Skip Navigation LinksHome > January 2003 - Volume 98 - Issue 1 > Optimal Oxygen Concentration during Induction of General Ane...
Clinical Investigations

Optimal Oxygen Concentration during Induction of General Anesthesia

Edmark, Lennart M.D., D.E.A.A.*; Kostova-Aherdan, Kamelia M.D.†; Enlund, Mats M.D., Ph.D.‡; Hedenstierna, Göran M.D., Ph.D.§

Free Access
Article Outline
Collapse Box

Author Information

Collapse Box


Background: The use of 100% oxygen during induction of anesthesia may produce atelectasis. The authors investigated how different oxygen concentrations affect the formation of atelectasis and the fall in arterial oxygen saturation during apnea.
Methods: Thirty-six healthy, nonsmoking women were randomized to breathe 100, 80, or 60% oxygen for 5 min during the induction of general anesthesia. Ventilation was then withheld until the oxygen saturation, assessed by pulse oximetry, decreased to 90%. Atelectasis formation was studied with computed tomography.
Results: Atelectasis in a transverse scan near the diaphragm after induction of anesthesia and apnea was 9.8 ± 5.2 cm2 (5.6 ± 3.4% of the total lung area; mean ± SD), 1.3 ± 1.2 cm2 (0.6 ± 0.7%), and 0.3 ± 0.3 cm2 (0.2 ± 0.2%) in the groups breathing 100, 80, and 60% oxygen, respectively (P < 0.01). The corresponding times to reach 90% oxygen saturation were 411 ± 84, 303 ± 59, and 213 ± 69 s, respectively (P < 0.01).
Conclusion: During routine induction of general anesthesia, 80% oxygen for oxygenation caused minimal atelectasis, but the time margin before unacceptable desaturation occurred was significantly shortened compared with 100% oxygen.
THE use of 100% oxygen during induction of general anesthesia has become a standard in many institutions, although preoxygenation was initially proposed as an optional precaution. 1 There are strong logical merits for this standard regarding maximal safety during the transition from an awake to an anesthetic state. 2 Lately, evidence has appeared that 100% oxygen is a major cause of atelectasis during the induction and maintenance of anesthesia. 3 Thirty percent oxygen during induction of anesthesia was not associated with atelectasis. This was true even in patients with a high body mass index. 4
The current study was designed to see whether 80 or 60% oxygen would produce less atelectasis than 100% oxygen during anesthesia induction and to what extent lower oxygen concentrations during induction shorten the time to hypoxia, defined as a saturation of 90% or less, as measured by pulse oximetry. We aimed at finding a compromise between acceptable safety (apnea) time and minimum atelectasis formation.
Back to Top | Article Outline

Materials and Methods

The study was approved by the Regional Ethics Committee (Uppsala, Sweden), and all patients gave their written informed consent to participate. Thirty-six healthy, nonsmoking females with American Society of Anesthesiologists physical status class I or II and with a body mass index (weight in kilograms divided by the square of the height in meters) of 31 or less, scheduled for elective hysterectomy due to benign disease, were enrolled in the study. Preoperative evaluation was carried out the day before surgery. All patients had normal electrocardiograms. Their arterial oxygen and carbon dioxide tensions were normal (ABL 505; Radiometer, Copenhagen, Denmark), and their spirometry and lung volumes (by helium dilution technique), measured in the supine position, were also normal. Patients’ oxygen uptake and carbon dioxide output at rest were measured, and major differences in metabolic rate between groups were excluded (integrative cardiopulmonary testing; Jaeger, Wurzburg, Germany). Patients were randomized to one of three oxygenation groups: 100, 80, or 60% oxygen (in nitrogen).
Back to Top | Article Outline
Anesthesia and Monitoring
Premedication consisted of acetaminophen 1 g orally, and five patients were also given 10 mg diazepam orally. Anesthesia was induced and measurements were performed at the Radiology Department before transport to surgery. The patients were hydrated with 200 ml Ringer's acetate and 300 ml of the colloid dextran before induction to reduce the risk of postinduction hypotension. The electrocardiogram and peripheral oxygen saturation (Spo2) were continuously assessed during the procedure. End-tidal carbon dioxide (Fetco2) and end-tidal oxygen concentrations (Feto2) were continuously monitored. Blood pressure was measured intermittently. The monitor for all measurements was a CS 3 (Datex-Ohmeda, Helsinki, Finland).
Data collection started when the patients began to breathe the randomly chosen oxygen concentration through a tightly fitted mask. After breathing spontaneously for 1 min, the patients were given bolus doses of fentanyl, 0.2 mg, and alfentanil, 1 mg. A target-controlled propofol infusion (Diprifusor; AstraZeneca, Macclesfield, Cheshire, United Kingdom) was started 2 min after the beginning of preoxygenation, aiming for an initial target blood concentration of 8 μg/ml, which was reduced to 6 μg/ml after tracheal intubation. Rocuronium, 30 mg, was given approximately 30 s after starting the propofol infusion to facilitate tracheal intubation. All patients lost consciousness and stopped breathing 30–60 s after the start of the propofol infusion.
Fig. 1
Fig. 1
Image Tools
The experimental procedure during anesthesia in the different groups is outlined in figure 1.
Back to Top | Article Outline
The strict preoxygenation period with normal spontaneous ventilation was 1 min. This period was followed by an induction phase with decreased spontaneous ventilation. An oropharyngeal airway was used to facilitate positive-pressure mask ventilation when spontaneous breathing ceased. The oxygenation continued until the patient was fully asleep and a steady state in end-tidal oxygen concentration was achieved. The end-tidal values of oxygen and carbon dioxide at steady state were noted before ventilation was stopped. The mask was removed, and the patient's trachea was immediately intubated. Five and a half minutes elapsed from the start of preoxygenation to the start of the intubation maneuver. No fresh gas was connected to the endotracheal tube during the period of apnea. The apnea time was defined as the period after stopping the ventilation until the saturation, as measured by pulse oximetry, had fallen to 90%. 5 The oxygen saturation was continuously registered. The fresh gas was connected to the patient, and manual ventilation with 40% oxygen in nitrogen was started in all three groups at the time when Spo2 had decreased to 90%. The lowest oxygen saturation and the time when it occurred were registered, as was the time to return to a saturation of 96%. The patients breathed and were ventilated through the Mentell system (Anmedic, Vallentuna, Sweden), a hybrid low-flow anesthetic circuit. 6 This circuit has a built-in positive end-expiratory pressure (PEEP) of 3 cm H2O. No other level of PEEP was used. A fresh gas flow of 6 l/min was used to prevent rebreathing during the period of preoxygenation and during the period of anesthesia induction. As spontaneous breathing ceased during induction, manual ventilation on mask began with the aim to keep end-tidal Pco2 normal and fresh gas flow unaltered. This was achieved with tidal volumes of 7–10 ml/kg body weight and respiratory rates less than 10 breaths/min. After the period of apnea, the patient was connected to the respirator (Anmedic), and a standard ventilatory setting was used, consisting of a tidal volume of 10 ml/kg body weight and a respiratory rate of 12 breaths/min. A fresh gas flow of 6 l/min with 40% oxygen in nitrogen was used when ventilation was started after the apnea period. The fresh gas flow was lowered to approximately 1 l/min, still with 40% oxygen, to avoid hyperventilation, as soon as Spo2 was raised to 96% and end-tidal carbon dioxide was normalized. Airway pressure did not exceed 25 cm H2O in any patient.
Back to Top | Article Outline
Computed Tomography
The lungs were studied with computed tomography (CT; Siemens Somatom HiQ; Siemens, Erlangen, Germany). The patients were placed in the supine position, with the arms parallel to the body, horizontally on the CT table. All CT scans were carried out in apnea at the end of expiration. Three scans were made: a basal scan 10 mm above the dome of the right diaphragm, a scan at the hilus, and one at the apex of the lungs. A control CT was taken in the conscious patient to exclude any atelectasis before anesthesia. During anesthesia, the three scans were performed as soon as ventilation was started after apnea. In the 100% group, this occurred approximately 14 min from the start of preoxygenation. As the three groups were apneic for different time periods until the saturation had fallen to 90%, depending on their initial inspiratory oxygen concentration, the 60 and 80% groups were split into two subgroups each. One subgroup (first six patients) had their three scans performed immediately after controlled ventilation was started, as was the situation in the 100% group. The other subgroup (last six patients) had only a basal scan immediately after apnea, and then three scans were undertaken approximately 14 min after start of preoxygenation. Thereby, scans were taken at the same time point in the 60 and 80% subgroups as in the 100% group. Performing the scanning procedure including positioning took 1.5 min.
The radiologist was unaware of the group affiliation of the individual patient when making the examination of the CT scans. Calculations were made using the region of interest presented in the Somatom computer program. For tracing the atelectasis, the window level and width were set at −500 and ± 1,500 Hounsfield units, respectively. Atelectasis was defined as areas with attenuation values between −100 and +100 Hounsfield units and was expressed in square centimeters and in percent of the total lung area. 7 The dorsal border was traced manually between the atelectasis and the pleura. The ventral border was drawn a few centimeters above the dense area, and the atelectasis was calculated by the region of interest program. The total lung area was calculated as the inner thorax area, excluding the heart and great vessels. Each region of interest was redrawn two times, and the mean value was used.
Back to Top | Article Outline
Statistical Analysis
The sample size for this study was based on the knowledge from earlier studies 8,9 and the assumption that a reduction of atelectasis of 50% or more would be of clinical importance. We did not assume the main variables in the study, i.e., the amount of atelectasis and the apnea time, to have a normal distribution. Therefore, and since three groups were involved, the Kruskal-Wallis nonparametric one-way analysis of variance was applied, and a P value of 0.01 or less was considered significant.
Back to Top | Article Outline


Table 1
Table 1
Image Tools
The three study groups were similar in demographic and physiologic data collected the day before the investigation (table 1).
Table 2
Table 2
Image Tools
Fig. 2
Fig. 2
Image Tools
No patient presented with atelectasis in the awake state before anesthesia induction. During anesthesia, immediately after the period of apnea, the mean atelectasis area in the basal scan was close to 10 cm2 (5.6%) in the 100% group compared to 1.3 cm2 (0.6%) and 0.3 cm2 (0.2%) in the 80 and 60% groups, respectively(P < 0.001;table 2 and fig. 2). The atelectatic area in the hilus scans was much smaller, although the relation between the three groups was the same as at the basal cut. The apex scans indicated less than 0.1 cm2 atelectasis in any group.
The time from start of preoxygenation until apnea commenced, corresponding to the time of oxygenation with either 100, 80, or 60% oxygen, was approximately 5.5 min, with no difference between the groups (table 2).
Fig. 3
Fig. 3
Image Tools
Fig. 4
Fig. 4
Image Tools
All patients had an Spo2 of 99% at the beginning of the apnea period. The mean time for Spo2 to decrease to 90% during the apnea was close to 7 min in the 100% group, 5 min in the 80% group, and 3.5 min in the 60% group (P < 0.01;table 2 and fig. 3). The pattern in which Spo2 decreased during the period of apnea is shown in figure 4. Immediately after apnea, ventilation was commenced, and then CT scanning was performed and completed in 1.5 min. Thus, the total time from the initiation of preoxygenation to the completion of CT scanning was 14 min in the 100% oxygen group and 12 and 10.5 min in the 80 and 60% oxygen groups, respectively.
There was no statistically significant change in the atelectasis formation in the 80 and 60% oxygen groups immediately after apnea compared with when CT scans were repeated at 14 min (corresponding to the time of CT in the 100% oxygen group;table 2).
Table 3
Table 3
Image Tools
The lowest saturation, the time at which Spo2 started to increase, the time to recover to normal saturation, and the difference between end-tidal Pco2 before and immediately after apnea are summarized in table 3.
Back to Top | Article Outline


A major finding in the current study was that breathing 100% oxygen during preoxygenation and anesthesia induction caused significantly more atelectasis formation than did breathing 80 or 60% oxygen. This atelectasis causes intrapulmonary shunting, 10 and the clinical impression is that it contributes to postoperative pulmonary complications. 11
The anesthetic procedure was uneventful in all but one patient. This patient showed signs of heavy mucus production during the operation, and suction of the endotracheal tube was carried out several times. It must be observed that this patient had more atelectasis (19.3 cm2) at the basal scan directly after apnea than did any other patient. However, even after the exclusion of this patient, the atelectatic area (now 9.0 ± 4.5 cm2) remained significantly larger than the areas in the 80 or 60% oxygen groups (P < 0.01). This patient also had the shortest apnea tolerance (239 s) in comparison with the group average of 411 s. Excluding this patient from the results in the 100% group increased the mean apnea tolerance to 428 s in the 100% group. We chose not to exclude her, as she most certainly demonstrates a major mechanism in the development of a larger than normal amount of atelectasis during a routine induction of anesthesia.
An expected finding was that the safe time of apnea, defined as keeping peripheral oxygen saturation more than 90%, was significantly longer when breathing 100% oxygen than 80 or 60% oxygen. In a patient with signs of a difficult airway or with any other reason to have maximal safety during induction, 100% oxygen is always preferable in order to have an extra minute or two for securing the airway. A “cannot ventilate, cannot intubate” situation may unpredictably occur during induction of anesthesia and supports the use of 100% oxygen at all times during preoxygenation. However, if morbidity or mortality from atelectasis formation can be proven, this has to be considered against the probability of an unpredictable “cannot ventilate, cannot intubate” situation. The risk–benefit ratio for the 60% group versus the 80% group seemed unfavorable. There was a small and probably clinically unimportant difference in atelectasis formation between the groups, while there was 1.5 min less time to decrease to 90% saturation.
Did the prolonged apnea per se increase the size of the atelectasis? The design of the study excluded the possibility of addressing this question, as we judged the information regarding apnea tolerance in the 80 and 60% oxygen groups to be of paramount interest. This limitation warrants a study without prolonged apnea to be properly investigated. For the time being, we can only compare with earlier studies of atelectasis formation during anesthesia with a short apnea for the intubation of the airway, in which the amount of atelectasis has been as large as in the present patients on 100% oxygen. 4,12,13
Another key question was whether the prolonged apnea increased the size of the atelectasis more so in the 100% oxygen group than in the others, since the apnea period was longer in this group. We tested the impact of this time difference by performing CT scans in a subgroup of patients breathing 80 or 60% oxygen at the same time point as we did in the 100% oxygen group. There was no difference in atelectasis in the 60 or 80% groups when comparing values directly after apnea (10.5 or 12 min after start of preoxygenation) with values at the time point when the 100% oxygen group was studied (14 min). It must be observed, however, that the patients in the 60 and 80% groups were ventilated with tidal volumes of 10 ml/kg some minutes longer before the new CT scans at 14 min, in contrast to the patients in the 100% group, who were ventilated only during the 1.5 min it took to complete the scans. It may be argued that this longer period of positive-pressure ventilation could have prevented or reversed atelectasis formation in these subgroups. However, it has been shown that reopening of collapsed lung tissue requires inflation of the lungs up to 40 cm H2O, corresponding to a vital capacity maneuver. 14 It can also be proposed that complete airway closure with gas trapping and gas absorption is one likely mechanism of atelectasis during anesthesia, as hypothesized in clinical studies 15 and shown in mathematical modeling. 16 Whether the lungs are ventilated need not affect gas absorption, provided that airways remain closed over the respiratory cycle.
Application of PEEP can open up closed airways and may reduce the formation of atelectasis. 10 The level of PEEP in this study was only 3 cm H2O. It might have reduced atelectasis formation, but equally so in the three groups since all groups had the same PEEP. PEEP is effective only as long as it is applied, and during the period of apnea, there was apparently no PEEP.
The effect on postoperative atelectasis of using 80% oxygen during anesthesia was recently investigated by Akça et al.17 In their study, 80% oxygen was compared with 30% given during colon resection and for 2 h after the procedure. No difference in incidence and severity of atelectasis was seen the first postoperative day. In the light of our results, the amount of atelectasis in the study by Akça et al.17 may have originated from the use of 100% oxygen during induction of anesthesia. The use of 80% oxygen might be of borderline importance to produce atelectasis. If so, no difference might be expected between the 30 and 80% groups.
Although there were no statistical differences in the current study among patients regarding physiologic data, some details deserve a comment. In the 80% group, the mean hemoglobin value was 8–11 g higher per liter than in the other two groups. This might have enhanced the apnea tolerance in the 80% group. On the other hand, patients in the 100% group were 4 yr younger than in the 80% group, and the body mass index was slightly higher in the 80% group, as was the preoperative oxygen consumption awake at rest. These three factors may decrease apnea tolerance. However, this study was too small to discriminate between the significance of factors other than oxygen level in influencing the formation of atelectasis during anesthesia induction. Clearly, those other factors vary in impact in different patients, as illustrated by the large variation in atelectasis formation in the 100% group.
We may conclude that preoxygenation with 80% oxygen seemed to be beneficial in reducing atelectasis formation during anesthesia induction, compared with 100% oxygen, but with a reduction in apnea tolerance. This reduction in apnea tolerance can make a difference in unpredictable, complicated situations during anesthesia induction. Until a large clinical trial can prove significant morbidity from atelectasis during or after anesthesia, the standard of using 100% oxygen for preoxygenation should continue.
The authors thank registered nurses Malin Engdahl, Majny Thorell, and Siv Johansson (Department of Anesthesiology and Intensive Care), Lotta Hjelm and Kerstin Thuveson (Department of Radiology), Lena Lundgren (Department of Obstetrics and Gynecology), and Monica Quarfordt and Annika Öhrn (Department of Clinical Physiology, all at Central Hospital, Västerås, Sweden) for skillful technical assistance. The authors also thank Hans U. Rothen, M.D., Ph.D. (Department of Anaesthesiology and Intensive Care, University Hospital, Bern, Switzerland), for methodological advice and Ivar Ringqvist, Ph.D. (Professor, Centre for Clinical Research, Central Hospital, Västerås, Sweden), for valuable advice.
Back to Top | Article Outline


1. Stone DJ, Gal TJ: Airway management, Anesthesia, 5th edition. Edited by Miller RD. Philadelphia, Churchill Livingstone, 2000, pp 1414–51

2. Benumof JL: Preoxygenation (editorial). A nesthesiology 1999; 91: 603–5

3. Rothen HU, Sporre B, Engberg G, Wegenius G, Reber A, Hedenstierna G: Prevention of atelectasis during general anaesthesia. Lancet 1995; 345: 1387–91

4. Rothen HU, Sporre B, Engberg G, Wegenius G, Reber A, Hedenstierna G: Atelectasis and pulmonary shunting during induction of general anaesthesia: Can they be avoided? Acta Anaesthesiol Scand 1996; 40: 524–29

5. Jense H, Dubin S, Silverstein P, O'Leary-Escolas U: Effect of obesity on safe duration of apnea in anesthetized humans. Anesth Analg 1991; 72: 89–93

6. Mentell O, Revenäs B, Jonsson L: A new hybrid anaesthetic circuit for a low-flow rebreathing technique. Acta Anaesthesiol Scand 1994; 38: 840–44

7. Lundquist H, Hedenstierna G, Strandberg Å, Tokics L, Brismar B: CT-assessment of dependent lung densities in man during general anaesthesia. Acta Radiol 1995; 36: 626–32

8. Brismar B, Hedenstierna G, Lundquist H, Strandberg Å, Svensson L, Tokics L: Pulmonary densities during anesthesia with muscular relaxation: A proposal of atelectasis. A nesthesiology 1985; 62: 422–8

9. Gunnarsson L, Tokics L, Gustavsson H, Hedenstierna G: Influence of age on atelectasis formation and gas exchange impairment during general anesthesia. Br J Anaesth 1991; 66: 423–32

10. Tokics L, Hedenstierna G, Strandberg Å, Brismar B, Lundqvist H: Lung collapse and gas exchange during general anesthesia: Effects of spontaneous breathing, muscle paralysis, and positive end-expiratory pressure. A nesthesiology 1987; 66: 157–67

11. Warner DO: Preventing postoperative pulmonary complications. A nesthesiology 2000; 92: 1467–72

12. Rothen HU, Sporre B, Engberg G, Wegenius G, Hedenstierna G: Reexpansion of atelectasis during general anaesthesia may have a prolonged effect. Acta Anaesthesiol Scand 1995; 39: 118–25

13. Rothen HU, Sporre B, Engberg G, Wegenius G, Hedenstierna G: Airway closure, atelectasis and gas exchange during general anaesthesia. Br J Anaesth 1998; 81: 681–6

14. Rothen HU, Sporre B, Engberg G, Wegenius G, Hedenstierna G: Re-expansion of atelectasis during general anaesthesia: A computed tomography study. Br J Anaesth 1993; 71: 788–795

15. Rothen HU, Sporre B, Engberg G, Wegenius G, Högman M, Hedenstierna G: Influence of gas composition on recurrence of atelectasis after a reexpansion maneuver during general anesthesia. A nesthesiology 1995; 82: 832–42

16. Joyce CJ, Williams AB: Kinetics of absorption atelectasis during anesthesia: A mathematical model. J Appl Physiol 1999; 86: 1116–25

17. Akça O, Podolsky A, Eisenhuber E, Panzer O, Hetz H, Lampl K, Lackner F, Wittman K, Grabenwoeger F, Kurz A, Schultz A-M, Negishi C, Sessler D: Comparable postoperative pulmonary atelectasis in patients given 30% or 80% oxygen during and 2 hours after colon resection. A nesthesiology 1999; 91: 991–8

Cited By:

This article has been cited 67 time(s).

Journal of Anesthesia
Higher fraction of inspired oxygen in anesthesia induction does not affect functional residual capacity reduction after intubation: a comparative study of higher and lower oxygen concentration
Kanaya, A; Satoh, D; Kurosawa, S
Journal of Anesthesia, 27(3): 385-389.
Respiratory Care
Ventilator-Induced Lung Injury: Minimizing Its Impact in Patients With or at Risk for ARDS
Biehl, M; Kashiouris, MG; Gajic, O
Respiratory Care, 58(6): 927-934.
Journal of Clinical Monitoring and Computing
Clinical refinement of the automatic lung parameter estimator (ALPE)
Thomsen, LP; Karbing, DS; Smith, BW; Murley, D; Weinreich, UM; Kjaergaard, S; Toft, E; Thorgaard, P; Andreassen, S; Rees, SE
Journal of Clinical Monitoring and Computing, 27(3): 341-350.
Canadian Journal of Anaesthesia-Journal Canadien D Anesthesie
Lung recruitment during general anesthesia
Johnson, D
Canadian Journal of Anaesthesia-Journal Canadien D Anesthesie, 51(7): 649-653.

Annales Francaises D Anesthesie Et De Reanimation
Fast track rehabilitation in colonic surgery
Merat, S; Rouquie, D; Bordier, E; LeGulluche, Y; Baranger, B
Annales Francaises D Anesthesie Et De Reanimation, 26(): 649-655.
Acta Anaesthesiologica Scandinavica
Population pharmacokinetics of sevoflurane in conjunction with the AnaConDa (R): toward target-controlled infusion of volatiles into the breathing system
Enlund, M; Kietzmann, D; Bouillon, T; Zuechner, K; Meineke, I
Acta Anaesthesiologica Scandinavica, 52(4): 553-560.
Comparison of algorithms for management of the difficult airway
Heidegger, T; Gerig, HJ; Keller, C
Anaesthesist, 52(5): 381-392.
Critical Care
Uneven distribution of ventilation in acute respiratory distress syndrome
Rylander, C; Tylen, U; Rossi-Norrlund, R; Herrmann, P; Quintel, M; Bake, B
Critical Care, 9(2): R165-R171.
Perioperative oxygen fraction - effect on surgical site infection and pulmonary complications after abdominal surgery: a randomized clinical trial. Rationale and design of the PROXI-Trial
Meyhoff, CS; Wetterslev, J; Jorgensen, LN; Henneberg, SW; Simonsen, I; Pulawska, T; Walker, LR; Skovgaard, N; Helto, K; Gocht-Jensen, P; Carlsson, PS; Rask, H; Karim, S; Carlsen, CG; Jensen, FS; Rasmussen, LS
Trials, 9(): -.
Anasthesiologie & Intensivmedizin
Anaesthesia in patients with pre-existing lung disease
Heinke, W; Reske, A; Kaisers, UX
Anasthesiologie & Intensivmedizin, 50(): 36-49.

Archivos De Bronconeumologia
Pen-Operative Atelectasis and Alveolar Recruitment Manoeuvres
Rama-Maceiras, P
Archivos De Bronconeumologia, 46(6): 317-324.
American Journal of Respiratory and Critical Care Medicine
Using electric impedance tomography to assess regional ventilation at the bedside
Hedenstierna, G
American Journal of Respiratory and Critical Care Medicine, 169(7): 777-778.
Archives of Surgery
Perioperative Supplemental Oxygen Therapy and Surgical Site Infection A Meta-analysis of Randomized Controlled Trials
Qadan, M; Akca, O; Mahid, SS; Hornung, CA; Polk, HC
Archives of Surgery, 144(4): 359-366.

Journal of Aerosol Medicine and Pulmonary Drug Delivery
Influence of Jet Nebulization and Oxygen Delivery on the Fraction of Inspired Oxygen: An Experimental Model
Caille, V; Ehrmann, S; Boissinot, E; Perrotin, D; Diot, P; Dequin, PF
Journal of Aerosol Medicine and Pulmonary Drug Delivery, 22(3): 255-261.
Acta Anaesthesiologica Scandinavica
Both lung recruitment maneuver and PEEP are needed to increase oxygenation and lung volume after cardiac surgery
Dyhr, T; Nygard, E; Laursen, N; Larsson, A
Acta Anaesthesiologica Scandinavica, 48(2): 187-197.

Journal of Cardiothoracic and Vascular Anesthesia
The value of end-tidal carbon dioxide monitoring during systemic-to-pulmonary artery shunt insertion in cyanotic children
Tugrul, M; Camci, E; Sungur, Z; Pembeci, K
Journal of Cardiothoracic and Vascular Anesthesia, 18(2): 152-155.
Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie
High FlO(2) during mechanical ventilation: Pro - Con
Rothen, HU
Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie, 40(): 604-608.
Anaesthesia, Pain, Intensive Care and Emergency Medicine
Physiopathology of atelectasis during anaesthesia
Hedenstierna, G
Anaesthesia, Pain, Intensive Care and Emergency Medicine, (): 353-359.

Journal of Applied Physiology
Reproduction of MIGET retention and excretion data using a simple mathematical model of gas exchange in lung damage caused by oleic acid infusion
Rees, SE; Kjaergaard, S; Andreassen, S; Hedenstierna, G
Journal of Applied Physiology, 101(3): 826-832.
Acta Anaesthesiologica Scandinavica
Arterial oxygen tension increase 2-3 h after hyperbaric oxygen therapy: a prospective observational study
Ratzenhofer-Komenda, B; Offner, A; Ofner, P; Klemen, H; Prause, G; Smolle-Juttner, FM; Toller, W
Acta Anaesthesiologica Scandinavica, 51(1): 68-73.
13Th International Conference on Electrical Bioimpedance and the 8Th Conference on Electrical Impedance Tomography 2007
Analysis of ventilatory conditions under different inspiratory oxygen concentrations and positive end-expiratory pressure levels by EIT
Schmitz, G; Pulletz, S; Schadler, D; Zick, G; Scholz, J; Weiler, N; Frerichs, I
13Th International Conference on Electrical Bioimpedance and the 8Th Conference on Electrical Impedance Tomography 2007, 17(): 524-527.

Anesthesia and Analgesia
Prevention of atelectasis formation during the induction of general anesthesia in morbidly obese patients
Coussa, M; Proietti, S; Schnyder, P; Frascarolo, P; Suter, M; Spahn, DR; Magnusson, L
Anesthesia and Analgesia, 98(5): 1491-1495.
Biocybernetics and Biomedical Engineering
The virtual cardio-respiratory system: a sub-model of gas exchange and transfer
Golczewski, T; Darowski, M
Biocybernetics and Biomedical Engineering, 28(1): 29-40.

Clinical Physiology and Functional Imaging
Alveolar collapse and closure of airways: regular effects of anaesthesia
Hedenstierna, G
Clinical Physiology and Functional Imaging, 23(3): 123-129.

Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie
Routine use of high inspired oxygen concentration - Pro
Danzeisen, O; Priebe, HJ
Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie, 40(6): 350-353.
Anaesthesia, Pain, Intensive Care and Emergency Medicine - Apice 19
Effects of body position on ventilation/perfusion matching
Hedenstierna, G
Anaesthesia, Pain, Intensive Care and Emergency Medicine - Apice 19, (): 3-15.

Acta Anaesthesiologica Scandinavica
Effects of PEEP levels following repeated recruitment maneuvers on ventilator-induced lung injury
Ko, SC; Zhang, H; Haitsma, JJ; Cheng, KC; Li, CF; Slutsky, AS
Acta Anaesthesiologica Scandinavica, 52(4): 514-521.
International Journal of Artificial Organs
Gas exchange in a virtual respiratory system - simulation of ventilation without lung movement
Golczewski, T
International Journal of Artificial Organs, 30(): 1047-1056.

Jama-Journal of the American Medical Association
Supplemental oxygen and risk of surgical wound infection
Suttner, S; Boldt, J; Piper, S
Jama-Journal of the American Medical Association, 295(): 1641-1642.

Intensive Care Medicine
The hidden pulmonary dysfunction in acute lung injury
Hedenstierna, G
Intensive Care Medicine, 32(): 1933-1934.
Anesthesia and Analgesia
Positive end-expiratory pressure during induction of general anesthesia increases duration of nonhypoxic apnea in morbidly obese patients
Gander, S; Frascarolo, P; Suter, M; Spahn, DR; Magnusson, L
Anesthesia and Analgesia, 100(2): 580-584.

Pediatric Anesthesia
Oxygen - elixir of life or Trojan horse? Part 2: oxygen and neonatal anesthesia
van der Walt, J
Pediatric Anesthesia, 16(): 1205-1212.
Pediatric Anesthesia
Oxygen in neonatal and infant anesthesia - current practice in the UK
Short, JA; van der Walt, JH
Pediatric Anesthesia, 18(5): 378-387.
British Journal of Anaesthesia
Comparison of two ventilatory strategies in elderly patients undergoing major abdominal surgery
Weingarten, TN; Whalen, FX; Warner, DO; Gajic, O; Schears, GJ; Snyder, MR; Schroeder, DR; Sprung, J
British Journal of Anaesthesia, 104(1): 16-22.
Canadian Journal of Anaesthesia-Journal Canadien D Anesthesie
Airway patency matters
Ratsiu, J; Jonmarker, C
Canadian Journal of Anaesthesia-Journal Canadien D Anesthesie, 57(4): 387.
The effect of positive airway pressure during pre-oxygenation and induction of anaesthesia upon duration of non-hypoxic apnoea
Herriger, A; Frascarolo, P; Spahn, DR; Magnusson, L
Anaesthesia, 59(3): 243-247.

Jama-Journal of the American Medical Association
Supplemental oxygen and risk of surgical wound infection - Reply
Belda, FJ; Sessler, DI
Jama-Journal of the American Medical Association, 295(): 1642-1643.

Obesity Surgery
Pressure-controlled ventilation does not improve gas exchange in morbidly obese patients undergoing abdominal surgery
Hans, GA; Pregaldien, AA; Kaba, A; Sottiaux, TM; DeRoover, A; Lamy, ML; Joris, JL
Obesity Surgery, 18(1): 71-76.
Canadian Journal of Anaesthesia-Journal Canadien D Anesthesie
Airway patency matters Reply
Tanoubi, I; Drolet, P; Donati, F
Canadian Journal of Anaesthesia-Journal Canadien D Anesthesie, 57(4): 387-388.

Anasthesiologie & Intensivmedizin
Oxygen as carrier gas in general anoesthesic
Baum, J; von Bormann, B; Meyer, J; Van Aken, H
Anasthesiologie & Intensivmedizin, 45(3): 124-+.

Anasthesiologie & Intensivmedizin
Risks and benefits of mechanical ventilation with positive end-expiratory pressure during the perioperative phase
Neumann, P; Klockgether-Radke, A; Quintel, M
Anasthesiologie & Intensivmedizin, 45(3): 137-146.

Intensive Care Medicine
The effects of anesthesia and muscle paralysis on the respiratory system
Hedenstierna, G; Edmark, L
Intensive Care Medicine, 31(): 1327-1335.
Anesthesia and Analgesia
Muscle relaxation for rapid sequence induction
Donati, F
Anesthesia and Analgesia, (): 40-46.

British Journal of Anaesthesia
Just a little oxygen to breathe as you go off to it always a good idea?
Lumb, AB
British Journal of Anaesthesia, 99(6): 769-771.
Obesity Surgery
Postoperative results after desflurane or sevoflurane combined with remifentanil in morbidly obese patients
De Baerdemaeker, LEC; Jacobs, S; Den Blauwen, NMM; Pattyn, P; Herregods, LLG; Mortier, EP; Struys, MMRF
Obesity Surgery, 16(6): 728-733.

Anesthesia and Analgesia
The impact of positive end-expiratory pressure on functional residual capacity and ventilation homogeneity impairment in anesthetized children exposed to high levels of inspired oxygen
von Ungern-Sternberg, BS; Regli, A; Schibler, A; Hammer, J; Frei, FJ; Erb, TO
Anesthesia and Analgesia, 104(6): 1364-1368.
Acta Anaesthesiologica Scandinavica
Effects of thoracic epidural anaesthesia on pulmonary venous admixture and oxygenation during one-lung ventilation
Ozcan, PE; Senturk, M; Ulke, ZS; Toker, A; Dilege, S; Ozden, E; Camci, E
Acta Anaesthesiologica Scandinavica, 51(8): 1117-1122.
Jama-Journal of the American Medical Association
Effect of High Perioperative Oxygen Fraction on Surgical Site Infection and Pulmonary Complications After Abdominal Surgery The PROXI Randomized Clinical Trial
Meyhoff, CS; Wetterslev, J; Jorgensen, LN; Henneberg, SW; Hogdall, C; Lundvall, L; Svendsen, PE; Mollerup, H; Lunn, TH; Simonsen, I; Martinsen, KR; Pulawska, T; Bundgaard, L; Bugge, L; Hansen, EG; Riber, C; Gocht-Jensen, P; Walker, LR; Bendtsen, A; Johansson, G; Skovgaard, N; Helto, K; Poukinski, A; Korshin, A; Walli, A; Bulut, M; Carlsson, PS; Rodt, SA; Lundbech, LB; Rask, H; Buch, N; Perdawid, SK; Reza, J; Jensen, KV; Carlsen, CG; Jensen, FS; Rasmussen, LS
Jama-Journal of the American Medical Association, 302(): 1543-1550.

Minerva Anestesiologica
Interfacing spontaneous breathing and mechanical ventilation - New insights
Hedenstierna, G; Lichtwarck-Aschoff, M
Minerva Anestesiologica, 72(4): 183-198.

Prehospital Emergency Care
Rate of decline in oxygen saturation at various pulse oximetry values with prehospital rapid sequence intubation
Davis, DP; Hwang, JQ; Dunford, JV
Prehospital Emergency Care, 12(1): 46-51.
Acta Anaesthesiologica Scandinavica
LMA: a big choice
Larsson, A
Acta Anaesthesiologica Scandinavica, 53(4): 421-422.
Canadian Journal of Anaesthesia-Journal Canadien D Anesthesie
Optimizing preoxygenation in adults
Tanoubi, I; Drolet, P; Donati, F
Canadian Journal of Anaesthesia-Journal Canadien D Anesthesie, 56(6): 449-466.
Anesthesia and Analgesia
Noninvasive Ventilation Immediately After Extubation Improves Lung Function in Morbidly Obese Patients with Obstructive Sleep Apnea Undergoing Laparoscopic Bariatric Surgery
Neligan, PJ; Malhotra, G; Fraser, M; Williams, N; Greenblatt, EP; Cereda, M; Ochroch, EA
Anesthesia and Analgesia, 110(5): 1360-1365.
Oxygen failure alarms
Mitton, M
Anaesthesia, 58(4): 389-390.

International Journal of Obstetric Anesthesia
What's new and novel in obstetric anesthesia? Contributions from the 2003 scientific literature
Tsen, LC
International Journal of Obstetric Anesthesia, 14(2): 126-146.
Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie
Routine use of high inspired oxygen concentration - Con
Suttner, S; Boldt, J
Anasthesiologie Intensivmedizin Notfallmedizin Schmerztherapie, 40(6): 354-357.
Bmc Veterinary Research
Fire ignition during laser surgery in pet rodents
Collarile, T; Di Girolamo, N; Nardini, G; Ciraci, IA; Selleri, P
Bmc Veterinary Research, 8(): -.
ARTN 177
Comprehensive Physiology
Respiratory Function During Anesthesia: Effects on Gas Exchange
Hedenstierna, G; Rothen, HU
Comprehensive Physiology, 2(1): 69-96.
Nitrous Oxide or Nitrogen Effect
Dawson, JS; Hardman, JG
Anesthesiology, 108(3): 540.
PDF (238) | CrossRef
Pulmonary Atelectasis: A Pathogenic Perioperative Entity
Duggan, M; Kavanagh, BP
Anesthesiology, 102(4): 838-854.

PDF (1160)
Continuous Positive Airway Pressure via the Boussignac System Immediately after Extubation Improves Lung Function in Morbidly Obese Patients with Obstructive Sleep Apnea Undergoing Laparoscopic Bariatric Surgery
Neligan, PJ; Malhotra, G; Fraser, M; Williams, N; Greenblatt, EP; Cereda, M; Ochroch, EA
Anesthesiology, 110(4): 878-884.
PDF (238) | CrossRef
Current Opinion in Anesthesiology
Oxygen in neonatal anesthesia: friend or foe?
Sola, A
Current Opinion in Anesthesiology, 21(3): 332-339.
PDF (144) | CrossRef
Current Opinion in Critical Care
Respiratory complications after major surgery
Ferreyra, G; Long, Y; Ranieri, VM
Current Opinion in Critical Care, 15(4): 342-348.
PDF (132) | CrossRef
European Journal of Anaesthesiology (EJA)
Ventilatory management during routine general anaesthesia
Hans, GA; Sottiaux, TM; Lamy, ML; Joris, JL
European Journal of Anaesthesiology (EJA), 26(1): 1-8.
PDF (164) | CrossRef
European Journal of Anaesthesiology (EJA)
Vital capacity manoeuvre in general anaesthesia: useful or useless?
Oczenski, W; Schwarz, S; Fitzgerald, RD
European Journal of Anaesthesiology (EJA), 21(4): 253-259.

PDF (1029)
European Journal of Anaesthesiology (EJA)
The influence of perioperative oxygen concentration on postoperative lung function in moderately obese adults
Zoremba, M; Dette, F; Hunecke, T; Braunecker, S; Wulf, H
European Journal of Anaesthesiology (EJA), 27(6): 501-507.
PDF (329) | CrossRef
European Journal of Anaesthesiology (EJA)
Intermittent manual positive airway pressure for the treatment and prevention of atelectasis
Schulz-Stübner, S; Rickelman, J
European Journal of Anaesthesiology (EJA), 22(9): 730-732.
PDF (56) | CrossRef
Back to Top | Article Outline

© 2003 American Society of Anesthesiologists, Inc.

Publication of an advertisement in Anesthesiology Online does not constitute endorsement by the American Society of Anesthesiologists, Inc. or Lippincott Williams & Wilkins, Inc. of the product or service being advertised.

Article Tools