The Upper Respiratory Tract Infection (URI) Dilemma: Fear of a Complication or Litigation?
Coté, Charles J. M.D.
EVERY day, each of us faces the dilemma of the child with an upper respiratory tract infection (URI), and we must decide whether to proceed or postpone the procedure and how long to postpone it. The decision often rests on our individual comfort level in managing predictable complications as well as our comfort level with the potential for litigation should an adverse outcome occur. In this issue of Anesthesiology, Tait et al.1
provide further insight into this dilemma. They conclude that “children with active and recent URIs (within 4 weeks) are at increased risk for adverse respiratory events” but that “with careful management, most of these children can undergo elective procedures safely without increased morbidity.”
How does the practitioner sort out the science and doing what is right for the patient versus
fear of lawyers? Reported adverse respiratory events include bronchospasm, laryngospasm, airway obstruction, postintubation croup, desaturation, 2–9
and anecdotal reports of atelectasis, pneumonia, and even death. 10–12
One of these URI-associated deaths was in reality related to unrecognized myocarditis, and the other was likely caused by inadequate monitoring and premature extubation. 11,12
Several, as the study by Tait et al.
, found an increased risk in children passively exposed to smoke. 1,5,13
No studies are completely free of bias in terms of preselecting the population studied, i.e.
, sending patients deemed to be at increased risk home to recuperate. No controlled study has demonstrated increased mortality.
Every anesthesiologist knows that airway-related events are increased. The greatest problem with the literature is that there is no single definition for a URI. Additionally, there is no uniformity regarding the types and duration of surgical procedures, types of airway instrumentation, or preferred choice of anesthetic agents for the child with a URI. Risk for a specific patient is unknown. The study by Tait et al. provides guidance for children with mild URI symptoms as well as those who have had a URI within the previous 4 weeks. The strength of the study is that specific anesthetic management was left to the discretion of the anesthesia team.
Children with a URI present with a broad spectrum of signs and symptoms. We have those with fever, purulent rhinitis, productive cough, and rhonchi. This cohort is easy—“canceled.” Another cohort is those in whom symptoms develop a day or two before the elective procedure. The parents call the surgeon the night before, surgery is canceled, and then they return 2 weeks later with minimal or no symptoms. Alternatively, a conversation with the family clarifies the severity of the symptoms, and a decision is made to reevaluate the child the morning of surgery. Most children fall in the middle, i.e., they have had a URI for days or even weeks, and they are stable or improving.
The study by Tait et al.
excluded patients deemed to be ill and some who became ill just before elective surgery. It included primarily patients who had a recent URI and those with a URI. The diagnosis of a URI required only two symptoms and confirmation by a parent. I agree that the easiest way to make the diagnosis is to ask. Parents can tell us if the child is better, worse, or improving. Most of the patients studied by Tait et al.
had what I consider a very mild URI; most anesthesiologists would have proceeded because in the winter, nearly half our population has these symptoms. 14
The decision to cancel a procedure should not be made lightly because the mother, the father, or both, took the day off from work and the economic consequences for the family are great. It is of most interest that the children with a recent URI fared as well as those with an acute URI. Delaying a procedure will not significantly change the incidence of adverse respiratory events. Little is gained except to create inconvenience for the family, the surgeon, and the surgical schedule.
It is not surprising that Tait et al.
found airway instrumentation to be associated with adverse respiratory events because an irritated airway is further irritated by a foreign body, hence, a reduced incidence with face mask or laryngeal mask airway. 1,15,16
Association with airway procedures is also not a surprise because airway manipulation occurs. 3
The association with copious secretions and nasal congestion makes the obvious connection that the more symptomatic children are those most likely to have more events. History of prematurity as a risk factor was a new observation but also is not a surprise because many of these children have some degree of bronchopulmonary dysplasia and thus have long-term pulmonary dysfunction and a tendency to airway reactivity. 17,18
It is of interest that Tait et al.
did not find an increased incidence of bronchospasm 2,9
; if strict criteria, such as altered carbon dioxide wave form, had been used, I suspect there would have been a difference. We also do not know how many received prophylactic bronchodilator therapy before anesthesia, nor do we know whether the use of atropine to block vagally mediated bronchoconstriction or the airway irritant effects of secretions would have made any difference. 19,20
The association with passive smoke exposure confirms the observations of other studies. 5,21
This is important because it places some responsibility on the parents.
What is the take-home message? Most children with mild URIs can be safely managed without the need to postpone surgery. Postponing does not reduce the incidence of adverse respiratory events if anesthesia is administered within 4 weeks of the URI. Airway hyperreactivity may require 6 or more weeks to heal, implying that a longer wait may be required. 22
One study reported no increased risk in patients who had had a URI within the previous 6 weeks. 5
Another study demonstrated that nearly 2,000 procedures would have to be canceled to prevent 15 cases of laryngospasm. 8
Does it make economic and practical sense to families to cancel this many cases to prevent an easily treatable problem occurring in a minority of patients?
If one examines the causes of pediatric cardiac arrest and death during anesthesia, the majority relate to anesthetic overdose, drug reactions, and underlying congenital heart disease or malformations. Inadequate ventilation, in particular laryngospasm, accounted for 9 of 150 cardiac arrests, 8 of which occurred at the time of induction; none were reported to have been associated with a URI, and all these patients were successfully resuscitated. 23
Likewise, in the closed claims studies of adults and children, no cases were reported to have been associated with URIs. 24–26
My conclusion is that anesthesia is safe and without significant morbidity and virtually no mortality in the majority of children with mild to moderate active URIs and those who have had a recent URI. Over the years, I have reviewed a number of malpractice cases in which the first thing the lawyer looks at is whether the child had symptoms of a URI. To associate bad outcome with any trivial symptom of a URI is ludicrous. Adverse events occur with anesthesia; generally, a bad outcome is caused by lack of experience with a particular age group or lack of timely recognition of the event or appropriate decisions to intervene and rescue the patient. The anesthesia community around the world anesthetizes thousands of children with varying degrees of URIs safely and without significant morbidity every day. We have the technology to deal with reasonably foreseeable complications. We have muscle relaxants to relieve laryngospasm, we have bronchodilators and inhalation agents to treat bronchospasm, we have laryngeal mask airways to avoid intubation in appropriate cases, and we have oxygen to treat hypoxemia. Children who are obviously ill and scheduled to undergo elective surgery should have their surgeries postponed until they are better if only for humane reasons, i.e.
, so they do not have the double effects of a systemic illness, coughing, and the pain of a surgical incision. Of greater concern are reports of deaths during anesthesia in children with unknown myocarditis. 27–31
I am much more frightened that someday I will be one of the unlucky ones to anesthetize the child with a URI who also has unknown viral myocarditis. There is nothing any of us can do to avoid such situations because even postponing these patients’ surgeries a few weeks is unlikely to alter the risk for fatal arrhythmias.
Anecdotally, the worst cases of laryngospasm that I have seen were induced with desflurane, 32
and the worst case of bronchospasm occurred in a child with anaphylaxis; neither had a URI. I believe that despite all the studies, all we can say regarding children with URIs is yes, there is an increased risk for laryngospasm, bronchospasm, desaturation, and postintubation croup. Yes, these are more likely if someone in the child’s home smokes. No, waiting may not significantly reduce these risks unless we wait 4–6 weeks or longer. Yes, the child will likely have another URI by then if it is wintertime. Yes, I will provide the safest anesthesia possible for your child. Yes, I can reduce the risk for these complications because I will tailor my anesthetic prescription (e.g.
, propofol instead of thiopental, laryngeal mask airway or face mask instead of an endotracheal tube if appropriate, albuterol in the operating room, and so forth) around the child’s needs and the needs for the surgical procedure, but I cannot reduce that risk to zero. Yes, these same complications can occur even when the child does not have a URI. Yes, administration of anesthesia is risky and occasionally associated with unpredictable responses to anesthetic drugs.
We are left with our best clinical judgment about an individual patient undergoing a specific procedure for a specific duration of time by a specific surgeon that requires endotracheal intubation that may or may not involve admission to the hospital who also has or has had a recent URI and, by the way, whose grandparents have flown across the country and both parents (smokers) have taken a day off work. Good judgment, common sense, clinical experience, and informed consent always take precedence in making the decision to proceed with a specific case. As for the lawyers, I always make a note in the record that these issues have been discussed with both the surgeon and the family and that everyone has been informed of the risks and has agreed to proceed.
1. Tait AR, Malviya S, Voepel-Lewis T, Munro HM, Siewert M, Pandit UA: Risk factors for perioperative adverse respiratory events in children with upper respiratory tract infections. A nesthesiology 2001; 95: 299–306
2. Olsson GL: Bronchospasm during anaesthesia: A computer-aided incidence study of 136,929 patients. Acta Anaesthesiol Scand 1987; 31: 244–52
3. Koka BV, Jeon IS, Andre JM, MacKay I, Smith RM: Postintubation croup in children. Anesth Analg 1977; 56: 501–5
4. Cohen MM, Cameron CB: Should you cancel the operation when a child has an upper respiratory tract infection? Anesth Analg 1991; 72: 282–8
5. Parnis SJ, Barker DS, van der Walt JH: Clinical predictors of anaesthetic complications in children with respiratory tract infections. Paediatr Anaesth 2001; 11: 29-40
6. Olsson GL, Hallen B: Laryngospasm during anaesthesia: A computer-aided incidence study in 136,929 patients. Acta Anaesthesiol Scand 1984; 28: 567–75
7. DeSoto H, Patel RI, Soliman IE, Hannallah RS: Changes in oxygen saturation following general anesthesia in children with upper respiratory infection signs and symptoms undergoing otolaryngological procedures. A nesthesiology 1988; 68: 276–9
8. Schreiner MS, O’Hara I, Markakis DA, Politis GD: Do children who experience laryngospasm have an increased risk of upper respiratory tract infection? A nesthesiology 1996; 85: 475–80
9. Rolf N, Coté CJ: Frequency and severity of desaturation events during general anesthesia in children with and without upper respiratory infections. J Clin Anesth 1992; 4: 200–3
10. McGill WA, Coveler LA, Epstein BS: Subacute upper respiratory infection in small children. Anesth Analg 1979; 58: 331–3
11. Jones AG: Anaesthetic death of a child with a cold (letter). Anaesthesia 1993; 48: 642
12. Konarzewski WH, Ravindran N, Findlow D, Timmis PK: Anaesthetic death of a child with a cold. Anaesthesia 1992; 47: 624
13. Skolnick ET, Vomvolakis MA, Buck KA, Mannino SF, Sun LS: Exposure to environmental tobacco smoke and the risk of adverse respiratory events in children receiving general anesthesia. A nesthesiology 1998; 88: 1144–53
14. Fennelly ME, Hall GM: Anaesthesia and upper respiratory tract infections: A non-existent hazard? Br J Anaesth 1990; 64: 535–6
15. Ferrari LR, Goudsouzian NG: The use of the laryngeal mask airway in children with bronchopulmonary dysplasia. Anesth Analg 1995; 81: 310–3
16. Tait AR, Pandit UA, Voepel-Lewis T, Munro HM, Malviya S: Use of the laryngeal mask airway in children with upper respiratory tract infections: A comparison with endotracheal intubation. Anesth Analg 1998; 86: 706–11
17. Jacob SV, Coates AL, Lands LC, MacNeish CF, Riley SP, Hornby L, Outerbridge EW, Davis GM, Williams RL: Long-term pulmonary sequelae of severe bronchopulmonary dysplasia. J Pediatr 1998; 133: 193–200
18. Baraldi E, Filippone M, Trevisanuto D, Zanardo V, Zacchello F: Pulmonary function until two years of life in infants with bronchopulmonary dysplasia. Am J Respir Crit Care Med 1997; 155: 149–55
19. Empey DW, Laitinen LA, Jacobs L, Gold WM, Nadel JA: Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am Rev Respir Dis 1976; 113: 131–9
20. Gross NJ, Skorodin MS: Anticholinergic, antimuscarinic bronchodilators. Am Rev Respir Dis 1984; 129: 856–70
21. Mainwaring RD, Capparelli E, Schell K, Acosta M, Nelson JC: Pharmacokinetic evaluation of triiodothyronine supplementation in children after modified Fontan procedure. Circulation 2000; 101: 1423–9
22. Empey DW: Effect of airway infections on bronchial reactivity. Eur J Resp Dis 1983; 128 (suppl): 366–8
23. Morray JP, Geiduschek JM, Ramamoorthy C, Haberkern CM, Hackel A, Caplan RA, Domino KB, Posner K, Cheney FW: Anesthesia-related cardiac arrest in children: Initial findings of the Pediatric Perioperative Cardiac Arrest (POCA) Registry. A nesthesiology 2000; 93: 6–14
24. Morray JP, Geiduschek JM, Caplan RA, Posner KL, Gild WM, Cheney FW: A comparison of pediatric and adult anesthesia closed malpractice claims. A nesthesiology 1993; 78: 461–7
25. Cheney FW, Posner KL, Caplan RA: Adverse respiratory events infrequently leading to malpractice suits: A closed claims analysis. A nesthesiology 1991; 75: 932–9
26. Caplan RA, Posner KL, Ward RJ, Cheney FW: Adverse respiratory events in anesthesia: A closed claims analysis. A nesthesiology 1990; 72: 828–33
27. Tabib A, Loire R, Miras A, Thivolet-Bejui F, Timour Q, Bui-Xuan B, Malicier D: Unsuspected cardiac lesions associated with sudden unexpected perioperative death. Eur J Anaesthesiol 2000; 17: 230–5
28. Critchley LA: Yet another report of anesthetic death due to unsuspected myocarditis. J Clin Anesth 1997; 9: 676–7
29. Liberthson RR: Sudden death from cardiac causes in children and young adults. N Engl J Med 1996; 334: 1039–44
30. Smith NM, Bourne AJ, Clapton WK, Byard RW: The spectrum of presentation at autopsy of myocarditis in infancy and childhood. Pathology 1992; 24: 129–31
31. Fayon M, Gauthier M, Blanc VF, Ahronheim GA, Michaud J: Intraoperative cardiac arrest due to the oculocardiac reflex and subsequent death in a child with occult Epstein-Barr virus myocarditis. A nesthesiology 1995; 83: 622–4
32. Zwass MS, Fisher DM, Welborn LG, Coté CJ, Davis PJ, Dinner M, Hannallah RS, Liu LM, Sarner J, McGill WA, Alifimoff JK, Embree PB, Cook DR: Induction and maintenance characteristics of anesthesia with desflurane and nitrous oxide in infants and children. A nesthesiology 1992; 76: 373–8
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