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Anesthesiology:
Case Reports

Low-dose Propofol Infusion for Controlling Acute Hyperspasticity after Withdrawal of Intrathecal Baclofen Therapy

Ackland, Gareth L. Ph.D.,D., F.R.C.A.*; Fox, Rick F.R.C.A.†

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BACLOFEN, a potent γ-aminobutyric acid (GABA) type B receptor agonist, has been used widely as an antispasticity drug since the 1970s.1 Baclofen decreases synaptic transmission by binding to the presynaptic GABA type B receptor at the primary sensory afferent terminal through a second-messenger pathway, thereby decreasing calcium influx and neurotransmitter release.2 Binding of baclofen to the presynaptic GABA type B receptor also decreases neurotransmitter release by activating potassium channels,3 contributing to its presynaptic inhibitory effect. Baclofen may also act at supraspinal sites, including enhancement of vagal tone4 and inhibition of mesolimbic5 and nigrostriatal neurons.6 Although baclofen has major postsynaptic effects on motoneurons and interneurons, experimental models of chronic spinal cord injury do not support a postsynaptic action contributing to its antispasticity effect.7
Intrathecal baclofen has benefitted patients with a wide range of conditions characterized by hyperspasticity who are unresponsive to, or intolerant of, therapeutic doses of oral baclofen.8–10 However, the U.S. Food and Drug Administration, together with several case reports, have highlighted the potentially life-threatening problems of acute baclofen withdrawal syndrome.11–21 Because acute baclofen withdrawal may present in many different ways, this syndrome mimics several common critical care presentations. The neuropathophysiologic syndrome of baclofen withdrawal is due to the loss of GABAergic inhibition, resulting in the predominance of excitatory effects with central nervous system hyperexcitability and severe spasticity. Although benzodiazepines are used in the treatment of baclofen withdrawal, high doses are associated with the potential risk of prolonged ventilation in patients with poor ventilatory reserve, as well as other iatrogenic complications.22 Therefore, an easy-to-titrate, rapidly acting agent in doses that avoid excessive sedation and cardiorespiratory compromise would be preferable. Propofol possesses several neuropharmacologic properties that suggest it should be the drug of choice for acute treatment of acute baclofen withdrawal. This report provides clinical data to support this assertion.
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Case Reports

Case 1
A 65-yr-old man was admitted to the hospital with suspected baclofen pump failure. The pump had been sited 6 yr previously for severe spasms after a complete C5 injury, necessitating ambulatory noninvasive ventilation. The patient had felt increasingly unwell over the previous 24 h, with increasing spasticity and pyrexia (38.1°C). Laboratory investigations did not indicate an infective component. Five hours after admission, the hyperspasticity became more marked, with bilateral clonus and increased abdominal and respiratory muscle tone despite oral loading with baclofen. At admission to the critical care unit, arterial blood gas analysis revealed a metabolic acidosis (base deficit = 3.2). Plasma creatinine kinase was and remained within normal limits. Propofol was infused intravenously at 5–15 mg/h. Within 2 h, the base deficit had normalized, and both the spasms and clonus were markedly reduced. Abdominal and respiratory muscle tone decreased, with the patient feeling settled. Low-dose propofol had no effect on cardiorespiratory parameters or sedation status. The propofol infusion (target-controlled plasma concentration 0.6 μg/ml) was then continued, preventing the return of hyperspasticity, and stopped 2 days later, during which time a new baclofen pump was resited surgically.
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Case 2
Three separate episodes of acute hyperspasticity were treated in a 34-yr-old man who required intrathecal baclofen therapy after a complete C4 spinal cord lesion.
Admission 1 After an elective change of intrathecal baclofen pump, severe hyperspasticity developed within 24 h, accompanied by hyperpyrexia (40.1°C), tachycardia (160 beats/min), hypertension, and a respiratory rate of 33 breaths/min. Propofol was infused intravenously at 20–150 mg/h, in addition to 20 mg sublingual nifedipine and 100 mg dantrolene. Within 1.5 h after commencing the propofol, the spasms ceased. Within 5 h, heart rate and respiratory rate had decreased to 110 beats/min and 22 breaths/min, respectively, with normal core temperature and conscious level throughout the admission. The plasma creatinine kinase concentration was also normal throughout. During the first 5 h of admission, the patient also received 100 μg intrathecal baclofen via a newly introduced intrathecal catheter. Surgical relocation of the catheter was undertaken the next day. Propofol was infused for optimal control of spasms for a further 24 h while intrathecal baclofen was reintroduced via a newly inserted pump.
Admission 2 Two years after admission 1, the patient was admitted with new onset spasms, pyrexia (38.6°C), and respiratory discomfort (respiratory rate 24 breaths/min, no metabolic acidosis). Propofol was administered solely, with two boluses of 50 mg plus a 20-mg/h background infusion resulting in complete resolution of hyperspasticity, pyrexia, and respiratory rate within 2 h. The spasms returned after 7 h, during which time the propofol infusion had been reduced. The spasms resolved after increasing the propofol background infusion (50–150 mg/h). No changes in gas exchange or sedation levels were observed throughout the admission.
Admission 3 Three yr after admission 2, pyrexia (37.6°C) and increasingly severe spasms were noted 4 days after the scheduled reimplantation of a new baclofen pump. Propofol was commenced solely (10 mg/h), with resolution of tachycardia, pyrexia, and spasms within 1.5 h. Propofol was continued for 20 h, over which time pump-delivered baclofen administration was established. Again, no changes in gas exchange or sedation levels were observed throughout the admission.
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Discussion

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Fig. 1
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Oral baclofen administration is usually inadequate to treat or prevent intrathecal baclofen withdrawal.20 The clinical data presented support the hypothesis that propofol is the agent of choice for acute control of acute hyperspasticity. Although the neuropharmacologic actions of propofol and baclofen are incompletely understood, they share many similarities (fig. 1). Propofol enhances GABA-mediated synaptic inhibition in a number of neuronal systems.23 Propofol enhances presynaptic inhibition at primary afferent terminals in human spinal cord24 and dose-dependently decreases the firing rate and burst activity of nigral dopaminergic neurons, an effect reversed by a selective GABA type B antagonist.25 Interestingly, propofol administered via both intrathecal and intraperitoneal routes produces antinociception in rats by acting on spinal cord Δ-opioid receptors, whereas only intrathecally administered midazolam produces the same effect.26 This may mirror our clinical experience of low-dose propofol infusions being effective in contrast to several previous case reports requiring high-doses of benzodiazepines for control of hyperspasticity. Furthermore, the antiinflammatory27 and antinociceptive28,29 effects of propofol may also confer some protective effect during baclofen withdrawal.
These clinical data lend support to the idea that propofol is the agent of choice for treatment of this and perhaps other hyperspasticity syndromes. Propofol possesses important neurophysiologic, neuropharmacologic, and pharmacokinetic properties to ameliorate the symptoms and prevent the pathophysiologic progression of acute baclofen withdrawal. In clinical practice, titration of propofol therapy using a target-controlled intravenous infusion against an objective score of spasticity (such as the Ashworth scale score30 or Penn Spasm Scale score31) offers a new therapeutic approach to this potentially life-threatening syndrome.
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References

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‡ MedWatch 2002 Safety Alert: Lioresal (baclofen injection). Available at: http://www.fda.gov/medwatch/safety/2002/baclofen.htm]. Accessed April 15, 2005. Cited Here...

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