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Anesthesiology:
Case Reports

Early Fat Embolism after Liposuction

Fourme, Thierry MD; Vieillard-Baron, Antoine MD; Loubieres, Yann MD; Julie, Catherine MD; Page, Bernard MD; Jardin, Francois MD

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FAT embolism syndrome (FES) is an uncommon and severe complication that occurs mainly in patients with long-bone fractures. This clinical syndrome includes acute respiratory failure, global neurologic dysfunction, and petechial rash following the precipitating event by 12 to 72 h. Nevertheless, one or more of these findings may be absent, making the diagnosis difficult to establish clinically, particularly after a surgical procedure such as liposuction. The authors report a case of isolated acute dyspnea early after liposuction.
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Case Report
A 29-yr-old woman who was a healthy ballet-dancer without previous significant medical history underwent suction lipectomy of the abdomen, hips, and trocanteric area. The operation was uneventful, removing a total of only 600 ml of fatty tissue. Anesthesia (which lasted 2 h) consisted of fentanyl, midazolam, propofol (loading dose of 2 mg/kg and then 5 mg [middle dot] kg (-1) [middle dot] h-1 infusion), and atracurium. There was no blood loss. Total volume of intravenous fluids intraoperatively and postoperatively were 1,500 ml, and urine output was 500 ml. Intraoperative oxygen saturations were 95-99%. One hour postoperatively, while breathing room air, the patient felt suddenly anxious and short of breath, oxygen saturation by pulse oximetry (SpO2) decreased from 93% to 82%, without hemodynamic change. A pulmonary embolism was eliminated immediately by pulmonary angiography. The patient was admitted to the intensive care unit for management and diagnosis. At examination, she was dyspneic, with a respiratory rate of 25 breaths/min, a blood pressure of 110/60 mmHg and a heart rate of 95 beats/min. Mental status was normal without focal neurologic signs. No petechiae was found. Lung auscultation revealed diffuse inspiratory rales. Temperature was 38.5 [degree sign]C. Arterial blood gas analysis while the patient was breathing 81 breaths/min of oxygen indicated that the pH was 7.44, arterial oxygen tension (PaO2) was 62 mmHg, arterial carbon dioxide tension (PaCO2) was 31 mmHg, and bicarbonate (HCO3 -) was 24 mM. Chest roentgenography showed diffuse bilateral pulmonary alveolointerstitial infiltrates. Electrocardiography was normal, with sinus tachycardia (95 beats/min). Doppler echocardiography was normal without right ventricular enlargement. Left ventricular ejection fraction was normal, and systolic pulmonary artery pressure was 27 mmHg. Computed tomography of the chest (Figure 1) revealed patchy bilateral ground glass densities, macronodular opacities, and alveolar consolidation without pleural effusion.
Figure 1
Figure 1
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Bronchoalveolar lavage, performed 15 h after (Figure 2), was hemorrhagic with 520 103/ml (59% macrophages, 27% neutrophils, 14% lymphocytes); 60% of the macrophages contained red fat droplets after staining with an Oil Red O stain. Protected minibronchoalveolar lavage samples were sterile on the culture.
Figure 2
Figure 2
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Serum total calcium and cholesterol concentrations were decreased to 2.02 mM and 3.5 mM, respectively. C reactive protein was increased to 30 mg/l (N < 10). Hemoglobin level was the same level before and after the procedure (11 g/dl) and there was no thrombocytopenia. Fundoscopic evaluation results were normal. No fat globules were found in the urine.
The patient's symptoms improved rapidly with trivial fluid support and supplementary oxygen. Results of chest radiography and blood gas analysis returned to normal within 2 days and allowed early hospital discharge on day 3. Subsequent chest computed tomography was normal 10 days after the acute event.
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Discussion
Fat embolism syndrome severity can vary from mild adult respiratory distress syndrome to profound refractory hypoxemia leading to coma and death. Rupture of vessels and damage to adipocytes allow microthombi of lipids to enter the venous circulation. After being trapped in the pulmonary capillaries and hydrolyzed by a pulmonary lipase, free fatty acids cause direct toxic damage of the microvascular and alveolocapillary units and subsequently cause release of vasoactive amines and prostaglandins. The histopathology of FES is characterized by interstitial edema, transudate, and later exudate in the alveoli, the death of type II pneumocytes, and hyaline membrane formation. [1]
Fat embolism syndrome is a well-known complication of traumatic injuries (1% to 35% after long-bone fractures [2,3]), cardiopulmonary resuscitation, or lipid infusion for parenteral feeding [4] but seems to be quite rare after liposuction, only five cases have been reported. [5,6,7,8,9] Of these five cases, four were suspected after evidence of adult respiratory distress syndrome with fever was seen, the fifth after transient, focal neurologic signs were noted after surgery. The latter was diagnosed during fundoscopic evaluation, others were diagnosed during autopsy, pulmonary arteriography, or chest radiography without further investigation. Four patients survived. This patient with FES underwent isolated liposuction without other combined procedures, as described in the other case reports. It does not agree with the assumption that FES after liposuction occurs only after time-consuming, multiple and combined procedures, such as mastopexie or abdominoplasty. [10]
The five reports plus ours emphasized the difficulty of making the diagnosis of FES postoperatively. Many of the diagnostic criteria are insensitive and may reflect response to trauma rather than fat embolism per se. The classic clinical triad occurs within 48 h in only 85% of patients, after a free interval of 12 - 30 h after injury. [11] In our patient, acute respiratory failure was isolated and occurred immediately after the procedure with concomitant infiltrates seen on the chest X-ray. This finding indicates that the inflammatory process might begin earlier than previously reported. It is consistent with experimental data that show that oleic acid-induced pulmonary edema occurs less than 1 h after injection. [12]
In patients with isolated respiratory symptoms, the presence of hypoxemia and pulmonary infiltrates are easily confused with other more commonly encountered problems, such as aspiration pneumonia, left ventricular overload with pulmonary edema, lung contusion, or massive transfusion. In the current case, normal echocardiography excluded heart failure, and sterile, protected minibronchoalveolar lavage eliminated sepsis. Moreover, the outcome was simple without specific therapy. To further establish the diagnosis of FES, bronchoalveolar lavage was performed, and contributed to the diagnosis.
This case report emphasizes that microscopic evaluation of cells obtained by bronchoalveolar lavage allows rapid identification of patients with FES. According to Chastre et al., [13] a cut-off point of 5% of cells containing fat droplets was the diagnosis of FES. In our patient, the high percentage (60%) of cells containing fat droplets contrasted with the limited surgical procedure. Nevertheless, no data are available concerning normal bronchoalveolar lavage fat stain after uneventful liposuction. Although Vedrinne et al. [14] reported that bronchoalveolar lavage is not a reliable method for diagnosis of FES and that many conditions are associated with fat droplets in alveolar macrophages (multiple organ failure, sepsis, trauma, neoplasia, lipid infusion, or hypertriglyceridemia), historic background, clinical pattern, and chest imaging results are highly suggestive of this diagnosis. We considered the liposuction to have caused this FES rather than the propofol, which has been described to be an explanation for lipid deposition, but only during long-term infusion. [15]
In conclusion, after liposuction, the incidence of FES might be underestimated because this diagnosis is not systematically considered and because the clinical pattern of FES often is not specific.
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REFERENCES
1. Shier MR, Wilson RF: Fat embolism syndrome: Traumatic coagulopathy with respiratory distress. Surg Annu 1980; 12:139-42

2. Chan KM, Than DT, Path MRC: Post-traumatic fat embolism: Its clinical and subclinical presentations. J Trauma 1984; 24:45-9

3. Bulger EM, Smith DG, Maier RV, Jurkovich GJ: Fat Embolism Syndrome. A ten-year review. Arch Surg 1997; 132:435-9

4. Hulman G: Pathogenesis of non-traumatic fat embolism. Lancet 1988; i:1366-7

5. Boezaart AP, Clinton CW, Braun S, Oettle C, Lee NP: Fulminant adult respiratory distress syndrome after suction lipectomy. S Afr Med J 1990; 78(11):693-5

6. Laub DR Jr, Laub DR: Fat embolism after liposuction: A case report and review of the literature. Ann Plast Surg 1990; 2:48-52

7. Christman KD: Death following suction lipectomy and abdominoplasty. Plast Reconstr Surg 1986; 78:428-30

8. Ross RM, Johnson GW: Fat embolism after liposuction. Chest 1988; 93:1294-5

9. Abbes M, Bourgeon Y: Case report of fat embolism after dermolipectomy and liposuction. Ann Chir Plast Esthet 1989; 34:160-1

10. Dillerud E: Abdominoplasty combined with suction lipoplasty: A study of complications, revisions, and risk factors in 487 cases. Ann Plast Surg 1990; 25:48-53

11. Gossling HR, Donohue TA: The fat embolism syndrome. JAMA 1979; 241:2740-2

12. Groosman RF, Jones JG, Murray JF: Effects of oleic acid-induced pulmonary edema on lung mechanics. J Appl Physiol 1980; 48:1045-51

13. Chastre J, Fagon J-Y, Soler P, Fichelle A, Dombret M-C, Huten D, Hance A, Gibert C: Bronchoalveolar lavage for rapid diagnosis of the fat embolism syndrom in trauma patients. Ann Intern Med 1990; 113:583-8

14. Vedrinne JM, Guillaume C, Gagnieu, Gratadour P, Fleuret C, Motin J: Bronchoalveolar lavage in trauma patients for diagnosis of fat embolism syndrome. Chest 1992; 102:1323-7

15. El-Ebiary, Torres A, Ramirez J, Xaubet A, Rodriguez-Roisin R: Lipid deposition during the long-term infusion of propofol. Crit Care Med 1995; 23:1928-30

Keywords:
Bronchoalveolar lavage; computed tomography of the chest; fat embolism syndrome; liposuction.

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