palibrk, I; Milicic, B; Sabljak, V; Antonijevic, V; Ivanovic, B; Ugrinovic, D; Zivaljevic, V
Medical Science Monitor, 19(): 236-241.

British Journal of Anaesthesia
Survival from perioperative anaphylaxis in Western Australia 2000-2009
Gibbs, NM; Sadleir, PH; Clarke, RC; Platt, PR
British Journal of Anaesthesia, 111(4): 589-593.
10.1093/bja/aet117
CrossRef
Anesthesiology
Adverse Events with Medical Devices in Anesthesia and Intensive Care Unit Patients Recorded in the French Safety Database in 2005–2006
Beydon, L; Ledenmat, PY; Soltner, C; Lebreton, F; Hardin, V; Benhamou, D; Clergue, F; Laguenie, G
Anesthesiology, 112(2): 364-372.
10.1097/ALN.0b013e3181ca2e55
PDF (457) | CrossRef
Anesthesiology
A Comparison of Epinephrine Only, Arginine Vasopressin Only, and Epinephrine Followed by Arginine Vasopressin on the Survival Rate in a Rat Model of Anaphylactic Shock
Dewachter, P; Raëth-Fries, I; Jouan-Hureaux, V; Menu, P; Vigneron, C; Longrois, D; Mertes, PM
Anesthesiology, 106(5): 977-983.
10.1097/01.anes.0000265157.09438.1f
PDF (747) | CrossRef
Anesthesiology
Lung Injury and Recovery in a Murine Model of Unilateral Acid Aspiration: Functional, Biochemical, and Morphologic Characterization
Amigoni, M; Bellani, G; Scanziani, M; Masson, S; Bertoli, E; Radaelli, E; Patroniti, N; Di Lelio, A; Pesenti, A; Latini, R
Anesthesiology, 108(6): 1037-1046.
10.1097/ALN.0b013e318173f64f
PDF (1657) | CrossRef
Anesthesiology
Time to Widen Our Horizons in Perioperative Medicine: A Plea in Favor of Using Patient-centered Outcomes
Auroy, Y; Benhamou, D; Amalberti, R
Anesthesiology, 110(2): 209-211.
10.1097/ALN.0b013e318194caea
PDF (118) | CrossRef
Anesthesiology
Epidemiology of Anesthesia-related Mortality in the United States, 1999–2005
Li, G; Warner, M; Lang, BH; Huang, L; Sun, LS
Anesthesiology, 110(4): 759-765.
10.1097/ALN.0b013e31819b5bdc
PDF (315) | CrossRef
Anesthesiology
Long-term Consequences of Anesthetic Management
Sessler, DI
Anesthesiology, 111(1): 1-4.
10.1097/ALN.0b013e3181a913e1
PDF (229) | CrossRef
Anesthesiology
Ultrasound Assessment of Gastric Content and Volume
Perlas, A; Chan, VW; Lupu, CM; Mitsakakis, N; Hanbidge, A
Anesthesiology, 111(1): 82-89.
10.1097/ALN.0b013e3181a97250
PDF (979) | CrossRef
Anesthesiology
Incidence of Intraoperative Hypotension as a Function of the Chosen Definition: Literature Definitions Applied to a Retrospective Cohort Using Automated Data Collection
Bijker, JB; van Klei, WA; Kappen, TH; van Wolfswinkel, L; Moons, KG; Kalkman, CJ
Anesthesiology, 107(2): 213-220.
10.1097/01.anes.0000270724.40897.8e
PDF (301) | CrossRef
Anesthesiology
Patient Blood Management and Transfusion
de Saint Maurice, G; Pequignot, F; Auroy, Y; Aouba, A; Benhamou, D; Jougla, E; Lienhart, A
Anesthesiology, 111(2): 444-445.
10.1097/ALN.0b013e3181ac1e43
PDF (77) | CrossRef
Anesthesiology
Mortality Related to Anesthesia and Sleep Deprivation in Medical Doctors
Mion, G; Ricouard, S
Anesthesiology, 107(3): 512.
10.1097/01.anes.0000278995.23009.8e
PDF (441) | CrossRef
Anesthesiology
Anaphylaxis and Anesthesia: Controversies and New Insights
Dewachter, P; Mouton-Faivre, C; Emala, CW
Anesthesiology, 111(5): 1141-1150.
10.1097/ALN.0b013e3181bbd443
PDF (765) | CrossRef
Anesthesiology
Anesthesia-related Mortality
de Saint Maurice, G; Aouba, A; Pequignot, F; Auroy, Y; Benhamou, D; Jougla, E; Lienhart, A
Anesthesiology, 111(5): 1165.
10.1097/ALN.0b013e3181bbc49b
PDF (64) | CrossRef
Anesthesiology
To See or Not to See
Lagasse, RS
Anesthesiology, 105(6): 1071-1073.

PDF (315)
Anesthesiology
Intraoperative Hypotension and 1-Year Mortality after Noncardiac Surgery
Bijker, JB; van Klei, WA; Vergouwe, Y; Eleveld, DJ; van Wolfswinkel, L; Moons, KG; Kalkman, CJ
Anesthesiology, 111(6): 1217-1226.
10.1097/ALN.0b013e3181c14930
PDF (668) | CrossRef
Current Opinion in Anesthesiology
Outcome after cardiovascular surgery: where do we stand?
De Hert, SG
Current Opinion in Anesthesiology, 21(1): 47-49.
10.1097/ACO.0b013e3282f357c8
PDF (67) | CrossRef
Current Opinion in Anesthesiology
Anesthetic process, organization, management and economic issues: the French perspective
Marty, J; Plaud, B
Current Opinion in Anesthesiology, 22(2): 249-254.
10.1097/ACO.0b013e32832922a6
PDF (135) | CrossRef
Current Opinion in Anesthesiology
Outcomes in perioperative care
Mantz, J; Dahmani, S; Paugam-Burtz, C
Current Opinion in Anesthesiology, 23(2): 201-208.
10.1097/ACO.0b013e328336aeef
PDF (5786) | CrossRef
Current Opinion in Anesthesiology
Epidemiology and morbidity of regional anaesthesia in children
Lacroix, F
Current Opinion in Anesthesiology, 21(3): 345-349.
10.1097/ACO.0b013e3282ffabc5
PDF (84) | CrossRef
Current Opinion in Anesthesiology
What next targets for anaesthesia safety?
Clergue, F
Current Opinion in Anesthesiology, 21(3): 360-362.
10.1097/ACO.0b013e3282ff8c62
PDF (60) | CrossRef
Current Opinion in Anesthesiology
What investigation after an anaphylactic reaction during anaesthesia?
Dewachter, P; Mouton-Faivre, C
Current Opinion in Anesthesiology, 21(3): 363-368.
10.1097/ACO.0b013e3282ff85e1
PDF (110) | CrossRef
European Journal of Anaesthesiology (EJA)
Hypovolaemic hypotension after abdominal aortic surgery is predicted by initial distribution volume of glucose
Orban, J; Blasin-Chadoutaud, A; Zolfaghari, P; Ishihara, H; Grimaud, D; Ichai, C
European Journal of Anaesthesiology (EJA), 27(4): 364-368.
10.1097/EJA.0b013e328334257c
PDF (378) | CrossRef
European Journal of Anaesthesiology (EJA)
The Helsinki Declaration on Patient Safety in Anaesthesiology
Mellin-Olsen, J; Staender, S; Whitaker, DK; Smith, AF
European Journal of Anaesthesiology (EJA), 27(7): 592-597.
10.1097/EJA.0b013e32833b1adf
PDF (121) | CrossRef
Back to Top | Article Outline

© 2006 American Society of Anesthesiologists, Inc.

Publication of an advertisement in Anesthesiology Online does not constitute endorsement by the American Society of Anesthesiologists, Inc. or Lippincott Williams & Wilkins, Inc. of the product or service being advertised.
Login

Article Tools

Images

Share