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Anesthesiology:
Clinical Investigations

Differential Effects of Propofol and Sevoflurane on Heart Rate Variability

Kanaya, Noriaki M.D., Ph.D.*; Hirata, Naoyuki M.D.†; Kurosawa, Saori M.D.†; Nakayama, Masayasu M.D., Ph.D.‡; Namiki, Akiyoshi M.D., Ph.D.§

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Abstract

Background: Propofol is reported to reduce both sympathetic and parasympathetic tone; however, it is not clear whether the changes in heart rate variability are associated with depth of anesthesia. The purposes of the present study were (1) to evaluate the changes in heart rate variability at different depths of hypnosis and (2) to compare the effects of propofol on heart rate variability with that of sevoflurane.
Methods: Thirty patients were randomly allocated into the propofol or sevoflurane for induction of anesthesia. The depth of hypnosis was monitored by the Bispectral Index (BIS). Spectral analysis of heart rate variability using a maximum-entropy method resulted in a characteristic power spectrum with two main regions, a high frequency (HF) and a low frequency (LF). Hemodynamics, entropy, LF, HF, and LF/HF were monitored when the patients were awake and after induction of anesthesia.
Results: Both propofol and sevoflurane decreased blood pressure in a BIS-dependent manner, whereas heart rate showed no significant changes during the study period. In the propofol group, entropy and HF decreased with a reduction in the BIS value. Although LF decreased after induction of anesthesia, propofol caused no further decrease in LF in spite of a reduction in the BIS value. In the sevoflurane group, LF decreased with a reduction in the BIS value. Entropy and HF decreased after induction of anesthesia (BIS at 80); however, no further decreases were observed in spite of a reduction in the BIS value.
Conclusions: Induction of anesthesia with propofol decreased blood pressure, entropy, and HF in a BIS-dependent manner, indicating that propofol reduces cardiac parasympathetic tone depending on the depth of hypnosis. Conversely, sevoflurane did not show the BIS-dependent decreases in heart rate, blood pressure, HF, and entropy, indicating that sevoflurane has little or no effect on cardiac parasympathetic tone.
PROPOFOL is now widely used in clinical practice because of its favorable recovery profile and low incidence of side effects. 1 However, induction of anesthesia with propofol is often associated with a significant decrease in arterial blood pressure and heart rate (HR). 2,3 The hypotensive effect of propofol has been attributed to a decrease in systemic vascular resistance 1,4 or in cardiac output 5 caused by a combination of venous and arterial vasodilation, 4,6 impaired baroreflex mechanisms, 7,8 and depression of myocardial contractility. 9 Although an inhibition of the sympathetic nervous system may explain all the propofol-induced hemodynamic changes, 6,7 the precise mechanism by which this may occur is unknown. If propofol reduces cardiac sympathetic nerve activity, it would cause a decrease in HR. However, induction of anesthesia with propofol resulted in relatively large reductions in peripheral sympathetic nerve activity and blood pressure in spite of an increase in HR in humans. 7,8 In addition, prophylactic anticholinergics did not prevent profound bradycardia and asystole with the use of propofol in healthy adult patients. 3,10,11 These findings suggest that propofol may have differential effects on the peripheral and cardiac autonomic nervous systems.
Spectral analysis of heart rate variability (HRV) is a widely used, noninvasive technique to assess autonomic indexes of neural cardiac control. 12–15 The presence of low-frequency (LF) and high-frequency (HF) oscillatory rhythms in the variability of the R-R interval (RRI) is well established. To date, it is believed that LF is mediated by the parasympathetic and sympathetic systems, whereas HF is mediated primarily by the parasympathetic system.
Although there is general agreement that induction of anesthesia with propofol is associated with a reduction in HRV, 16–18 there are some conflicting data regarding the effects of propofol on cardiac sympathetic or parasympathetic tone. Deutschman et al.16 examined the changes in HRV under propofol anesthesia in 10 women undergoing laparoscopy. They observed a significant reduction in total, LF, and HF power after propofol. Addition of opioids and muscle relaxants resulted in further reductions in total and LF, but not HF, power. They concluded that propofol anesthesia reduces parasympathetic tone to a lesser degree than sympathetic tone, resulting in parasympathetic dominance. In contrast, Galletly et al.17 reported that induction of anesthesia with propofol resulted in a greater reduction in HF power than LF power. Similar results were observed after induction of anesthesia with a bolus injection of propofol. 18 The later two reports indicate that propofol anesthesia reduces parasympathetic tone greater than sympathetic tone. At least two factors might be responsible for these conflicting results. First, analysis of HRV is a study of the spontaneous, seemingly random fluctuations about some mean value that are always present when HR is measured on a beat-to-beat basis, even in subjects in a “quiet state.” Interpreting information contained in such seemingly chaotic signals is most often provided by mathematical analyses in the time domain, in the frequency domain, or as a measure of entropy. 12–15 Thus, differences in methods for analyzing HRV may be responsible for these conflicting results. Second, lack of information concerning the depth of anesthesia may present difficulty in interpreting the results. Because HRV is controlled under the central nervous system, the depth of anesthesia should be considered to estimate the effects of anesthetics on HRV.
Therefore, the first goal of this study was to test the hypothesis that propofol anesthesia would affect HRV depending on the depth of hypnosis. To assess the depth of hypnosis, we used the Bispectral Index (BIS®; Aspect Medical Systems, Inc., Newton, MA), a single composite electroencephalogram measure, which is widely accepted to track electroencephalographic changes associated with different anesthetic states. 19,20 We used the MemCalc method, 21–24 a combination of the maximum-entropy method for spectral analysis and the nonlinear least squares method for fitting analysis, to assess the HRV. This enabled us to achieve a reliable analysis of HRV over a minimum interval of 30 s.
Sevoflurane is a volatile anesthetic agent with a low blood–gas solubility (0.6). Sevoflurane is now widely used for its desirable properties of rapid induction and emergence and quick control of anesthetic depth. 25 It is noteworthy that sevoflurane also has been shown to decrease sympathetic nerve activity in rabbits and appears to reduce myocardial contractility. 26,27 However, in humans, sevoflurane has little or no effect on peripheral sympathetic nerve activity. 28 In contrast, we have reported that ephedrine-induced increase in HR was abolished under sevoflurane anesthesia. 29 Because ephedrine acts via activation of sympathetic nervous system, our results indicate sevoflurane may have some effects on sympathetic or parasympathetic nerve tone. To our knowledge, published human studies have not examined HRV during sevoflurane anesthesia. Thus, a second goal of the present research was to evaluate the effect of sevoflurane induction on HRV and to compare it with that of propofol.
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Materials and Methods

The Institutional Ethics Committee at Sapporo Medical University (Sapporo, Japan) approved this study, and all patients granted their written informed consent. The authors studied 30 patients (American Society of Anesthesiologists physical status class I) scheduled for elective oral surgery. Patients were excluded if they suffered from severe ischemic heart disease, congestive heart failure, diabetes mellitus, or other disorders known to affect autonomic function. None of the patients was taking medications that affect cardiovascular function.
Each patient fasted for at least 11 h prior to testing. On arrival to the operating room, standard monitoring and a BIS® monitor were employed. BIS (version 3.4) was measured continuously on an electroencephalogram monitor (Model A1050; Aspect Medical Systems, Natick, MA) using BisSensor strips (Aspect Medical Systems). The strips consisted of three pregelled electrodes, two active and one ground. The impedance of each electrode was maintained at less than 2 KΩ. Patients were studied while supine. HR was monitored from leads II and V5 of the electrocardiogram. An 18-gauge catheter was inserted into a forearm vein and used for fluid and drug administration. Each subject received 10 ml/kg saline before initiation of the study. The inspired oxygen and end-tidal concentrations of carbon dioxide and sevoflurane were measured continuously with a calibrated infrared gas analyzer. Before induction of anesthesia, patients were randomized to one of two groups by use of flipping a coin. All patients received 100% oxygen via face mask for 2 to 3 min prior to induction of general anesthesia, and control recordings were obtained from patients lying quietly in the supine position and breathing spontaneously. In the propofol group, patients received propofol infusion at a rate of 300 μg · kg−1 · min−1. In the sevoflurane group, anesthesia was induced with 5% sevoflurane in oxygen. Arterial oxygen saturation (Spo2) and end-tidal carbon dioxide (ETco2) were monitored, and normoventilation was maintained with gentle IPPV via mask if required. In our preliminary experiment, the BIS decreased gradually after induction of anesthesia in both anesthesia regimens. However, the minimum value of BIS did not reached to 20. Therefore, the hemodynamic and HRV measurements were performed at BIS values of 80, 60, 40, and 30.
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Heart Rate Variability Measurements
Equation U2
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Equation 1
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The fast peaks of R waves on the electrocardiogram were detected, and RRI was measured. The RRI data were analyzed by the maximum-entropy method with high resolution (MemCalc; Suwa Trust, Tokyo, Japan), as described previously. 21–24 In brief, in the program of MemCalc, a time series is assumed to be composed of underlying variation and fluctuating parts; the underlying variation is expressed as the function xuv(t), which can be given by a linear combination of sine and cosine functions where fn is the frequency of the nth component, an and bn are the amplitudes of the nth periodic component, Np is the total number of components, and a0 is a constant that indicates the mean value of the time series. The value of fn is determined by the peaks in the power spectral density. Its estimate, P(f), can be expressed as MATH where Pm is the output power of the prediction error filter of the order m, and γm,k is the corresponding filter coefficient, m = 0, 1, 2, …, M (M = optimum filter order). Pm and γm are determined by Yule-Walker equations using Burg's algorithm. Ohtomo and Tanaka 21 demonstrated that equation 1 gives a basis for determining the filter order, and the optimum order should be determined by the condition; the filter order is > 1/fmin, where fmin is the minimum among the central frequencies of the components. In this program, the filter order was much higher than those obtained from the first minima of conventional information criteria. 30 MemCalc does not cause distortion of the power calculation even if the underlying variation is changed. 30
For real-time analysis of HRV, the data on RRI were obtained through on-line computer analysis with 2-ms sampling intervals. The powers of the RRI (ms2) with LF (0.04–0.15 Hz) and HF (0.15–0.5 Hz) bands were calculated. LF/HF in RRI variability was also assessed. In addition, in the program of MemCalc, an entropy was calculated from pulse time series of 4 RRI. HRV is expressed as randomness of pulse interval. Thus, entropy is expressed as percentage from 0% (pulse series of regular interval, no variability) to 100% (maximal randomness, such as noise).
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Data Analysis
Data are expressed as mean ± SD. Mean blood pressure (MBP) was calculated as diastolic blood pressure (DBP) + 1/3 × (systolic blood pressure [SBP] − DBP). Changes in LF and HF were expressed as percent change from baseline (awake) values. LF/HF and entropy were expressed as percentages. We decided that a 10% difference in percentage changes of HRV parameters relative to baseline between the groups would be important. Therefore, n = 15 patients in each group would be necessary to detect such a difference if α = 0.05 and β = 0.1. Continuous variables were analyzed using analysis of variance, and the chi-square test was used for descriptive (categorical) variables. Bonferroni correction was used for multiple comparisons between groups and for repeated comparisons over time. P values less than 0.05 were considered statistically significant.
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Results

Table 1
Table 1
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Table 2
Table 2
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The two study groups were comparable with respect to age, weight, height, and sex (table 1). Baseline values of SBP, DBP, MBP, and HR in awake patients were similar in the both groups (table 2). BIS values at the awake state were 97 ± 2 and 96 ± 3 in the propofol and sevoflurane groups, respectively. Time from induction of anesthesia to BIS values of 30 were 9 ± 2 and 9 ± 3 min in the propofol and sevoflurane groups, respectively.
Administration of propofol resulted in a significant reduction in SBP, DBP, and MBP in a BIS-dependent manner; however, induction of anesthesia with propofol had no significant effect on HR (table 2). In the sevoflurane group, HR did not show any significant change throughout the study period. The inhalation via mask of 5% sevoflurane resulted in a significant reduction in MBP at a BIS value of 80, and no further reduction in MBP has been seen at the lower BIS values. Although propofol anesthesia tended to cause a further hemodynamic depression as compared to sevoflurane anesthesia, there were no significant differences in MBP and HR between the propofol and sevoflurane groups.
Fig. 1
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Fig. 2
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Fig. 3
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Fig. 4
Fig. 4
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Changes in HRV parameters during anesthetic induction with propofol or sevoflurane are depicted in figures 1–4. Figure 1 shows the changes in LF during anesthetic induction with propofol or sevoflurane. After administration of propofol, LF showed no significant change from its baseline value except for a transient reduction at BIS value of 60. In contrast, LF markedly decreased after sevoflurane inhalation, and it reached to approximately 40% of baseline value at BIS value of 80. LF further decreased to approximately 20% of baseline value when BIS became 60; however, no further reduction has been seen at the lower BIS values. Figure 2 shows the changes in HF during anesthetic induction with propofol or sevoflurane. HF significantly decreased after propofol administration in a BIS-dependent manner. In contrast, sevoflurane inhalation did not cause any significant changes in HF. Figure 3 shows the changes in entropy during anesthetic induction with propofol or sevoflurane. Propofol anesthesia caused a significant decrease in entropy in a BIS-dependent manner, whereas sevoflurane anesthesia caused a transient decrease in entropy only at the BIS value of 80. Figure 4 shows the changes in LF/HF during anesthetic induction with propofol or sevoflurane. Propofol anesthesia tended to increase LF/HF in a BIS-dependent manner; however, a statistically significance was obtained only at the lowest BIS value. In contrast, sevoflurane anesthesia showed basically no effect on LF/HF except for a transient decrease at the BIS value of 40.
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Discussion

The major findings of this study were as follows: (1) Induction of anesthesia with propofol was associated with significant decreases in BP, HF or entropy in a BIS-dependent manner, whereas propofol anesthesia basically had no effects on HR or LF. (2) In contrast to propofol, inhalation of sevoflurane via mask was associated with decreases in BP or LF independent of the changes in BIS, and sevoflurane anesthesia did not show any significant effects on HR or HF. (3) Both propofol and sevoflurane anesthesia had little effect on LF/HF, except that at the lower BIS values, propofol anesthesia tended to increase LF/HF, whereas sevoflurane tended to decrease LF/HF.
The concept of entropy, as it applies to signals like RRI, is to quantify the repetition of patterns in that signal. Larger values of entropy correspond to greater apparent randomness or irregularity, whereas smaller values correspond to more instances of recognizable patterns in the data. The entropy calculations, here applied to beat-to-beat HR, can be shown to obliquely provide a positively correlated barometer of the extent of complication of an underlying network model in many diverse systems, with larger values implying a more complex feedback or feedforward system. 31 In fact, the entropy of RRI is reported to reflect parasympathetic modulation of HR under varying physiologic conditions and in response to pharmacological denervation. 14 This is consistent with our finding that changes in entropy were directionally similar to changes in HF.
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Effects of Propofol on Heart Rate Variability
Because the autonomic nervous system, especially the sympathetic nervous system, plays an major role in regulating cardiovascular homeostasis, knowledge of how anesthetic agents modify sympathetic activity is important for understanding subsequent cardiovascular responses. Propofol is known to cause a reduction in BP and HR in humans, and inhibition of sympathetic nerve activity is believed as one major mechanism underlying the propofol-induced hemodynamic depression. 6,7 In a study measuring the peripheral sympathetic nerve activity, propofol anesthesia is reported to reduce muscle sympathetic nerve activity and renal sympathetic nerve activity in humans and rabbits, respectively. 7,32 These results indicate that propofol anesthesia reduces sympathetic nerve activity. However, the effect of propofol on parasympathetic nerve activity has not been studied well.
In the present study, propofol anesthesia caused a reduction in HF but not in LF, indicating rapid sequence induction of anesthesia with propofol might reduce a cardiac parasympathetic tone more than sympathetic tone. Similar results were observed after induction of anesthesia with propofol in humans. 17,18 Galletly et al.17 examined the effect of intravenous propofol anesthesia (2 mg/kg followed by a infusion of 0.17 mg · kg−1 · min−1) on HRV using a fast Fourier transform. Although they observed a single time point for comparison with the awake state, total spectral power decreased (−53%) after anesthesia induction with propofol, while individual component periodicities were affected differently. The reduction in LF power (−33%, P = 0.053) was significantly less than that of midfrequency (−65%) and HF (−62%) power. Therefore, the ratio of spectral power showed a shift toward LF in the HRV spectrum, suggesting sympathetic dominance. Scheffer et al.18 investigated the effects of thiopentone, etomidate, and propofol on beat-to-beat HR and blood pressure fluctuations in 35 unpremedicated female patients. They observed changes in HRV after a bolus injection of 4 mg/kg thiopentone, 2.5 mg/kg propofol, or 0.3 mg/kg etomidate. Propofol decreased HF (−62%) without significant change in LF, suggesting sympathetic dominance. In contrast, thiopentone decreased both LF (−46%) and HF (−59%), and etomidate had no effect. Their results clearly indicate that propofol, thiopentone, and etomidate show differences in their effects on HRV. These findings concerning the effects of propofol on HRV are in reasonably good agreement with our present results.
Anesthesia with propofol is sometimes associated with bradycardia; however, the mechanism underlying this is not known. Because the autonomic nervous system plays an important role in regulating HR, propofol might induce bradycardia by altering the relative activities of the sympathetic and parasympathetic components. Deutshchman et al.16 examined the effects of propofol anesthesia on HRV in female patients scheduled for laparoscopic surgery. They observed that induction of anesthesia with propofol was associated with a significant reduction in total, LF, and HF power. Maintenance of anesthesia with propofol resulted in further reductions in total and LF, but not HF, power. They speculate that propofol anesthesia reduces parasympathetic tone to a lesser degree than sympathetic tone, developing to bradycardia. However, several points should be discussed to resolve the question. First, induction and maintenance of anesthesia with propofol did not cause a reduction in HR in their study, indicating a discrepancy between HR and autonomic tone. Similarly, in our present results, propofol anesthesia caused a reduction in HF, but not in LF, without significant change in HR. HRV is a measure of an end-organ response to peripheral and central neural centers that both produce and respond to HR and blood pressure oscillations. Anesthetics that may disrupt integrative processes of the central nervous system or communication between the central nervous system and the end organ or the direct effects of anesthetics on the end organ itself will obviously affect changes in how the end organ responds and the measurement of it. Therefore, interpretation of HRV data must consider (1) the ability of the end organ to respond appropriately to neural regulation, (2) the ability of the two respective neural rhythms (sympathetic and vagal) to arrive at the heart, and (3) the ability of the neural regulatory centers to receive and integrate information from peripheral receptors. Such multifactors might be associated with lack of correlation between HR and autonomic tone. In addition, the fact that induction of anesthesia with propofol caused larger decreases in muscle sympathetic nerve activity and blood pressure, indicating a decrease in peripheral sympathetic nerve activity, with a small increase in HR, indicating a decrease in cardiac parasympathetic nerve activity, in humans 7,8 support our HRV data. However, the direct negative chronotropic effect of propofol 33 may offset an increase in HR response to HRV in the present study.
Second, a lack of information about the depth of anesthesia might cause misinterpretation of the results because they observed HRV at just after and after 5 min of propofol administration. Because they administered a 2.5-mg/kg intravenous bolus of propofol followed by an infusion at a rate of 150 μg · kg−1 · min−1, the depth of anesthesia should be lightening during the anesthesia. In fact, HF and entropy decreased in a BIS-dependent manner in our results. Third, propofol may decrease HR via its direct effect on heart. In animal experiments, propofol exerts a negative inotropic and chronotropic effect. 9,33 Recently, the negative chronotropic effect of propofol is reported to be mediated in part by M2-acetylcholine receptor activation, which involves the enhancement of nitric oxide production in cultured rat ventricular myocytes. 33 Although the differences in species may exist, the ineffectiveness of prophylactic anticholinergics and inadequate response to atropine on propofol-induced bradycardia support this idea. 3,10,11 Therefore, it is unlikely that changes in autonomic tone are the sole reason for modulation of HRV resulting in bradycardia during propofol anesthesia.
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Effects of Sevoflurane on Heart Rate Variability
Although sevoflurane is widely used for its favorable property of low blood–gas solubility that permits more rapid induction and emergence from anesthesia and more rapid control of anesthetic depth, 25 little is known about the effects of sevoflurane on HRV. However, it can be speculated that sevoflurane has little or no effect on HRV because of its mild cardiovascular depression. Several studies have examined the effects of sevoflurane on the autonomic nervous system by means of measuring sympathetic nerve activity or baroreflex sensitivity as an alternative to measuring HRV. 28,34 In humans, sevoflurane attenuates baroreflex control of HR. 34 Because sevoflurane attenuated both pressor and depressor baroreflex sensitivities, both sympathetic- and vagal nerve–mediated reflex would be attenuated. In the present study, sevoflurane attenuated the LF without any significant effects in HF and entropy, indicating sevoflurane may inhibit sympathetic nerve activity without any significant changes in parasympathetic nerve activity. Differences in autonomic nervous tone during the study period would explain the differences in the effect of sevoflurane on sympathetic or parasympathetic nerve activities. Our results showed the direct effects of anesthetics on HRV, i.e., static side of the autonomic nervous system. In contrast, the effects of anesthetics on the baroreflex showed the dynamic side of autonomic nervous system–mediated responses. Therefore, it is not surprising that sevoflurane showed different effects between HRV and baroreflex. In fact, sevoflurane has been reported to have different effects on spontaneous efferent renal sympathetic nerve activity and the baroreceptor-sympathetic reflex in rabbits. 26 Although differences in species should be considered to interpret the findings to humans, the idea supports our findings and helps us to understand the differences.
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Limitations
We recognize several limitations of our study. First, we did not measure sympathetic and parasympathetic nerve activity per se. Although HRV is a widely used, noninvasive technique to assess autonomic indexes of neural cardiac control, the changes in HRV might not reflect the effects of anesthetics on the autonomic nervous system but on the reflex arc. In fact, baroreflex function and the autonomic nervous system are influenced by various physiologic and pathophysiologic factors, 15 including sex, 35 age, 36 hypothermia, 37 and preexisting cardiopulmonary diseases. 36,38 However, there is no alternative method to assess the effects of the autonomic nervous system on the cardiovascular system in vivo. Second, anesthesia-induced changes in respiratory rate and tidal volume should influence HRV. The HF component of HRV has been known to result from respiratory-related vagal modulation of HR, and the amplitude has been demonstrated to correlate with cardiac vagal tone. 15 However, it has also been recognized that the amplitude decreases with respiratory frequency and increases with tidal volume. 39–41 The respiratory influence on RRI fluctuations in the 0.01- to 0.05-Hz range has been associated with tidal volume changes and is considered to be a sign of instability of the ventilatory chemoreceptor feedback mechanisms. 15,42 Because the intrathoracic pressure changes are relatively low, the direct mechanical transfer of tidal volume oscillations to the heart rate fluctuations was not taken into consideration. 39,41 Therefore, we might underestimate the effects of anesthetics on HRV if the induction of anesthesia resulted in decreases in respiratory rate and tidal volume. In the present study, we tried to maintain steady state respiration to minimize the influences on HRV. Third, it was uncertain whether the equal depth of anesthesia was achieved at the same BIS value between propofol and sevoflurane anesthesia. Although BIS has been found to be an effective measure of depth of sedation with propofol, midazolam, isoflurane, and sevoflurane, 19,20,43 the BIS demonstrates significant variability among the anesthetics. To date, the precise mechanism underlying these variations in BIS is not known. Moreover, there is no convincing evidence that the BIS value was independent of the depth of anesthesia in our present study. Therefore, we believe that the gradual decreases in the BIS values correlated with the depth of anesthesia during propofol and sevoflurane anesthesia.
In summary, propofol decreased HF and entropy rather than LF in the BIS-dependent manner, indicating that cardiac parasympathetic nerve would be inhibited to a greater degree than sympathetic nerve during induction of anesthesia with propofol. Therefore, it is unlikely that propofol-mediated bradycardia is due to cardiac parasympathetic nerve stimulation. Conversely, sevoflurane maintains hemodynamics, HF, and entropy, indicating that sevoflurane has little or no effect on cardiac parasympathetic tone.
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