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Clinical Investigations

Effect of Intraoperative Fluid Management on Outcome after Intraabdominal Surgery

Nisanevich, Vadim M.D.*; Felsenstein, Itamar M.D.†; Almogy, Gidon M.D.†; Weissman, Charles M.D.‡; Einav, Sharon M.D.§; Matot, Idit M.D.∥

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Background: The debate over the correct perioperative fluid management is unresolved.
Methods: The impact of two intraoperative fluid regimes on postoperative outcome was prospectively evaluated in 152 patients with an American Society of Anesthesiologists physical status of I–III who were undergoing elective intraabdominal surgery. Patients were randomly assigned to receive intraoperatively either liberal (liberal protocol group [LPG], n = 75; bolus of 10 ml/kg followed by 12 ml · kg−1 · h−1) or restrictive (restrictive protocol group [RPG], n = 77; 4 ml · kg−1 · h−1) amounts of lactated Ringer's solution. The primary endpoint was the number of patients who died or experienced complications. The secondary endpoints included time to initial passage of flatus and feces, duration of hospital stay, and changes in body weight, hematocrit, and albumin serum concentration in the first 3 postoperative days.
Results: The number of patients with complications was lower in the RPG (P = 0.046). Patients in the LPG passed flatus and feces significantly later (flatus, median [range]: 4 [3–7] days in the LPG vs. 3 [2–7] days in the RPG; P < 0.001; feces: 6 [4–9] days in the LPG vs. 4 [3–9] days in the RPG; P < 0.001), and their postoperative hospital stay was significantly longer (9 [7–24] days in the LPG vs. 8 [6–21] days in the RPG; P = 0.01). Significantly larger increases in body weight were observed in the LPG compared with the RPG (P < 0.01). In the first 3 postoperative days, hematocrit and albumin concentrations were significantly higher in the RPG compared with the LPG.
Conclusions: In patients undergoing elective intraabdominal surgery, intraoperative use of restrictive fluid management may be advantageous because it reduces postoperative morbidity and shortens hospital stay.
PERIOPERATIVE fluid management continues to be a daily challenge in anesthesia practice. Abdominal surgical procedures in particular are associated with dehydration from preoperative fasting, bowel preparation, underlying illness, and intraoperative and postoperative fluid and electrolyte loss.1 The exact quantity of this fluid loss is difficult to ascertain, and estimates for replacement with balanced salt solutions range from 0 to 67 ml · kg−1 · h−1 of surgery.2 The widespread use of “dry” fluid regimen in pulmonary surgery with resulting decrease in pulmonary morbidity supports the safety of this regimen in high-risk patients undergoing major surgical procedures.1.3,4 Nevertheless, no widely accepted recommendations are currently available for the optimal perioperative fluid regimen to be used in nonthoracic surgery. According to textbook recommendations, intraoperative fluid administration in patients undergoing intraabdominal procedures should be in the range of 10–15 ml · kg−1 · h−1.5–7 This regimen, however, is not evidence based. Recent studies that investigated the effects of different amounts of perioperative fluids on outcome reported conflicting results depending on the patient population, the type of surgery, and the regimen. Holte et al.8 tried to mimic the perioperative course of minor to moderately sized surgery in healthy volunteers and found that infusion of 40 ml/kg lactated Ringer's (RL) solution over 3 h caused significant increases in body weight and reductions in pulmonary function compared with infusions of 5 ml/kg. In a subsequent study,9 the same investigators reported that the intraoperative administration of 40 ml/kg rather than 15 ml/kg RL solution to patients with an American Society of Anesthesiologists (ASA) physical status of I or II who were undergoing laparoscopic cholecystectomy led to improved pulmonary function, exercise capacity, and general well-being and shortened hospital stay. The benefit of administering a “high” volume of fluids (20 ml/kg) has also been demonstrated in patients undergoing general anesthesia for short ambulatory procedures.10 Recently, the effect of different fluid regimens on outcome was evaluated in patients undergoing more extensive operations. Two studies in patients undergoing colectomy11,12 or colorectal resection12 found that restricted postoperative11 and perioperative12 fluid administration resulted in reduced hospital stays, faster return of gastrointestinal function,11 and reduced postoperative complications.12 The objective of the current study was to evaluate whether the postulated benefits of fluid restriction can be demonstrated in a more diverse population of surgical patients, i.e., patients with an ASA physical status of I–III who are undergoing a variety of extensive intraabdominal surgery. Because the use of liberal fluid regimens has, as reported before,1 deleterious effects on recovery of gastrointestinal motility, wound/anastomotic healing, coagulation, and cardiac and pulmonary function, we tested the hypothesis that restrictive fluid administration for patients undergoing intraabdominal surgery is associated with a lower incidence of adverse outcomes.
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Materials and Methods

After institutional review board (Hadassah University Medical Center, Jerusalem, Israel) approval and written, informed patient consent, 156 adult patients with an ASA physical status of I–III who were presenting for major elective intraabdominal surgery were prospectively studied. Surgical procedures included all types of colon/rectum procedures, small bowel resections, gastric resections, and pancreaticoduodenectomy/partial pancreas resections. Patients undergoing hepatectomy were not included in the study because relative fluid restriction and low central venous pressures during certain stages of the operation have been shown to be beneficial.13,14 Also excluded from the study were patients aged younger than 18 yr; pregnant patients; and those with coagulopathy, significant hepatic (liver enzymes > 50% upper limit of normal value) or renal (creatinine > 50% upper limit of normal value) dysfunction, and congestive heart failure.
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Intraoperative Management
Patients were randomized into one of two groups, a liberal protocol group (LPG) or a restricted protocol group (RPG), by using a random number generator in sealed envelopes. Study investigators and research personnel were not directly involved in the care of these patients and hence were blinded to the treatment assignments. Diuretics were discontinued the day before surgery. All patients received identical bowel preparation, which consisted of 3 l Precolonoscopic Solution (polyethylene glycol). One liter of 5% dextrose–0.45% NaCl was administered during the night intravenously. All patients fasted after midnight and received 10 mg diazepam orally as premedication 1 h before surgery. Anesthesia was induced using thiopental (4–5 mg/kg), fentanyl (2 μg/kg), and vecuronium (0.1 mg/kg) and was maintained with a balanced technique involving isoflurane, nitrous oxide, and oxygen. Neuromuscular blockade was performed with intravenous vecuronium. Additional doses of 1.5 μg/kg intravenous fentanyl were given when the mean arterial blood pressure or heart rate increased 25% above baseline value. Ventilation was adjusted to maintain an arterial carbon dioxide tension of 35–40 mmHg, and temperature was maintained at greater than 35.5°C throughout surgery. Patients received epidural analgesia for postoperative pain relief. No drugs (local anesthetic or narcotic) were administered via the epidural catheter during surgery. Postoperatively, all patients received continuous epidural administration of bupivacaine (0.5%) and methadone (0.2%) (9 ml bupivacaine and 7 ml methadone at a rate of 60–80 mm/24 h) until postoperative day 3. Thereafter, patients' pain treatment consisted of nonsteroidal antiinflammatory drugs.
Fig. 1
Fig. 1
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Patients in the RPG received 4 ml · kg−1 · h−1 RL solution throughout the intraoperative period, whereas patients in the LPG received an initial bolus of 10 ml/kg RL solution before skin incision followed by 12 ml · kg−1 · h−1. No additional boluses of fluid were administered before skin incision, and all hemodynamic changes during this period were treated pharmacologically. Intraoperative treatment of tachycardia (heart rate > 90 beats/min or > 20% above baseline) accompanied by low blood pressure (< 90 mmHg or > 20% below baseline) was guided by a fluid algorithm (fig. 1). Fluid boluses (250 ml RL solution) were also provided if urine output decreased below 0.5 ml · kg−1 · h−1 for 2 h. Patients were reassessed after each fluid challenge to determine whether the target hemodynamic/urine output goals were achieved. If hemodynamics or urine output were not improved with the first bolus of fluid, additional boluses of RL solution were administered in accordance with the fluid algorithm to a maximum of 1,500 ml. A central venous catheter was introduced thereafter if no response was observed in urine output or hemodynamics. In a hemodynamically unstable patient, a central venous pressure of less than 15 mmHg could trigger one of two treatment options: intravenous administration of colloid (6% hydroxyethyl starch) or pharmacologic circulatory support. A central venous pressure of greater than 15 mmHg could trigger the intravenous administration of furosemide or pharmacologic circulatory support, depending on the patient's hemodynamics. Further insertion of a pulmonary artery catheterization was left to the discretion of the attending anesthesiologist. The fluid regimen was continued until admission to the recovery room, where departmental routines ensued. For management of surgical hemorrhage, in both groups, lost blood was replaced with RL solution in a 3:1 volume replacement. Blood was transfused during acute massive hemorrhage, when the hematocrit was less than 24% in patients with no history of coronary artery disease or no evidence of myocardial ischemia, when the hematocrit was less than 30% in patients with a history of coronary artery disease or evidence of myocardial ischemia, and when the hematocrit was less than 30% and greater than 24% but with ongoing bleeding. To ensure uniformity, transfusion guidelines were also established for administration of fresh frozen plasma (prothrombin time, activated partial thromboplastin time > 1.5 times normal), cryoprecipitate (fibrinogen concentrations < 100 mg/dl), and platelets (< 50 × 103/mm3) in the presence of continuous uncontrolled bleeding with no evidence of clot formation.15 Blood loss (estimated by assessment of the suction bottles, sponges, and the surgical drapes and gowns), urine output, and doses of drugs (fentanyl, furosemide) given during the surgical procedure or the need to start vasoactive infusion were recorded.
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Postoperative Management and Monitoring
In the postoperative period, the surgical staff, who were unaware of the patient's group assignment and were not part of the investigator team, guided fluid therapy. The routine in our General Surgery department is not to feed patients during the early postoperative period. The volumes of crystalloids administered in the first 3 postoperative days were recorded. The “standard” fluid treatment of the surgical department consists of 5% dextrose–0.45% NaCl at 1–1.5 ml · kg−1 · h−1. In addition, the number of units of blood and blood products administered until hospital discharge was also recorded. Postoperative follow-up included measurements of body weight (with standardized hospital uniforms), oxygen saturation, hematocrit, potassium, sodium, albumin, and creatinine concentrations in the first 3 postoperative days and before discharge. All measurements were made in the morning (between 8:00 am and 10:00 am). Additional blood tests, electrocardiography, and measurements of cardiac enzymes were performed when clinically indicated. Time to first passage of flatus and feces was also recorded. Postoperatively, all patients were examined and interviewed daily. Complications that were detected by the examining physician were validated by two investigators who were not aware of the patient's group assignment. Postoperative day 1 was defined as starting from patient admittance to the recovery room and ending 24 h later than postoperative day 2 would start.
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The primary endpoint of the study combined the number of patients who died or experienced complications. The secondary endpoints included time to initial passage of flatus and feces; duration of hospital stay; differences in body weight, hematocrit, creatinine, and albumin serum concentrations in the first 3 postoperative days; changes in oxygen saturation in the first 3 postoperative days; and number of patients receiving transfusion of blood and blood products.
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Definition of Complications
Wounds were considered infected when pus could be expressed from the incision or aspirated from a loculated mass within the wound and when bacteria were cultured from the pus. Wound dehiscence was diagnosed clinically and was treated by secondary suturing. Peritonitis, gastrointestinal bleeding, anastomotic leak, and intestinal obstruction would not be considered complications unless they necessitated surgery. Intraabdominal abscess required diagnosis by an ultrasound or computerized tomography scan. Diagnosis of pneumonia required new infiltrate on chest x-ray combined with two of the following: temperature greater than 38°C, leukocytosis, and positive sputum culture. Urinary tract infection was diagnosed when symptoms consistent with the diagnosis, such as dysuria, frequency, fever, or an increased peripheral leukocyte count, prompted urinary analysis that showed bacterial counts greater than 100,000 and positive culture. Diagnosis of sepsis required bacterial infection and at least two of the following clinical signs: abnormalities of body temperature (hypothermia or hyperthermia), heart rate (tachycardia), respiratory rate (tachypnea), and leukocyte count (leukocytopenia or leukocytosis). Diagnosis of myocardial infarction required an increase of the creatine kinase MB isoenzyme or troponin T concentration above the hospital laboratory's myocardial infarction threshold and either new Q waves (duration ≥ 0.03 s) or persistent changes (4 days) in ST-T segment. Congestive heart failure and pulmonary edema were defined by clinical (shortness of breath, rales, jugular venous distention, peripheral edema, third heart sound) and radiologic (cardiomegaly, interstitial edema, alveolar edema) signs that required a change in medication involving at least treatment with diuretic drugs. Arrhythmias required 12-lead electrocardiographic confirmation. Cerebrovascular accident was diagnosed when a new focal neurologic deficit of presumed vascular etiology persisted more than 24 h with a neurologic imaging study that did not indicate a different etiology. A diagnosis of acute respiratory distress syndrome was established when there was an acute onset of respiratory distress, evidence on chest radiographs of airspace changes in all four quadrants, a ratio of partial pressure of oxygen to inspired fraction of oxygen of less than 200, and pulmonary artery wedge pressure less than 18 mmHg or no clinical evidence of left atrial hypertension. Pulmonary embolism was diagnosed only after evidenced by spiral computerized tomography scanning. Renal dysfunction was defined by creatinine greater than 50% upper limit of normal value.
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Statistical Analysis
Categorical data were analyzed using the chi-square test or Fisher exact test. Differences between the means of the two groups and the median units of blood transfused were compared using the Student t test and the Mann–Whitney test, respectively. Data within each group were analyzed using analysis of variance for repeated measurements. When appropriate, post hoc analyses were performed with the Newman-Keuls test. Exact confidence intervals were computed for the overall rate of complications. Analysis was performed using Statistical Analysis System software (version 6.12; SAS Institute, Cary, NC). P < 0.05 was considered to represent statistical significance. Results are expressed as mean ± SD. Analysis was by intention to treat. A power analysis for postoperative complication rate as an outcome, with 80% power to detect a 20% reduction in this outcome and significance of 0.05 or greater, indicated that 75 patients were required in each group.
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Demographic and Surgical Data
Table 1
Table 1
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Table 2
Table 2
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Table 3
Table 3
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A total of 156 patients who fulfilled the entry criteria were enrolled in the study, 78 in each group; among them, 4 (3 from the LPG) were excluded because surgery was not extensive. Demographic and surgical data are listed in tables 1 and 2. Randomization was successful in achieving comparable groups for all characteristics listed, including sex, age, weight, height, ASA physical status, and percentage of patients with concomitant diseases. The same was true for the type and duration of surgery and estimated blood loss. Significantly more patients in the RPG received, in accordance with the fluid algorithm (fig. 1), fluid boluses. Despite the administration of fluid boluses in a third of the patients in the RPG, the intraoperative volumes of fluid administered were significantly lower in the RPG compared with the LPG. Also, in the first 3 postoperative days, the mean amounts of fluid infused were similar among the groups (table 3). Compared with the LPG, significantly more patients in the RPG experienced episodes of hypotension. Hypotension that required the administration of a fluid bolus occurred in 21 patients, 1 from the LPG (1 episode of hypotension) compared with 20 from the RPG (who experienced a total of 36 episodes of hypotension). A subgroup of patients who received daily cardiac medication was evaluated separately for parameters that could reflect hemodynamic instability. There was no significant difference between patients receiving cardiac medications in the LPG versus the RPG in the need for pharmacologic support after induction of anesthesia and before skin incision. In this subgroup of patients, significantly more patients in the RPG compared with the LPG needed intraoperative bolus fluid administration: 11 versus 0, respectively.
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Table 4
Table 4
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None of the patients died during the perioperative period. The number of patients with complications was smaller in the RPG compared with the LPG (P = 0.046; table 4). Significantly greater increases in body weight were observed in patients in the LPG compared with patients in the RPG in the early postoperative period (1.93 ± 0.52 and 1.85 ± 0.62 kg on the first and third postoperative days, respectively, in the LPG vs. 0.51 ± 0.67 and 0.24 ± 0.61 kg in the RPG; P < 0.01). Patients in the LPG passed flatus and feces significantly later than RPG patients (flatus, median [range]: 4 [3–7] days in the LPG vs. 3 [2–7] days in the RPG; P < 0.001; feces: 6 [4–9] days in the LPG vs. 4 [3–9] days in the RPG; P < 0.001). The duration of hospital stay was 9 days (7–24) in the LPG compared with 8 days (6–21) in the RPG (P = 0.01). There were no significant differences between the groups in the number of patients receiving blood or blood product transfusion or in the median number of units of blood transfused.
Fig. 2
Fig. 2
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Table 5
Table 5
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Preoperative hematocrit, creatinine, albumin, and arterial oxygen saturation were similar in both groups. In the immediate postoperative period (first 3 postoperative days), hematocrit and serum albumin concentration were significantly higher in the RPG compared with the LPG; however, at discharge there were no significant differences between the groups (fig. 2). Mean creatinine serum concentrations were within the normal range and were not significantly different between the groups at all times. Postoperative oxygen saturation decreased significantly in the first 3 postoperative days in both groups; however, values were not different between groups. Baseline and postoperative values for sodium and potassium were comparable among the groups (data not shown). Hemodynamic data at baseline, before skin incision, at skin closure, and 8 and 24 h after the operation were not significantly different between the groups (table 5).
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The major finding of the current study is that relative intraoperative fluid restriction in patients with an ASA physical status of I–III who are undergoing major intraabdominal surgery reduces the number of patients who experience complications and shortens the time to recovery of gastrointestinal function and to hospital discharge. Our study extends previous work of Lobo et al. and Brandstrup et al., who demonstrated the efficacy of using postoperative9 and perioperative12 fluid restriction in patients undergoing intraabdominal operations. In contrast to our study, however, these studies were performed in relatively homogenous groups of healthy patients (mainly with an ASA physical status of I or II) undergoing either colectomy or colorectal resection, whereas the current study included patients undergoing a variety of major intraabdominal surgeries, a quarter of whom had an ASA physical status of III. In addition, unlike the study by Brandstrup et al.,12 in which oral intake was started on the first postoperative day, in the current study, patients were treated in the first few postoperative days with intravenous fluid only, as in the study by Lobo et al.11 Other major differences between the study of Brandstrup et al.12 and the current study include the higher percentage of alcohol consumers (approximately two third of patients vs. none in our study) and the use of a different type of fluids, mostly normal saline in the standard group, as well as 5% glucose, all of which could have affected outcome.9,16 In the current study, RL and 5% dextrose–0.45% NaCl were used.
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Fluid Regimen
The volumes of intraoperative and postoperative fluid administered in the LPG seem high. However, these volumes are consistent with previous studies, recommendations, and hospital routines described in previous articles. In a recent study8 designed to mimic minor to moderate operations, healthy volunteers in the “liberal group” received 40 ml/kg lactated Ringer's solution over 3 h (i.e., approximately 13 ml · kg−1 · h−1). In laparoscopic cholecystectomy,9 patients received either 40 or 15 ml/kg lactated Ringer's solution infused over 1.5 h (i.e., 26.7 vs. 10 ml · kg−1 · h−1). In yet another study8 of ambulatory surgery lasting approximately 30 min, patients received preoperatively either 20- or 2-ml/kg infusions of isotonic solution. According to textbook recommendations, intraoperative fluid administration in patients undergoing intraabdominal procedures should range from 10 to 15 ml · kg−1 · h−1.5–7 In this patient population, Jenkins et al.17 suggested that the fluid regimen should consist of 12–15 ml/kg for the first hour and 6–10 ml/kg for the next 2 h. Similarly, Campbell et al.18 observed that cardiovascular stability during major operations is much better preserved when intraoperative crystalloids are given at the rate of 10–15 ml · kg−1 · h−1. The amount of intraoperative fluid used in the LPG in the current study is therefore consistent with these recommendations. Two recent prospective studies used different fluid regimens in patients undergoing colectomy. In one study in which surgery lasted less than 2 h and involved minimal bleeding,11 the authors compared postoperative administration of 3 l fluid/day (liberal group) with 1.5–2 l/day. Intraoperatively, all patients received 2.5–2.8 l fluid. In the second study,12 the median amounts of fluid administered on the day of surgery were 2,740 and 5,388 ml in the restrictive and standard groups, respectively. Postoperatively, the total amount of fluid administered (intravenous plus oral) was in the range of 2.5 l (restrictive group) versus 3.5 l. In the current study, the volume of fluid administered in the postoperative period in both groups (1.5–2.5 l) was similar to the restrictive groups in both previous studies.11,12
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Effect on Outcome
Studies in minor/ambulatory surgery suggest that high-dose fluid regimens may improve early recovery measures such as dizziness, drowsiness,9,19 nausea, and thirst; improve pulmonary function and exercise capacity; and shorten hospital stay.9 The results of these studies, however, cannot be extrapolated to major intraabdominal surgical procedures in which substantially larger third space loss, larger stress response, and altered capillary permeability occur. The decreases in hemoglobin and albumin concentrations that were observed only in patients from the LPG in the current study are in accord with previous studies11,12 and probably reflect the dilutional effect of the larger fluid volumes. Also, the increase in body weight is most probably the result of fluid overload as changes in weight have been shown to reflect fluid balance.20,21 The current study also found that the median time to flatus and feces passage was significantly longer in the LPG compared with the RPG. Positive postoperative fluid balance can result in gut edema, which may contribute to intestinal dysfunction.1,22 In the 1930s, Mecray et al.23 found that modest positive salt and water balance caused weight gain after elective colectomy and was associated with delayed recovery of gastrointestinal function, increased complication rates, and extended hospital stays. Similar findings were demonstrated later in human studies.11,24–26 Hypoproteinemia has been associated with extended gastric emptying, delayed small bowel transit, and postoperative ileus.11,23–26 Whether the effect is due to hypoalbuminemia per se or the result of positive fluid balance is unknown because it is difficult to separate these two conditions.20 Others have challenged these findings and reported that increased perioperative fluid administration was associated with improved indices of gut perfusion and reduced intestinal dysfunction.27,28 These studies, however, were unblinded and involved a different patient population (cardiac28 and mostly urologic and gynecologic patients27). In the study by Gan et al.,27 both groups received “liberal” fluid administration (approximately 4.5 l clear crystalloids for surgeries with a mean duration of 4 h), with no significant difference in the amount of crystalloids administered between the groups. Moreover, in both studies, the differences in outcome could have been attributed to the type of fluid, because patients in the protocol group received more colloids. The finding that more patients in the high-volume group had complications is consistent with previous reports in similar patient populations.12 Larger fluid volumes may exert harmful effects on cardiac and pulmonary function, tissue oxygenation, coagulation, wound healing, and gastrointestinal function.1 The exact mechanism by which liberal intraoperative fluid administration increases morbidity was not evaluated in this study, but possible mechanisms have been recently reviewed.1
There are several limitations to this study. The possibility that the observed differences were due to factors other than the amount of resuscitation fluid cannot be excluded. However, this is a prospective study with an intent-to-treat design and with well-defined endpoints. In addition, the study was not conducted in a totally blinded fashion. Although the anesthesiologist treating the patient in the intraoperative period was not blinded to the patient's group assignment, the indications for additional fluid administration were standardized. During the postoperative period, adverse outcomes were detected by the examining physician, who was not aware of the patient's assignment. Late complications could have been missed because we followed patients only until hospital discharge. In addition, the design of this study does not enable us to compare its results with studies that used algorithms focused on achieving endpoints directed by invasive monitoring. In those studies, however, patients did not receive overly large volumes of fluid but were adequately resuscitated to optimize oxygen delivery. Finally, the postoperative management of patients undergoing intraabdominal surgery is frequently institution and department specific. Some surgical centers start oral intake of fluid early in the postoperative period. Nevertheless, this may add up to a significant amount as shown in a recent study,12 and the results may therefore be applicable to these patients as well. Further studies are needed to address this point.
Significant healthcare resources are used to provide care to patients with prolonged postoperative hospitalization. Clinicians, hospitals, and healthcare payers are increasingly focusing on reducing “unnecessary” days of hospitalization after surgery. Gastrointestinal dysfunction has a substantial effect on resource utilization.29 In two large studies that included patients undergoing major noncardiac surgeries, Bennett-Guerrero et al.30,31 demonstrated that gastrointestinal dysfunction was the most common morbid event that was associated with prolongation of hospital stay. The current study found that intraoperative use of “restrictive” fluid regimen shortens return of gastrointestinal function and reduces the number of patients experiencing postoperative complications with subsequent shortening of hospital stay. The results from this trial demonstrate that some morbidity observed in surgical patients may be preventable by using this fluid strategy. As this study evaluated only two volumes of fluid and focused only on intraoperative management; it is possible to speculate that a different dose regimen might have further improved outcome. Therefore, additional studies are needed to establish the optimal volume of fluid to be infused during and after intraabdominal surgery and other major procedures.
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ARTN 244
Supportive Care in Cancer
Fast-track rehabilitation program and conventional care after esophagectomy: a retrospective controlled cohort study
Cao, SQ; Zhao, GB; Cui, J; Dong, Q; Qi, SH; Xin, YZ; Shen, BZ; Guo, QF
Supportive Care in Cancer, 21(3): 707-714.
Biomed Research International
Skeletal Muscle Oxygen Saturation (StO(2)) Measured by Near-Infrared Spectroscopy in the Critically Ill Patients
Mesquida, J; Gruartmoner, G; Espinal, C
Biomed Research International, (): -.
ARTN 502194
Surgical Endoscopy and Other Interventional Techniques
Effect of epidural analgesia on bowel function in laparoscopic colorectal surgery: a systematic review and meta-analysis
Khan, SA; Khokhar, HA; Nasr, ARH; Carton, E; El-Masry, S
Surgical Endoscopy and Other Interventional Techniques, 27(7): 2581-2591.
Journal of Surgical Oncology
Intraoperative fluid management and complications following pancreatectomy
Grant, FM; Protic, M; Gonen, M; Allen, P; Brennan, MF
Journal of Surgical Oncology, 107(5): 529-535.
Anaesthesia and Intensive Care
Epidural anaesthesia with goal-directed administration of ropivacaine improves haemodynamic stability when combined with general anaesthesia in elderly patients undergoing major abdominal surgery
Zhou, QH; Xiao, WP; Yun, X
Anaesthesia and Intensive Care, 41(1): 82-89.

Plos One
Are Non-cardiac Surgeries Safe for Dialysis Patients? - A Population-Based Retrospective Cohort Study
Cherng, YG; Liao, CC; Chen, TH; Xiao, D; Wu, CH; Chen, TL
Plos One, 8(3): -.
ARTN e58942
British Journal of Anaesthesia
Balanced crystalloid compared with balanced colloid solution using a goal-directed haemodynamic algorithm
Feldheiser, A; Pavlova, V; Bonomo, T; Jones, A; Fotopoulou, C; Sehouli, J; Wernecke, KD; Spies, C
British Journal of Anaesthesia, 110(2): 231-240.
British Journal of Anaesthesia
Ability of stroke volume variation measured by oesophageal Doppler monitoring to predict fluid responsiveness during surgery
Guinot, PG; de Broca, B; Abou Arab, O; Diouf, M; Badoux, L; Bernard, E; Lorne, E; Dupont, H
British Journal of Anaesthesia, 110(1): 28-33.
Anesthesia and Analgesia
Supplemental intravenous crystalloid administration and risk of surgical wound infection
Tornero-Campello, G
Anesthesia and Analgesia, 103(4): 1040.
Mayo Clinic Proceedings
Perioperative care of patients undergoing bariatric surgery
McGlinch, BP; Que, FG; Nelson, JL; Wrobleski, DA; Grant, JE; Collazo-Clavell, ML
Mayo Clinic Proceedings, 81(): S25-S33.

Swiss Medical Weekly
Automatic algorithm for monitoring differences in systolic pressure and pulse pressure variation
Leibundgut, D; Hartwich, V; Schumacher, PM; Pestel, G
Swiss Medical Weekly, 137(): 15S.

Elective colon resection in Germany - A survey of the perioperative anaesthesiological management
Hasenberg, T; Niedergethmann, M; Rittler, P; Post, S; Jauch, KW; Senkal, M; Spies, C; Schwenk, W; Shang, E
Anaesthesist, 56(): 1223-+.
Intensive Care Medicine
Intestinal motility disturbances in intensive care patients pathogenesis and clinical impact
Fruhwald, S; Holzer, P; Metzler, H
Intensive Care Medicine, 33(1): 36-44.
Clinical update: perioperative fluid management
Jacob, M; Chappell, D; Rehm, M
Lancet, 369(): 1984-1986.

Anaesthesiological aspects of the fast-track concept in vascular medicine
Kruska, P; Spies, C; Debus, ES; Schwenk, W; Kerner, T
Gefasschirurgie, 15(3): 183-190.
Acta Anaesthesiologica Scandinavica
Influence of pre-operative fluid infusion on volume status during oesophageal resection - a prospective trial
Raue, W; Haase, O; Langelotz, C; Neuss, H; Muller, JM; Schwenk, W
Acta Anaesthesiologica Scandinavica, 52(9): 1218-1225.
World Journal of Surgery
Clinical Benefits After the Implementation of a Protocol of Restricted Perioperative Intravenous Crystalloid Fluids in Major Abdominal Operations
de Aguilar-Nascimento, JE; Diniz, BN; do Carmo, AV; Silveira, EAO; Silva, RM
World Journal of Surgery, 33(5): 925-930.
Anesthesia and Analgesia
The Effect of Duration of Surgery on Fluid Balance During Abdominal Surgery: A Mathematical Model
Tatara, T; Nagao, Y; Tashiro, C
Anesthesia and Analgesia, 109(1): 211-216.
British Journal of Anaesthesia
Evaluation of stroke volume variation obtained by arterial pulse contour analysis to predict fluid responsiveness intraoperatively
Lahner, D; Kabon, B; Marschalek, C; Chiari, A; Pestel, G; Kaider, A; Fleischmann, E; Hetz, H
British Journal of Anaesthesia, 103(3): 346-351.
Haemodynamic monitoring in the perioperative phase
Wittkowski, U; Spies, C; Sander, M; Erb, J; Feldheiser, A; von Heymann, C
Anaesthesist, 58(8): 764-+.
International Journal of Colorectal Disease
Colloid vs. crystalloid infusions in gastrointestinal surgery and their different impact on the healing of intestinal anastomoses
Marjanovic, G; Villain, C; Timme, S; zur Hausen, A; Hoeppner, J; Makowiec, F; Holzner, P; Hopt, UT; Obermaier, R
International Journal of Colorectal Disease, 25(4): 491-498.
Vascular and Endovascular Surgery
Intraoperative Fluid Restriction Predicts Improved Outcomes in Major Vascular Surgery
Adesanya, A; Rosero, E; Timaran, C; Clagett, P; Johnston, WE
Vascular and Endovascular Surgery, 42(6): 531-536.
Archives of Surgery
Consensus Review of Optimal Perioperative Care in Colorectal Surgery Enhanced Recovery After Surgery (ERAS) Group Recommendations
Lassen, K; Soop, M; Nygren, J; Cox, PBW; Hendry, PO; Spies, C; von Meyenfeldt, MF; Fearon, KCH; Revhaug, A; Norderval, S; Ljungqvist, O; Lobo, DN; Dejong, CHC
Archives of Surgery, 144(): 961-969.

Regional Anesthesia and Pain Medicine
Labat Lecture 2005: Surgical stress and postoperative outcome - From here to where?
Kehlet, H
Regional Anesthesia and Pain Medicine, 31(1): 47-52.
Annales Francaises D Anesthesie Et De Reanimation
Anaesthetic management of oesophagectomy: advances and perspectives
Michelet, P; Jaber, S; Eledjam, JJ; Auffray, JP
Annales Francaises D Anesthesie Et De Reanimation, 26(3): 229-241.
British Journal of Anaesthesia
Liberal or restrictive fluid administration in fast-track colonic surgery: a randomized, double-blind study
Holte, K; Foss, NB; Andersen, J; Valentiner, L; Lund, C; Bie, P; Kehlet, H
British Journal of Anaesthesia, 99(4): 500-508.
Restricted peri-operative fluid administration adjusted by serum lactate level improved outcome after major elective surgery for gastrointestinal malignancy
Yu, WK; Li, N; Gong, JF; Li, WQ; Tang, SQ; Tong, ZH; Gao, T; Zhang, JJ; Xi, FC; Shi, H; Zhu, WM; Li, JS
Surgery, 147(4): 542-552.
Anesthesia and Analgesia
Intravascular fluid administration and hemodynamic performance during open abdominal surgery
Svensen, CH; Olsson, J; Hahn, RG
Anesthesia and Analgesia, 103(3): 671-676.
Brazilian Journal of Medical and Biological Research
Comparison of the effects of lactated Ringer solution with and without hydroxyethyl starch fluid resuscitation on gut edema during severe splanchnic ischemia
Lobo, SM; Orrico, SRP; Queiroz, MM; Contrim, LM; Cury, PM
Brazilian Journal of Medical and Biological Research, 41(7): 634-639.

Presse Medicale
Perioperative modifications in kidney function
Bourgeois, E; Bataille, A; Jacob, L
Presse Medicale, 38(): 1621-1629.
British Journal of Surgery
Randomized clinical trial of the effect of postoperative intravenous fluid restriction on recovery after elective colorectal surgery (Br J Surg 2006; 93: 1469-1474)
Tornero-Campello, G
British Journal of Surgery, 94(3): 382.
Anesthesia and Analgesia
The Volume of Lactated Ringer's Solution Required to Maintain Preload and Cardiac Index During Open and Laparoscopic Surgery
Concha, MR; Mertz, VF; Cortinez, LI; Gonzalez, KA; Butte, JM; Lopez, F; Pinedo, G; Zuniga, A
Anesthesia and Analgesia, 108(2): 616-621.
Anesthesia and Analgesia
Automatic Algorithm for Monitoring Systolic Pressure Variation and Difference in Pulse Pressure
Pestel, G; Fukui, K; Hartwich, V; Schumacher, PM; Vogt, A; Hiltebrand, LB; Kurz, A; Fujita, Y; Inderbitzin, D; Leibundgut, D
Anesthesia and Analgesia, 108(6): 1823-1829.
Fast track in vascular surgery
Debus, ES; Kruska, P; Ivoghli, A; Castan, J; Kerner, T
Chirurg, 80(8): 711-718.
Anesthesia and Analgesia
Perioperative Crystalloid and Colloid Fluid Management in Children: Where Are We and How Did We Get Here?
Bailey, AG; McNaull, PP; Jooste, E; Tuchman, JB
Anesthesia and Analgesia, 110(2): 375-390.
Hepatobiliary & Pancreatic Diseases International
Effect of perioperative fluid therapy on early phase prognosis after liver transplantation
Jiang, GQ; Peng, MH; Yang, DH
Hepatobiliary & Pancreatic Diseases International, 7(4): 367-372.

Notfall & Rettungsmedizin
The role of endothelial glycocalyx for fluid management in emergency medicine
Chappell, D; Jacob, M
Notfall & Rettungsmedizin, 12(3): 169-175.
Hemorrhage and operation cause a contraction of the extracellular space needing replacement - evidence and implications? A systematic review
Brandstrup, B; Svensen, C; Engquist, A
Surgery, 139(3): 419-432.

International Journal of Clinical Practice
Doppler-guided intral-operative fluid management during major abdominal surgery: systematic review and meta-analysis
Walsh, SR; Tang, T; Bass, S; Gaunt, ME
International Journal of Clinical Practice, 62(3): 466-470.
Anesthesia and Analgesia
Does Infusion of Colloid Influence the Occurrence of Postoperative Nausea and Vomiting After Elective Surgery in Women?
Haentjens, LL; Ghoundiwal, D; Touhiri, K; Renard, M; Engelman, E; Anaf, V; Simon, P; Barvais, L; Ickx, BE
Anesthesia and Analgesia, 108(6): 1788-1793.
Journal of the American College of Surgeons
Fluid therapy and surgical outcomes in elective surgery: A need for reassessment in fast-track surgery
Holte, K; Kehlet, H
Journal of the American College of Surgeons, 202(6): 971-989.
Acta Anaesthesiologica Scandinavica
Monitoring of peri-operative fluid administration by individualized goal-directed therapy
Bundgaard-Nielsen, M; Holte, K; Secher, NH; Kehlet, H
Acta Anaesthesiologica Scandinavica, 51(3): 331-340.
Critical Care
Goal-directed fluid management based on pulse pressure variation monitoring during high-risk surgery: a pilot randomized controlled trial
Lopes, MR; Oliveira, MA; Pereira, VOS; Lemos, IPB; Auler, JOC; Michard, F
Critical Care, 11(5): -.
Chirurgische Gastroenterologie
Aspects of modern anesthetic management in Fast-Track colon surgery - Anesthesia, body temperature, and fluid therapy
Grebe, D; von Heymann, C; Bloch, A; Spies, C
Chirurgische Gastroenterologie, 21(4): 318-323.
Perioperative fluid management. An analysis of the present situation
Zausig, Y; Weigand, M; Graf, B
Anaesthesist, 55(4): 371-+.
Presse Medicale
Rehabilitation after abdominal surgery
Bonnet, F; Szymkiewicz, O; Marret, E; Houry, S
Presse Medicale, 35(6): 1016-1022.

British Journal of Surgery
Letter: Randomized clinical trial to evaluate the effects of perioperative supplemental oxygen administration on the colorectal anastomosis (Br J Surg 2006;93 : 698-706)
Tornero-Campello, G
British Journal of Surgery, 93(9): 1148.
Swiss Medical Weekly
Inter observer agreement of manually assessed differences in pulse pressure (dPP)
Leibundgut, D; Hartwich, V; Schumacher, PM; Caruso, ALG; Pestel, G
Swiss Medical Weekly, 137(): 15S.

Expedition glycocalyx. A newly discovered "Great Barrier Reef"
Chappell, D; Jacob, M; Becker, BF; Hofmann-Kiefer, K; Conzen, P; Rehm, M
Anaesthesist, 57(): 959-969.
British Journal of Surgery
Acute colonic pseudo-obstruction
De Giorgio, R; Knowles, CH
British Journal of Surgery, 96(3): 229-239.
European Journal of Vascular and Endovascular Surgery
Effect of Postoperative Restrictive Fluid Therapy in the Recovery of Patients with Abdominal Vascular Surgery
Gonzalez-Fajardo, JA; Mengibar, L; Brizuela, JA; Castrodeza, J; Vaquero-Puerta, C
European Journal of Vascular and Endovascular Surgery, 37(5): 538-543.
American Journal of Veterinary Research
Fluid balance, glomerular filtration rate, and urine output in dogs anesthetized for an orthopedic surgical procedure
Boscan, P; Pypendop, BH; Siao, KT; Francey, T; Dowers, K; Cowgill, L; Ilkiw, JE
American Journal of Veterinary Research, 71(5): 501-507.

Annales Francaises D Anesthesie Et De Reanimation
Is it more necessary to prescribe hydroxyethylstarch?
Mimoz, O; Capdevila, X
Annales Francaises D Anesthesie Et De Reanimation, 28(6): 515-516.
Anesthesia and Analgesia
Less is not more: A lack of evidence for intraoperative fluid restriction improving outcome after major elective gastrointestinal surgery
Hamilton, MA; Mythen, MG; Ackland, GL
Anesthesia and Analgesia, 102(3): 970-971.

Anesthesia and Analgesia
The role of the anesthesiologist in fast-track surgery: From multimodal analgesia to perioperative medical care
White, PF; Kehlet, H; Neal, JM; Schricker, T; Carr, DB; Carli, F
Anesthesia and Analgesia, 104(6): 1380-1396.
Anesthesia and Analgesia
Fluid therapy might be more difficult than you think
Hahn, RG
Anesthesia and Analgesia, 105(2): 304-305.
Determinants of insensible fluid loss. Perspiration, protein shift and endothelial glycocalyx
Jacob, M; Chappell, D; Hofmann-Kiefer, K; Conzen, P; Peter, K; Rehm, M
Anaesthesist, 56(8): 747-+.
International Journal of Colorectal Disease
Perioperative fluid retention and clinical outcome in elective, high-risk colorectal surgery
Kleespies, A; Thiel, M; Jauch, KW; Hartl, WH
International Journal of Colorectal Disease, 24(6): 699-709.
Anasthesiologie & Intensivmedizin
Intraoperative infusion therapy in fast-track colonic surgery
Schwenk, W; Langelotz, C; Haase, O
Anasthesiologie & Intensivmedizin, 50(): 401-406.

Seminars in Dialysis
Perioperative fluid management: Current consensus and controversies
Yeager, MP; Spence, BC
Seminars in Dialysis, 19(6): 472-479.

Critical Care
Bench-to-bedside review: Routine postoperative use of the nasogastric tube - utility or futility?
Tanguy, M; Seguin, P; Malledant, Y
Critical Care, 11(1): -.
ARTN 201
Anesthesia and Analgesia
Liberal versus restrictive fluid management in knee arthroplasty: A randomized, double-blind study
Holte, K; Kristensen, BB; Valentiner, L; Foss, NB; Husted, H; Kehlet, H
Anesthesia and Analgesia, 105(2): 465-474.
Acta Anaesthesiologica Scandinavica
Blood volume is normal after pre-operative overnight fasting
Jacob, M; Chappell, D; Conzen, P; Finsterer, U; Rehm, M
Acta Anaesthesiologica Scandinavica, 52(4): 522-529.
Intravenous fluid restriction after major abdominal surgery: a randomized blinded clinical trial
Vermeulen, H; Hofland, J; Legemate, DA; Ubbink, DT
Trials, 10(): -.
American Journal of Kidney Diseases
Fluid Overload and Mortality in Children Receiving Continuous Renal Replacement Therapy: The Prospective Pediatric Continuous Renal Replacement Therapy Registry
Sutherland, SM; Zappitelli, M; Alexander, SR; Chua, AN; Brophy, PD; Bunchman, TE; Hackbarth, R; Somers, MJG; Baum, M; Symons, JM; Flores, FX; Benfield, M; Askenazi, D; Chand, D; Fortenberry, JD; Mahan, JD; McBryde, K; Blowey, D; Goldstein, SL
American Journal of Kidney Diseases, 55(2): 316-325.
Anz Journal of Surgery
Optimization of perioperative care for colonic surgery: A review of the evidence
Zargar-Shoshtari, K; Hill, AG
Anz Journal of Surgery, 78(): 13-23.
Medical Education
Textbook coverage of a common topic: fluid management of patients after surgery
Chawla, G; Drummond, GB
Medical Education, 42(6): 613-618.
British Journal of Surgery
Meta-analysis of standard, restrictive and supplemental fluid administration in colorectal surgery
Rahbari, NN; Zimmermann, JB; Schmidt, T; Koch, M; Weigand, MA; Weitz, J
British Journal of Surgery, 96(4): 331-341.
Acta Anaesthesiologica Scandinavica
'Liberal' vs. 'restrictive' perioperative fluid therapy - a critical assessment of the evidence
Bundgaard-Nielsen, M; Secher, NH; Kehlet, H
Acta Anaesthesiologica Scandinavica, 53(7): 843-851.
Fast track rehabilitation in visceral surgery
Schwenk, W
Chirurg, 80(8): 690-+.
Zentralblatt Fur Chirurgie
Clinical pathway (workflow) for diagnostic, therapy and follow-up in patients with rectal cancer
Buhr, HJ; Dommisch, K; Fleischer, GM; Gastinger, I; Grundmann, RT; Hermanek, P; Hopt, UT; Jauch, KW; Junginger, T; Kockerling, F; Merkel, S; Raab, HR; Roder, J; Schwenk, W; Tannapfel, A; De Vries, A
Zentralblatt Fur Chirurgie, 131(4): 285-297.
Isbt Science Series, Vol 1, No 1
Volume expanders: crystalloid vs. plasma colloids vs. synthetic colloids
James, M
Isbt Science Series, Vol 1, No 1, 1(1): 52-58.

British Journal of Anaesthesia
Goal-directed haemodynamic therapy and gastrointestinal complications in major surgery: a meta-analysis of randomized controlled trials
Giglio, MT; Marucci, M; Testini, M; Brienza, N
British Journal of Anaesthesia, 103(5): 637-646.
Nature Reviews Nephrology
Fluid balance and acute kidney injury
Prowle, JR; Echeverri, JE; Ligabo, EV; Ronco, C; Bellomo, R
Nature Reviews Nephrology, 6(2): 107-115.
British Journal of Anaesthesia
Wet, dry or something else?
Bellamy, MC
British Journal of Anaesthesia, 97(6): 755-757.
European Journal of Applied Physiology
A definition of normovolaemia and consequences for cardiovascular control during orthostatic and environmental stress
Truijen, J; Bundgaard-Nielsen, M; van Lieshout, JJ
European Journal of Applied Physiology, 109(2): 141-157.
British Journal of Surgery
Randomized clinical trial of the effect of postoperative intravenous fluid restriction on recovery after elective colorectal surgery
MacKay, G; Fearon, K; McConnachie, A; Serpell, MG; Molloy, RG; O'Dwyer, PJ
British Journal of Surgery, 93(): 1469-1474.
Anasthesiologie & Intensivmedizin
Optimizing clinical pathways by regional anaesthesia procedures
Heller, AR; Litz, RJ; Koch, T
Anasthesiologie & Intensivmedizin, 48(): 306-+.

American Journal of Clinical Nutrition
Glutamine is an important precursor for de novo synthesis of arginine in humans
Ligthart-Melis, GC; van de Poll, MCG; Boelens, PG; Dejong, CHC; Deutz, NEP; van Leeuwen, PAM
American Journal of Clinical Nutrition, 87(5): 1282-1289.

Anesthesia and Analgesia
Back to the future: Intraoperative fluid restriction in gastrointestinal surgery - A new practice to the west, but an old one to sub-Sahara Africa
Baelani, I; Dunser, MW
Anesthesia and Analgesia, 102(4): 1297.

Anesthesia and Analgesia
Supplemental intravenous crystalloid administration and risk of surgical wound infection - Reply
Kabon, B; Sessler, DI
Anesthesia and Analgesia, 103(4): 1040-1041.

Perioperative fluid restriction reduces complications after major gastrointestinal surgery
Walsh, SR; Tang, TY; Farooq, N; Coveney, EC; Gaunt, ME
Surgery, 143(4): 466-468.
Clinical Nutrition
The history of 0.9% saline
Awad, S; Allison, SP; Lobo, DN
Clinical Nutrition, 27(2): 179-188.
Nephron Clinical Practice
New insights on intravenous fluids, diuretics and acute kidney injury
Townsend, DR; Bagshaw, SM
Nephron Clinical Practice, 109(4): C205-C215.
Anaesthesia and Intensive Care
Perioperative fluid prescription, complications and outcomes in major elective open gastrointestinal surgery
Warrillow, SJ; Weinberg, L; Parker, F; Calzavacca, P; Licari, E; Aly, A; Bagshaw, S; Christophi, C; Bellomo, R
Anaesthesia and Intensive Care, 38(2): 259-265.

Fluid Overload: Diagnosis and Management
Oliguria and Fluid Overload
Rimmele, T; Kellum, JA
Fluid Overload: Diagnosis and Management, 164(): 39-45.

Anesthesia and Analgesia
Perioperative fluid management
Prough, DS; Svensen, CH
Anesthesia and Analgesia, (): 84-91.

Invited commentary: Hemorrhage and surgery cause a contraction of the extra cellular space needing replacement - evidence and implications
Flint, L
Surgery, 139(3): 432-434.

Acta Anaesthesiologica Scandinavica
Patterns in current anaesthesiological peri-operative practice for colonic resections: a survey in five northern-European countries
Hannemann, P; Lassen, K; Hausel, J; Nimmo, S; Ljungqvist, O; Nygren, J; Soop, M; Fearon, K; Andersen, J; Revhaug, A; von Meyenfeldt, MF; Dejong, CHC; Spies, C
Acta Anaesthesiologica Scandinavica, 50(9): 1152-1160.
Journal of the American College of Surgeons
Improving Perioperative Outcomes: Fluid Optimization with the Esophageal Doppler Monitor, a Metaanalysis and Review
Phan, TD; Ismail, H; Heriot, AG; Ho, KM
Journal of the American College of Surgeons, 207(6): 935-941.
Anasthesiologie & Intensivmedizin
Optimisation of intraoperative fluid management - an unresolved problem
Pestel, G; Markstaller, K
Anasthesiologie & Intensivmedizin, 50(): 382-388.

Journal of Gastrointestinal Surgery
Enhanced Recovery After Surgery (ERAS) Versus Conventional Postoperative Care in Colorectal Surgery
Teeuwen, PHE; Bleichrodt, RP; Strik, C; Groenewoud, JJM; Brinkert, W; van Laarhoven, CJHM; van Goor, H; Bremers, AJA
Journal of Gastrointestinal Surgery, 14(1): 88-95.
European Surgery-Acta Chirurgica Austriaca
Fast-track surgery for colonic and rectal resections in Austria - Results from a survey on the perioperative anaesthesia management
Hasenberg, T; Reibenwein, B; Langle, F; Schindler, K; Post, S; Spies, C; Schwenk, W; Shang, E
European Surgery-Acta Chirurgica Austriaca, 42(2): 83-90.
Anesthesia and Analgesia
Supplemental oxygen, but not supplemental crystalloid fluid, increases tissue oxygen tension in healthy and anastomotic colon in pigs
Kimberger, O; Fleischmann, E; Brandt, S; Kugener, A; Kabon, B; Hiltebrand, L; Krejci, V; Kurz, A
Anesthesia and Analgesia, 105(3): 773-779.
Expert Opinion on Pharmacotherapy
Pharmacological interventions and concepts of fast-track perioperative medical care for enhanced recovery programs
Kranke, P; Redel, A; Schuster, F; Muellenbach, R; Eberhart, L
Expert Opinion on Pharmacotherapy, 9(9): 1541-1564.
Neurosurgery Clinics of North America
Anesthesia techniques in complex spine surgery
Ornstein, E; Berko, R
Neurosurgery Clinics of North America, 17(3): 191-+.
Critical Care
Prospective, randomized trial comparing fluids and dobutamine optimization of oxygen delivery in high-risk surgical patients [ISRCTN42445141]
Lobo, SM; Lobo, FR; Polachini, CA; Patini, DS; Yamamoto, AE; de Oliveira, NE; Serrano, P; Sanches, HS; Spegiorin, MA; Queiroz, MM; Christiano, AC; Savieiro, EF; Alvarez, PA; Teixeira, SP; Cunrath, GS
Critical Care, 10(3): -.
Journal De Chirurgie
Accelerated postoperative recovery after colorectal surgery
Alfonsi, P; Schaack, E
Journal De Chirurgie, 144(3): 191-196.

Zentralblatt Fur Chirurgie
Intraoperative fluid therapy
Schwenk, W
Zentralblatt Fur Chirurgie, 133(2): 166-167.
Zentralblatt Fur Chirurgie
Intraloperative fluid management in pancreatic resections - The surgeon's view
Lindenblatt, N; Park, S; Alsfasser, G; Gock, M; Klar, E
Zentralblatt Fur Chirurgie, 133(2): 168-175.
Pediatric Anesthesia
Plasma volume replacement with HES 130/0.42 obviates negative side effects of pneumoperitoneum in piglets
Osthaus, WA; Huber, D; Baumker, C; Witt, L; Metzelder, M; Kuebler, J; Sumpelmann, R
Pediatric Anesthesia, 18(): 922-928.
Veterinary Anaesthesia and Analgesia
Plasma colloid osmotic pressure and total protein in horses during colic surgery
Boscan, P; Steffey, EP
Veterinary Anaesthesia and Analgesia, 34(6): 408-415.
Wiener Klinische Wochenschrift
Gastrointestinal motility in acute illness
Fruhwald, S; Holzer, P; Metzler, H
Wiener Klinische Wochenschrift, 120(): 6-17.
Arterial pressure curve and fluid status
Pestel, G; Fukui, K
Anaesthesist, 58(4): 415-420.
Anasthesiologie & Intensivmedizin
Perioperative fluid management - fiction and facts
Jacob, M; Chappell, D
Anasthesiologie & Intensivmedizin, 50(): 358-+.

European Surgical Research
Volume Therapy and Cardiocircular Function during Hyperthermic Intraperitoneal Chemotherapy
Raue, W; Tsilimparis, N; Bloch, A; Menenakos, C; Hartmann, J
European Surgical Research, 43(4): 365-372.
British Journal of Surgery
Randomized clinical trial of multimodal optimization of surgical care in patients undergoing major colonic resection (Br J Surg 2005; 92, 1354-1362)
Tornero-Campello, G
British Journal of Surgery, 93(7): 891.
British Journal of Surgery
Randomized clinical trial of goal-directed fluid therapy within an enhanced recovery protocol for elective colectomy
Srinivasa, S; Taylor, MHG; Singh, PP; Yu, TC; Soop, M; Hill, AG
British Journal of Surgery, 100(1): 66-74.
World Journal of Surgery
Guidelines for Perioperative Care in Elective Colonic Surgery: Enhanced Recovery After Surgery (ERAS((R))) Society Recommendations
Gustafsson, UO; Scott, MJ; Schwenk, W; Demartines, N; Roulin, D; Francis, N; McNaught, CE; MacFie, J; Liberman, AS; Soop, M; Hill, A; Kennedy, RH; Lobo, DN; Fearon, K; Ljungqvist, O
World Journal of Surgery, 37(2): 259-284.
British Journal of Surgery
Quality-of-care initiative in patients treated surgically for perforated peptic ulcer
Moller, MH; Larsson, HJ; Rosenstock, S; Jorgensen, H; Johnsen, SP; Madsen, AH; Adamsen, S; Jensen, AG; Zimmermann-Nielsen, E; Thomsen, RW
British Journal of Surgery, 100(4): 543-552.
Clinical Nutrition
Guidelines for perioperative care in elective colonic surgery: Enhanced Recovery After Surgery (ERAS (R)) Society recommendations
Gustafsson, UO; Scott, MJ; Schwenk, W; Demartines, N; Roulin, D; Francis, N; McNaught, CE; MacFie, J; Liberman, AS; Soop, M; Hill, A; Kennedy, RH; Lobo, DN; Fearon, K; Ljungqvist, O
Clinical Nutrition, 31(6): 783-800.
British Journal of Anaesthesia
Effect of intravenous fluid therapy on postoperative vomiting in children undergoing tonsillectomy
Elgueta, MF; Echevarria, GC; De la Fuente, N; Cabrera, F; Valderrama, A; Cabezon, R; Munoz, HR; Cortinez, LI
British Journal of Anaesthesia, 110(4): 607-614.
Colorectal Disease
The impact of intravenous fluid administration on complication rates in bowel surgery within an enhanced recovery protocol: a randomized controlled trial
Zakhaleva, J; Tam, J; Denoya, PI; Bishawi, M; Bergamaschi, R
Colorectal Disease, 15(7): 892-899.
Critical Care
Fluid balance and urine volume are independent predictors of mortality in acute kidney injury
Teixeira, C; Garzotto, F; Piccinni, P; Brienza, N; Iannuzzi, M; Gramaticopolo, S; Forfori, F; Pelaia, P; Rocco, M; Ronco, C; Anello, CB; Bove, T; Carlini, M; Michetti, V; Cruz, DN
Critical Care, 17(1): -.
Best Practice & Research Clinical Obstetrics & Gynaecology
Surgery in elderly people: Preoperative, operative and postoperative care to assist healing
Hughes, S; Leary, A; Zweizig, S; Cain, J
Best Practice & Research Clinical Obstetrics & Gynaecology, 27(5): 753-765.
European Urology
Parenteral Nutrition Does Not Improve Postoperative Recovery from Radical Cystectomy: Results of a Prospective Randomised Trial
Roth, B; Birkhauser, FD; Zehnder, P; Thalmann, GN; Huwyler, M; Burkhard, FC; Studer, UE
European Urology, 63(3): 475-482.
British Journal of Anaesthesia
Dexamethasone, light anaesthesia, and tight glucose control (DeLiT) randomized controlled trial
Abdelmalak, BB; Bonilla, A; Mascha, EJ; Maheshwari, A; Tang, WHW; You, J; Ramachandran, M; Kirkova, Y; Clair, D; Walsh, RM; Kurz, A; Sessler, DI
British Journal of Anaesthesia, 111(2): 209-221.
World Journal of Surgery
Perioperative Fluid Restriction in Major Abdominal Surgery: Systematic Review and Meta-analysis of Randomized, Clinical Trials
Boland, MR; Noorani, A; Varty, K; Coffey, JC; Agha, R; Walsh, SR
World Journal of Surgery, 37(6): 1193-1202.
Chinese Medical Journal
Responsiveness of stroke volume variation and central venous pressure during acute normovolemic and hypervolemic hemodilution
Ji, FH; Li, WJ; Li, J; Peng, K; Yang, JP; Liu, H
Chinese Medical Journal, 126(): 1838-1843.
Goal-directed Colloid Administration Improves the Microcirculation of Healthy and Perianastomotic Colon
Kimberger, O; Arnberger, M; Brandt, S; Plock, J; Sigurdsson, GH; Kurz, A; Hiltebrand, L
Anesthesiology, 110(3): 496-504.
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The Anesthesiologist's Role in the Prevention of Surgical Site Infections
Mauermann, WJ; Nemergut, EC
Anesthesiology, 105(2): 413-421.

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A Rational Approach to Perioperative Fluid Management
Chappell, D; Jacob, M; Hofmann-Kiefer, K; Conzen, P; Rehm, M
Anesthesiology, 109(4): 723-740.
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Annals of Surgery
Impact of Different Crystalloid Volume Regimes on Intestinal Anastomotic Stability
Marjanovic, G; Villain, C; Juettner, E; Hausen, Az; Hoeppner, J; Hopt, UT; Drognitz, O; Obermaier, R
Annals of Surgery, 249(2): 181-185.
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Critical Care Medicine
Oliguria, volume overload, and loop diuretics
Bagshaw, SM; Bellomo, R; Kellum, JA
Critical Care Medicine, 36(4): S172-S178.
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Current Opinion in Critical Care
Optimizing perioperative management of patients undergoing colorectal surgery: what is new?
Soop, M; Nygren, J; Ljungqvist, O
Current Opinion in Critical Care, 12(2): 166-170.
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Current Opinion in Critical Care
Using oxygen delivery targets to optimize resuscitation in critically ill patients
Rampal, T; Jhanji, S; Pearse, RM
Current Opinion in Critical Care, 16(3): 244-249.
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Current Opinion in Critical Care
The influence of volume management on outcome
Bagshaw, SM; Bellomo, R
Current Opinion in Critical Care, 13(5): 541-548.
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Diseases of the Colon & Rectum
The Authors Reply
Shoshtari, KZ; Hill, AG
Diseases of the Colon & Rectum, 52(10): 1804-1805.
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Diseases of the Colon & Rectum
Fast-Track Surgery May Reduce Complications Following Major Colonic Surgery
Zargar-Shoshtari, K; Connolly, AB; Israel, LH; Hill, AG
Diseases of the Colon & Rectum, 51(11): 1633-1640.
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European Journal of Anaesthesiology (EJA)
Perioperative fluid management: comparison of high, medium and low fluid volume on tissue oxygen pressure in the small bowel and colon
Hiltebrand, LB; Pestel, G; Hager, H; Ratnaraj, J; Sigurdsson, GH; Kurz, A
European Journal of Anaesthesiology (EJA), 24(11): 927-933.
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Plastic and Reconstructive Surgery
Physiology to Improve Surgical Wound Outcomes
Tornero-Campello, G
Plastic and Reconstructive Surgery, 119(6): 1957.
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Plastic and Reconstructive Surgery
Physiology to Improve Surgical Wound Outcomes: Reply
Hopf, HW; Ueno, C; Hunt, TK
Plastic and Reconstructive Surgery, 119(6): 1957-1958.
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Influence of “Liberal” versus “Restrictive” Intraoperative Fluid Administration on Elimination of a Postoperative Fluid Load
Holte, K; Hahn, RG; Ravn, L; Bertelsen, KG; Hansen, S; Kehlet, H
Anesthesiology, 106(1): 75-79.

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Does Restrictive Intraoperative Fluid Management Alter Outcome after Intraabdominal Surgery?
Beach, ML
Anesthesiology, 104(4): 889.

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Goals Neither Validated Nor Met in Goal-directed Colloid versus Crystalloid Therapy
Kimberger, O; Hiltebrand, LB; Sigurdsson, GH
Anesthesiology, 111(4): 926-927.
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Avoidance of Perioperative Acute Renal Failure: Land in Sight?
Chappell, D; Rehm, M; Jacob, M
Anesthesiology, 109(6): 1140.
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Annals of Surgery
Fluid Overload and Surgical Outcome: Another Piece in the Jigsaw
Lobo, DN
Annals of Surgery, 249(2): 186-188.
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Current Opinion in Anesthesiology
Current aspects of perioperative fluid handling in vascular surgery
Jacob, M; Chappell, D; Hollmann, MW
Current Opinion in Anesthesiology, 22(1): 100-108.
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Current Opinion in Clinical Nutrition & Metabolic Care
Motility disorders in the ICU: recent therapeutic options and clinical practice
Röhm, KD; Boldt, J; Piper, SN
Current Opinion in Clinical Nutrition & Metabolic Care, 12(2): 161-167.
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Current Opinion in Critical Care
The use of early intervention to prevent postoperative complications
Jhanji, S; Pearse, RM
Current Opinion in Critical Care, 15(4): 349-354.
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Diseases of the Colon & Rectum
An Enhanced-Recovery Protocol Improves Outcome After Colorectal Resection Already During the First Year: A Single-Center Experience in 168 Consecutive Patients
Nygren, J; Soop, M; Thorell, A; Hausel, J; Ljungqvist, O; on behalf of the ERAS Group,
Diseases of the Colon & Rectum, 52(5): 978-985.
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European Journal of Anaesthesiology (EJA)
Fluid management of patients undergoing abdominal surgery – more questions than answers*
Boldt, J
European Journal of Anaesthesiology (EJA), 23(8): 631&hyhen;640.
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Journal of Trauma and Acute Care Surgery
A Comparison Between Pulse Pressure Variation and RightEnd Diastolic Volume Index as Guides to Resuscitation in a Modelof Hemorrhagic Shock in Pigs
de Oliveira, MA; Otsuki, DA; Noel-Morgan, J; Leite, VF; Fantoni, DT; Auler, JO
Journal of Trauma and Acute Care Surgery, 67(6): 1225-1232.
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Auler, JO; Galas, FR; Sundin, MR; Hajjar, LA
Shock, 30(7): 18-22.
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